CN215641281U - Liquid path system of biological sample detection analyzer and biological sample detection analyzer - Google Patents
Liquid path system of biological sample detection analyzer and biological sample detection analyzer Download PDFInfo
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- CN215641281U CN215641281U CN202121171746.0U CN202121171746U CN215641281U CN 215641281 U CN215641281 U CN 215641281U CN 202121171746 U CN202121171746 U CN 202121171746U CN 215641281 U CN215641281 U CN 215641281U
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Abstract
The utility model discloses a liquid path system of a biological sample detection analyzer and the biological sample detection analyzer, wherein the liquid path system of the biological sample detection analyzer comprises a sampling module and a cleaning module, the sampling module comprises a sampling needle and a sample suction plunger pump, the cleaning module comprises a swab, a pure water barrel, a cleaning liquid barrel, a cleaning pool and a waste liquid barrel, an upper end outlet of the sampling needle is connected with an upper end port of the sample suction plunger pump, a cleaning liquid pipeline is connected between lower end ports of the cleaning liquid barrel and the sample suction plunger pump, a first three-way valve and a pure water plunger pump are arranged between a liquid inlet end of the swab and the pure water barrel, three ports of the first three-way valve are respectively connected with an outlet of the pure water barrel, a liquid inlet end of the swab and an upper end port of the pure water plunger pump, an outlet end of the swab and the waste liquid barrel are connected through the waste liquid pipeline, a second three-way valve is arranged on the waste liquid pipeline, and three ports of the second three-way valve are respectively connected with an outlet of the cleaning pool, The liquid outlet end of the swab is connected with the inlet of the waste liquid pool.
Description
Technical Field
The utility model relates to a liquid path system of a biological sample detection analyzer and the biological sample detection analyzer, belonging to the technical field of medical diagnosis sample detection equipment.
Background
The blood detection of complex components is an important analysis field, and because various components in blood are complex, a layering phenomenon can occur after long-term storage, particularly peripheral blood samples; when analyzing the concentration of the blood sample components, the samples need to be effectively mixed and then correspondingly tested. In order to ensure the accuracy and repeatability of the analysis results, an efficient blending method is generally applied to an analysis instrument. In order to ensure the effects of uniform mixing and cleaning in the prior art, a liquid path system in an analytical instrument is very complex, the failure rate is high, and the production cost is also high. The analyzer in the prior art can only quantitatively suck samples and quantitatively dilute, so the technical defect that the sample amount and the diluent amount are fixed exists.
Disclosure of Invention
The utility model aims to provide a liquid path system of a biological sample detection analyzer with a simple structure, which can realize the steps of uniformly mixing samples, cleaning the inner wall and the outer wall of a sampling needle, sampling and sample adding through the design of the simple liquid path system, thereby comprehensively improving the convenience and the automation degree of the analyzer. Meanwhile, the utility model also provides a biological sample detection analyzer using the liquid path system.
The utility model adopts the following technical scheme: the liquid path system of the biological sample detection analyzer comprises a sampling module and a cleaning module, wherein the sampling module comprises a sampling needle and a sample sucking plunger pump, the cleaning module comprises a swab, a pure water barrel, a cleaning liquid barrel, a cleaning pool and a waste liquid barrel, the upper end outlet of the sampling needle is connected with the upper end interface of the sample suction plunger pump, a cleaning solution pipeline is connected between the cleaning solution barrel and the lower end interface of the sample suction plunger pump, a first three-way valve and a pure water plunger pump are arranged between the liquid inlet end of the swab and the pure water barrel, three ports of the first three-way valve are respectively connected with the outlet of the pure water barrel, the liquid inlet end of the swab and the upper port of the pure water plunger pump, the liquid outlet end of the swab is connected with the waste liquid barrel through a waste liquid pipeline, a second three-way valve is arranged on the waste liquid pipeline, and three ports of the second three-way valve are respectively connected with the outlet of the cleaning pool, the liquid outlet end of the swab and the inlet of the waste liquid pool.
And a cleaning liquid pump and a two-way valve are arranged on the cleaning liquid pipeline, the cleaning liquid pump is close to the cleaning liquid barrel, and the two-way valve is positioned between the cleaning liquid pump and the sample sucking plunger pump.
The cleaning liquid pump is a diaphragm pump.
And a waste liquid pump is arranged on the waste liquid pipeline close to the waste liquid barrel and is positioned between the second three-way valve and the waste liquid barrel.
The waste liquid pump is a diaphragm pump.
The swab liquid inlet end is connected with the swab liquid inlet end, and the swab liquid inlet end is connected with the swab liquid inlet end.
The swab cleaning device comprises a swab liquid outlet end, a first three-way valve, a second three-way valve, a cleaning pool outlet, a swab liquid outlet end and a swab liquid outlet end, wherein one end of the swab liquid outlet end, which is connected with the swab liquid outlet end, of the swab liquid outlet end is connected with the swab liquid outlet end, and the swab liquid outlet end is connected with the swab liquid outlet end.
The biological sample detection analyzer comprises the liquid path system of the biological sample detection analyzer.
Biological sample detection analysis appearance still includes dilutes the module, dilutes the module and includes dilutes the board, dilutes and distributes on the board and has dilutes hole or dilute the cup.
The utility model has the beneficial effects that: the liquid path system is simple in design, the cost and the failure rate of a machine are greatly reduced, the sample can be uniformly mixed, the inner wall and the outer wall of the sampling needle can be cleaned, the sampling step and the sample adding step can be realized through the simple liquid path system design, meanwhile, the device can realize the adjustment of different dilution ratios of the sample, the defects of the prior art that the sample amount and the dilution liquid amount are fixed are overcome, and the convenience and the automation degree of an analysis instrument are comprehensively improved.
(1) And (3) uniformly mixing the peripheral blood sample: the sampling needle enters the position below the peripheral blood liquid level of the sample tube, sucks a certain amount of peripheral blood sample under the action of the sample sucking plunger pump, spits back the sample under the action of the sample sucking plunger pump, and circularly executes the action for a certain number of times until the samples are uniformly mixed.
(2) Sample adding process: and the sample sucking plunger pump sucks a certain amount of peripheral blood samples through the sampling needle, and the sampling needle moves to the reagent card to spit out the samples to finish sample adding.
(3) Cleaning the outer wall of the sampling needle: after the peripheral blood mixing step is finished, the sampling needle returns to the initial position of the Z axis of the analyzer, before the sampling needle rises, the pure water plunger pump sucks pure water from the pure water bucket through the first three-way valve to finish pure water storage, the outer wall of the sampling needle is cleaned in the rising process of the sampling 1, and the pure water enters the swab from the liquid inlet end of the swab through the normally closed end of the first three-way valve 8 to clean the outer wall of the sampling needle; and simultaneously, the cleaned waste liquid is discharged into a waste liquid barrel through a second three-way valve and a waste liquid pipeline.
(4) Cleaning the inner wall of the sampling needle: after the outer wall washs the flow, begin to wash the sampling needle inner wall, the cleaning solution washs contaminated sampling needle, specifically is to move the sampling needle to the washing pond in, and the washing liquid gets into inside and the downward play of sampling needle from the washing liquid bucket and washs the pond to the washing of sampling needle inner wall, after accomplishing the washing, the sampling needle gets back to the initial position of analysis appearance Z axle, and the sampling needle is in the ready state.
(5) Sample dilution procedure: the sampling needle enters a diluent reagent bottle, a sample sucking plunger pump sucks a certain amount of diluent through the sampling needle, the diluent is added into a diluting hole or a diluting cup on a diluting plate, the sampling needle sucks the uniformly mixed sample again, and the sample is added into the diluting hole or the diluting cup with the diluent to complete dilution.
Drawings
In order to more clearly illustrate the technical solution of the present invention, the drawings needed to be used in the embodiments will be briefly introduced, the drawings in the following description are only some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a schematic diagram of a fluid path system of a biological sample detection analyzer according to an embodiment of the present invention.
Fig. 2 is a schematic view of a dilution plate in a biological sample detection analyzer according to an embodiment of the present invention.
In the figure: 1-sampling needle, 2-swab, 3-sample sucking plunger pump, 4-pure water barrel, 5-cleaning liquid barrel, 6-cleaning pool, 7-waste liquid barrel, 8-first three-way valve, 9-pure water plunger pump, 10-cleaning liquid pump, 11-two-way valve, 12-second three-way valve, 13-waste liquid pump, 14-dilution plate, and 15-dilution hole.
Detailed Description
The utility model is described in detail below with reference to the figures and specific embodiments.
As shown in fig. 1, the fluid path system of the biological sample detection analyzer according to an embodiment of the present invention includes a sampling module and a cleaning module, the sampling module includes a sampling needle 1 and a sample suction plunger pump 3, the cleaning module includes a swab 2, a pure water barrel 4, a cleaning fluid barrel 5, a cleaning pool 6 and a waste fluid barrel 7, an upper end outlet of the sampling needle 1 is connected to an upper end port of the sample suction plunger pump 2, a cleaning fluid pipeline is connected between the lower end ports of the cleaning fluid barrel 5 and the sample suction plunger pump 3, the cleaning fluid pipeline is provided with a cleaning fluid pump 10 and a two-way valve 11, the cleaning fluid pump 10 is close to the cleaning fluid barrel 5, the two-way valve 11 is located between the cleaning fluid pump 10 and the sample suction plunger pump 3, and the cleaning fluid pump 10 is a diaphragm pump.
Be equipped with first three-way valve 8 and pure water plunger pump 9 between the feed liquor end of swab 2 and pure water bucket 4, three port of first three-way valve 8 is connected with the export of pure water bucket 4, 2 feed liquor ends of swab, pure water plunger pump 9 upper end interface respectively, the one end that first three-way valve 8 and pure water plunger pump 9 are connected is the common port, the one end of first three-way valve 8 and 4 exit linkage of pure water bucket is the open end that normally, the one end that first three-way valve 8 and 2 feed liquor ends of swab are connected is the end that normally closes.
The liquid outlet end of the swab 2 is connected with the waste liquid barrel 7 through a waste liquid pipeline, a second three-way valve 12 is arranged on the waste liquid pipeline, and three ports of the second three-way valve 12 are respectively connected with an outlet of the cleaning pool 6, the liquid outlet end 2 of the swab and an inlet of the waste liquid pool 6. The end of the second three-way valve 12 connected with the inlet of the waste liquid barrel 7 is a public end, the end of the second three-way valve 12 connected with the outlet of the cleaning pool 6 is a normally open end, and the end of the second three-way valve 12 connected with the liquid outlet of the swab 2 is a normally closed end. And a waste liquid pump 13 is arranged on the waste liquid pipeline close to the waste liquid barrel 7, the waste liquid pump 13 is positioned between the second three-way valve 12 and the waste liquid barrel 7, and the waste liquid pump 13 is a diaphragm pump.
The working process of the liquid path system of the biological sample detection analyzer of the embodiment is as follows:
(1) and (3) uniformly mixing the peripheral blood sample: the sampling needle 1 enters the position below the peripheral blood liquid level of the sample tube, the sampling needle 1 sucks a certain amount of peripheral blood samples under the action of the sample sucking plunger pump 2, then the samples are spit back under the action of the sample sucking plunger pump 2, and the action is executed circularly for a certain number of times until the samples are mixed uniformly.
(2) Sample adding process: and the sample sucking plunger pump 2 sucks a certain amount of peripheral blood samples through the sampling needle 1, and the sampling needle moves to the reagent card to spit out the samples to finish sample adding.
(3) Cleaning the outer wall of the sampling needle: after the peripheral blood mixing step is finished, the sampling needle 1 returns to the initial position of the Z axis of the analyzer, before the sampling needle 1 ascends, the pure water plunger pump 9 sucks pure water from the pure water barrel 4 through the first three-way valve 8 to finish pure water storage, the outer wall of the sampling needle 1 is cleaned in the ascending process of the sampling needle 1, the normally closed end on the first three-way valve 8 is opened, and the pure water enters the swab 2 from the liquid inlet end of the swab 2 through the normally closed end of the first three-way valve 8 to clean the outer wall of the sampling needle 1; meanwhile, the second three-way valve 12 is powered on, and the waste liquid pump 13 is powered on to suck the waste liquid in the swab 2 and discharge the waste liquid into the waste liquid barrel 7.
(4) Cleaning the inner wall of the sampling needle: after the outer wall washs the flow, begin to wash 1 inner wall of sampling needle, the cleaning solution washs contaminated sampling needle, specifically moves sampling needle 1 to washing 6 in, two-way valve 11 is gone up the electricity, and washing liquid pump 10 is gone up the electricity, and the washing liquid gets into the inside and flow of sampling needle and to washing 6 from washing liquid bucket 5, washs 1 inner wall of sampling needle, and after accomplishing the washing, sampling needle 1 gets back to the analysis appearance Z axle initial position, and sampling needle 1 is in the ready state.
The liquid path system of the biological sample detection analyzer can realize the steps of uniformly mixing the sample, cleaning the inner wall and the outer wall of the sampling needle, sampling and adding sample through simple liquid path system design, improves the convenience and the automation degree of the analyzer, is simple, and reduces the production cost of the analyzer.
The biological sample detection analyzer of an embodiment of the present invention includes a liquid path system and a dilution module, wherein the liquid path system is the same as the liquid path system of the biological sample detection analyzer of the above embodiment, and details thereof are omitted here.
The structure of the diluting module is as shown in fig. 2, the diluting module comprises a diluting plate 14, diluting holes 15 are distributed on the diluting plate, west is empty 15 and can be replaced by a diluting cup, the diluting plate is a disposable consumable, and the diluting cup or the diluting holes can contain samples to dilute the samples. Multiple dilution cups or dilution wells can support different ratios of dilution tests.
Sample dilution procedure: the sampling needle 1 enters a diluent reagent bottle, a sample sucking plunger pump sucks a certain amount of diluent through the sampling needle 1, the diluent is added into a dilution hole 15 on a dilution plate 14, the sampling needle 1 sucks the uniformly mixed sample again, and the diluent is added into the dilution hole 15 with the diluent to complete dilution.
Compared with the prior art, the biological sample detection analyzer of the embodiment has the advantages that the blood collection amount is not fixed, only 50-100 ul of blood collection amount is required, and dilution tests with different proportions are supported. The liquid path system is simple in design, and the cost and the failure rate of the machine are greatly reduced. Can realize the mixing to the sample, the washing of sampling needle inside and outside wall, sampling step, the application of sample step through simple liquid way system design, this equipment can realize the different dilution proportion adjustment to the sample simultaneously, has solved the fixed prior art defect of sample volume and dilution liquid volume, has improved analytical instrument's convenience and degree of automation comprehensively.
The above-described embodiments are preferred embodiments of the present invention, and the description of the embodiments and the description is only for illustrating the principle of the present invention, and there are variations and modifications of the present invention without departing from the spirit and scope of the present invention, which fall within the scope of the claimed invention.
Claims (9)
1. Biological sample detection and analysis appearance's fluid circuit system, it includes sampling module and cleaning module, and sampling module includes sampling needle and inhale a kind plunger pump, and cleaning module includes swab, pure water bucket, washing liquid bucket, washing pond and waste liquid bucket, its characterized in that: the upper end of sampling needle export with inhale the last port connection of appearance plunger pump, be connected with the washing liquid pipeline between the lower extreme interface of washing liquid bucket and inhale appearance plunger pump, be equipped with first three-way valve and pure water plunger pump between the feed liquor end of swab and the pure water bucket, the three port of first three-way valve is connected with pure water bucket export, swab feed liquor end, pure water plunger pump last port respectively, connect through the waste liquid pipeline between the play liquid end of swab and the waste liquid bucket, be equipped with the second three-way valve on the waste liquid pipeline, the three port of second three-way valve respectively with wash pond export, swab play liquid end, waste liquid pool access connection.
2. The fluid path system of a biological sample testing analyzer, according to claim 1, wherein: and a cleaning liquid pump and a two-way valve are arranged on the cleaning liquid pipeline, the cleaning liquid pump is close to the cleaning liquid barrel, and the two-way valve is positioned between the cleaning liquid pump and the sample sucking plunger pump.
3. The fluid path system of a biological sample testing analyzer, according to claim 2, wherein: the cleaning liquid pump is a diaphragm pump.
4. The fluid path system of a biological sample testing analyzer, according to claim 1, wherein: and a waste liquid pump is arranged on the waste liquid pipeline close to the waste liquid barrel and is positioned between the second three-way valve and the waste liquid barrel.
5. The fluid path system of a biological sample testing analyzer, according to claim 4, wherein: the waste liquid pump is a diaphragm pump.
6. The fluid path system of a biological sample testing analyzer, according to claim 1, wherein: the swab liquid inlet end is connected with the swab liquid inlet end, and the swab liquid inlet end is connected with the swab liquid inlet end.
7. The fluid path system of a biological sample testing analyzer, according to claim 1, wherein: the swab cleaning device comprises a swab liquid outlet end, a first three-way valve, a second three-way valve, a cleaning pool outlet, a swab liquid outlet end and a swab liquid outlet end, wherein one end of the swab liquid outlet end, which is connected with the swab liquid outlet end, of the swab liquid outlet end is connected with the swab liquid outlet end, and the swab liquid outlet end is connected with the swab liquid outlet end.
8. Biological sample detection analysis appearance, its characterized in that: comprising the fluid path system of the biological sample detection analyzer of any one of claims 1-7.
9. The biological sample detection analyzer of claim 8, wherein: the dilution module comprises a dilution plate, and dilution holes or dilution cups are distributed on the dilution plate.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115301639A (en) * | 2022-07-13 | 2022-11-08 | 瑞莱谱(杭州)医疗科技有限公司 | Liquid path system of mass spectrum pretreatment equipment |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115301639A (en) * | 2022-07-13 | 2022-11-08 | 瑞莱谱(杭州)医疗科技有限公司 | Liquid path system of mass spectrum pretreatment equipment |
| CN115301639B (en) * | 2022-07-13 | 2023-07-28 | 瑞莱谱(杭州)医疗科技有限公司 | Liquid path system of mass spectrum pretreatment equipment |
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