CN1127657A

CN1127657A - Tonic hypoglycemic capsule and preparing process thereof

Info

Publication number: CN1127657A
Application number: CN 95116521
Authority: CN
Inventors: 张文龙
Original assignee: Individual
Current assignee: Individual
Priority date: 1995-10-04
Filing date: 1995-10-04
Publication date: 1996-07-31
Anticipated expiration: 2015-10-04
Also published as: CN1053826C

Abstract

The Chinese patent medicine in the form of capsule for reducing blood sugar and fat and urosaccharide with high effect is prepared from 20 Chinese-medicinal materials such as prepared rehmannia root, astragalus root, wolfberry fruit, red sage root, anemarrhena rhizome, etc.

Description

Tonic hypoglycemic capsule and preparation method thereof

The present invention relates to a kind of Chinese patent medicine formula for the treatment of non-insulin-dependent diabetes mellitus and preparation method thereof.

Diabetes, motherland's medical science is referred to as " diabetes ", be common clinical, frequently-occurring disease, it also is one of difficult and complicated illness, the syndrome of multisystem metabolism disorders such as the sugar that it is absolute by insulin or relative deficiency causes, albumen, fat, multi-organ function infringement, its Clinical symptoms is polydipsia, polyphagia, polyuria, it is weak to become thin, blood glucose height, the glucose in urine positive, glucose tolerance attenuating etc. are shown in chemical examination, belong to the general incretion metabolism disease, according to statistics, diabetes are to be only second to tumor and cardiovascular disease, become the third-largest disease of harm humans life.At present, the whole world has 100,000,000 people ill approximately, and China's prevalence is about 6.09 ‰, and the trend that increases is year by year arranged, and wherein is non-insulin-dependent diabetes mellitus (hereinafter to be referred as type ii diabetes) more than 90%.

To the treatment of type ii diabetes, the following a few class medicines of the many employings of doctor trained in Western medicine:

1, sulphanylureas: as D860, glyburide, diamicron etc., though to type ii diabetes light, moderate person is effective, has some side effect, as erythra, gastrointestinal reaction, hemocyte and hepatic and renal function injure etc.

2, biguanides:,, exist gastrointestinal tract, the prejudicial untoward reaction of Liver and kidney have also been limited its application though type ii diabetes is had certain effect as insoral etc.

3, insulin: be suitable for the type ii diabetes people of severe, and stress use under the situation, so most patient insulinize not with complication, wound, gestation etc.

4, Chinese medicine: some Chinese patent medicines (as JIANGTANGSHU) and diabetes pill (adding the part Western medicine in the Chinese medicine) etc., curative effect is not good enough; Some Chinese medicine adopts honeyed pill all undesirable.

The objective of the invention is to: the manufacture method of the therapeutic agent that a kind of type ii diabetes is provided---tonic hypoglycemic capsule.

Solution of the present invention is to select following plant amedica (by weight preparation) for use:

1 part in 1 part of Radix Rehmanniae of 1 part of Poria of 1 part of Radix Astragali Preparata of Radix Codonopsis

1 part of 1 part of Radix Trichosanthis of 1 portion of Rhizoma Dioscoreae of 1 part of Fructus Corni of Radix Rehmanniae Preparata

1 part of 1 part of Radix Salviae Miltiorrhizae of 1 part of Cortex Moutan of 1 part of Rhizoma Atractylodis of Rhizoma Alismatis

1 part of 1 portion of Cortex Phellodendri of 1 part of Radix Scutellariae of 1 portion of Rhizoma Coptidis of Fructus Lycii

0.5 portion of Cortex Cinnamomi of 1 part of Radix Aconiti Lateralis Preparata of 1 part of Rhizoma Anemarrhenae of Radix Scrophulariae is 20 flavor plant amedica more than 0.5 part, the conventional method decontamination, and clean it up is behind the sterilization, combination drying after the pulverizing, is crossed 100 mesh sieves, becomes fine powder, reinstall in " 0 " number Capsules, every heavy 0.5 the gram, this Chinese patent medicine.

Wherein the concocting method of several plant medicine is: (1) Radix Aconiti Lateralis Preparata is dipped to the surface repeatedly with saline solution will crystallization degree of being, taking out again, water cooks; (2) the Rhizoma Atractylodis water logging runs through, and section is fried to little Huang; (3) Radix Scrophulariae shines to inner blackout; (4) Rhizoma Alismatis, the Rhizoma Anemarrhenae, Cortex Phellodendri are fried with the salt low baking temperature and process.

The time that sight is quenched one's thirst, see more become thin weak, tiredness with no desire to speak, dysphoria with smothery sensation is urinated red, pale tongue is fat, the few Tianjin of thin fur, thready pulse without strength etc. are by due to spleen kidney deficiency, the impairment of both QI and YIN.The deficiency of YIN is hyperactivity of fire then, on steam the lung stomach, the then thirsty easy famine of consumption of body fluid by heat.Deficiency of vital energy promoting the circulation of blood is unable, and the heat venation of then burning so cause giving birth in the blood stasis, produces apoplexy, economizes order cataract etc.So the dominant mechanism of type ii diabetes (diabetes) can be described as void, heat, stasis of blood three elements, at pathogenesis, take the principle of " treatment must aim at the pathogenesis of disease ", select above-mentioned prescription for use, wherein process yellow late-maturing, Radix Codonopsis, Poria, the Rhizoma Dioscoreae invigorating the spleen and benefiting QI, " then body fluid is spontaneous to support spleen ", the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Corni, Fructus Lycii nourishing kidney yin, Rhizoma Alismatis play cloudy gas, the stopping leak essence pouring drop of quenching one's thirst, Radix Scrophulariae, pollen increases liquid, the dry spleen of Rhizoma Atractylodis is wet, and the product of anti-nourishing hinder spleen fortuneization, the Cortex Moutan cooling blood and removing stasis, the Radix Salviae Miltiorrhizae nourshing blood and promoting blood circulation, the profit kidney is dry under the Rhizoma Anemarrhenae bitter cold, last lung heat clearing gold, the clear part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels heat of Cortex Phellodendri, Rhizoma Coptidis, during Radix Scutellariae is clear, upper and middle portions of the body cavity heat, the exquisite part of filling a prescription more is Radix Aconiti Lateralis Preparata, Cortex Cinnamomi two medicines, get the reason of its " junior fire supporting vital QI ", make the warm then gas of kidney rise and the lung profit " upper-jiao resembling a sprayer ", rule liquid four cloth are quenched one's thirst from ending.Above medicine amounts to strengthening spleen, tonifying kidney, supplementing QI and nourishing YIN, the effect of heat clearing and blood stasis dispersing.

People with the similar II type glycosuria of these capsule for treating 188 routine state of an illness, sex, age, be divided into two groups at random, tonic hypoglycemic capsule group 108 examples, glyburide group 80 examples have shown the curative effect of this prescription from disappear fructosamine, blood fat, serum insulin several respects of doing well,improving and blood glucose, glucose in urine, glycolated hemoglobin, blood.The tonic hypoglycemic capsule group is obeyed 8～10, every day 3 times, taking medicine before meal 3 months courses of treatment at every turn.The glyburide group is obeyed 1～2, every day 3 times three months courses of treatment at every turn.

Cardinal symptom contrast before and after the treatment of table 1 tonic hypoglycemic capsule group

Before treatment back (routine number n) effective percentage symptom smelting is treated

(routine number n) basic constant (%) polydipsia 78 58 20 0 100 polyphagia 60 42 18 0 100 polyurias 70 60 10 0 100 weak 108 82 26 0 100 that are clearly better that disappear

Cardinal symptom contrast before and after the treatment of table 2 glyburide group

Before (routine number n) the effective percentage symptom treatment of treatment back

(routine number n) basic constant (%) polydipsia 40 12 10 18 55 polyphagia 35 8 10 17 51,43 polyurias 38 10 12 16 57,89 weak 80 13 35 32 60 that are clearly better that disappear

Contrast before and after table 3 blood glucose, the glycolated hemoglobin treatment (X ± S)

The blood glucose glycolated hemoglobin group example number n time

(mmol/L) (%) 8.42 ± 2.7 △ △ △ ※ ※ ※, 8.21 ± 2.51 △ △ ※ glyburide, 80 treatments preceding 12.8 ± 2.31 12.38 ± 3.0 of preceding 12.36 ± 02.38 11.64 ± 2.55 carbohydrate gum capsules treatment of 108 treatments back fall in giving young employees remedial-courses in general knowledge and vocational skills

Treatment back 10.72 ± 2.36 10.2 5 ± 2.35 △

Illustrate: compare (t check), △ P＜0.05, △ △ P＜0.01, △ △ △ P＜0.001 before and after the treatment; ※ P＜0.05, ※ ※ ※ P＜0.001 are compared in two groups of treatment backs.

Contrast before and after table 4 serum fructosamine, the insulinize (X ± S)

The fructosamine insulin group example number n time

(mmol/L) 2.75 ± 0.72 △ △ ※, 31.09 ± 8.12 glyburide, 80 treatments preceding 3.82 ± 0.92 24 ± 7.8 of preceding 3.68 ± 0.87 26.4 ± 4.72 carbohydrate gum capsules treatment of 108 treatments back fall in (μ U/ml) giving young employees remedial-courses in general knowledge and vocational skills

Treatment back 3.16 ± 0.82 △ 27.62 ± 6.6

Illustrate: compare (t check), △ P＜0.05, △ △ P＜0.01 before and after the treatment; ※ P＜0.05 is compared in two groups of treatment backs.

By table 3, table 4 as can be known, treatment back blood glucose, glycolated hemoglobin, fructosamine all have decline, and more obvious with the tonic hypoglycemic capsule group, two groups relatively have notable difference (P＜0.05 or P＜0.01); Tonic hypoglycemic capsule group treatment back insulin content rises (P＜0.05), and the glyburide group is only seen ascendant trend.

Glucose in urine contrast before and after the treatment of table 5 tonic hypoglycemic capsule group

Treatment back (routine number n) effective percentage glucose in urine is qualitative before the treatment

(routine number n)-+++ +++++ ++ (%) ++ ++ 78 30 21 8 10 9 88.46+++, 20 10 541 95++ 10 532 80 add up to 108 45 29 14 11 9 88.89

Glucose in urine contrast before and after the treatment of table 6 glyburide group

(routine number n)-+++ +++++ ++ (%) ++ ++ 32 128 11 10 68.75+++ 30 26 10 12 60 ++ 18 4 10 4 77.78 add up to 80 7 18 22 23 10 67.5

Find out that by table 5 and table 6 the tonic hypoglycemic capsule group has tangible hypoglycemic effect.

(group example number (n) the time cholesterol triglyceride of X ± S) of contrast before and after the treatment of table 7 cholesterol, triglyceride

(mmol/L) (mmol/L) behind preceding 4.34 ± 0.71 2.16 ± 0.62 capsule for treating of tonic hypoglycemic treatment 3.32 ± 0.48 △ △ ※ ※ ※, 1.32 ± 0.5 △ △ ※ glyburide treat preceding 4.26 ± 0.57 1.03 ± 0.52

3.86 ± 0.52 1.02 ± 0.60 explanations of treatment back: the treatment front and back are (t check) relatively, △ △ P＜0.01; Two groups of treatment backs relatively

※ P＜0.05, tonic hypoglycemic capsule group rate and blood-lipid decreased is obvious as shown in Table 7 in ※ ※ ※ P＜0.001.

Table 8 liang group curative effect relatively (routine number n) group produce effects enabledisable adds up to total effective rate (%) giving young employees remedial-courses in general knowledge and vocational skills to fall 80 20 8 108 92.6 carbohydrate gum capsule glyburide 20 34 26 80 67.5

An important feature of the present invention is to make Chinese patent medicine after plant amedica is pulverized, and therefore, content of cellulose is a lot, and it can slow down the absorption of sugar, so curative effect is stable and persistent.

The advantage of medicine of the present invention is:

1, is raw material with plant amedica, is mixed with Chinese patent medicine by a certain percentage,, human body is had no side effect in order to the treatment type ii diabetes.

2, medicine of the present invention still can improve the beta Cell of islet secretory function to improving effective percentage height such as type ii diabetes symptom, blood sugar lowering, blood fat reducing, and this has good influence to complication such as treatment diabetes and prevention blood vessels.

3, medicine of the present invention does not add honey, does not decoct, make simply, and taking convenience, general pharmaceutical factory all can produce.

Claims

1, a kind of medicine for the treatment of type ii diabetes---the compound method of tonic hypoglycemic capsule.

It is characterized in that it is the medicament of being prepared by the plant amedica of following weight ratio:

1 part in 1 part of Radix Rehmanniae of 1 part of Poria of 1 part of Radix Codonopsis of Radix Astragali Preparata

1 part of 1 part of Fructus Lycii of 1 part of Radix Salviae Miltiorrhizae of 1 part of Cortex Moutan of Rhizoma Alismatis

1 part of 1 part of Rhizoma Anemarrhenae of 1 portion of Cortex Phellodendri of 1 part of Radix Scutellariae of Rhizoma Coptidis

0.5 part of 0.5 portion of Cortex Cinnamomi of 1 part of Radix Aconiti Lateralis Preparata of 1 portion of Radix Scrophulariae of Rhizoma Atractylodis

2, method for preparation of drug according to claim 1 is characterized in that the concocting method of each medicine is:

(1) Radix Aconiti Lateralis Preparata is dipped to the surface repeatedly with Sal, water and crystallization degree of being will occur, takes out the back water and cooks;

(2) the Rhizoma Atractylodis water logging runs through, and section is fried to little Huang;

(3) Radix Scrophulariae shines to inner blackout;

(4) Rhizoma Alismatis, the Rhizoma Anemarrhenae, Cortex Phellodendri are fried with the salt low baking temperature and process;

(5) with other plant amedica decontamination according to a conventional method, behind the clean it up, with all 20 flavor medicine combination dryings, sterilization after the grinding and processing, is crossed 100 mesh sieves, becomes fine powder, and it is standby to reinstall " 0 " number Capsules.