CN112791150A - Traditional Chinese medicine composition for treating neck vascular plaque and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating neck vascular plaque and preparation method thereof Download PDF

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CN112791150A
CN112791150A CN202110133204.2A CN202110133204A CN112791150A CN 112791150 A CN112791150 A CN 112791150A CN 202110133204 A CN202110133204 A CN 202110133204A CN 112791150 A CN112791150 A CN 112791150A
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parts
radix
traditional chinese
chinese medicine
medicine composition
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贺兴欢
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Hunan Hongrui Traditional Chinese Medicine Pieces Co ltd
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Hunan Hongrui Traditional Chinese Medicine Pieces Co ltd
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Abstract

The invention belongs to the field of medicine, and particularly relates to a traditional Chinese medicine composition for treating neck vascular plaque and a preparation method thereof, wherein the composition comprises, by mass, 8-15 parts of astragalus membranaceus, 8-15 parts of prepared fleece flower root, 1-6 parts of pseudo-ginseng, 5-10 parts of peach kernel, 5-10 parts of cassia occidentalis, 3-8 parts of gentian, 6-12 parts of safflower, 7-14 parts of raw hawthorn, 8-11 parts of selfheal, 8-15 parts of whole angelica, 5-12 parts of rhizoma alismatis, 5-15 parts of prepared rhizoma polygonati, 5-12 parts of ligusticum wallichii, 5-15 parts of salvia miltiorrhiza, 5-15 parts of gynostemma pentaphylla, 5-15 parts of red paeony root, 10-20 parts of radix puerariae, 1-5 parts of roasted leech, 8-13 parts of wolfberry fruit, 8-12 parts of glossy privet fruit, 8-11 parts of semen cuscut, 7-12 parts of white peony root and 3-7 parts of prepared rehmannia root. The invention provides a traditional Chinese medicine composition for quickly treating neck vascular plaques, and improves the strange taste of the traditional Chinese medicine composition.

Description

Traditional Chinese medicine composition for treating neck vascular plaque and preparation method thereof
Technical Field
The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine composition for treating neck vascular plaque and a preparation method thereof.
Background
The cervical vascular plaque is a manifestation of carotid atherosclerosis, and the mechanism of causing ischemic stroke may be: plaque augmentation is approximate carotid stenosis causing intracranial hypoperfusion and plaque sloughing off forming emboli, leading to intracranial arterial embolism.
In the prior art, treatment methods for neck vascular plaques are generally lifestyle changes, drug therapy and surgical therapy; the existing medicine treatment mostly controls blood pressure, blood fat and blood sugar, and reduces the incidence of vascular diseases through the blood pressure, the blood fat and the blood sugar, so that the incidence of neck vascular plaques is influenced, but the treatment effect is not obvious.
Taohong Siwu Tang is one of the essential prescriptions for regulating menstruation, and is a prescription in Yi base Yuan-Rong from Wu Ji Wei Yi (five mechanisms and one minute), also called Jia Wei Siwu Tang. The Taohong Siwu Tang is originally recorded in Yi Zong jin Jian. The prescription is prepared from four-ingredient decoction, flavored peach kernels and safflower. Has the effects of nourishing blood and promoting blood circulation. Modern medical research shows that the peach blossom decoction of four ingredients has the effects of expanding blood vessels, resisting inflammation, resisting fatigue, resisting shock, regulating immune function, reducing blood fat, supplementing trace elements, resisting allergy and the like, but has no effect of quickly curing neck vascular plaques.
Patent CN202010950055.4, an external traditional Chinese medicine composition for treating neck vascular plaque, discloses 10g of earthworm, 20 g of trogopterus dung, 10g of myrrh, 5 g of borneol, 15 g of szechuan lovage rhizome, 20 g of suberect spatholobus stem, 10g of common burreed rhizome, 15 g of garden balsam stem and 15 g of belvedere fruit; the invention also provides the application of the medicine in preparing the neck vascular plaque diseases, the medicine can realize the specific and rapid treatment of the neck vascular plaque diseases, but the borneol is contained in the medicine, so that the medicine is not suitable for children and pregnant women, meanwhile, the borneol is taken by people with spleen deficiency, diarrhea and liver and kidney deficiency, and the existing patients are mostly suffered from the diseases of spleen deficiency, diarrhea and liver and kidney deficiency, so that the use of the medicine is limited. .
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for quickly treating neck vascular plaques, and the strange taste of the traditional Chinese medicine is improved.
In order to realize the purpose, the invention adopts the technical scheme that:
a Chinese medicinal composition for treating neck blood vessel plaque comprises (by mass), the composition comprises 8-15 parts of astragalus membranaceus, 8-15 parts of prepared fleece-flower root, 1-6 parts of pseudo-ginseng, 5-10 parts of peach kernel, 5-10 parts of cassia occidentalis, 3-8 parts of gentian, 6-12 parts of safflower, 7-14 parts of raw hawthorn, 8-11 parts of selfheal, 8-15 parts of whole angelica, 5-12 parts of rhizoma alismatis, 5-15 parts of prepared rhizoma polygonati, 5-12 parts of ligusticum wallichii, 5-15 parts of salvia miltiorrhiza, 5-15 parts of gynostemma pentaphylla, 5-15 parts of red paeony root, 10-20 parts of radix puerariae, 1-5 parts of roasted leech, 8-13 parts of wolfberry fruit, 8-12 parts of glossy privet fruit, 8-11 parts of semen cuscutae, 8-11 parts of kelp, 7-12 parts of radix paeoniae alba and 3.
Further, the composition comprises, by mass, 8 parts of astragalus membranaceus, 8 parts of prepared fleece-flower root, 1 part of pseudo-ginseng, 5 parts of peach kernel, 5 parts of cassia occidentalis, 3 parts of gentian, 6 parts of safflower, 7 parts of raw hawthorn, 8 parts of selfheal, 8 parts of whole angelica, 5 parts of rhizoma alismatis, 5 parts of prepared rhizoma polygonati, 5 parts of ligusticum wallichii, 5 parts of salvia miltiorrhiza, 5 parts of gynostemma pentaphylla, 5 parts of red paeony root, 10 parts of radix puerariae, 1 part of roasted leech, 8 parts of wolfberry fruit, 8 parts of glossy privet fruit, 8 parts of semen cuscutae, 8 parts of kelp, 7 parts of radix paeoniae alba.
Further, the composition comprises, by mass, 15 parts of astragalus membranaceus, 15 parts of prepared fleece-flower root, 6 parts of pseudo-ginseng, 10 parts of peach kernel, 10 parts of cassia occidentalis, 8 parts of gentian, 12 parts of safflower, 14 parts of raw hawthorn, 11 parts of selfheal, 15 parts of whole angelica, 12 parts of rhizoma alismatis, 15 parts of prepared rhizoma polygonati, 12 parts of ligusticum wallichii, 15 parts of salvia miltiorrhiza, 15 parts of gynostemma pentaphylla, 15 parts of red paeony root, 20 parts of radix puerariae, 5 parts of roasted leech, 13 parts of wolfberry fruit, 12 parts of glossy privet fruit, 11 parts of semen cuscutae, 11 parts of kelp, 12 parts of radix paeoniae alba and.
Further, the composition comprises, by mass, 10 parts of astragalus membranaceus, 10 parts of radix polygoni multiflori preparata, 3 parts of pseudo-ginseng, 8 parts of peach kernel, 10 parts of cassia occidentalis, 5 parts of felwort, 10 parts of safflower, 10 parts of raw hawthorn, 10 parts of selfheal, 10 parts of whole angelica, 10 parts of rhizoma alismatis, 10 parts of prepared rhizoma polygonati, 10 parts of ligusticum wallichii, 10 parts of salvia miltiorrhiza, 10 parts of gynostemma pentaphylla, 10 parts of radix paeoniae rubra, 15 parts of astragalus membranaceus, 2 parts of roasted leech, 10 parts of wolfberry fruit, 10 parts of glossy privet fruit, 10 parts of semen cuscutae, 10 parts of kelp, 10 parts of radix paeonia.
Furthermore, the traditional Chinese medicine composition is any medicinal dosage form.
Further, the traditional Chinese medicine composition contains a pharmaceutically acceptable carrier.
Further, the traditional Chinese medicine composition is a capsule preparation.
A preparation method of a traditional Chinese medicine composition for treating neck vascular plaque comprises the following steps:
the method comprises the following steps: weighing the above components, selecting fresh fructus Lycii, semen Persicae, fructus crataegi, Carthami flos, radix Polygoni Multiflori Preparata, radix Puerariae and semen Cuscutae, washing with water for 2-3 times, mixing fructus Lycii, semen Persicae, fructus crataegi, Carthami flos, radix Polygoni Multiflori Preparata, radix Puerariae and semen Cuscutae, pulverizing, and sieving with 140 or 180 mesh sieve;
step two: adding water 8-10 times the weight of the medicinal materials into the mixture obtained in the step one, carrying out three-stage reflux extraction for 0.5-1.5 hours, filtering, and concentrating the filtrate under reduced pressure to obtain a concentrate I;
step three: mixing radix astragali, radix Notoginseng, semen Cassiae, radix Gentianae, Spica Prunellae, radix Angelicae sinensis, rhizoma Alismatis, rhizoma Polygonati preparata, rhizoma Chuanxiong, radix Salviae Miltiorrhizae, gynostemma pentaphyllum, radix Paeoniae Rubra, Hirudo preparata, fructus Ligustri Lucidi, thallus laminariae, radix Paeoniae alba, and radix rehmanniae Preparata, pulverizing the mixture, sieving with 140 or 180 mesh sieve, adding 50% ethanol solution with mass concentration of 8-10 times of the weight of the raw materials, performing three-stage reflux extraction for 0.5-1.5 hr each time, filtering, concentrating the filtrate under reduced pressure, and recovering ethanol to obtain concentrate II;
step four: uniformly mixing the obtained concentrate I and concentrate II; and (5) packaging and processing.
Further, the Chinese medicine mixture obtained in the third step is steamed and then crushed.
Further, the concentration of the traditional Chinese medicine serous fluid entering and exiting each time in the three-stage reflux is gradually reduced, and the concentration of the traditional Chinese medicine serous fluid in the first-stage reflux is 25-40 wt% of the traditional Chinese medicine stock solution; the concentration of the traditional Chinese medicine serous fluid of the secondary reflux is 20 to 25 weight percent; the concentration of the traditional Chinese medicine serous fluid of the third-stage reflux is 15wt% -20 wt%.
The traditional Chinese medicine composition comprises the following medicinal materials:
astragalus root: contains saponin, sucrose, and polysaccharide. Various amino acids, folic acid, and trace elements such as selenium, zinc, and copper, and has effects of enhancing immunity, protecting liver, promoting urination, resisting aging, resisting stress, lowering blood pressure, and resisting bacteria.
Peach kernel: promote blood circulation to remove blood stasis, moisten intestines to relieve constipation. Ming Dynasty Li Shizhen Ben Cao gang mu Guo I peach: unprocessed with Pi and Jian is indicated for peach kernel which promotes blood circulation.
Safflower: promoting blood circulation, removing blood stasis, promoting metabolism, increasing melanin produced by melanocyte, promoting decomposition of retained melanin, preventing pigmentation, or decomposing precipitated pigment to discharge.
Whole Chinese angelica: according to traditional Chinese medicine, the angelica is sweet and heavy in taste, so that the angelica can enrich the blood; it is mild and pungent in qi and can promote blood circulation. Tonify the middle energizer and tonify the middle energizer, which are the essential herbs in blood. Therefore, it can tonify blood, promote blood circulation, dredge meridians and dredge collaterals.
Prepared rhizome of rehmannia: nine major functions: firstly, nourishing yin and enriching blood; ② delaying senility; ③ strengthening heart and promoting urination; fourthly, tonifying the kidney; lowering blood pressure; sixthly, symptoms of liver-kidney yin deficiency; seventhly, promoting the hemopoiesis of bone marrow; eighty, immunity enhancement; ninthly, inhibiting thrombus.
Ligusticum wallichii: promote blood circulation and move qi, dispel wind and alleviate pain. The rhizome of Sichuan lovage is pungent, warm, fragrant and dry, and can be scattered and ascended to the vertex; it enters the blood system and goes down to reach the blood sea.
White peony root: inhibiting spasm, astringing yin, arresting sweating, regulating menstruation, relieving pain, protecting liver, and caring skin.
Prepared fleece flower root has the efficacies and main indications of nourishing liver and kidney, benefiting essence and blood, strengthening muscles and bones, eliminating turbid pathogen and reducing blood fat.
Pseudo-ginseng: li Shizhen Yu is "jin Bu Shi", and is called "ren Shen tonifies qi the first time and san Qi tonifies blood the first time. It is also called ginseng and pseudo-ginseng as the most precious of Chinese herbs because they have the same flavor and function. Unprocessed is used for stopping bleeding, removing blood stasis, relieving swelling and pain, and is the main component of Yunnan Baiyao.
And (3) cassia seed: clear heat, improve eyesight, moisten intestines and relax bowels. Semen Cassiae mainly contains compounds such as chrysophanol and emodin.
Gentian: clear heat and dry dampness, purge liver and arrest convulsion. The book Ben Cao Xin Hui says that gentian, which is effective in treating dysentery and detumescence, can cure damp and remove jaundice and other diseases with eyes. "
Raw hawthorn: according to modern pharmacological research, the raw hawthorn mainly contains citric acid, oxalic acid, ascorbic acid, protein and carbohydrate, and has the effects of promoting gastrointestinal digestion, reducing fat and dissolving turbidity.
Selfheal: refreshing brain, lowering blood pressure, inducing diuresis, relieving inflammation, improving eyesight, and resolving hard mass. The title of Ben Cao Yan Yi Bu Yi (supplement to the enuresis) is to nourish the blood vessels.
Rhizoma alismatis: the medical inspiration is: for stranguria with urine, it can remove sweat from yin. Remove old water, nourish new water, promote urination, eliminate edema, and relieve thirst by seeping and draining. Modern pharmacological research shows that the traditional Chinese medicine composition has the effects of promoting urination, reducing blood fat and protecting heart and cerebral vessels and liver.
Rhizoma polygonati: the product contains liquid, starch, amino acids, sugar, vitamins, and anthraquinone compounds. Therefore, the sealwort can improve the body immunity and enhance the disease resistance of the human body. Also has effects in replenishing essence and resisting aging.
Red sage root: the Saviae Miltiorrhizae radix mainly contains tanshinone, and has effects of promoting blood circulation for removing blood stasis, and improving cardiovascular and cerebrovascular function. Because the salvia miltiorrhiza contains bioactive substances, on one hand, the activity of body cells can be improved, and on the other hand, redundant free radicals in the body can be eliminated, so that the free radicals are prevented from being overoxidized, and the effect of delaying senescence is achieved.
Gynostemma pentaphylla: the product has slightly sweet and cold taste, and has effects of clearing away heat and toxic materials, reducing blood lipid, reducing cholesterol, lowering blood pressure, increasing coronary artery and brain blood flow, resisting DNA variation, improving immunity, preventing and treating arteriosclerosis, and protecting liver.
Red peony root: the red peony root has the effects of resisting blood coagulation, promoting blood circulation to arrest pain, increasing coronary blood flow, dissipating heat to arrest pain and the like.
Kudzu root: the flavonoid compounds contained in the product have very obvious effects of softening blood vessels, increasing blood microcirculation, eliminating plaques in the blood vessels and preventing arteriosclerosis.
Leech: the hirudin contained in the product has anticoagulant and antithrombotic effects.
Wolfberry fruit: the medlar is called as Chinese cherry tomato in America, mainly contains rich medlar polysaccharide, beta-carotene, vitamin E, selenium, flavonoids and other antioxidant substances, and has better antioxidation effect. Can resist free radical peroxidation and reduce damage of free radical peroxidation, thereby being helpful for delaying aging and prolonging life. For modern people, the medlar has the functions of protecting liver, reducing blood sugar, reducing cholesterol, resisting fatigue and reducing blood pressure.
Glossy privet fruit: the product has effects in nourishing liver, improving eyesight, invigorating kidney, and nourishing blood. Has effects of promoting blood circulation, protecting liver, improving vision, and reducing blood lipid, blood glucose and cholesterol.
Dodder seed: dodder seed, semen Cuscutae enters liver, kidney and spleen channels, and has the effects of tonifying kidney and replenishing vital essence.
Kelp: a seaweed with high medicinal value is provided. Has the effects of softening and resolving hard mass, relieving swelling, inducing diuresis, moistening lower energizer and eliminating phlegm. It has been reported that it can also be used for cancer.
The invention has the beneficial effects that:
1. in the clinical practice of years, the invention adopts the astragalus and the kudzuvine root as monarch drugs, is matched with other auxiliary drugs, takes the blood stasis removing and the freckle removing as the core, and is assisted with the functions of tonifying the kidney, nourishing the blood and promoting the circulation of qi; the strong blood-breaking products in the formula mainly comprise peach kernels, safflower, leeches and pseudo-ginseng, and have the effects of promoting blood circulation to remove blood stasis, dredging plaques in capillaries and large blood vessels and softening blood vessels; radix rehmanniae Preparata, radix Angelicae sinensis, radix Polygoni Multiflori Preparata, fructus Lycii, and semen Cuscutae etc. with sweet and warm properties are used for nourishing yin, tonifying liver, nourishing blood, and regulating menstruation; peony root, radix Paeoniae alba, radix. The hemlock parsley, the salvia miltiorrhiza, the raw hawthorn, the kelp and the like have the effects of activating blood and promoting qi circulation and regulating qi and blood so as to help the blood circulation; astragalus root, gynostemma pentaphylla and the like are used for benefiting qi and nourishing blood, increasing the immune function and resisting aging; the formula is characterized by proper compatibility, follows the ancient way without the ancient way, removes blood stasis without damaging the body, removes blood stasis, generates new blood, has smooth qi movement, achieves the aims of removing blood stasis and promoting tissue regeneration, and prolongs the life, and is different from blood circulation activating and blood stasis removing medicines such as blood stasis removing capsules, blood blockage removing pills, big activating collateral pills and the like on the market at present, can stabilize plaque, gradually remove blood stasis and remove freckles, and can be used for treating spleen deficiency, abdominal diarrhea and liver and kidney deficiency diseases.
2. The invention has the functions of expanding blood vessels, removing spot blocks, reducing blood fat, resisting fatigue, resisting anoxia, resisting inflammation, supplementing trace elements and the like; the kudzu root and the gentian root have the effect of effectively stabilizing the plaque, can quickly stabilize the neck vascular plaque, and are matched with other auxiliary medicines to treat the neck vascular plaque by taking blood stasis removing and freckle removing as a core; the preparation method provided by the invention is provided with three-stage reflux extraction, so that the traditional Chinese medicine components are purified, and the neck vascular plaque can be accurately treated, the blood vessels are softened and expanded, and the freckle blocks are removed.
3. The method is provided with three-stage reflux extraction, the concentration and the component proportion of the traditional Chinese medicine extracted by reflux each time are different, the traditional Chinese medicine is subjected to reduced pressure concentration after the reflux extraction, and the impurities in the concentrate are reduced through the coordination of the traditional Chinese medicine and the component proportion, so that the insoluble traditional Chinese medicine and the traditional Chinese medicine with low solubility are left in the filtrate to be extracted after the next dissolution and filtration; the purity of the traditional Chinese medicine is improved, the solubility of the effective substances is improved, the design requirement of a subsequent process on a homogenization procedure of the traditional Chinese medicine is reduced, and the action performance of the effective components in the extracting solution is improved; meanwhile, active ingredients in the raw material medicines are retained to the greatest extent, and the problems of strange taste and difficulty in swallowing of the traditional Chinese medicine are solved.
4. The invention has the functions of removing blood stasis, relieving pain, promoting blood circulation, relieving swelling, softening hardness and dissipating stagnation, has excellent curative effect on neck, shoulder, waist and leg pain and hyperplasia of mammary glands, and can be used for children and pregnant women; in long-term clinical treatment, the inventor tries different proportions of the traditional Chinese medicinal materials in the traditional Chinese medicine composition, and finally determines the most appropriate proportion range of the traditional Chinese medicinal materials through a large amount of statistical data.
Detailed Description
The present invention is described in detail below for the purpose of better understanding technical solutions of the present invention by those skilled in the art, and the description of the present invention is only exemplary and explanatory and should not be construed as limiting the scope of the present invention in any way.
Example 1:
a traditional Chinese medicine composition for treating neck vascular plaque comprises, by mass, 10 parts of radix astragali, 10 parts of radix polygoni multiflori preparata, 3 parts of pseudo-ginseng, 8 parts of peach kernel, 10 parts of semen cassiae torae, 5 parts of radix gentianae, 10 parts of safflower, 10 parts of raw hawthorn, 10 parts of selfheal, 10 parts of angelica sinensis, 10 parts of rhizoma alismatis, 10 parts of rhizoma polygonati preparata, 10 parts of ligusticum wallichii, 10 parts of radix salviae miltiorrhizae, 10 parts of gynostemma pentaphylla, 10 parts of radix paeoniae rubra, 15 parts of radix astragali, 2 parts of leech preparata, 10 parts of fructus lycii, 10 parts of fructus ligustri lucidi, 10 parts of semen cuscutae, 10 parts of kelp.
The traditional Chinese medicine composition is a capsule preparation.
A preparation method of a traditional Chinese medicine composition for treating neck vascular plaque comprises the following steps:
the method comprises the following steps: weighing the components according to the weight, selecting fresh medlar, peach kernel, raw hawthorn, safflower, prepared fleece flower root, kudzuvine root and dodder, washing for 2 times by using water, mixing the medlar, peach kernel, raw hawthorn, safflower, prepared fleece flower root, kudzuvine root and dodder, crushing, and sieving by using a 140-mesh sieve;
step two: adding water 8 times the weight of the medicinal materials into the mixture obtained in the step one, carrying out three-stage reflux extraction for 0.5 hour, filtering, and concentrating the filtrate under reduced pressure to obtain a concentrate I;
step three: mixing radix astragali, radix Notoginseng, semen Cassiae, radix Gentianae, Spica Prunellae, radix Angelicae sinensis, rhizoma Alismatis, rhizoma Polygonati preparata, rhizoma Chuanxiong, radix Salviae Miltiorrhizae, gynostemma pentaphyllum, radix Paeoniae Rubra, Hirudo preparata, fructus Ligustri Lucidi, thallus laminariae, radix Paeoniae alba, and radix rehmanniae Preparata, pulverizing the mixture, sieving with 180 mesh sieve, adding 10 times of 50% ethanol solution, performing three-stage reflux extraction for 0.5 hr each time, filtering, concentrating the filtrate under reduced pressure, and recovering ethanol to obtain concentrate II; steaming the obtained Chinese medicinal mixture in the third step, and pulverizing. The concentration of the traditional Chinese medicine serous fluid entering and exiting each time in the three-stage reflux is gradually reduced, and the concentration of the traditional Chinese medicine serous fluid in the first-stage reflux is 25wt% of the traditional Chinese medicine stock solution; the concentration of the traditional Chinese medicine serous fluid of the secondary reflux is 20 wt%; the concentration of the traditional Chinese medicine serous fluid of the third-stage reflux is 15 wt%.
Step four: uniformly mixing the obtained concentrate I and concentrate II; and (5) packaging and processing.
Example 2
A traditional Chinese medicine composition for treating neck vascular plaque comprises, by mass, 8 parts of radix astragali, 8 parts of radix polygoni multiflori preparata, 1 part of radix notoginseng, 5 parts of peach kernel, 5 parts of semen cassiae torae, 3 parts of radix gentianae, 6 parts of safflower, 7 parts of raw hawthorn, 8 parts of selfheal, 8 parts of angelica sinensis, 5 parts of rhizoma alismatis, 5 parts of rhizoma polygonati preparata, 5 parts of ligusticum wallichii, 5 parts of radix salviae miltiorrhizae, 5 parts of gynostemma pentaphylla, 5 parts of radix paeoniae rubra, 10 parts of radix puerariae, 1 part of honey-fried leech, 8 parts of fructus lycii, 8 parts of fructus ligustri lucidi, 8 parts of semen cuscutae, 8.
The traditional Chinese medicine composition is a capsule preparation.
A preparation method of a traditional Chinese medicine composition for treating neck vascular plaque comprises the following steps:
the method comprises the following steps: weighing the above components, selecting fresh fructus Lycii, semen Persicae, fructus crataegi, Carthami flos, radix Polygoni Multiflori Preparata, radix Puerariae and semen Cuscutae, washing with water for 3 times, mixing fructus Lycii, semen Persicae, fructus crataegi, Carthami flos, radix Polygoni Multiflori Preparata, radix Puerariae and semen Cuscutae, pulverizing, and sieving with 180 mesh sieve;
step two: adding water which is 10 times of the weight of the medicinal materials into the mixture obtained in the step one, carrying out three-stage reflux extraction for 1.5 hours, filtering, and concentrating the filtrate under reduced pressure to obtain a concentrate I;
step three: mixing radix astragali, radix Notoginseng, semen Cassiae, radix Gentianae, Spica Prunellae, radix Angelicae sinensis, rhizoma Alismatis, rhizoma Polygonati preparata, rhizoma Chuanxiong, radix Salviae Miltiorrhizae, gynostemma pentaphyllum, radix Paeoniae Rubra, Hirudo preparata, fructus Ligustri Lucidi, thallus laminariae, radix Paeoniae alba, and radix rehmanniae Preparata, pulverizing the mixture, sieving with 140 mesh sieve, adding 50% ethanol solution 10 times the weight of the raw materials, performing three-stage reflux extraction for 1.5 hr each time, filtering, concentrating the filtrate under reduced pressure, and recovering ethanol to obtain concentrate II; steaming the obtained Chinese medicinal mixture in the third step, and pulverizing. The concentration of the traditional Chinese medicine serous fluid entering and exiting each time in the three-stage reflux is gradually reduced, and the concentration of the traditional Chinese medicine serous fluid in the first-stage reflux is 40wt% of the traditional Chinese medicine stock solution; the concentration of the traditional Chinese medicine serous fluid of the secondary reflux is 25 wt%; the concentration of the traditional Chinese medicine serous fluid of the third-stage reflux is 20 wt%.
Step four: uniformly mixing the obtained concentrate I and concentrate II; and (5) packaging and processing.
Example 3:
a traditional Chinese medicine composition for treating neck vascular plaque comprises, by mass, 15 parts of astragalus membranaceus, 15 parts of prepared fleece flower root, 6 parts of pseudo-ginseng, 10 parts of peach kernel, 10 parts of cassia occidentalis, 8 parts of gentian, 12 parts of safflower, 14 parts of raw hawthorn, 11 parts of selfheal, 15 parts of whole angelica, 12 parts of rhizoma alismatis, 15 parts of prepared rhizoma polygonati, 12 parts of ligusticum wallichii, 15 parts of salvia miltiorrhiza, 15 parts of gynostemma pentaphylla, 15 parts of red peony root, 20 parts of radix puerariae, 5 parts of roasted leech, 13 parts of wolfberry fruit, 12 parts of glossy privet fruit, 11 parts of semen cuscutae, 11 parts of kelp, 12 parts of radix paeoniae alba and 7 parts.
The traditional Chinese medicine composition is a capsule preparation.
A preparation method of a traditional Chinese medicine composition for treating neck vascular plaque comprises the following steps:
the method comprises the following steps: weighing the above components, selecting fresh fructus Lycii, semen Persicae, fructus crataegi, Carthami flos, radix Polygoni Multiflori Preparata, radix Puerariae and semen Cuscutae, washing with water for 3 times, mixing fructus Lycii, semen Persicae, fructus crataegi, Carthami flos, radix Polygoni Multiflori Preparata, radix Puerariae and semen Cuscutae, pulverizing, and sieving with 180 mesh sieve;
step two: adding water 9 times the weight of the medicinal materials into the mixture obtained in the step one, carrying out three-stage reflux extraction for 1 hour, filtering, and concentrating the filtrate under reduced pressure to obtain a concentrate I;
step three: mixing radix astragali, radix Notoginseng, semen Cassiae, radix Gentianae, Spica Prunellae, radix Angelicae sinensis, rhizoma Alismatis, rhizoma Polygonati preparata, rhizoma Chuanxiong, radix Salviae Miltiorrhizae, gynostemma pentaphyllum, radix Paeoniae Rubra, Hirudo preparata, fructus Ligustri Lucidi, thallus laminariae, radix Paeoniae alba, and radix rehmanniae Preparata, pulverizing the mixture, sieving with 180 mesh sieve, adding 50% ethanol solution with a mass concentration 9 times of the weight of the raw materials, performing three-stage reflux extraction for 1 hr each time, filtering, concentrating the filtrate under reduced pressure, and recovering ethanol to obtain concentrate II; steaming the obtained Chinese medicinal mixture in the third step, and pulverizing. The concentration of the traditional Chinese medicine serous fluid entering and exiting each time in the three-stage reflux is gradually reduced, and the concentration of the traditional Chinese medicine serous fluid in the first-stage reflux is 30wt% of the traditional Chinese medicine stock solution; the concentration of the traditional Chinese medicine serous fluid of the secondary reflux is 24 wt%; the concentration of the traditional Chinese medicine serous fluid of the third-stage reflux is 18 wt%.
Step four: uniformly mixing the obtained concentrate I and concentrate II; and (5) packaging and processing.
Comparative example 1
In this embodiment, the third-stage reflux extraction is not used in the second step and the third step, but only once, and the rest is the same as in embodiment 1.
In the comparative example, 30 groups of patients felt that the taste of the traditional Chinese medicine is strange and the curative effect is poorer than that of the example 1.
Comparative example 2
In this example, radix puerariae was not used, and the same amount of radix astragali was used instead, and the other examples were the same as example 1.
Comparative example 3
In this example, gentian was not used, and an equal amount of astragalus was used instead, and the other examples were the same as example 1.
Comparative example 4
In this example, the same amount of astragalus root was used instead of pueraria root and gentian, and the other examples were the same as example 1.
Clinical trial 1
The clinical medical effect of the invention is as follows: by using the auxiliary treatment of the invention, systematic clinical observation is carried out on 80 patients, all neck vascular plaques are in the age of 48-65 years, and the auxiliary treatment is used for 30 months in the treatment period. The cure rate is 95.6%, and the medicine is effective after two years of clinical tracking. The effective patients are followed up, and the clinical symptoms of the cardiovascular and cerebrovascular diseases such as dizziness, fullness in head, chest distress, palpitation, shortness of breath and the like of the patients are obviously improved. In patients with high blood pressure, the blood pressure tends to be stable.
Diagnostic criteria:
adopting color B ultrasonic to perform carotid artery blood flow graph contrast cure, and plaque falling or melting; effectively, the plaque parts fall off or melt; no effect, no change in plaque size from clinical evaluation criteria:
the present invention will be further described with reference to specific examples.
Patient 1: forest xx, 50 years old, female, 0.6mm to the left and 0.6mm to the right of the medial thickness in the common carotid artery. The bifurcation of the head and arm trunk shows inhomogeneous echoes of 9.8mm multiplied by 3.3mm, and part of the inhomogeneous echoes are enhanced echoes; the right common carotid artery bifurcation has a hypoechoic area of 7.6mm multiplied by 2.5mm, the local middle membrane at the left common carotid artery bifurcation has a thickness of 1.3mm, the plaque becomes small after 2 months of use, and the bifurcation has a thickness of 7.8mm multiplied by 3.0 mm.
Patient 2: left xx, 56 years old, male, right common carotid sinus 11.6mm by 3.7mm low echo plaque, normal blood flow signal, thickness of intima-media of artery 1.87mm, spleen deficiency diarrhea, 1.5 months after the plaque becomes stable.
Patient 3: yellow xx, 58 years old, male, 0.56mm left and 0.56mm right of the medial thickness in the common carotid artery. The split part of the head and arm trunk has an inhomogeneous echo of 10.0mm multiplied by 3.3 mm; the right common carotid artery bifurcation has a low echogenic zone of 10.6mm multiplied by 3.5mm, the middle membrane thickness of the left common carotid artery bifurcation reaches 1.2.5mm, meanwhile, the liver and kidney are deficient, the plaque becomes small after 3 months of use, the bifurcation has a thickness of 8.0mm multiplied by 3.0mm, and the right common carotid artery bifurcation has a low echogenic zone of 8.6mm multiplied by 3.1 mm.
Clinical trial 2
30 male patients and 50 female patients, 30 neck, shoulder, waist and leg pains and 40 mammary gland hyperplasia. The traditional Chinese medicine composition disclosed by the embodiment 1-3 is respectively adopted, 2 weeks are a treatment course, and the treatment course is 2-3.
The clinical treatment: the pain of the patient basically disappears, the affected part has no swelling and ecchymosis, the patient has no pain when pressing, and the daily life is not affected; pain of a patient suffering from neck, shoulder, waist and leg pain basically disappears, swelling and ecchymosis do not exist on a pain part, and daily life is not affected; the lump and the breast pain of the patient with hyperplasia of mammary glands disappear.
Clinical trial 3
First, test method
1. Grouping
Examples 1-3 the formulations prepared in example 1 were experimental group 1, experimental group 2, experimental group 3 at a time; troxerutin tablet for oral administration is prepared from blank control group, wherein the weight of substrate is 0.1 g/tablet, and the tablet is orally administered 3 tablets at a time, 2 times a day. Each group is treated with 6 weeks as 1 course of treatment, and 1 course of treatment is observed.
2. Observation index
And (4) safety observation: general item examination before and after treatment, routine examination of blood, urine and feces, and examination of heart, liver and kidney functions.
And (3) observation of curative effect: the effect is shown: plaque sloughing or thawing, effective: plaque parts slough off or melt, ineffective: the plaque size was unchanged and the blood plaque was unstable. Record 1 time per week.
Relevant signs: including heart rate, heart rhythm, blood pressure, pulse, tongue proper, tongue coating, pulse condition, etc. Relevant physicochemical examination: blood lipids, hemorheology, electrocardiogram, exercise test, etc.
4. Statistical treatment
The statistical method comprises the following steps: clinical data and data are examined and verified, then input into a computer, and measured by mean + -standard deviation (X + -SD) and multiple variance analysis or t-test.
Second, result in
1. The clinical overall efficacy is shown in table 1: the clinical curative effect of the four groups after treatment is obvious, and the significant efficiency is superior to that of a comparative example combined control group.
Table 1 comparison of total clinical efficacy.
Figure RE-691610DEST_PATH_IMAGE001
2. Effects on hemorheology: the whole blood viscosity, fibrinogen and plasma viscosity decreased significantly before and after each treatment, as shown in table 2.
Table 2, comparison of change in hemorheological indices before and after treatment (X ± SD).
Figure RE-290081DEST_PATH_IMAGE002
Note: p < 0.05 before and after treatment, P < 0.01 before and after treatment, and Δ P < 0.05 between the test and control groups after treatment.
Ultrasonic carotid artery examination is carried out on five groups of experimental personnel, and the carotid atherosclerotic plaques of the patients in the experimental groups 1-3 are all reduced, and the plaque reduction degree and the plaque reduction number of the experimental group are more than those of the control group. The clinical test results show that the components of the invention are quantitatively combined and compatible, not only has good curative effect, but also is safe and has no side effect.
Acute toxicity test
1 materials and methods
1.1 animals: selecting healthy and active mice with the body fat rate 5-15% higher than the normal body weight range, dividing the mice into two groups, wherein each group of the mice comprises 90 males and females, each group comprises 30 females, one group is an experimental group, one group is a comparative group, and the other group is a control group. Wherein, the normal weight range refers to mice with the weight of 20-26 g.
The tested drugs are: the Chinese medicinal composition in the patch prepared by the method of example 1-3.
1.2 Experimental methods
Referring to the research guidelines for new traditional Chinese medicines, in a laboratory at the room temperature of 23 ℃, the mice are repeatedly pre-tested to be infused with 300mg/kg of the traditional Chinese medicine composition, the toxic reaction and death condition of the mice are observed for one week, half of the lethal dose cannot be measured, and the maximum tolerance is selected for the experiment.
The weight of the mice is taken as standard, the mice in the experimental group and the comparative group are continuously taken once every 6h according to the dosage of 0.6mg for one month; the control group had free access to water and foraging without feeding the Chinese medicinal composition, and during the period of feeding the Chinese medicinal composition and after stopping feeding for two weeks, the state of the mice was observed, and the health status of the mice was judged by blood collection and analysis, biopsy of visceral organs, and other items.
1.3 results of the experiment
When the mice were fed with the Chinese medicinal composition prepared in examples 1 to 3, none of the mice died within 3 months, the biopsy result of the organ tissue showed normal, and the mental state of the mice was good.
When the traditional Chinese medicine compositions prepared in the comparative examples 2-4 are fed, mice die for 3 months at different degrees, and gastrointestinal problems and diarrhea occur at different degrees.
It should be noted that, in this document, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
The principles and embodiments of the present invention are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts of the present invention. The foregoing is only a preferred embodiment of the present invention, and it should be noted that there are objectively infinite specific structures due to the limited character expressions, and it will be apparent to those skilled in the art that a plurality of modifications, decorations or changes may be made without departing from the principle of the present invention, and the technical features described above may be combined in a suitable manner; such modifications, variations, combinations, or adaptations of the invention using its spirit and scope, as defined by the claims, may be directed to other uses and embodiments.

Claims (10)

1. A traditional Chinese medicine composition for treating neck vascular plaque is characterized in that, by mass, the composition comprises 8-15 parts of astragalus membranaceus, 8-15 parts of prepared fleece-flower root, 1-6 parts of pseudo-ginseng, 5-10 parts of peach kernel, 5-10 parts of cassia occidentalis, 3-8 parts of gentian, 6-12 parts of safflower, 7-14 parts of raw hawthorn, 8-11 parts of selfheal, 8-15 parts of whole angelica, 5-12 parts of rhizoma alismatis, 5-15 parts of prepared rhizoma polygonati, 5-12 parts of ligusticum wallichii, 5-15 parts of salvia miltiorrhiza, 5-15 parts of gynostemma pentaphylla, 5-15 parts of red paeony root, 10-20 parts of radix puerariae, 1-5 parts of roasted leech, 8-13 parts of wolfberry fruit, 8-12 parts of glossy privet fruit, 8-11 parts of semen cuscutae, 8-11 parts of kelp, 7-12 parts of radix paeoniae alba and 3.
2. The traditional Chinese medicine composition for treating neck vascular plaque as claimed in claim 1, wherein the composition comprises, by mass, 8 parts of radix astragali, 8 parts of radix polygoni multiflori preparata, 1 part of radix notoginseng, 5 parts of peach kernel, 5 parts of semen cassiae, 3 parts of radix gentianae, 6 parts of safflower, 7 parts of raw hawthorn, 8 parts of selfheal, 8 parts of whole angelica, 5 parts of rhizoma alismatis, 5 parts of rhizoma polygonati preparata, 5 parts of ligusticum wallichii, 5 parts of radix salviae miltiorrhizae, 5 parts of gynostemma pentaphylla, 5 parts of radix paeoniae rubra, 10 parts of radix puerariae, 1 part of leech preparata, 8 parts of fructus lycii, 8 parts of fructus ligustri lucidi, 8 parts of semen cuscutae, 8 parts of kelp, 7.
3. The traditional Chinese medicine composition of claim 1, wherein the composition comprises, by mass, 15 parts of radix astragali, 15 parts of radix polygoni multiflori preparata, 6 parts of radix notoginseng, 10 parts of peach kernel, 10 parts of semen cassiae, 8 parts of radix gentianae, 12 parts of safflower, 14 parts of raw hawthorn, 11 parts of selfheal, 15 parts of whole angelica, 12 parts of rhizoma alismatis, 15 parts of prepared rhizoma polygonati, 12 parts of ligusticum wallichii, 15 parts of radix salviae miltiorrhizae, 15 parts of gynostemma pentaphylla, 15 parts of radix paeoniae rubra, 20 parts of radix puerariae, 5 parts of prepared leech, 13 parts of fructus lycii, 12 parts of fructus ligustri lucidi, 11 parts of semen cuscutae, 11 parts of kelp, 12 parts.
4. The traditional Chinese medicine composition of claim 1, wherein the composition comprises, by mass, 10 parts of radix astragali, 10 parts of radix polygoni multiflori preparata, 3 parts of radix notoginseng, 8 parts of peach kernel, 10 parts of semen cassiae torae, 5 parts of radix gentianae, 10 parts of safflower, 10 parts of raw hawthorn, 10 parts of selfheal, 10 parts of whole angelica, 10 parts of rhizoma alismatis, 10 parts of prepared rhizoma polygonati, 10 parts of ligusticum wallichii, 10 parts of radix salviae miltiorrhizae, 10 parts of gynostemma pentaphylla, 10 parts of radix paeoniae rubra, 15 parts of radix puerariae, 2 parts of leech preparata, 10 parts of fructus lycii, 10 parts of fructus ligustri lucidi, 10 parts of semen cuscutae, 10 parts of kelp.
5. The traditional Chinese medicine composition for treating neck vascular plaque according to claim 1, wherein the traditional Chinese medicine composition is in any pharmaceutically acceptable dosage form.
6. The traditional Chinese medicine composition for treating neck vascular plaque according to claim 1, wherein the traditional Chinese medicine composition comprises a pharmaceutically acceptable carrier.
7. The traditional Chinese medicine composition for treating neck vascular plaque according to claim 1, wherein the traditional Chinese medicine composition is a capsule preparation.
8. A preparation method of a traditional Chinese medicine composition for treating neck vascular plaque is characterized by comprising the following steps:
the method comprises the following steps: weighing the above components, selecting fresh fructus Lycii, semen Persicae, fructus crataegi, Carthami flos, radix Polygoni Multiflori Preparata, radix Puerariae and semen Cuscutae, washing with water for 2-3 times, mixing fructus Lycii, semen Persicae, fructus crataegi, Carthami flos, radix Polygoni Multiflori Preparata, radix Puerariae and semen Cuscutae, pulverizing, and sieving with 140 or 180 mesh sieve;
step two: adding water 8-10 times the weight of the medicinal materials into the mixture obtained in the step one, carrying out three-stage reflux extraction for 0.5-1.5 hours, filtering, and concentrating the filtrate under reduced pressure to obtain a concentrate I;
step three: mixing radix astragali, radix Notoginseng, semen Cassiae, radix Gentianae, Spica Prunellae, radix Angelicae sinensis, rhizoma Alismatis, rhizoma Polygonati preparata, rhizoma Chuanxiong, radix Salviae Miltiorrhizae, gynostemma pentaphyllum, radix Paeoniae Rubra, Hirudo preparata, fructus Ligustri Lucidi, thallus laminariae, radix Paeoniae alba, and radix rehmanniae Preparata, pulverizing the mixture, sieving with 140 or 180 mesh sieve, adding 50% ethanol solution with mass concentration of 8-10 times of the weight of the raw materials, performing three-stage reflux extraction for 0.5-1.5 hr each time, filtering, concentrating the filtrate under reduced pressure, and recovering ethanol to obtain concentrate II;
step four: uniformly mixing the obtained concentrate I and concentrate II; and (5) packaging and processing.
9. The method for preparing a Chinese medicinal composition according to claim 8, wherein the Chinese medicinal mixture obtained in step three is steamed and then pulverized.
10. The method for preparing a Chinese medicinal composition according to claim 8, wherein the concentration of Chinese medicinal serous fluid entering and exiting each time in the three-stage reflux is gradually decreased, and the concentration of Chinese medicinal serous fluid in the first-stage reflux is 25-40 wt% of the Chinese medicinal stock solution; the concentration of the traditional Chinese medicine serous fluid of the secondary reflux is 20 to 25 weight percent; the concentration of the traditional Chinese medicine serous fluid of the third-stage reflux is 15wt% -20 wt%.
CN202110133204.2A 2021-02-01 2021-02-01 Traditional Chinese medicine composition for treating neck vascular plaque and preparation method thereof Pending CN112791150A (en)

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