CN112823154A - 式(iv)化合物的工艺路线、晶型及其制备方法 - Google Patents

式(iv)化合物的工艺路线、晶型及其制备方法 Download PDF

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Publication number
CN112823154A
CN112823154A CN201980066989.7A CN201980066989A CN112823154A CN 112823154 A CN112823154 A CN 112823154A CN 201980066989 A CN201980066989 A CN 201980066989A CN 112823154 A CN112823154 A CN 112823154A
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China
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compound
degrees
formula
preparation
solvent
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CN201980066989.7A
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English (en)
Inventor
罗志
李小林
杨亚讯
杨乐乐
李鹏
贺海鹰
黎健
陈曙辉
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Shandong Danhong Pharmaceutical Co Ltd
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Shandong Danhong Pharmaceutical Co Ltd
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Publication of CN112823154A publication Critical patent/CN112823154A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

公开了式(IV)化合物的工艺路线、晶型及其制备方法，还公开了所述晶型在制备治疗与SSAO相关疾病药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (30)

  1. PCT国内申请，权利要求书已公开。
CN201980066989.7A 2018-12-20 2019-12-20 式(iv)化合物的工艺路线、晶型及其制备方法 Pending CN112823154A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018115653013 2018-12-20
CN201811565301 2018-12-20
PCT/CN2019/127155 WO2020125776A1 (zh) 2018-12-20 2019-12-20 式(iv)化合物的工艺路线、晶型及其制备方法

Publications (1)

Publication Number Publication Date
CN112823154A true CN112823154A (zh) 2021-05-18

Family

ID=71102539

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980066989.7A Pending CN112823154A (zh) 2018-12-20 2019-12-20 式(iv)化合物的工艺路线、晶型及其制备方法

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Country Link
US (1) US12077513B2 (zh)
EP (1) EP3901143B1 (zh)
JP (1) JP7245911B2 (zh)
KR (1) KR102583801B1 (zh)
CN (1) CN112823154A (zh)
AU (1) AU2019408509B2 (zh)
ES (1) ES2981573T3 (zh)
WO (1) WO2020125776A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112480073B (zh) * 2020-12-02 2022-03-22 武汉药明康德新药开发有限公司 1-烷基-3,5-芳基取代的1,2,4三氮唑化合物的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007120528A2 (en) * 2006-03-31 2007-10-25 La Jolla Pharmaceutical Company Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases
WO2018158140A1 (en) * 2017-03-01 2018-09-07 Boehringer Ingelheim International Gmbh TRANSITION METAL-CATALYZED PROTODECARBOXYLATION OF α-HALO-ACRYLIC ACID DERIVATIVES
WO2018233633A1 (zh) * 2017-06-20 2018-12-27 南京明德新药研发股份有限公司 Ssao 抑制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013255103B2 (en) 2012-05-02 2016-09-29 Pharmaxis Ltd. Substituted 3-haloallylamine inhibitors of SSAO and uses thereof
EP3617186A1 (en) * 2017-04-28 2020-03-04 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Fluoroallylamine derivative and use thereof
WO2019024924A1 (zh) 2017-08-04 2019-02-07 广东东阳光药业有限公司 抑制ssao/vap-1的胺类化合物及其在医药上的应用
WO2019241751A1 (en) 2018-06-15 2019-12-19 Metacrine, Inc. Ssao inhibitors and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007120528A2 (en) * 2006-03-31 2007-10-25 La Jolla Pharmaceutical Company Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases
WO2018158140A1 (en) * 2017-03-01 2018-09-07 Boehringer Ingelheim International Gmbh TRANSITION METAL-CATALYZED PROTODECARBOXYLATION OF α-HALO-ACRYLIC ACID DERIVATIVES
WO2018233633A1 (zh) * 2017-06-20 2018-12-27 南京明德新药研发股份有限公司 Ssao 抑制剂

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLAIRE TACON ET AL: ""Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agent"", 《BIOORGANIC & MEDICINAL CHEMISTRY》 *
MIGUEL A. PEREZ ET AL: ""Regioselective Synthesis of 1,2,4-Triazole and 1,2,4-Oxadiazole Derivatives"", 《SYNTHESIS》 *

Also Published As

Publication number Publication date
KR102583801B1 (ko) 2023-09-26
US12077513B2 (en) 2024-09-03
AU2019408509A1 (en) 2021-06-03
JP2022514714A (ja) 2022-02-14
KR20210109562A (ko) 2021-09-06
JP7245911B2 (ja) 2023-03-24
EP3901143B1 (en) 2024-05-29
ES2981573T3 (es) 2024-10-09
WO2020125776A1 (zh) 2020-06-25
EP3901143A4 (en) 2022-09-14
AU2019408509B2 (en) 2022-02-10
EP3901143A1 (en) 2021-10-27
US20220024880A1 (en) 2022-01-27

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