WO2023207207A1 - Sample analysis apparatus and control method therefor - Google Patents

Abstract

A sample analysis apparatus and a control method therefor. The sample analysis apparatus comprises a cleaning member (2), which is provided with a cleaning cavity (21), and a liquid inlet (22) and a liquid outlet (23) communicating with the cleaning cavity (21). A ventilation hole (13) of a sampling needle (1) is close to a fixed end of the sampling needle (1). In a cleaning mode, a transmission mechanism drives the sampling needle (1) to move back and forth in the cleaning cavity (21) in an axial direction of the cleaning member (2), and the sampling hole (12) is at a first distance (D1) and a second distance (D2) respectively from the liquid inlet (22) and the liquid outlet (23) in the axial direction of the cleaning member (2). When the sampling needle (1) is positioned at a first position, the first distance (D1) is less than the second distance (D2), a pumping system (3) supplies cleaning liquid to the liquid inlet (22) and sucks cleaning liquid from the liquid outlet (23) to clean an outer wall of the sampling needle (1). When the sampling needle (1) is positioned at a second position, the first distance (D1) is greater than the second distance (D2), the pumping system (3) supplies cleaning liquid into a sampling channel (11) from the ventilation hole (13) and sucks cleaning liquid output from the sampling hole (12) from the liquid outlet (23) to clean an inner wall of the sampling needle (1). The sample analysis apparatus can prevent the cleaning liquid from leaking from a bottom of the cleaning member (2).

Description

Sample analysis equipment and control method thereof

Cross-references to related applications

This application claims priority based on Chinese patent application 2022104532596 filed on April 27, 2022, the entire contents of which are incorporated herein by reference.

Technical field

The present invention relates to the technical field of medical devices, and in particular to a sample analysis device and a control method thereof.

Background technique

During the use of the in vitro diagnostic analyzer, a sampling needle is usually used to draw the sample into the corresponding detection device, and then the sample is tested to obtain the test result of the corresponding sample. However, since every time the sampling needle takes a sample, part of the sample will remain on the inner and outer surfaces of the side wall of the sampling needle. In order to avoid these residual samples from affecting the accuracy of the analysis of the next sample, it is necessary to collect the next sample for analysis. Clean both the inner and outer surfaces of the side wall of the sampling needle.

Currently, cleaning components are generally used to clean the inner and outer surfaces of the side wall of the sampling needle. Specifically, the cleaning component has a liquid inlet and a liquid outlet; when the cleaning component is used to clean the outer surface of the side wall of the sampling needle, the tip of the sampling needle moves upward from the end away from the cleaning component, and finally the needle tip stays at the liquid inlet of the cleaning component. position, at the same time, the cleaning liquid enters from the liquid inlet of the cleaning component under the action of positive pressure, and flows out from the liquid outlet of the cleaning component under the action of negative pressure. The cleaning fluid flows through the outer surface of the side wall of the sampling needle, thereby achieving The entire outer surface of the side wall of the sampling needle is cleaned. When the cleaning component is used to clean the inner surface of the side wall of the sampling needle, the sampling needle stays at the end of the cleaning of the outer surface of the side wall, and the cleaning liquid flows out from the inner cavity of the sampling needle under the action of positive pressure, and at the same time under negative pressure It flows out from the liquid outlet of the cleaning component to clean the inner surface of the side wall of the sampling needle.

However, during the cleaning process, if the flow rate of the cleaning fluid is large or the negative pressure fluctuates, the cleaning fluid will leak from the bottom of the cleaning component. If the leaked cleaning fluid enters the sample area or detection area, further damage will occur. This can lead to sample contamination and inaccurate test results, as well as biological risks to operators.

technical problem

Cleaning fluid leaks from the bottom of the cleaning unit.

Technical solutions

In order to solve the above technical problems, one technical solution adopted by this application is to provide a sample analysis device. The sample analysis equipment includes a cleaning component, a transmission mechanism and a pumping system; wherein, the cleaning component is provided with a liquid inlet and a liquid outlet;

The transmission mechanism is used to load and drive the sampling needle. The sampling needle is provided with a sampling channel and a sampling hole and a ventilation hole connected to the sampling channel. The ventilation hole is close to the part where the sampling needle is connected to the transmission mechanism. At the fixed end, the sampling hole is close to the free end of the sampling needle. In the cleaning mode, the sampling hole is separated from the liquid inlet and the liquid outlet by a first distance along the axial direction of the cleaning component. distance and second distance;

A pumping system, when the sampling needle is in the first position, the pumping system provides cleaning liquid to the liquid inlet and sucks the cleaning liquid from the liquid outlet to correct the sampling needle. External wall cleaning; when the sampling needle is in the second position, the pumping system provides cleaning liquid from the vent hole into the sampling channel, and absorbs all the liquid output from the sampling hole from the liquid outlet. The cleaning liquid is used to clean the inner wall of the sampling needle;

Wherein, when the sampling needle is in the first position, the first distance is smaller than the second distance, and when the sampling needle is in the second position, the first distance is larger than the second distance.

In one embodiment, the liquid inlet and the liquid outlet are spaced apart from each other along the axial direction of the cleaning component, wherein when the sampling needle is in the first position, the sampling hole is in the cleaning component. The projection in the axial direction and the projection of the liquid inlet in the axial direction of the cleaning component overlap each other.

In one embodiment, the liquid inlet and the liquid outlet are spaced apart from each other along the axial direction of the cleaning component. When the sampling needle is in the second position, the sampling hole is located on the axis of the cleaning component. The projection in the axial direction and the projection of the liquid outlet in the axial direction of the cleaning component overlap with each other.

In one embodiment, the axial direction of the cleaning component is arranged along the vertical direction, and the liquid outlet is located above the liquid inlet.

In one embodiment, the liquid inlet and the liquid outlet are provided on the side wall of the cleaning component, the sampling hole is provided on the side wall of the sampling needle, and the first distance is the distance between the liquid inlet and the side wall of the cleaning component. The separation distance between the axis of the liquid outlet and the axial direction of the sampling hole along the axis of the cleaning component, the second distance is the axis of the liquid outlet and the axis of the sampling hole along the axial direction of the cleaning component direction separation distance.

In one embodiment, when the sampling needle is in the first position, the axial direction of the liquid inlet and the axial direction of the sampling hole coincide with each other, and when the sampling needle is in the second position, the axial direction of the liquid inlet and the axial direction of the sampling hole coincide with each other. The axial direction of the liquid outlet and the axial direction of the sampling hole coincide with each other.

In one embodiment, when the sampling needle is in the first position, the sampling hole and the liquid inlet are located at the same height in the axial direction of the cleaning component; and the axis of the liquid inlet It is arranged at an angle with the axis of the sampling hole.

In one embodiment, when the sampling needle is in the second position, the sampling hole and the liquid outlet are at the same height in the axial direction of the cleaning component; and the axis of the liquid outlet It is arranged at an angle with the axis of the sampling hole.

In one embodiment, the cleaning component is provided with a cleaning chamber extending along the axial direction of the cleaning component, and the liquid inlet and the liquid outlet are respectively connected with the cleaning chamber; when the sampling needle is in In the first position and the second position, the free end of the sampling needle is located in the cleaning chamber.

In one embodiment, the sample analysis device further includes a control system. After the sampling needle collects the sample to be tested, the control system controls the transmission mechanism to move the sampling needle to the first position and controls the sampling needle. The pumping system cleans the outer wall of the sampling needle, and the control system further controls the transmission mechanism to move the sampling needle to the first position and the second position after the sampling needle releases the sample to be tested, and The pumping system is controlled to clean the outer wall and the inner wall of the sampling needle respectively.

In one embodiment, during the initialization process, the control system moves the sampling needle so that the free end of the sampling needle is flush with the bottom of the cleaning component, and takes the position of the sampling needle as Initial position, the control system further calculates the actual position of the sampling hole based on the movement distance of the sampling needle from the initial position and the separation distance between the sampling hole and the free end of the sampling needle.

In one embodiment, the control system controls the transmission mechanism to keep the sampling needle in the first position and the second position until the corresponding cleaning action is completed.

In one embodiment, the cleaning component is provided with a cleaning chamber extending along the axial direction of the cleaning component, and the liquid inlet and the liquid outlet are respectively connected with the cleaning chamber; the liquid inlet is in The projection of the cleaning component on the transverse section and the projection of the liquid outlet on the transverse section of the cleaning component are located on opposite sides of the cleaning chamber.

In one embodiment, the projection of the liquid inlet on the transverse section of the cleaning component and the projection of the liquid outlet on the transverse section of the cleaning component are arranged at a preset angle.

In one embodiment, the pumping system includes a first container, an injection mechanism, a first control valve, a second control valve, a filter, a waste liquid pump, and a second container; wherein the first container is used to hold Contains cleaning fluid; the second container is used to contain the waste liquid formed after the cleaning fluid cleans the sampling needle.

In one embodiment, the injection mechanism includes a first syringe and a second syringe, wherein the first syringe is in communication with the first container through a first line of the first control valve to draw from the The cleaning liquid is sucked into the first container; the second syringe is connected to the first syringe through the second pipeline of the first control valve, and passes through the third pipeline and fourth pipeline of the second control valve. The paths are respectively connected with the liquid inlet and the vent hole of the sampling needle; the filter is connected with the liquid outlet and is used to filter impurities carried out by the cleaning liquid during the cleaning process; the waste liquid pump is connected with the The filter is connected to provide negative pressure to suck cleaning liquid from the liquid outlet.

In order to solve the above technical problems, another technical solution adopted by this application is to provide a control method for sample analysis equipment. The control method includes: controlling the transmission mechanism to insert the sampling needle into the cleaning component and keeping it in the first position; controlling the pumping system to provide cleaning fluid to the liquid inlet of the cleaning component and from the cleaning component. The liquid outlet sucks the cleaning liquid to clean the outer wall of the sampling needle; controls the transmission mechanism to move and maintain the sampling needle in the second position; controls the passage of the pumping system to the sampling needle. The air hole provides cleaning liquid, and absorbs the cleaning liquid output from the sampling hole of the sampling needle from the liquid outlet to clean the inner wall of the sampling needle; wherein, along the axial direction of the cleaning component, The axis of the sampling hole is separated from the axis of the liquid inlet by a first distance, and the axis of the sampling hole is separated by a second distance from the axis of the liquid outlet. When the sampling needle is in the first position, , the first distance is smaller than the second distance, and when the sampling needle is in the second position, the first distance is larger than the second distance.

In one embodiment, the control pumping system provides cleaning liquid to the liquid inlet of the cleaning component, and sucks the cleaning liquid from the liquid outlet of the cleaning component to clean the outer wall of the sampling needle. The steps include: controlling the first pipeline, the second pipeline of the first control valve of the pumping system and the third pipeline of the second control valve to open, and controlling the first syringe to pass from the first container through the third pipeline. The first pipeline of a control valve sucks a certain amount of cleaning liquid; the cleaning liquid is sequentially passed through the second pipeline of the first control valve, the second syringe, and the third pipeline of the second control valve from the cleaning component. The liquid inlet flows into the cleaning cavity of the cleaning component, and flushes the outer wall of the sampling needle; and controls the waste liquid pump to start working, so that the liquid discharged from the cleaning component is discharged from the cleaning component under the negative pressure of the waste liquid pump. Suck out the cleaning fluid through your mouth.

In one embodiment, the pumping system is controlled to provide cleaning liquid to the ventilation hole of the sampling needle, and suck the cleaning liquid output from the sampling hole of the sampling needle from the liquid outlet, so as to The step of cleaning the inner wall of the sampling needle includes: the control system controls the third pipeline of the second control valve to close, the fourth pipeline of the second control valve to open, and the first syringe continues to flow from the The cleaning liquid is sucked into the first container, and the cleaning liquid passes through the first pipeline of the first control valve, the first syringe, the second pipeline of the first control valve, the second syringe, and the The fourth pipeline of the second control valve flows from the ventilation hole of the sampling needle into the sampling channel of the sampling needle, and flows out through the sampling hole of the sampling needle, and under the negative pressure of the waste liquid pump , the cleaning liquid flowing out of the sampling hole is sucked out from the liquid outlet of the cleaning component.

In one embodiment, the step of controlling the transmission mechanism to insert the sampling needle into the cleaning component and keep it in the first position includes: the projection of the sampling hole in the axial direction of the cleaning component and the The projections of the liquid inlet in the axial direction of the cleaning component overlap each other; and the axis of the liquid inlet and the axial direction of the sampling hole coincide with each other.

In one embodiment, the step of controlling the transmission mechanism to move and maintain the sampling needle at the second position includes: the projection of the sampling hole in the axial direction of the cleaning component and the output The projections of the liquid port in the axial direction of the cleaning component overlap each other; and the axial direction of the liquid outlet and the axial direction of the sampling hole coincide with each other.

beneficial effects

Compared with the existing technology: the sample analysis equipment and its control method provided by this application are provided with a cleaning component, a transmission mechanism and a pumping system to use the transmission mechanism to drive the sampling needle along the cleaning component in the cleaning mode. The axial direction moves back and forth in the cleaning chamber so that the sampling needle is in the first position or the second position, and when the sampling needle is in the first position, the pumping system is used to provide cleaning fluid to the liquid inlet of the cleaning component, and The cleaning liquid is sucked from the liquid outlet to clean the outer wall of the sampling needle; when the sampling needle is in the second position, the ventilation hole of the self-cleaning component of the pumping system is used to provide cleaning liquid into the sampling channel, and the cleaning liquid is sucked from the liquid outlet. The cleaning fluid output from the sampling hole is used to clean the inner wall of the sampling needle, thereby preventing samples remaining on the inner and/or outer wall of the sampling needle from affecting the analysis accuracy of the next sample. At the same time, by using the transmission mechanism to drive the sampling needle, when the sampling needle is in the first position, the first distance between the sampling hole and the liquid inlet along the axial direction of the cleaning component is smaller than the first distance between the sampling hole and the liquid inlet along the axial direction of the cleaning component. The second distance between the direction and the liquid outlet; this allows more parts of the sampling needle to be located in the space between the liquid inlet and the liquid outlet in the cleaning chamber of the cleaning component, thereby enabling pumping under the same negative pressure It is easier for the system to suck out the cleaning fluid from the liquid outlet, which greatly reduces the negative pressure requirements of the pumping system for removing the cleaning liquid from the liquid outlet, effectively avoiding the wear, negative pressure fluctuations and negative pressure attenuation of the cleaning components caused by long-term use. And the cleaning liquid output pipeline is squeezed, causing the problem of leakage of cleaning parts, which can effectively prevent the leaked cleaning liquid from entering the sample area or detection area, causing sample contamination and inaccurate test results, and also avoids Issues that pose biological risks to operators occur. In addition, by making the first distance greater than the second distance when the sampling needle is in the second position, the sampling hole of the sampling needle can be closer to the liquid outlet of the cleaning component, that is, the negative pressure distance to the pumping system Recently, compared to when the sampling needle is in the first position, or other further positions, the negative pressure of the pumping system to draw the cleaning liquid from the liquid outlet is more efficiently utilized, further greatly reducing the impact of removing the cleaning liquid from the liquid outlet. The negative pressure requirement of the pumping system effectively avoids the leakage of cleaning parts caused by wear of cleaning parts, extrusion of cleaning fluid output pipelines, negative pressure fluctuations and negative pressure attenuation.

Description of the drawings

Figure 1 is a schematic structural diagram of a sample analysis device provided by an embodiment of the present application;

Figure 2 is a partial schematic diagram of one end of the sampling needle provided by an embodiment of the present application;

Figure 3 is a vertical cross-sectional view of the cleaning component provided by an embodiment of the present application;

Figure 4 is a schematic diagram of the process of inserting the sampling needle into the cleaning chamber by the transmission mechanism;

Figure 5 is a schematic diagram of the position between the sampling needle and the cleaning component when it is in the first position according to an embodiment of the present application;

Figure 6 is a schematic diagram of the positions of the sampling hole and the liquid inlet of the cleaning component when the sampling needle is in the first position according to an embodiment of the present application;

Figure 7 is a schematic diagram of the position between the sampling needle and the cleaning component when it is in the second position according to an embodiment of the present application;

Figure 8 is a schematic diagram of the positions of the sampling hole and the liquid outlet of the cleaning component when the sampling needle is in the second position according to an embodiment of the present application;

Figure 9 is a schematic diagram of the relative position between the sampling hole of the debugging sampling needle and the liquid outlet of the cleaning component;

Figure 10 is a flow chart of a control method of a sample analysis device provided by an embodiment of the present application.

Explanation of reference signs

Sampling needle 1, sampling channel 11, sampling hole 12, ventilation hole 13, cleaning component 2, cleaning chamber 21, liquid inlet 22, liquid outlet 23, pumping system 3, first container 31, injection mechanism 32, first Syringe 321, second syringe 322, first control valve 33, first pipeline 331, second pipeline 332, second control valve 34, third pipeline 341, fourth pipeline 342, filter 35, waste liquid Pump 36, second container 37.

Detailed ways

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, rather than all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of this application.

The terms “first”, “second” and “third” in this application are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the quantity of indicated technical features. Thus, features defined as "first", "second", and "third" may explicitly or implicitly include at least one of these features. In the description of this application, "plurality" means at least two, such as two, three, etc., unless otherwise clearly and specifically limited. All directional indications (such as up, down, left, right, front, back...) in the embodiments of this application are only used to explain the relative positional relationship between the components in a specific posture (as shown in the drawings) , sports conditions, etc., if the specific posture changes, the directional indication will also change accordingly. Furthermore, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system, product or device that includes a series of steps or units is not limited to the listed steps or units, but optionally also includes steps or units that are not listed, or optionally also includes Other steps or units inherent to such processes, methods, products or devices.

Reference herein to "an embodiment" means that a particular feature, structure or characteristic described in connection with the embodiment can be included in at least one embodiment of the present application. The appearances of this phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. Those skilled in the art understand, both explicitly and implicitly, that the embodiments described herein may be combined with other embodiments.

The present application will be described in detail below with reference to the drawings and embodiments.

Please refer to Figures 1 and 2. Figure 1 is a schematic structural diagram of a sample analysis device provided by an embodiment of the present application; Figure 2 is a partial schematic diagram of one end of a sampling needle provided by an embodiment of the present application where the sampling hole is located.

In this embodiment, a sample analysis device is provided. The sample analysis device includes a sampling needle 1, a cleaning component 2, a transmission mechanism (not shown) and a pumping system 3.

As shown in FIGS. 1 and 2 , the sampling needle 1 is provided with a sampling channel 11 and a sampling hole 12 and a vent hole 13 connected with the sampling channel 11 . The port at one end of the sampling needle 1 used for sampling is a closed end. The sampling hole 12 is provided on the side wall of the closed end of the sampling needle 1 and extends along the radial direction of the sampling needle 1 . The vent hole 13 is connected to a pipeline that can provide suction force (such as negative pressure), so that under the action of the suction force, the sampling needle 1 draws the sample through the sampling hole 12 and temporarily stores it in the sampling channel 11; and when it needs to be discharged When the sample is sucked, the pipeline inputs discharge pressure (such as positive pressure) into the sampling channel 11 through the vent hole 13 so that the sample located in the sampling channel 11 can be discharged through the sampling hole 12 . The specific structure and function of the sampling needle 1 are the same as or similar to those of existing sampling needles, and can achieve the same or similar technical effects. For details, please refer to the prior art, and will not be described again here.

As shown in Figure 3, Figure 3 is a vertical cross-sectional view of the cleaning component 2 provided by an embodiment of the present application; the cleaning component 2 is provided with a cleaning chamber 21 extending along the axial direction A of the cleaning component 2 and a cleaning chamber 21 connected to the cleaning chamber 21. Liquid inlet 22 and liquid outlet 23, the cleaning liquid enters the cleaning chamber 21 from the liquid inlet 22 of the cleaning component 2, and flows out from the liquid outlet 23 under the action of the pumping system 3 to insert into the cleaning cavity 21 Clean the inner and/or outer wall of the sampling needle 1 to avoid residual samples from affecting the analysis accuracy of the next sample. The inner wall of the sampling needle 1 refers to the inner surface of the side wall of the sampling channel 11 , and the outer wall of the sampling needle 1 refers to the outer surface of the entire side wall of the sampling needle 1 .

Please continue to refer to Figure 3. The axial direction A of the cleaning component 2 is arranged along the vertical direction. The liquid inlet 22 and the liquid outlet 23 of the cleaning component 2 are arranged on the side wall of the cleaning component 2, and optionally along the vertical direction of the cleaning component. The liquid inlet 22 and the liquid outlet 23 are spaced apart from each other along the axial direction A of the cleaning member 2, that is, the liquid inlet 22 and the liquid outlet 23 are located on the axial direction A of the cleaning member 2. The projections in the axial direction A do not coincide. Specifically, the liquid outlet 23 is located above the liquid inlet 22 along the axial direction A of the cleaning component 2; that is, when the cleaning component 2 is placed vertically and the insertion port of the cleaning cavity 21 faces upward, the liquid outlet 23 is in the cleaning component. The projection in the axial direction A of the cleaning component 2 is higher than the projection of the liquid inlet 22 in the axial direction A of the cleaning component 2 .

In a specific embodiment, the projection of the liquid inlet 22 on the transverse section of the cleaning component 2 and the projection of the liquid outlet 23 on the transverse section of the cleaning component 2 are located on opposite sides of the cleaning chamber 21 . Of course, in other embodiments, the projection of the liquid inlet 22 on the transverse section of the cleaning component 2 and the projection of the liquid outlet 23 on the transverse section of the cleaning component 2 can also be arranged at a preset angle. The preset angle is greater than 0° and less than 180°.

Among them, other specific structures and functions of the cleaning component 2 are the same or similar to those of the existing cleaning component 2 and can achieve the same or similar technical effects. For details, please refer to the prior art and will not be described again here.

The transmission mechanism is used to load and drive the sampling needle 1 to drive the sampling needle 1 to reciprocate up and down in the cleaning cavity 21 of the cleaning component 2 along the axial direction A of the cleaning component 2, and to be located in a first position and a different second position. Specifically, the sampling needle 1 has a fixed end and a free end extending along its axial direction A and arranged oppositely; the fixed end of the sampling needle 1 is fixed to the transmission structure, and the transmission mechanism drives the free end of the sampling needle 1 along the axis of the cleaning chamber 21 It moves up and down in the cleaning chamber 21 in direction A. In a specific embodiment, the ventilation hole 13 of the sampling needle 1 is close to the fixed end of the sampling needle 1 , and the sampling hole 12 is close to the free end of the sampling needle 1 .

Referring to Figure 4, Figure 4 is a schematic diagram of the process of the transmission mechanism driving the sampling needle to insert into the cleaning chamber. In the cleaning mode, the transmission mechanism drives the sampling needle 1 to be inserted into the cleaning chamber 21 along the axial direction A of the cleaning component 2, and the sampling hole 12 is connected to the liquid inlet 22 and the liquid outlet 23 respectively along the axial direction A of the cleaning component 2. There is a first distance D1 and a second distance D2; where, the first distance D1 is the separation distance between the axis a of the liquid inlet 22 and the axis c of the sampling hole 12 along the axial direction A of the cleaning component 2, and the second distance D2 is The axis b of the liquid outlet 23 and the axis c of the sampling hole 12 are spaced apart along the axial direction A of the cleaning component 2 .

The pumping system 3 is used to provide cleaning fluid and suck the cleaning fluid from the liquid outlet 23 of the cleaning component 2 . In a specific embodiment, see FIG. 5 , which is a schematic diagram of the position between the sampling needle 1 and the cleaning component 2 when it is in the first position according to an embodiment of the present application; when the sampling needle 1 is in the first position of the cleaning chamber 21 , when the free end of the sampling needle 1 is located in the cleaning chamber 21, and at least part of the side wall of the sampling needle 1 is located in the space between the liquid inlet 22 and the liquid outlet 23 of the cleaning component 2 along the axial direction A of the cleaning component 2 , the pumping system 3 provides cleaning fluid to the liquid inlet 22 and absorbs the cleaning liquid from the liquid outlet 23. The cleaning liquid flows through the outer surface of the side wall of the sampling needle 1 between the liquid inlet 22 and the liquid outlet 23. , to clean the outer surface of the sampling needle 1.

Specifically, when the sampling needle 1 is in the first position, the first distance D1 is smaller than the second distance D2; this allows more parts of the sampling needle 1 to be located in the cleaning cavity 21 of the cleaning component 2 from the liquid inlet 22 to the liquid outlet. The space between the ports 23 makes it easier for the pumping system 3 to suck out the cleaning liquid from the liquid outlet 23 under the same negative pressure, which greatly reduces the negative pressure of the cleaning liquid discharged from the liquid outlet 23 on the pumping system 3 requirements, effectively avoiding the problems of leakage of the cleaning component 2 caused by long-term use of the cleaning component 2 due to wear, negative pressure fluctuations, negative pressure attenuation, and extrusion of the cleaning fluid output pipeline, thereby effectively preventing leakage of cleaning fluid Entering the sample area or testing area will cause sample contamination and inaccurate test results. It also avoids biological risks to operators.

Specifically, as shown in Figure 5, when the sampling needle 1 is in the first position, the projection of the sampling hole 12 in the axial direction A of the cleaning component 2 is the same as the projection of the liquid inlet 22 in the axial direction A of the cleaning component 2. The centers of the projections overlap each other; that is, the sampling hole 12 and the liquid inlet 22 are located at the same height in the axial direction A of the cleaning component 2 . This not only allows the sampling needle 1 to be located in the largest part of the space between the liquid inlet 22 and the liquid outlet 23 in the cleaning chamber 21, thereby increasing the cleaning area of the outer wall of the sampling needle 1; it also allows the cleaning liquid to flow from the liquid inlet When the port 22 enters the cleaning chamber 21, the outer wall of the sampling needle 1 can be cleaned, which improves the utilization rate of the cleaning fluid; at the same time, the negative pressure requirement of the pumping system 3 due to the cleaning fluid discharged from the liquid outlet 23 is greatly reduced, so that During the process of cleaning the outer wall of the sampling needle 1, the negative pressure requirement of the pumping system 3 is reached to the minimum, which can effectively avoid cleaning caused by wear of the cleaning component 2, extrusion of the waste liquid pipeline, negative pressure fluctuations and negative pressure attenuation. Part 2 is leaking.

Specifically, in this embodiment, as shown in FIG. 5 , the axis a of the liquid inlet 22 and the axis c of the sampling hole 12 may coincide with each other. Or, as shown in Figure 6, Figure 6 is a schematic diagram of the positions of the sampling hole and the liquid inlet of the cleaning component when the sampling needle is in the first position according to an embodiment of the present application; the axis a of the liquid inlet 22 and the axis a of the sampling hole 12 The axis c is set at an angle α. The angle value of the included angle α can be any other angle such as 30°, 60°, 90° or 180°, which is sufficient to successfully aspirate or discharge the sample.

As shown in Figure 7, Figure 7 is a schematic diagram of the position between the sampling needle 1 and the cleaning component 2 when it is in the second position according to an embodiment of the present application; when the sampling needle 1 is in the second position, the free end of the sampling needle 1 is located In the cleaning chamber 21, the pumping system 3 provides cleaning fluid from the ventilation hole 13 of the sampling needle 1 to the sampling channel 11. The cleaning fluid flows through the sampling channel 11 of the sampling needle 1 and is output from the sampling hole 12. The pumping system 3 further The cleaning liquid output from the sampling hole 12 is sucked from the liquid outlet 23 of the cleaning component 2 to clean the inner wall of the sampling channel 11 of the sampling needle 1 to prevent residual samples from affecting the test of the next sample.

Specifically, when the sampling needle 1 is in the second position, the first distance D1 is greater than the second distance D2; this can make the sampling hole 12 of the sampling needle 1 closer to the liquid outlet 23 of the cleaning component 2, that is, closer to the pump. The negative pressure of the pumping system 3 is the closest. Compared with the sampling needle 1 in the first position or other further positions, the utilization rate of the negative pressure of the pumping system 3 to draw the cleaning liquid from the liquid outlet 23 is higher, which further greatly improves the utilization rate of the negative pressure. It reduces the negative pressure requirement of the pumping system 3 by discharging the cleaning fluid from the liquid outlet 23, effectively avoiding the damage to the cleaning component 2 due to wear of the cleaning component 2, extrusion of the cleaning fluid output pipeline, negative pressure fluctuations and negative pressure attenuation. A leakage problem occurs.

Specifically, referring to Figure 7, when the sampling needle 1 is in the second position, the projection of the sampling hole 12 in the axial direction A of the cleaning component 2 is specifically the same as the projection of the liquid outlet 23 in the axial direction A of the cleaning component 2. overlap each other; that is, the sampling hole 12 and the liquid outlet 23 are located at the same height in the axial direction A of the cleaning component 2 . In this way, the sampling hole 12 of the sampling needle 1 is closest to the liquid outlet 23 of the cleaning part 2 along the axial direction A of the cleaning part 2, that is, the distance to the negative pressure of the pumping system 3 is the shortest. Compared with the sampling needle 1 Located in the first position, or other further positions, the pumping system 3 has a higher utilization rate of the negative pressure of sucking the cleaning liquid from the liquid outlet 23, further greatly reducing the impact of the discharge of cleaning liquid from the liquid outlet 23 on the pumping system 3 The negative pressure requirement effectively avoids the problem of leakage of the cleaning component 2 due to wear of the cleaning component 2, squeezing of the cleaning fluid output pipeline, negative pressure fluctuations and negative pressure attenuation.

Specifically, in this embodiment, as shown in FIG. 7 , the axial direction b of the liquid outlet 23 and the axial direction c of the sampling hole 12 may coincide with each other, and the orifice of the sampling hole 12 is disposed toward the liquid outlet 23; thus The cleaning liquid flowing out from the sampling hole 12 can directly enter the liquid outlet 23, which not only improves the utilization rate of the negative pressure of the pumping system, but also avoids the problem of leakage caused by the cleaning liquid flowing through the cleaning chamber 21. Of course, as shown in Figure 8, Figure 8 is a schematic diagram of the positions of the sampling hole and the liquid outlet of the cleaning component when the sampling needle is in the second position according to an embodiment of the present application; the axial direction b of the liquid outlet 23 and the sampling hole 12 The axial direction c can also be set at an included angle β. The value of the included angle β can be any other angle such as 30°, 60°, 90° or 180°, as long as the cleaning fluid can be discharged smoothly.

Furthermore, in one embodiment, the sample analysis device further includes a control system (not shown). The control system is connected to the transmission mechanism and the pumping system 3. After the sampling needle 1 collects the sample to be measured, the control system controls the transmission mechanism to move the sampling needle 1 to the first position, and controls the pumping system 3 to clean the outer wall of the sampling needle 1. , the control system further controls the transmission mechanism to move the sampling needle 1 to the first position and the second position after the sampling needle 1 releases the sample to be tested, and controls the pumping system 3 to clean the outer wall of the sampling needle 1 again, and performs sampling Clean the inner wall of needle 1. Specifically, the control system controls the transmission mechanism to keep the sampling needle 1 in the first position and the second position until the corresponding cleaning action is completed.

In a specific embodiment, the control system needs to be initialized to debug the initial position of the sampling needle 1 along the axial direction A of the cleaning component 2 to ensure that the transmission mechanism can accurately drive the sampling needle 1 to move to the first position respectively. and second position. Specifically, see Figure 9, which is a schematic diagram of the relative position between the sampling hole of the debugging sampling needle and the liquid outlet of the cleaning component 2; during the initialization process of the control system, the control system controls the transmission mechanism to move the sampling needle 1 so that The free end of the sampling needle 1 is flush with the bottom of the cleaning part 2, and the position of the sampling needle 1 at this time is taken as the initial position and recorded through the software; after that, the control system further adjusts the movement distance of the sampling needle 1 from the initial position. And the actual position of the sampling hole 12 is calculated based on the distance between the sampling hole 12 and the free end of the sampling needle 1 .

In a specific embodiment, as shown in Figure 9, the distance between the liquid outlet 23 of the cleaning component 2 and the bottom of the cleaning component 2 along the axial direction A of the cleaning component 2 is L1, and the liquid inlet of the cleaning component 2 The distance between 22 along the axial direction A of the cleaning component 2 and the bottom of the cleaning component 2 is L2, and the distance between the sampling hole 12 of the sampling needle 1 and the end surface of the free end of the sampling needle 1 along its axial direction is S. Then when the sampling needle 1 moves upward from the initial position along the axial direction A of the cleaning component 2 by a distance L0=L1-S, the axis c of the sampling hole 12 of the sampling needle 1 and the axis b of the liquid outlet 23 of the cleaning component 2 The projections in the axial direction A of the cleaning element 2 overlap each other. When the sampling needle 1 moves upward from the initial position along the axial direction A of the cleaning component 2 by a distance L0=L2-S, the axis c of the sampling hole 12 of the sampling needle 1 and the axis a of the liquid inlet 22 of the cleaning component 2 are at The projections in the axial direction A of the cleaning element 2 overlap each other.

In a specific embodiment, as shown in Figure 1, the pumping system 3 specifically includes a first container 31, an injection mechanism 32, a first control valve 33, a second control valve 34, a filter 35, a waste liquid pump 36, a second Container 37. Among them, the first container 31 is used to hold cleaning liquid. The second container 37 is used to hold the waste liquid formed after the cleaning liquid cleans the sampling needle 1 .

The injection mechanism 32 includes a first syringe 321 and a second syringe 322 , wherein the first syringe 321 is connected to the first container 31 through the first pipeline 331 of the first control valve 33 to draw cleaning liquid from the first container 31 . The second syringe 322 communicates with the first syringe 321 through the second pipeline 332 of the first control valve 33 , and communicates with the liquid inlet of the cleaning component 2 through the third pipeline 341 and the fourth pipeline 342 of the second control valve 34 respectively. The port 22 is connected to the vent hole 13 of the sampling needle 1 . The filter 35 is connected with the liquid outlet 23 of the cleaning component 2 and is used to filter impurities carried by the cleaning liquid during the cleaning process. The waste liquid pump 36 is connected to the filter 35 and is used to provide negative pressure to suck the cleaning liquid from the liquid outlet 23 of the cleaning component 2 .

In a specific embodiment, before the sampling needle 1 takes a sample, the control system controls the first pipeline 331 and the second pipeline 332 of the first control valve 33 and the third pipeline 341 of the second control valve 34 to open, And control the first syringe 321 to suck a certain amount of cleaning liquid from the first container 31 through the first pipeline 331 of the first control valve 33; then after the sampling needle 1 has sucked the sample from the sample container, it is necessary to clean the outer wall of the sampling needle 1 When the sample attached to the sample is cleaned, the control system controls the transmission mechanism to start working, so that the sampling needle 1 moves out of the sample container under the action of the transmission mechanism, and the sampling hole 12 of the sampling needle 1 moves in the direction close to the liquid inlet 22 of the cleaning component 2 ; During the movement, the cleaning fluid passes through the first pipeline 331 of the first control valve 33, the first syringe 321, the second pipeline 332 of the first control valve 33, and the second pipeline in sequence under the action of the first syringe 321. The syringe 322 and the third pipeline 341 of the second control valve 34 flow into the cleaning chamber 21 from the liquid inlet 22 of the cleaning component 2 and flush the outer wall of the sampling needle 1. At the same time, under the negative pressure of the waste liquid pump 36, the liquid flows from the cleaning component The liquid outlet 23 of 2 sucks out the cleaning liquid, so that the cleaning liquid flows from the liquid outlet 23 of the cleaning component 2 to the second container 37 along the outer wall of the sampling needle 1 . Finally, the transmission mechanism controls the axis of the sampling hole 12 of the sampling needle 1 to stay in the first position; and then continues to clean the outer wall of the sampling needle 1 for a period of time until the free end of the sampling needle 1 is completely clean before stopping cleaning.

The sampling needle 1 moves into the sample reaction cup under the action of the transmission mechanism and the control system. After spitting out the sample under the action of the second syringe 322, the sampling needle 1 moves out of the sample reaction cup under the action of the transmission mechanism and moves toward the cleaning chamber. The liquid inlet 22 of the component 2 moves in the direction, and the cleaning component 2 cleans the sample adhered to the outer wall of the sampling needle 1 again in the same manner as the above-mentioned cleaning of the outer wall of the sampling needle 1. After the outer wall of the sampling needle 1 is cleaned, the first syringe 321 Stop injecting cleaning fluid. Then the sampling needle 1 moves upward to the second position under the action of the transmission mechanism; after that, the control system controls the third pipeline 341 of the second control valve 34 to close, and controls the fourth pipeline 342 of the second control valve 34 to open, The first syringe 321 continues to draw cleaning fluid from the first container 31 , and the cleaning fluid passes through the first pipeline 331 of the first control valve 33 , the first syringe 321 , the second pipeline 332 of the first control valve 33 , and the second pipeline 332 of the first control valve 33 . The syringe 322 and the fourth pipeline 342 of the second control valve 34 flow into the sampling channel 11 of the sampling needle 1 from the ventilation hole 13 of the sampling needle 1 , and flow out through the sampling hole 12 of the sampling needle 1 , and are connected to the negative side of the waste liquid pump 36 Under the action of pressure, the cleaning liquid flowing out of the sampling hole 12 is sucked out from the liquid outlet 23 of the cleaning component 2; finally, it flows into the second container 37.

The sample analysis equipment provided in this embodiment is provided with a cleaning component 2, a transmission mechanism and a pumping system 3, so that in the cleaning mode, the transmission mechanism is used to drive the sampling needle 1 along the axial direction A of the cleaning component 2 in the cleaning chamber 21 Move back and forth so that the sampling needle 1 is in the first position or the second position, and when the sampling needle 1 is in the first position, the pumping system 3 is used to provide cleaning liquid to the liquid inlet 22 of the cleaning component 2, and the liquid is discharged from the liquid inlet 22. The cleaning liquid is sucked through the port 23 to clean the outer wall of the sampling needle 1; when the sampling needle 1 is in the second position, the pumping system 3 is used to provide cleaning liquid from the vent 13 of the cleaning component 2 into the sampling channel 11, and from The liquid outlet 23 absorbs the cleaning liquid output from the sampling hole 12 to clean the inner wall of the sampling needle 1, thereby preventing samples remaining on the inner and/or outer wall of the sampling needle 1 from affecting the analysis accuracy of the next sample. At the same time, by using the transmission mechanism to drive the sampling needle 1, when the sampling needle 1 is in the first position, the first distance D1 between the sampling hole 12 and the liquid inlet 22 along the axial direction A of the cleaning component 2 is smaller than the sampling point. The hole 12 is a second distance D2 away from the liquid outlet 23 along the axial direction A of the cleaning component 2; this allows more parts of the sampling needle 1 to be located in the cleaning cavity 21 of the cleaning component 2 from the liquid inlet 22 to the liquid outlet. The space between the ports 23 makes it easier for the pumping system 3 to suck out the cleaning liquid from the liquid outlet 23 under the same negative pressure, which greatly reduces the negative pressure of the cleaning liquid discharged from the liquid outlet 23 on the pumping system 3 requirements, effectively avoiding the problems of leakage of the cleaning component 2 caused by long-term use of the cleaning component 2 due to wear, negative pressure fluctuations, negative pressure attenuation, and extrusion of the cleaning fluid output pipeline, thereby effectively preventing leakage of cleaning fluid Entering the sample area or testing area will cause sample contamination and inaccurate test results. It also avoids biological risks to operators. In addition, by making the first distance D1 greater than the second distance D2 when the sampling needle 1 is in the second position, the distance between the sampling hole 12 of the sampling needle 1 and the liquid outlet 23 of the cleaning component 2 can be made closer, that is, the distance The negative pressure of the pumping system 3 is the closest. Compared with the sampling needle 1 in the first position or other further positions, the utilization rate of the negative pressure of the pumping system 3 to draw the cleaning liquid from the liquid outlet 23 is higher. Further, The negative pressure requirement of the pumping system 3 due to the discharge of cleaning fluid from the liquid outlet 23 is greatly reduced, effectively avoiding the damage to the cleaning component due to wear of the cleaning component 2, extrusion of the cleaning fluid output pipeline, negative pressure fluctuations and negative pressure attenuation. 2. Liquid leakage occurs.

The sample analysis equipment provided in this embodiment adjusts the cleaning position of the sampling needle 1 when cleaning the outer wall and the inner wall of the sampling needle 1, so that the sampling needle 1 can be in different cleaning positions as needed, achieving no matter what the cleaning position is. In the process of cleaning the outer wall or inner wall of the sampling needle 1, the negative pressure of absorbing the cleaning liquid can be fully utilized to achieve reliable cleaning, improve the utilization rate of the negative pressure, and also reduce the impact on the negative pressure of the pumping system. requirements, and the design is ingenious.

In one embodiment, see FIG. 10 , which is a flow chart of a control method of a sample analysis device provided by an embodiment of the present application. A method for controlling a sample analysis device is provided. The sample analysis device is the sample analysis device provided in any of the above embodiments. Its specific structure and function can be found in the above related text descriptions, and will not be described again here.

The control method specifically includes:

Step S1: Control the transmission mechanism to insert the sampling needle into the cleaning cavity of the cleaning component along the axial direction of the cleaning component, and keep it in the first position.

In the specific implementation process, before the sampling needle 1 takes a sample, and after the sampling needle 1 absorbs the sample and spits out the sample, the control system controls the transmission mechanism so that the transmission mechanism drives the sampling needle 1 to move to the cleaning chamber of the cleaning component 2 21, and moves along the axial direction A of the cleaning component 2 and is located in the first position. Among them, along the axial direction A of the cleaning component 2, the axis of the sampling hole 12 of the sampling needle 1 is separated from the axis of the liquid inlet 22 by a first distance D1, and the axis of the sampling hole 12 is separated by a third distance D1 from the axis of the liquid outlet 23. Second distance D2, when the sampling needle 1 is located at the first position, the first distance D1 is smaller than the second distance D2. In a preferred embodiment, the projection of the sampling hole 12 in the axial direction A of the cleaning component 2 and the projection of the liquid inlet 22 in the axial direction A of the cleaning component 2 overlap with each other; and the axis a of the liquid inlet 22 and the axial direction c of the sampling hole 12 coincide with each other.

Step S2: Control the pumping system to provide cleaning liquid to the liquid inlet of the cleaning component, and suck the cleaning liquid from the liquid outlet of the cleaning component to clean the outer wall of the sampling needle.

Specifically, the control system controls the first pipeline 331, the second pipeline 332 of the first control valve 33 of the pumping system 3 and the third pipeline 341 of the second control valve 34 to open, and controls the first syringe 321 to open from the A certain amount of cleaning liquid is sucked into a container 31 through the first pipeline 331 of the first control valve 33; and then the cleaning liquid is sequentially passed through the second pipeline 332 of the first control valve 33, the second syringe 322, and the second control valve. The third pipeline 341 of 34 flows into the cleaning chamber 21 from the liquid inlet 22 of the cleaning component 2, and flushes the outer wall of the sampling needle 1; at the same time, the waste liquid pump 36 is controlled to start working, so that under the negative pressure of the waste liquid pump 36, the The liquid outlet 23 of the cleaning component 2 sucks out the cleaning liquid, so that the cleaning liquid flows from the liquid outlet 23 of the cleaning component 2 to the second container 37 along the outer surface of the side wall of the sampling needle 1 .

In a specific embodiment, the transmission mechanism controls the axis c of the sampling hole 12 of the sampling needle 1 to stay in the first position; and then continues to clean the outer wall of the sampling needle 1 for a period of time until the free end of the sampling needle 1 is completely cleaned. Stop cleaning.

Step S3: Control the transmission mechanism to move the sampling needle along the axial direction of the cleaning component and maintain it at the second position.

Specifically, the transmission mechanism moves the sampling needle 1 upward along the axial direction A of the cleaning component 2 to be located in the second position. When the sampling needle 1 is located at the second position, the first distance D1 is greater than the second distance D2. In a preferred embodiment, the projection of the sampling hole 12 in the axial direction A of the cleaning component 2 and the projection of the liquid outlet 23 in the axial direction A of the cleaning component 2 overlap with each other; and the axial direction of the liquid outlet 23 b and the axial direction c of the sampling hole 12 coincide with each other.

Step S4: Control the pumping system to provide cleaning fluid to the vent hole of the sampling needle, and suck the cleaning fluid output from the sampling hole of the sampling needle from the liquid outlet to clean the inner wall of the sampling needle.

Specifically, the control system controls the third pipeline 341 of the second control valve 34 to close, the fourth pipeline 342 of the second control valve 34 to open, the first syringe 321 continues to draw the cleaning liquid from the first container 31, and the cleaning liquid is sequentially Through the first pipeline 331 of the first control valve 33 , the first syringe 321 , the second pipeline 332 of the first control valve 33 , the second syringe 322 , and the fourth pipeline 342 of the second control valve 34 from the sampling needle 1 The vent hole 13 flows into the sampling channel 11 of the sampling needle 1, and flows out through the sampling hole 12 of the sampling needle 1. Under the negative pressure of the waste liquid pump 36, the cleaning liquid flowing out of the sampling hole 12 is discharged from the cleaning part 2 The liquid is sucked out through the liquid port 23; finally, it flows into the second container 37.

The control method of the sample analysis equipment provided by this embodiment is to insert the sampling needle 1 into the cleaning chamber 21 of the cleaning component 2 along the axial direction A of the cleaning component 2 by controlling the transmission mechanism, and keep it in the first position; and then control the pumping system 3. Provide cleaning fluid to the liquid inlet 22 of the cleaning component 2, and suck the cleaning fluid from the liquid outlet 23 of the cleaning component 2 to clean the outer wall of the sampling needle 1; then, control the transmission mechanism to move the sampling needle 1 along the cleaning component The axial direction A of 2 moves and maintains the sampling needle 1 in the second position; and controls the pumping system 3 to provide cleaning liquid to the ventilation hole 13 of the sampling needle 1, and sucks the sampling hole from the sampling needle 1 from the liquid outlet 23 12 output cleaning fluid to clean the inner wall of the sampling needle 1; thereby effectively preventing sample liquid remaining on the inner and/or outer wall of the sampling needle 1 from affecting the analysis accuracy of the next sample. Wherein, when the sampling needle 1 is in the first position, the first distance D1 is smaller than the second distance D2; in this way, more parts of the sampling needle 1 can be located in the cleaning cavity 21 of the cleaning component 2 from the liquid inlet 22 to the outlet. The space between the liquid ports 23 makes it easier for the pumping system 3 to suck out the cleaning fluid from the liquid outlet 23 under the same negative pressure, which greatly reduces the negative pressure on the pumping system 3 when the cleaning liquid is discharged from the liquid outlet 23 requirements, effectively avoiding the problem of leakage of the cleaning component 2 caused by long-term use of the cleaning component 2 due to wear, negative pressure fluctuations, negative pressure attenuation, and extrusion of the cleaning fluid output pipeline, thereby effectively preventing leakage of cleaning fluids Liquid enters the sample area or detection area, causing sample contamination and inaccurate test results. It also avoids biological risks to operators. When the sampling needle 1 is in the second position, making the first distance D1 greater than the second distance D2 can make the sampling hole 12 of the sampling needle 1 closer to the liquid outlet 23 of the cleaning component 2, that is, closer to the pumping system. The negative pressure of 3 is the closest. Compared with the sampling needle 1 in the first position or other further positions, the utilization rate of the negative pressure of the pumping system 3 to draw the cleaning liquid from the liquid outlet 23 is higher, which further greatly reduces the The negative pressure requirement of the cleaning fluid on the pumping system 3 is eliminated from the liquid outlet 23, effectively avoiding leakage of the cleaning component 2 due to wear of the cleaning component 2, extrusion of the cleaning fluid output pipeline, negative pressure fluctuations and negative pressure attenuation. liquid problem.

The above are only embodiments of the present application, and do not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made using the contents of the description and drawings of this application, or directly or indirectly applied in other related technical fields, All are similarly included in the patent protection scope of this application.

Claims (21)

1. A sample analysis device, wherein the sample analysis device includes:

   The cleaning component is provided with a liquid inlet and a liquid outlet;

   The transmission mechanism is used to load and drive the sampling needle. The sampling needle is provided with a sampling channel and a sampling hole and a ventilation hole connected to the sampling channel. The ventilation hole is close to the part where the sampling needle is connected to the transmission mechanism. At the fixed end, the sampling hole is close to the free end of the sampling needle. In the cleaning mode, the sampling hole is separated from the liquid inlet and the liquid outlet by a first distance along the axial direction of the cleaning component. distance and second distance;

   A pumping system, when the sampling needle is in the first position, the pumping system provides cleaning liquid to the liquid inlet and sucks the cleaning liquid from the liquid outlet to correct the sampling needle. External wall cleaning; when the sampling needle is in the second position, the pumping system provides cleaning liquid from the vent hole into the sampling channel, and absorbs all the liquid output from the sampling hole from the liquid outlet. The cleaning liquid is used to clean the inner wall of the sampling needle;

   Wherein, when the sampling needle is in the first position, the first distance is smaller than the second distance, and when the sampling needle is in the second position, the first distance is larger than the second distance.
2. The sample analysis device according to claim 1, wherein the liquid inlet and the liquid outlet are spaced apart from each other along the axial direction of the cleaning component, and wherein when the sampling needle is in the first position, the sampling The projection of the hole in the axial direction of the cleaning component and the projection of the liquid inlet in the axial direction of the cleaning component overlap each other.
3. The sample analysis device according to claim 2, wherein the liquid inlet and the liquid outlet are spaced apart from each other along the axial direction of the cleaning component, and when the sampling needle is in the second position, the sampling hole The projection in the axial direction of the cleaning component and the projection of the liquid outlet in the axial direction of the cleaning component overlap with each other.
4. The sample analysis device according to claim 3, wherein the axial direction of the cleaning component is arranged along a vertical direction, and the liquid outlet is located above the liquid inlet.
5. The sample analysis device according to claim 1, wherein the liquid inlet and the liquid outlet are provided on the side wall of the cleaning component, the sampling hole is provided on the side wall of the sampling needle, and the first The distance is the separation distance between the axis of the liquid inlet and the axis of the sampling hole along the axial direction of the cleaning component, and the second distance is the distance along the axis of the liquid outlet and the axis of the sampling hole along the axial direction of the cleaning component. The spacing distance in the axial direction of the cleaning components.
6. The sample analysis device according to claim 5, wherein when the sampling needle is in the first position, the axial direction of the liquid inlet and the axial direction of the sampling hole coincide with each other, and when the sampling needle is in the first position, the axial direction of the liquid inlet and the axial direction of the sampling hole coincide with each other. In the second position, the axial direction of the liquid outlet and the axial direction of the sampling hole coincide with each other.
7. The sample analysis device according to claim 5, wherein when the sampling needle is in the first position, the sampling hole and the liquid inlet are located at the same height position in the axial direction of the cleaning component; and The axis of the liquid inlet and the axis of the sampling hole are arranged at an included angle.
8. The sample analysis device according to claim 5, wherein when the sampling needle is in the second position, the sampling hole and the liquid outlet are located at the same height position in the axial direction of the cleaning component; and The axis of the liquid outlet and the axis of the sampling hole are arranged at an included angle.
9. The sample analysis device according to claim 1, wherein the cleaning component is provided with a cleaning chamber extending along the axial direction of the cleaning component, and the liquid inlet and the liquid outlet are respectively connected with the cleaning chamber. ; When the sampling needle is in the first position and the second position, the free end of the sampling needle is located in the cleaning chamber.
10. The sample analysis device according to claim 1, wherein the sample analysis device further includes a control system that controls the transmission mechanism to move the sampling needle to the The first position, and controls the pumping system to clean the outer wall of the sampling needle. The control system further controls the transmission mechanism to move the sampling needle to the first position after the sampling needle releases the sample to be tested. position and the second position, and controls the pumping system to clean the outer wall and the inner wall of the sampling needle respectively.
11. The sample analysis device according to claim 10, wherein during the initialization process, the control system moves the sampling needle so that the free end of the sampling needle is flush with the bottom of the cleaning component, and the The position of the sampling needle is used as the initial position, and the control system further calculates the actual position of the sampling hole based on the movement distance of the sampling needle from the initial position and the separation distance between the sampling hole and the free end of the sampling needle. Location.
12. The sample analysis device according to claim 10, wherein the control system controls the transmission mechanism to maintain the sampling needle in the first position and the second position until the corresponding cleaning action is completed.
13. The sample analysis device according to claim 1, wherein the cleaning component is provided with a cleaning chamber extending along the axial direction of the cleaning component, and the liquid inlet and the liquid outlet are respectively connected with the cleaning chamber. ;

    The projection of the liquid inlet on the transverse section of the cleaning component and the projection of the liquid outlet on the transverse section of the cleaning component are located on opposite sides of the cleaning chamber.
14. The sample analysis device according to claim 1, wherein the projection of the liquid inlet on the transverse section of the cleaning component and the projection of the liquid outlet on the transverse section of the cleaning component are at a preset angle. set up.
15. The sample analysis device according to claim 1, wherein the pumping system includes a first container, an injection mechanism, a first control valve, a second control valve, a filter, a waste liquid pump, and a second container; wherein the The first container is used to hold the cleaning liquid; the second container is used to hold the waste liquid formed after the cleaning liquid cleans the sampling needle.
16. The sample analysis device according to claim 15, wherein the injection mechanism includes a first syringe and a second syringe, wherein the first syringe communicates with the first syringe through a first pipeline of the first control valve. The container is connected to draw cleaning liquid from the first container; the second syringe is connected to the first syringe through the second pipeline of the first control valve, and passes through the second line of the second control valve. The third pipeline and the fourth pipeline are respectively connected with the liquid inlet and the vent hole of the sampling needle; the filter is connected with the liquid outlet and is used to filter impurities carried out by the cleaning liquid during the cleaning process; The waste liquid pump is connected to the filter and is used to provide negative pressure to suck cleaning liquid from the liquid outlet.
17. A control method for sample analysis equipment, wherein the control method includes:

    Control the transmission mechanism to insert the sampling needle into the cleaning component and keep it in the first position;

    Control the pumping system to provide cleaning liquid to the liquid inlet of the cleaning component, and suck the cleaning liquid from the liquid outlet of the cleaning component to clean the outer wall of the sampling needle;

    Control the transmission mechanism to move and maintain the sampling needle in the second position;

    Control the pumping system to provide cleaning liquid to the vent hole of the sampling needle, and suck the cleaning liquid output from the sampling hole of the sampling needle from the liquid outlet to clean the inner wall of the sampling needle ;

    Wherein, along the axial direction of the cleaning component, the axis of the sampling hole is separated from the axis of the liquid inlet by a first distance, and the axis of the sampling hole is separated by a second distance from the axis of the liquid outlet. When the sampling needle is in the first position, the first distance is smaller than the second distance. When the sampling needle is in the second position, the first distance is larger than the second distance.
18. The control method of sample analysis equipment according to claim 17, wherein the control pumping system provides cleaning liquid to the liquid inlet of the cleaning component and absorbs the cleaning liquid from the liquid outlet of the cleaning component. , the steps of cleaning the outer wall of the sampling needle include:

    Control the first pipeline, the second pipeline of the first control valve of the pumping system and the third pipeline of the second control valve to open, and control the first syringe to pass from the first container through the third pipeline of the first control valve. One pipeline sucks in a certain amount of cleaning fluid;

    The cleaning liquid flows from the liquid inlet of the cleaning component into the cleaning cavity of the cleaning component through the second pipeline of the first control valve, the second syringe, and the third pipeline of the second control valve, and flushes the outer wall of the sampling needle; and control the waste liquid pump to start working, so as to suck out the cleaning liquid from the liquid outlet of the cleaning component under the negative pressure of the waste liquid pump.
19. The control method of a sample analysis device according to claim 18, wherein the control of the pumping system provides cleaning liquid to the vent hole of the sampling needle and sucks the cleaning liquid from the sampling needle from the liquid outlet. The step of cleaning the inner wall of the sampling needle with the cleaning liquid output from the sampling hole includes:

    The control system controls the third pipeline of the second control valve to close, the fourth pipeline of the second control valve to open, the first syringe continues to draw cleaning fluid from the first container, and the cleaning fluid passes through The first pipeline of the first control valve, the first syringe, the second pipeline of the first control valve, the second syringe, and the fourth pipeline of the second control valve are connected from the The vent hole of the sampling needle flows into the sampling channel of the sampling needle and flows out through the sampling hole of the sampling needle. Under the negative pressure of the waste liquid pump, the cleaning liquid flowing out of the sampling hole flows from the The liquid outlet of the cleaning part is sucked out.
20. The control method of sample analysis equipment according to claim 17, wherein the step of controlling the transmission mechanism to insert the sampling needle into the cleaning component and maintain it in the first position includes:

    The projection of the sampling hole in the axial direction of the cleaning component and the projection of the liquid inlet in the axial direction of the cleaning component overlap each other; and the axis of the liquid inlet and the sampling hole axes coincide with each other.
21. The control method of sample analysis equipment according to claim 17, wherein the step of controlling the transmission mechanism to move and maintain the sampling needle at the second position includes:

    The projection of the sampling hole in the axial direction of the cleaning component and the projection of the liquid outlet in the axial direction of the cleaning component overlap each other; and the axial direction of the liquid outlet and the sampling The axes of the holes coincide with each other.