CN219016327U - Liquid path system of immunity quantitative analyzer - Google Patents

Liquid path system of immunity quantitative analyzer Download PDF

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Publication number
CN219016327U
CN219016327U CN202223594922.9U CN202223594922U CN219016327U CN 219016327 U CN219016327 U CN 219016327U CN 202223594922 U CN202223594922 U CN 202223594922U CN 219016327 U CN219016327 U CN 219016327U
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dilution
module
sample
cleaning
needle
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阳交凤
罗红艳
蔡建雄
李署程
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Shanghai I Reader Biological Technology Co ltd
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Shanghai I Reader Biological Technology Co ltd
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    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract

The application provides a liquid path system of an immunity quantitative analyzer, which relates to the technical field of clinical detection and comprises a puncture sample suction module, a first dilution module, a second dilution module, a cleaning module and a waste liquid discharge module which are connected with each other, wherein the puncture sample suction module and the cleaning module are respectively connected with a puncture needle, the first dilution module, the second dilution module and the cleaning module; puncturing the sample tube, sucking the sample from the sample tube, transferring the sample to a first dilution module or a second dilution module for dilution, and cleaning the puncture needle through a cleaning module after transferring; after the first dilution module or the second dilution module dilutes the sample, the sample sucking needle transfers the diluted sample from the first dilution module or the second dilution module to the sample pad, and the sample sucking needle, the first dilution module and the second dilution module are cleaned by the cleaning module after transferring; the waste liquid discharge module is communicated with the first dilution module, the second dilution module and the cleaning module and is used for discharging the cleaned waste liquid.

Description

Liquid path system of immunity quantitative analyzer
Technical Field
The application relates to the technical field of clinical detection, in particular to a liquid path system of an immunity quantitative analyzer.
Background
The point of care testing (POCT) has been widely used in the technical field of reagent testing at home and abroad because of its simple, convenient and rapid characteristics. The liquid path system of the immunity quantitative analyzer is taken as POCT, is based on antigen-antibody specific immune response, and provides real and accurate data basis for diagnosis, prevention, treatment and health monitoring of clinical diseases by detecting different items of samples. Because the concentration of the sample is too high, the sample is diluted manually in the past, and then the diluted sample is put into an instrument for testing, so that the operation and the operation are inconvenient, and the detection efficiency is low.
The liquid path system of the full-automatic immunity quantitative analyzer appears in the later market, and the detection flow is as follows: the puncture needle sucks the sample in the sample tube, the puncture needle transfers the sample to the dilution tank for dilution, and the puncture needle drops the diluted sample to the sample pad for detection. The whole sample sucking and diluting and mixing actions are completed by adopting a puncture needle, the next sample sucking can be performed after the whole process of one sample is completed, and when the samples are diluted and mixed, the puncture needle is in a waiting state for a long time, the detection time interval of adjacent samples can be increased, and when the samples are more, the overall detection efficiency is lower.
Disclosure of Invention
An object of the embodiment of the application is to provide a liquid path system of an immunity quantitative analyzer, which adopts a double-needle system to respectively realize puncture sample suction and diluted sample transfer, shortens waiting time between adjacent samples, and increases detection efficiency of high-flux samples.
In one aspect of the embodiments of the present application, a liquid path system of an immune quantitative analyzer is provided, including a puncture sample-sucking module, a first dilution module, a second dilution module, a cleaning module and a waste liquid discharging module that are connected to each other, where the puncture sample-sucking module and the cleaning module are respectively connected to a puncture needle, the first dilution module, the second dilution module and the cleaning module are respectively connected to a sample-sucking needle;
puncturing the sample tube, sucking the sample from the sample tube, transferring the sample to a first dilution module or a second dilution module for dilution, and cleaning the puncture needle through a cleaning module after transferring; after the first dilution module or the second dilution module dilutes the sample, the sample sucking needle transfers the diluted sample from the first dilution module or the second dilution module to the sample pad, and the sample sucking needle, the first dilution module and the second dilution module are cleaned by the cleaning module after transferring;
the waste liquid discharge module is communicated with the first dilution module, the second dilution module and the cleaning module and is used for discharging the cleaned waste liquid.
Optionally, a first microinjection pump communicated with the puncture needle is arranged on the puncture sample sucking module, and the first microinjection pump provides power for sucking the sample for the puncture needle.
Optionally, the first dilution module comprises a first dilution liquid barrel, a quantitative pump and a first dilution container which are sequentially communicated, after the sample is transferred to the first dilution container, the quantitative pump is used for drawing and sucking quantitative first dilution liquid from the first dilution liquid barrel, and the quantitative pump is used for injecting the first dilution liquid into the first dilution container to dilute the sample;
the second dilution module comprises a two-position two-way valve, a second microinjection pump and a second dilution container which are sequentially communicated, and also comprises a second dilution liquid barrel, wherein the second microinjection pump is communicated with the sample sucking needle; the first channel of the two-position two-way valve is communicated with the second micro-injection pump, when the sample sucking needle moves into the second diluent barrel, the second micro-injection pump is used for sucking quantitative second diluent by the sample sucking needle, the sample sucking needle moves into the second diluent container, and the second diluent is injected into the second diluent container from the sample sucking needle by the second micro-injection pump for sample dilution.
Optionally, the first dilution module further comprises a bubble sensor arranged between the dosing pump and the first dilution vessel, the bubble sensor being for detecting bubbles on the pipeline.
Optionally, the cleaning module comprises a puncture needle cleaning module, the puncture needle cleaning module comprises a first two-position three-way valve and a first diaphragm pump which are communicated, and further comprises a cleaning liquid barrel, a second channel of the first two-position three-way valve is communicated with a swab through an outer wall cleaning branch pipe, and the swab is communicated with the puncture needle so as to clean the outer wall of the puncture needle; the first channel of the first two-position three-way valve is communicated with a first microinjection pump, and the first microinjection pump is communicated with the puncture needle through an inner wall cleaning branch pipe so as to clean the inner wall of the puncture needle.
Optionally, the cleaning module further comprises a sample suction needle cleaning module, and the sample suction needle cleaning module comprises a two-position two-way valve and a second microinjection pump which are communicated with the second diaphragm pump; the second channel of the two-position two-way valve is connected with a second microinjection pump, and the second microinjection pump is connected with the sample sucking needle through an inner wall cleaning branch pipe so as to clean the inner wall of the sample sucking needle.
Optionally, the cleaning module comprises a dilution container cleaning module, the dilution container cleaning module comprises a third diaphragm pump and a second two-position three-way valve which are sequentially communicated with the cleaning liquid barrel, and a first channel of the second two-position three-way valve is connected with a first cleaning liquid inlet of the first dilution container so as to clean the first dilution container; the second channel of the second two-position three-way valve is connected with the second cleaning liquid inlet of the second dilution container so as to clean the second dilution container.
Optionally, the waste liquid discharging module comprises a dilution waste liquid module and a puncture needle waste liquid module, the dilution waste liquid module is communicated with the first dilution module and the second dilution module, and the puncture needle waste liquid module is communicated with the cleaning module.
Optionally, the dilution waste liquid module comprises a waste liquid barrel and a third two-position three-way valve, the waste liquid port of the first dilution container is communicated with the waste liquid barrel through a first channel of the third two-position three-way valve, and the waste liquid port of the second dilution container is communicated with the waste liquid barrel through a second channel of the third two-position three-way valve.
Optionally, the puncture needle waste liquid module comprises a fourth diaphragm pump and a fifth diaphragm pump which is communicated with the first dilution container and the waste liquid barrel, and the fifth diaphragm pump is also communicated with the third two-position three-way valve first channel; the waste liquid barrel is communicated with the puncture needle through a fourth diaphragm pump so as to discharge the outer wall cleaning waste liquid of the puncture needle; injecting the inner wall cleaning waste liquid of the puncture needle into the first dilution container, and injecting the waste liquid into the waste liquid barrel through a fifth diaphragm pump; the cleaning waste liquid on the inner wall of the sample suction needle is injected into the second dilution container and is communicated with the waste liquid barrel through the second channel of the third two-position three-way valve.
The liquid path system of the immunity quantitative analyzer adopts a double-needle system, a puncture needle and a sample sucking needle are respectively provided with sample puncture and sample sucking functions, and samples are transferred to a first dilution module or a second dilution module for dilution; the sample suction needle transfers the diluted sample from the first dilution module or the second dilution module to the sample pad. The liquid path system comprises a puncture sample sucking module, a first dilution module, a second dilution module, a cleaning module and a waste liquid discharging module which are connected with each other, and a puncture needle sucks a sample from a sample tube and transfers the sample to the first dilution module or the second dilution module; after the sample is diluted in the first dilution module or the second dilution module, the sample sucking needle transfers the diluted sample from the first dilution module or the second dilution module to the sample pad; meanwhile, the cleaning module cleans the puncture needle, the sample suction needle, the first dilution module and the second dilution module after one-time operation is completed, so that cross infection is avoided in the next operation, and the cleaned waste liquid is discharged through the waste liquid discharge module after the cleaning is completed. After the puncture needle transfers the sample to the first dilution module or the second dilution module, the puncture needle finishes cleaning and returns to the sample position for next sample puncture and sample suction. The sample does not need to be diluted and uniformly mixed; when the previous sample is diluted and mixed uniformly in the first dilution module or the second dilution module, the sample sucking needle moves to the position above the first dilution module or the second dilution module, and after the sample is diluted and mixed uniformly, the sample sucking needle sucks the diluted sample and transfers the diluted sample to a sample pad for detection; when the sample is transferred by the sample sucking needle, the first dilution module or the second dilution module is cleaned, and then the puncture needle transfers the next sample into the dilution container, so that the sample sucking needle reciprocates to finish detection. Thus, by arranging the double-needle system, the waiting time between adjacent samples is shortened, and the detection efficiency of high-flux samples is improved. In addition, the first dilution module and the second dilution module can perform dilution with different proportions so as to meet different project requirements.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments of the present application will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and should not be considered as limiting the scope, and other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic diagram of a liquid path system of an immunoassay analyzer according to the present embodiment.
Icon: 1-a first diluent barrel; 2-a cleaning liquid barrel; 3-a waste liquid barrel; 4-a bubble sensor; 5-fourth diaphragm pump; 6-a first diaphragm pump; 7-a constant delivery pump; 8-a third diaphragm pump; 9-a second diaphragm pump; 10-a fifth diaphragm pump; 11-a second two-position three-way valve; 12-a third two-position three-way valve; 13-a filter; 14-a first dilution vessel; 15-a second dilution vessel; 16-two-position two-way valve; 17-a first two-position three-way valve; 18-puncture needle; 19-swab; 20-a sample sucking needle; 21-a second diluent tank; 22-a second microinjection pump; 23-a first microinjection pump; 141-a first diluent inlet; 142-a first cleaning liquid inlet; 143-a waste liquid port; 151-a second cleaning liquid inlet; 152-a waste liquid port; 191-swab liquid inlet; 192-swab outlet.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application.
In the description of the present application, it should be noted that, the azimuth or positional relationship indicated by the terms "inner", "outer", etc. are based on the azimuth or positional relationship shown in the drawings, or the azimuth or positional relationship that is commonly put when the product of the application is used, are merely for convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element to be referred to must have a specific azimuth, be configured and operated in a specific azimuth, and therefore should not be construed as limiting the present application. Furthermore, the terms "first," "second," and the like, are used merely to distinguish between descriptions and should not be construed as indicating or implying relative importance.
It should also be noted that the terms "disposed," "coupled," and "connected" are to be construed broadly, and may be, for example, fixedly coupled, detachably coupled, or integrally coupled, unless otherwise specifically defined and limited; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the terms in this application will be understood by those of ordinary skill in the art in a specific context.
Referring to fig. 1, an embodiment of the present application provides a liquid path system (hereinafter referred to as liquid path system) of an immune quantitative analyzer, including: the puncture sample sucking module, the first dilution module, the second dilution module, the cleaning module and the waste liquid discharging module are connected with each other, and the puncture sample sucking module and the cleaning module are respectively connected with the puncture needle 18, the first dilution module, the second dilution module and the cleaning module and are respectively connected with the sample sucking needle 20; the puncture needle 18 punctures the sample tube and sucks the sample from the sample tube, the sample is transferred to the first dilution module or the second dilution module to be diluted, and the puncture needle 18 is cleaned through the cleaning module after the sample is transferred; after the first dilution module or the second dilution module dilutes the sample, the sample sucking needle 20 transfers the diluted sample from the first dilution module or the second dilution module to the sample pad, and the sample sucking needle 20, the first dilution module and the second dilution module are cleaned by the cleaning module after transferring; the waste liquid discharge module is communicated with the first dilution module, the second dilution module and the cleaning module and is used for discharging the cleaned waste liquid.
The puncture sample suction module, the first dilution module, the second dilution module, the cleaning module and the waste liquid discharge module are mutually connected to form a liquid path system. Wherein the fluid path system connects the lancet 18 and the aspiration needle 20 to form a two-needle system. The puncture needle 18 punctures the sample tube according to a set time sequence to release negative pressure in the sample tube, the puncture needle 18 then sucks quantitative samples from the sample tube, the samples are conveyed to the first dilution module or the second dilution module according to a set process flow to be diluted, and the sample suction needle 20 transfers the diluted samples to the sample pad according to the set process flow to be detected.
The first dilution module and the second dilution module are used for diluting the sample, and dilution with different proportions can be performed in the first dilution module and the second dilution module respectively according to test items required by the sample.
From the foregoing, it will be appreciated that in this application, the lancet 18 need only transfer the sample from the sample tube to either the first dilution module or the second dilution module; the sample sucking needle 20 only needs to transfer the diluted sample from the first dilution module or the second dilution module to the sample pad; the lancet 18 and the aspiration needle 20 each perform only one transfer task. After the puncture needle 18 finishes the first sample transfer, the puncture needle 18 is cleaned by a cleaning module, so that the puncture needle 18 can perform the second sample transfer; meanwhile, the sample is diluted in the first dilution module or the second dilution module, and when the sample is transferred by the sample suction needle 20, the puncture needle 18 can simultaneously transfer the sample for the second time, so that the puncture needle 18 can directly return to the sample position to puncture and suck the next sample after transferring the sample to the first dilution module or the second dilution module and cleaning, and the sample dilution and uniform mixing are not required to be waited; when the previous sample is diluted and mixed uniformly in a dilution container (the dilution container of the first dilution module or the dilution container of the second dilution module), the sample sucking needle 20 moves to the upper part of the dilution container according to a set flow, and after the sample is diluted and mixed uniformly, the sample sucking needle 20 sucks the diluted sample and transfers the diluted sample to a sample pad for detection. At this point the wash module washes the dilution vessel, the pipette tip 20, and the lancet 18 transfers the next sample into the dilution vessel. By arranging the double-needle system, the waiting time between adjacent samples is shortened, and the detection efficiency of high-flux samples is improved.
After the cleaning is finished, the waste liquid after the cleaning of the first dilution module, the second dilution module and the sample suction needle 20 is discharged through the waste liquid discharge module, so that the next use is convenient, and the cross infection is avoided.
Therefore, the liquid path system of the immunity quantitative analyzer provided by the embodiment of the application adopts a double-needle system, namely the puncture needle 18 and the sample suction needle 20, the puncture needle 18 provides sample puncture and sample suction functions, and the sample is transferred into the first dilution module or the second dilution module for dilution; the sample-sucking needle 20 transfers the diluted sample from the first dilution module or the second dilution module onto the sample pad. The liquid path system comprises a puncture sample sucking module, a first dilution module, a second dilution module, a cleaning module and a waste liquid discharging module which are connected with each other, and the puncture needle 18 sucks a sample from the sample tube and transfers the sample to the first dilution module or the second dilution module; after the sample to be measured is diluted in the first dilution module or the second dilution module, the sample suction needle 20 transfers the diluted sample to the sample pad from the first dilution module or the second dilution module; meanwhile, the cleaning module cleans the puncture needle 18, the sample suction needle 20, the first dilution module and the second dilution module after one operation is completed, so that cross infection is avoided in the next operation, and the cleaned waste liquid is discharged through the waste liquid discharging module after the cleaning is completed. After the lancet 18 transfers the sample to the first dilution module or the second dilution module, the lancet 18 completes the cleaning and returns to the sample site for the next sample lancing and aspiration. The sample does not need to be diluted and uniformly mixed; when the previous sample is diluted and mixed uniformly in the first dilution module or the second dilution module, the sample sucking needle 20 moves to the position above the first dilution module or the second dilution module, and after the sample is diluted and mixed uniformly, the sample sucking needle 20 sucks the diluted sample and transfers the diluted sample to a sample pad for detection; when the sample is transferred from the sample-sucking needle 20, the first dilution module or the second dilution module is cleaned, and then the puncture needle 18 transfers the next sample to the dilution vessel, so that the sample is reciprocally moved to complete the detection. Thus, by arranging the double-needle system, the waiting time between adjacent samples is shortened, and the detection efficiency of high-flux samples is improved. In addition, the first dilution module and the second dilution module can perform dilution with different proportions so as to meet different project requirements.
Specifically, a first microinjection pump 23 communicated with the puncture needle 18 is arranged on the puncture sample sucking module, and the first microinjection pump 23 provides power for sucking samples for the puncture needle 18.
The puncture needle 18 is to puncture the sample tube and suck the sample from the sample tube, and after the sucking is completed, the sample is moved to the position above the first dilution module or the second dilution module, and the sample is released into the first dilution module or the second dilution module, and in this process, the power for sucking the sample by the puncture needle 18 is provided by the first microinjection pump 23. While the power of the lancet 18 to puncture the sample tube and to move between the sample tube and either the first dilution module or the second dilution module is provided by the mechanical structure, the power of the movement of the pipette 20 is also provided by the mechanical structure. For example, the movement of the puncture needle 18 and the sample suction needle 20 can be realized by a driver such as a motor, and the power for the puncture needle 18 to puncture the sample tube is provided, and the part is not in the present liquid path system, so that the description is omitted herein, and the conventional arrangement is referred to.
When a sample is transferred to the first dilution module or the second dilution module through the puncture needle 18 to be diluted, the first dilution module comprises a first dilution liquid barrel 1, a quantitative pump 7 and a first dilution container 14 which are sequentially communicated, specifically, after the sample is transferred to the first dilution container 14 through the puncture needle 18, a quantitative first dilution liquid is drawn and sucked from the first dilution liquid barrel 1 through the quantitative pump 7, and the quantitative pump 7 sucks and injects the first dilution liquid into the first dilution container 14 to dilute the sample.
The second dilution module comprises a two-position two-way valve 16, a second microinjection pump 22 and a second dilution container 15 which are communicated in sequence, and also comprises a second dilution liquid barrel 21, wherein the second microinjection pump 22 is communicated with a sample sucking needle 20; the first channel of the two-position two-way valve 16 is communicated with the second micro-injection pump 22 so that the sample sucking needle 20 moves into the second diluent barrel 21, the second micro-injection pump 22 is used for drawing out the fixed amount of the second diluent, the sample sucking needle 20 is controlled to move into the second diluent container 15 through a motor or a driver, and the second diluent is injected into the second diluent container 15 from the sample sucking needle 20 through the pushing of the second micro-injection pump 22 for sample dilution.
In one implementation of the present application, the first dilution vessel 14 has a larger volume than the second dilution vessel 15, that is, the first dilution vessel 14 can dilute a greater amount of sample. Therefore, when diluting the sample in the first dilution vessel 14, the first diluent is transferred to the first dilution vessel 14 by the constant displacement pump 7 and diluted and mixed with the sample; the second dilution container 15 has a smaller dilution amount, so that the pipette tip 20 can be used directly to transfer the second diluent into the second dilution container 15 for dilution and mixing with the sample.
The dosing pump 7 is respectively communicated with the first diluent barrel 1 and the first diluent inlet 141 and is used for sucking and injecting the first diluent to provide assistance for sucking the first diluent and injecting the liquid into the first diluent container 14; the first dilution module further comprises a bubble sensor 4 arranged between the dosing pump 7 and the first dilution vessel 14, the bubble sensor 4 being arranged to detect bubbles on the line. The second microinjection pump 22 is connected to the sample-sucking needle 20, and provides power for the sample-sucking needle 20 to draw the second diluent from the second diluent barrel 21 and push the second diluent into the second diluent container 15.
For the cleaning module, the cleaning module comprises a puncture needle 18 cleaning module, wherein the puncture needle 18 cleaning module comprises a first two-position three-way valve 17 and a first diaphragm pump 6 which are communicated, and further comprises a cleaning liquid barrel 2, a second channel of the first two-position three-way valve 17 is communicated with a swab 19 through an outer wall cleaning branch pipe, and the swab 19 is communicated with the puncture needle 18 to clean the outer wall of the puncture needle 18; the first channel of the first two-position three-way valve 17 is connected with the first diaphragm pump 6 and is communicated with the puncture needle 18 through the inner wall cleaning branch pipe through the first micro-injection pump 23, the first micro-injection pump 23 does not work, and the first diaphragm pump 6 provides power to clean the inner wall of the puncture needle 18.
Specifically, when the first diaphragm pump 6 works, the second channel of the first two-position three-way valve 17 is opened, cleaning liquid reaches the liquid inlet of the swab 19 through the outer wall cleaning branch pipe, and the outer wall of the puncture needle 18 is cleaned through the upward and downward movement of the puncture needle 18; the first channel of the first two-position three-way valve 17 is opened, and the cleaning liquid in the cleaning liquid barrel 2 is injected into the inner wall of the puncture needle 18 from the top end of the puncture needle 18 through the inner wall cleaning branch pipe to clean the inner wall of the puncture needle 18. This completes the cleaning of the puncture needle 18 from inside to outside.
The cleaning module further comprises a sample sucking needle 20 cleaning module, wherein the sample sucking needle 20 cleaning module comprises a two-position two-way valve 16 and a second microinjection pump 22 which are communicated with the second diaphragm pump 9; the second channel of the two-position two-way valve 16 is connected with a second microinjection pump 22, and the second microinjection pump 22 is connected with the sample sucking needle 20 through an inner wall cleaning branch pipe; when the first diaphragm pump 6 works, the second channel of the two-position two-way valve 16 is opened, and cleaning liquid in the cleaning liquid barrel 2 is injected into the inner wall of the sample suction needle 20 from the top end of the sample suction needle 20 through the inner wall cleaning branch pipe to clean the inner wall of the sample suction needle 20.
The cleaning module comprises a dilution container cleaning module, wherein the dilution container cleaning module comprises a third diaphragm pump 8 and a second two-position three-way valve 11 which are sequentially communicated with the cleaning liquid barrel 2, and a first channel of the second two-position three-way valve 11 is connected with a first cleaning liquid inlet 142 of the first dilution container 14 so as to clean the first dilution container 14; the second passage of the second two-position three-way valve 11 is connected to the second cleaning liquid inlet 151 of the second dilution vessel 15 to clean the second dilution vessel 15.
When the third diaphragm pump 8 works, the first channel of the second two-position three-way valve 11 is opened, and the cleaning liquid in the cleaning liquid barrel 2 is injected into the first dilution container 14 from the first cleaning liquid injection port for cleaning; the second channel of the second two-position three-way valve 11 is opened, and the cleaning liquid is injected into the second dilution vessel 15 from the second cleaning liquid inlet 151 for cleaning. As can be seen, the diaphragm pump is used to aspirate and inject the cleaning fluid.
After the cleaning is finished, waste liquid is discharged; the waste liquid discharging module comprises a dilution waste liquid module and a puncture needle 18 waste liquid module, wherein the dilution waste liquid module is communicated with the first dilution module and the second dilution module, and the puncture needle 18 waste liquid module is communicated with the cleaning module.
Specifically, the dilution waste liquid module comprises a waste liquid barrel 3 and a third two-position three-way valve 12, and the third two-position three-way valve 12 is respectively communicated with a first dilution container 14 and a second dilution container 15; the waste liquid port 143 of the first dilution vessel 14 is connected to the waste liquid tank 3 through the first passage of the third two-position three-way valve 12, and the waste liquid port 152 of the second dilution vessel 15 is connected to the waste liquid tank 3 through the second passage of the third two-position three-way valve 12.
After the first dilution vessel 14 is diluted, the waste liquid after washing is washed by the washing module, flows out from the waste liquid port 143 of the first dilution vessel 14, and flows into the waste liquid barrel 3 through the first channel of the third two-position three-way valve 12; similarly, after the second dilution vessel 15 is diluted, the waste liquid after washing is washed by the washing module, flows out from the waste liquid port 152 of the second dilution vessel 15, and flows into the waste liquid tank 3 through the second channel of the third two-position three-way valve 12.
The puncture needle 18 waste liquid pipeline is communicated with the waste liquid barrel 3, the fourth diaphragm pump 5, the swab 19 and the puncture needle 18; specifically, the puncture needle 18 waste liquid module comprises a fourth diaphragm pump 5 and a fifth diaphragm pump 10 which is communicated with the first dilution container 14 and the second dilution container 15, and the fifth diaphragm pump 10 is also communicated with a first channel of the third two-position three-way valve 12; the waste liquid barrel 3 is communicated with the puncture needle 18 through a fourth diaphragm pump 5 so as to discharge the outer wall cleaning waste liquid of the puncture needle 18; the inner wall cleaning waste liquid of the puncture needle 18 is injected into the first dilution vessel 14 and into the waste liquid tank 3 through the fifth diaphragm pump 10; the waste cleaning solution on the inner wall of the sample suction needle 20 is injected into the second dilution vessel 15 and is communicated with the waste liquid barrel 3 through the second channel of the third two-position three-way valve 12.
When the fourth diaphragm pump 5 works, the outer wall cleaning waste liquid of the puncture needle 18 is injected into the waste liquid barrel 3 from the swab liquid outlet 192; the inner wall cleaning waste liquid of the puncture needle 18 is injected into the first dilution container 14, and the inner wall cleaning waste liquid of the sample suction needle 20 is injected into the second dilution container 15; when the fifth diaphragm pump 10 works, the first channel of the third two-position three-way valve 12 is opened, and the waste liquid in the first dilution container 14 is injected into the waste liquid barrel 3 through the filter 13 and then through the fifth diaphragm pump 10.
In summary, the control process of the liquid path system is as follows:
sample dilution: different proportions of dilution are performed in the first dilution vessel 14 and the second dilution vessel 15, respectively, depending on the test items required for the sample. When the sample is diluted in the first dilution container 14, the first dilution liquid is injected into the first dilution container 14 by drawing and pushing the fixed displacement pump 7, and the first dilution liquid and the sample are uniformly mixed; when the sample is diluted in the second dilution vessel 15, the second diluent is injected into the second dilution vessel 15 by the second microinjection pump 22 and the pipette tip 20, and the sample and the diluent are mixed uniformly. After the dilution is completed, the pipette tip 20 transfers the diluted sample from the first dilution container 14 or the second dilution container 15 to a sample pad for detection.
The puncture needle 18 and the aspiration needle 20 are cleaned: the first channel of the first two-position three-way valve 17 is controlled to be opened, and the first diaphragm pump 6 works to clean the inner wall of the puncture needle 18; the first diaphragm pump 6 works by controlling the opening of the second channel of the first two-position three-way valve 17, and the outer wall of the puncture needle 18 is cleaned by communicating the swab liquid inlet 191. The second diaphragm pump 9 works to clean the inner wall of the sample-sucking needle 20 by controlling the second channel on the two-position two-way valve 16 to be opened.
And (3) cleaning a dilution container: the third diaphragm pump 8 works, and the first channel or the second channel of the second two-position three-way valve 11 is controlled to be opened to clean the first dilution container 14 or the second dilution container 15 respectively.
And (3) discharging waste liquid: the fourth diaphragm pump 5 is started, and the waste cleaning liquid on the outer wall of the puncture needle 18 is discharged through the swab liquid outlet 192; the fifth diaphragm pump 10 works, and the first channel or the second channel of the third two-position three-way valve 12 is controlled to be opened respectively to discharge waste liquid in the first dilution container 14 or the second dilution container 15, and the filter 13 filters impurities in the waste liquid and discharges the filtered impurities, so that damage to the fifth diaphragm pump 10 of the pipeline is prevented.
The foregoing is merely exemplary embodiments of the present application and is not intended to limit the scope of the present application, and various modifications and variations may be suggested to one skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims (10)

1. A fluid path system for an immunoassay quantitative analyzer, comprising: the puncture sample sucking module, the first dilution module, the second dilution module, the cleaning module and the waste liquid discharging module are connected with each other, and the puncture sample sucking module and the cleaning module are respectively connected with a puncture needle (18), the first dilution module, the second dilution module and the cleaning module and are respectively connected with a sample sucking needle (20);
the puncture needle (18) punctures a sample tube and sucks a sample from the sample tube, the sample is transferred to the first dilution module or the second dilution module to be diluted, and the puncture needle (18) is cleaned through the cleaning module after the sample is transferred; after the first dilution module or the second dilution module dilutes the sample, the sample sucking needle (20) transfers the diluted sample from the first dilution module or the second dilution module to a sample pad, and the sample sucking needle (20), the first dilution module and the second dilution module are cleaned through the cleaning module after transferring;
the waste liquid discharge module is communicated with the first dilution module, the second dilution module and the cleaning module and is used for discharging the cleaned waste liquid.
2. The liquid path system of an immunoassay quantitative analyzer according to claim 1, wherein the puncture sample-sucking module is provided with a first microinjection pump (23) in communication with the puncture needle (18), and the first microinjection pump (23) provides power for sucking a sample to the puncture needle (18).
3. The liquid path system of the quantitative immunity analyzer according to claim 2, wherein the first dilution module comprises a first dilution liquid barrel (1), a quantitative pump (7) and a first dilution container (14) which are communicated in sequence, and after a sample is transferred to the first dilution container (14), the quantitative pump (7) pumps and draws quantitative first dilution liquid from the first dilution liquid barrel (1), and the quantitative pump (7) injects the first dilution liquid into the first dilution container (14) for sample dilution;
the second dilution module comprises a two-position two-way valve (16), a second microinjection pump (22) and a second dilution container (15) which are communicated in sequence, and also comprises a second dilution liquid barrel (21), wherein the second microinjection pump (22) is communicated with the sample suction needle (20); the first channel of the two-position two-way valve (16) is communicated with the second micro injection pump (22), when the sample sucking needle (20) moves into the second diluent barrel (21), the second micro injection pump (22) is used for sucking a fixed amount of second diluent by the sample sucking needle (20), the sample sucking needle (20) moves into the second diluent container (15), and the second diluent is injected into the second diluent container (15) from the sample sucking needle (20) through the second micro injection pump (22) for sample dilution.
4. A liquid path system of an immunoassay quantitative analyzer according to claim 3, wherein the first dilution module further comprises a bubble sensor (4) disposed between the quantitative pump (7) and the first dilution vessel (14), the bubble sensor (4) being for detecting bubbles on a pipeline.
5. A liquid path system of an immunoassay quantitative analyzer according to claim 3, wherein the cleaning module comprises a puncture needle (18) cleaning module, the puncture needle (18) cleaning module comprises a first two-position three-way valve (17) and a first diaphragm pump (6) which are communicated, and further comprises a cleaning liquid barrel (2), a second channel of the first two-position three-way valve (17) is communicated with a swab (19) through an outer wall cleaning branch pipe, and the swab (19) is communicated with the puncture needle (18) to clean the outer wall of the puncture needle (18); the first channel of the first two-position three-way valve (17) is communicated with the first microinjection pump (23), and the first microinjection pump (23) is communicated with the puncture needle (18) through an inner wall cleaning branch pipe so as to clean the inner wall of the puncture needle (18).
6. The liquid path system of the quantitative immunity analyzer according to claim 5, wherein the cleaning module further comprises a sample sucking needle (20) cleaning module, and the sample sucking needle (20) cleaning module comprises a two-position two-way valve (16) and a second micro injection pump (22) which are communicated with the second diaphragm pump (9); the second channel of the two-position two-way valve (16) is connected with the second micro injection pump (22), and the second micro injection pump (22) is connected with the sample sucking needle (20) through the inner wall cleaning branch pipe so as to clean the inner wall of the sample sucking needle (20).
7. The liquid path system of an immunoassay quantitative analyzer according to claim 5, wherein the washing module comprises a dilution vessel washing module comprising a third diaphragm pump (8) and a second two-position three-way valve (11) which are sequentially communicated with the washing liquid barrel (2), wherein a first channel of the second two-position three-way valve (11) is connected with a first washing liquid inlet (142) of the first dilution vessel (14) to wash the first dilution vessel (14); the second channel of the second two-position three-way valve (11) is connected with a second cleaning liquid inlet (151) of the second dilution container (15) so as to clean the second dilution container (15).
8. A liquid pathway system of an immunoassay quantitative analyzer according to claim 3, wherein said waste discharge module comprises a dilution waste module and a spike (18) waste module, said dilution waste module being in communication with said first dilution module and said second dilution module, said spike (18) waste module being in communication with said cleaning module.
9. The liquid path system of an immunoassay quantitative analyzer according to claim 8, wherein the diluted waste liquid module comprises a waste liquid tank (3), a third two-position three-way valve (12), a waste liquid port (143) of the first dilution container (14) is communicated with the waste liquid tank (3) through a first passage of the third two-position three-way valve (12), and a waste liquid port (152) of the second dilution container (15) is communicated with the waste liquid tank (3) through a second passage of the third two-position three-way valve (12).
10. The liquid path system of an immunoassay quantitative analyzer according to claim 9, wherein the lancet (18) waste liquid module comprises a fourth membrane pump (5) and a fifth membrane pump (10) communicating the first dilution vessel (14) and the waste liquid tank (3), the fifth membrane pump (10) further communicating a third two-position three-way valve (12) first channel; the waste liquid barrel (3) is communicated with the puncture needle (18) through the fourth diaphragm pump (5) so as to discharge the outer wall cleaning waste liquid of the puncture needle (18); the waste cleaning liquid on the inner wall of the puncture needle (18) is injected into the first dilution container (14) and is injected into the waste liquid barrel (3) through the fifth diaphragm pump (10); the waste liquid from cleaning the inner wall of the sample sucking needle (20) is injected into the second dilution container (15) and is injected into the waste liquid barrel (3) through the second channel of the third two-position three-way valve (12) for communication.
CN202223594922.9U 2022-12-30 2022-12-30 Liquid path system of immunity quantitative analyzer Active CN219016327U (en)

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Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
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