CN1088793A - Health Pseudostellaria medicine - Google Patents
Health Pseudostellaria medicine Download PDFInfo
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- CN1088793A CN1088793A CN 92115281 CN92115281A CN1088793A CN 1088793 A CN1088793 A CN 1088793A CN 92115281 CN92115281 CN 92115281 CN 92115281 A CN92115281 A CN 92115281A CN 1088793 A CN1088793 A CN 1088793A
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Abstract
The invention relates to a kind of health Pseudostellaria medicine with diseases such as treatment child anorexia.It adopts Radix Pseudostellariae, Poria, Fructus Setariae Germinatus, Fructus Hordei Germinatus, Fructus Crataegi, Ganoderma and adds calcium, ferrum and trace element zinc, carries through boiling, concentrates, precipitate with ethanol, refining adjustment and make various preparations such as oral liquid, tablet, electuary.This medical instrument has the effect of supplementing QI for promoting the production of body fluid, strengthening the spleen to promote digestion, enhancing immune function of human body.Show through acute and chronic toxicity test: do not see apparent side effect, clinic trial is safe.Clinical trial shows: the apositia of children total effective rate is reached 93%, infantile dyspepsia disease total effective rate is reached 92.5%, the Iron deficiency anemia in children total effective rate is reached 95.0%.
Description
The present invention relates to Chinese patent medicine, particularly a kind of health Pseudostellaria medicine with treatment child anoretic effect, it comprises oral liquid, sugar-tablet, electuary (tea) and beverage preparation, and the production technology of this health care medicine.
Apositia of children, infantile dyspepsia and iron Deficiency Anemia are usual diseases of childhood, frequently-occurring disease, three's reciprocal causation relation.Existing medicine is many to reach a certain disease of single therapy to control, and does not have the power that keeps healthy and take into account multiple disease of taking good care of, very disadvantageous to the child who still is in growth and development stage like this.
For a bit, the objective of the invention is to according to traditional Chinese medical science traditional theory, develop treatment and combine, and can reach double controlling child's anorexia, infantile dyspepsia and iron Deficiency Anemia with taking good care of health care, and the crown prince of safe without toxic side effect treasured health care medicine and the method that is used to produce this medicine.
According to traditional Chinese medical science traditional theory, at children's's's " young sun of young the moon " body and physiology, pathological characteristics such as " the spleen tending to insufficiency usually ", the medicinal component of the precious health care medicine of crown prince of the present invention is selected for use:
Radix Pseudostellariae [latin name: Pax ex Pax et Hoffm Pseudostellaria heterophlla(Miq.)],
Poria [latin name: wolf Poria cocos(Schw.)],
Fructus Hordei Germinatus [latin name: Hordeum vulgare L.],
Fructus Setariae Germinatus [latin name: Beauv. Setaria italica(L.)],
Fructus Crataegi [latin name: Craegus pinnatifida Bge.var.major N.E.Br.],
The extract of Ganoderma [latin name: pat. Ganaderma applanatum(pers ex Grag)],
Calcium gluconate, ferric ammonium citrate and zinc sulfate.
The consumption (by wt%) of each medicinal component is in the precious health care medicine prescription of crown prince of the present invention: Radix Pseudostellariae 40～50, Poria 20～30, Fructus Hordei Germinatus 10～15, Fructus Setariae Germinatus 10～15, Fructus Crataegi 5～10, Ganoderma extract 1～3, calcium gluconate 0.5～2, ferric ammonium citrate 0.01～0.03 and zinc sulfate 0.01～0.03.
The precious health promoting medicated bag of crown prince of the present invention is drawn together (crown prince's treasured) oral liquid, (crown prince's treasured) tablet (crown prince's treasured) electuary, (crown prince's treasured) beverage.
The process that is used for the precious health care medicine of production crown prince of the present invention is as follows:
One, produce the method for oral liquid (crown prince's Bao oral liquid):
1,1, get crown prince and participate in decocting in water and carry 3～4 times, merge each time extracting solution, filter, filtrate concentrates and adds ethanol to ethanol content and reaches 70%, carries out alcohol and precipitates, and gets supernatant after leaving standstill;
1,2, get Poria, Fructus Hordei Germinatus, Fructus Setariae Germinatus, Fructus Crataegi and merge and add decocting in water and carry 2～3 times, merge each time extracting solution, filter, filtrate concentrates and adds ethanol to ethanol content and reaches 70%, carries out alcohol and precipitates, and gets supernatant after leaving standstill;
1,3, two kinds of supernatant getting above-mentioned " 1,1, " and " 1,2, " gained merge, and reclaim ethanol, concentrate, refining, add Ganoderma extract, ferric ammonium citrate, zinc sulfate, calcium gluconate and suitable amount of sucrose, the dissolving after-filtration adds water and adjusts, and packing, sterilization are promptly.
Two, produce the method for tablet (the precious sheet of crown prince):
2,1, get crown prince and participate in decocting in water and carry 3～4 times, merge each time extracting solution, filter, filtrate concentrates and adds ethanol and makes ethanol content reach 70%, carries out alcohol and precipitates, and gets supernatant after leaving standstill;
2,2, get Poria, Fructus Hordei Germinatus, Fructus Setariae Germinatus, Fructus Crataegi and merge and add decocting in water and carry 2～3 times, merge each time extracting solution, filter, filtrate concentrates and adds ethanol to ethanol content and reaches 70%, carries out alcohol and precipitates, and gets supernatant after leaving standstill;
2,3, two kinds of supernatant getting above-mentioned " 2,1, " and " 2,2, " gained merge, reclaim ethanol, concentrate, add the Ganoderma extract, calcium gluconate, ferric ammonium citrate, zinc sulfate and an amount of food coloring, the sucrose that grind into fine powder in advance, stir evenly, the granulation of sieving, in dry below 70 ℃, granulate adds magnesium stearate, mixing, compacting are in flakes.
Three, produce the method for electuary (the precious electuary of crown prince):
3,1, get Radix Pseudostellariae and make supernatant by " producing the method for oral liquid ";
3,2, getting Poria, Fructus Hordei Germinatus, Fructus Setariae Germinatus, Fructus Crataegi merges by " producing the method for oral liquid " and makes supernatant;
3,3, two kinds of supernatant getting above-mentioned " 3,1, " and " 3,2, " gained merge, reclaim ethanol, concentrate, add the Ganoderma extract, calcium gluconate, ferric ammonium citrate, zinc sulfate and the suitable amount of sucrose that grind into fine powder in advance, mixing, the granulation of sieving, in dry below 70 ℃, granulate, mixing is distributed into bag.
So far, the present invention has reached its intended purposes, the precious health care medicine of the crown prince who is developed has prescription rationally, demonstrated fully from prescription: Radix Pseudostellariae has the merit of replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung, be aided with the Poria invigorating spleen to remove dampness, assistant is more used the effect of eliminate indigestion in Fructus Hordei Germinatus, Fructus Setariae Germinatus, hawthorn digesting intestinal stasis relieving, the accent with the power of Ganoderma enhancing tonification.Realize the function of supplementing QI for promoting the production of body fluid, spleen benefiting and stimulating the appetite, strengthening by means of tonics, promotion appetite, increase immune function of human body, added the various trace elements that helps upgrowth and development of children essential simultaneously.The acute and chronic toxicity test that the precious health care medicine of crown prince of the present invention is carried out through the Academy of Traditional Chinese Medicine, Fujian Province shows: do not see obvious toxic and side effects, clinic trial is safe.Show through pharmacodynamics test: the present invention has anoxia enduring, resisting fatigue, raising reticuloendothelial system phagocytic function, suppresses wriggling and spasmolytic in the gastrointestinal, strengthens effects such as small intestinal absorption.Show through clinical trials such as attached Concord Hospital of Fujian Medical College department of pediatrics, Fujian Provincial Hospital's department of pediatrics, Foochow, Fujian Province children's hospitals: the precious health care medicine of crown prince of the present invention reaches 93% to apositia of children (testing 125 examples) total effective rate, infantile dyspepsia disease (testing 125 examples) total effective rate is reached 92.5%, Iron deficiency anemia in children (testing 91 examples) total effective rate is reached 95%.So, the present invention be a kind of aid digestion, increase appetite, improve anemia, increase body constitution, reduce the repeatability respiratory tract infection, and be particularly suitable for child's health nutrient medicine.
Example 1, system crown prince Bao oral liquid.
The consumption of each medicinal component is by the prescription amount of getting of the precious health care medicine of crown prince of the present invention.Get Radix Pseudostellariae 250g and add decocting in water and carry 3 times, boiled 1 hour at every turn, merge 3 extracting solution and be roughly equal to 5000ml, filter, be concentrated into about 650ml, add ethanol, leave standstill after 24 hours and get supernatant; Get Poria 150g, Fructus Hordei Germinatus 75g, Fructus Setariae Germinatus 75g, Fructus Crataegi 50g and merge and add decocting in water and carry 2 times, boiled 1 hour at every turn, merges 2 times and boil the about 9500ml of extracting solution, filtration is concentrated into 900ml, adds ethanol, leaves standstill after 24 hours and gets supernatant; Above-mentioned two kinds of supernatant are merged, reclaim ethanol, concentrate, make with extra care, it is an amount of to add powdered Ganoderma extract 10g, calcium gluconate 5g, ferric ammonium citrate 66mg, zinc sulfate 55mg and sucrose, add the water modulation 1000ml of institute behind the dissolution filter, be distributed into totally 100 bottles of every bottle of capacity 10ml, promptly through sterilization.
Example 2, the precious sheet (tablet) of system crown prince.
The consumption of each medicinal component is by the prescription amount of getting of the precious health care medicine of crown prince of the present invention.Get Radix Pseudostellariae 250g and add decocting in water and carry 3 times, boiled 1.5 hours at every turn, merge the about 5000ml of extracting solution 3 times, filter, be concentrated into 500ml, add ethanol, leave standstill after 24 hours and get supernatant; Get Poria 150g, Fructus Hordei Germinatus 75g, Fructus Setariae Germinatus 75g, Fructus Crataegi 50g and merge and add decocting in water and carry 2 times, boiled 1 hour at every turn, merges the about 9000ml of extracting solution 2 times, filtration is concentrated into 700ml, adds ethanol, leaves standstill after 24 hours and gets supernatant; Two kinds of supernatant that merge above-mentioned gained, reclaim ethanol, concentrate, be refined into 60ml, the ethanol 15ml that adds Ganoderma extract 10g, the calcium gluconate 5g make fine powder, ferric ammonium citrate 66mg, zinc sulfate 55mg and 95%, stir evenly, be divided into quarter, add each 170g of cane sugar powder respectively, and it is an amount of to add four kinds of food colorings such as carmine, lemon yellow, orange, bright orchid respectively, makes the granule with four kinds of colors, respectively oven dry, granulate is pressed into heart, ovum garden shape, the Fructus Citri tangerinae lobe shape of four kinds of colors, the sugar-tablet each 250 (1000 altogether) of key-way shape respectively.
Example 3, the precious electuary of system crown prince.
The consumption of each medicinal component is by the prescription amount of getting of the precious health care medicine of crown prince of the present invention.Get Radix Pseudostellariae 250g and add decocting in water and carry 3 times, boiled 1 hour at every turn, merge the about 5000ml of extracting solution 3 times, filter, be concentrated into 600ml, add ethanol, leave standstill after 24 hours and get supernatant; Get Poria 150g, Fructus Hordei Germinatus 75g, Fructus Setariae Germinatus 75g, Fructus Crataegi 50g and merge and add decocting in water and carry 2 times, boiled 1 hour at every turn, merges the about 9500ml of extracting solution 2 times, filtration is concentrated into 700ml, adds ethanol, leaves standstill after 24 hours and gets supernatant; Two kinds of supernatant getting above-mentioned gained merge, and reclaim alcohol, concentrate, are refined into 40ml, add powdered Ganoderma extract 10g, calcium gluconate 5g, ferric ammonium citrate 66mg, zinc sulfate 55mg, stir evenly, and add the sucrose of 470g, granulation, granulate, and packing is promptly.
Following example 4～example 12 is the pharmacodynamics test example of the precious health care medicine of crown prince of the present invention.
Example 4, the test of normobaric hypoxia tolerance.
Mice (10R, male) body weight 20 ± 1.3g or 24 ± 1g are divided into administration group and matched group, 10 every group at random.Give crown prince's Bao oral liquid 20ml/kgip of the present invention, give the normal saline of equivalent, positive controls gives propranolol injection (BJ Pharmaceutical Co., Ltd.) 20ml/kgip, after the administration 30 minutes, mice is put into ground glass stoppered bottle, and a bottle capacity is 150ml, in put a small amount of sodica calx to absorb CO
2And aqueous vapor, the bottle seal cover is tight, and the record mice time-to-live, the significance with equal difference between t test comparable group the results are shown in Table 1:
Example 5, anti-fatigue test.
Mice (10R, male) body weight is that 29 ± 2g is divided into administration group and matched group at random, 10 every group.Give crown prince's Bao oral liquid 10ml/kg of the present invention respectively, 20ml/kg, the water of oral liquid of American ginseng and royal jelly (dilution in 1: 1) (providing) 20ml/kg and equivalent by Inst. of Exploiting of Medical Plant Resource, Chinese Academy of Medical Scienc, every day ig once, successive administration 15 days, after the last administration 1 hour, drop into the treadmill of circulating water, force mice to be swum continuously with the circulation circulating water, with the unable water surface of going out of mice, sink under water and be index, record swimming time (flow velocity of water is 24cm/s) or with time of dead mouse be index (flow velocity of water is 12cm/s), with the mean significance of difference between t test comparable group, the result sees table 2 for details, 3.
Example 6, the anti-test of hungering and thirst.
40 of mices (10R), body weight is that 20.3 ± 0.6g is divided into administration group and matched group at random, every group 10, ig gives the water of crown prince's Bao oral liquid of the present invention (dilution in 1: 1) 20ml/kg, crown prince's Bao oral liquid 20ml/kg of the present invention, oral liquid of American ginseng and royal jelly (dilution in 1: 1, producer is with example 5) and equivalent, gd * 14d respectively, be positioned over mouse cage after the last administration, water is prohibited in fasting, observes it and anti-ly hungers and thirst until the time of death, the results are shown in Table 4.
Example 7, to the test of the blood tonification effect of losing blood property " blood deficiency ".
Get 17 of healthy SD rats, divide two batches of experiments, body weight is respectively 255 ± 12g, 394 ± 73g, according to rat body weight, take its whole body to contain the blood of blood volume about 1/5 or 1/4 from heart, cause losing blood property " blood deficiency " after 30 hours, survey hemoglobin (Hb) and erythrocyte (RBC) to cut the blood sampling of tail method, be divided into administration group and matched group at random according to measuring basic value pairing, ig crown prince's Bao oral liquid of the present invention 10ml/kg gh/5d and wait water gaging takes a blood sample behind the 5d and surveys Hb and RBC more respectively, calculate its increment rate, compare observation, the results are shown in Table 5, its result shows that crown prince's Bao oral liquid of the present invention has the recovery of obvious losing blood property of acceleration " blood deficiency " anemia.
Example 8, to the test of the influence of carbon clearance function.
Mice (10R) body weight 23.4 ± 1.3g is divided into administration group and matched group at random, water gd * the 7d of difference ig crown prince's Bao oral liquid of the present invention (dilution in 1: 1) 20ml/kg, crown prince's Bao oral liquid 20ml/kg of the present invention, levamisole (Foochow second pharmaceutical factory's system) 25ml/kg and equivalent, black juice (IndianInk) the Schmid Gmbh+Co(1 of iv India after the last administration: 1 dilution) 10ml/kg, inject back 1 minute (t1) and 5 minutes (t2) and get blood 10 μ l from the eye rear vein beard respectively, add 2ml0.1%Na
2Co
3Solution in, shake up, with the biochemical ultramicron automatic analyzer of GF-234A (A680
Nm) measure absorbance (OD), calculate phagocytic index K by following formula.
K＝ (log OD1-log OD5)/(t
5-t
1)
It the results are shown in Table 6.The result shows crown prince's Bao oral liquid of the present invention carbon clearance function that is significantly improved, in netted and system's phagocytic function potentiation is arranged.
Example 9, to the test of the influence of intestinal propulsion motion.
30 of mices (10R), body weight 20.3 ± 0.8g, be divided into administration group and matched group at random, after the fasting 12 hours, the administration group is ig crown prince's Bao oral liquid of the present invention respectively, matched group waits water gaging, and behind the ig 30 minutes, positive controls atropine sulfate SC, back 10 minutes, ig india ink (Indian Ink) 0.1ml/10g put to death mice after 20 minutes respectively, cut open the belly, with digestive tract from cardia to widely different blind complete taking-up, survey its total length, and the length in record prepared Chinese ink forward position, calculate prepared Chinese ink and advance percentage rate to be:
Prepared Chinese ink advances percentage rate=prepared Chinese ink Front distance ÷ small intestinal total length * 100%, and it the results are shown in Table 7.
Example 10, emptying test.
Mice (10, male), body weight 19.6 ± 0.7g imitates the Mangel method and (sees: Mangel AW, et al.Am J Physiol 1984; 246; G 342) the mice fasting was divided into administration group and matched group in 24 hours at random, 3 groups of positive controls.Give crown prince's Bao oral liquid 10ml/kg ig of the present invention respectively, equivalent normal saline and atropine sulfate 10ml/kg CS, every mice ig 0.05% phenol red 0.15ml after 1 hour put to death after 15 minutes, took out stomach immediately, whole body of stomach is put into the 0.1N NaOH solution of 5ml, shred mixing, left standstill 60 minutes, get supernatant 0.15ml, add 20% trichloroacetic acid 0.5ml, centrifugal, get supernatant 0.1ml, add the 0.5N NaOH solution colour developing of 0.8ml, measure absorbance with the 500nm wavelength, other get 4 mice ig phenol red after, put to death immediately, get stomach as matched group stomach absorbance at zero point, calculating formula is as follows, and it the results are shown in Table 8.
Gastric emptying rate=(1-(experimental group stomach absorbance)/(matched group stomach absorbance at zero point)) * 100%
Example 11, to the test of the widely different intestinal effect of exsomatizing.
Get 4 of SD rats, male and female have concurrently, get widely different blind routinely near one section intestinal tube, place in 37 ℃ of tyrode's solution baths of constant temperature, logical oxygen connects the muscular strength transducer, by the motion of monitor record intestinal segment, every rat is got the specimen two-stage nitration, and totally 8 sections, basically identical as a result, crown prince's Bao oral liquid concentration of the present invention is that 6 * 10～2ml/ml is inhibitory action to the widely different intestinal spontaneous activity of exsomatizing in the tyrode's solution, widely different intestinal shrinkage amplitude is reduced, and frequency deceleration and tension force descend, can be to anti-acetylcholine (10
-5～0.1ml) due to widely different enterospasm contraction, if do not occur earlier, also can resist the spastic contraction of intestinal segment due to the barium chloride (10%-0.2ml) with the spastic contraction of crown prince's treasured reuse acetylcholine.
Example 12, to the test of the influence of intestinal absorption function.
(1) to the influence of mice gastrointestinal absorption function
Mice (10R, female) 20, body weight 19.1 ± 0.6, be divided into administration group and matched group at random, give respectively crown prince's Bao oral liquid 20ml/kg ig gd * 21d of the present invention and etc. water gaging, fasting is 24 hours after the last administration, every mice ig50% glucose 30ml/kg, put to death after 1 hour, cut open the belly, take from cardia to the whole gastrointestinal tract of rectum, adding distil water 8ml wears into homogenate, be made into equal-volume (12.5ml), centrifugal, get supernatant 1.5ml, add 20% trichloroacetic acid 1.5ml, stir evenly, centrifugal, get supernatant 10ml, press glucoseoxidase (GOD) method and measure glucose content, the results are shown in Table 9.Its result shows that crown prince's Bao oral liquid of the present invention can obviously increase the function of mouse GI tract to glucose absorption.
(2) to rat D-xylose experimental observation.
36 of rats (SD, male), body weight 187 ± 13g, be divided into 5 groups at random: (one), normal control group (water), (2), normal administration group (crown prince's Bao oral liquid of the present invention), (3), insufficiency of the spleen group of Radix Et Rhizoma Rhei (water contrast), (4), Radix Et Rhizoma Rhei is insufficiency of the spleen group (crown prince's Bao oral liquid treatment of the present invention), (five), Radix Et Rhizoma Rhei is insufficiency of the spleen group [decoction of four noble drugs (fry in shallow oil into decoction of four noble drugs in Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae ratio routine].Normal administration group and normal control group give crown prince's Bao oral liquid 10ml/kg ig * 8d of the present invention respectively and wait water gaging.Radix Et Rhizoma Rhei is insufficiency of the spleen group with behind Radix Et Rhizoma Rhei decocting liquid 25g/kg ig gd * 8d, except that continuing to give the Radix Et Rhizoma Rheidecocted solution, by group give every day crown prince's Bao oral liquid 10ml/kg of the present invention, decoction of four noble drugs 25g/kg and etc. water gaging ig gd * 5d, fasting is 24 hours after the last administration, emptying in morning next day urine, behind the ig-xylose 0.3g/kg, rat is positioned over metabolic cage on an empty stomach, collect 7 hours urine amounts, [gold is respected kind Chinese journal of medical examination 1979 by document; 2(2) 91] measure the xylose discharge rate, the results are shown in Table 10.Its result shows: compare * * P＜0.05 with normal control group (water), compare △ P＞0.05 with normal control group (water), △ △ P＜0.05, compare ★ ★ P＜0.05 with Radix Et Rhizoma Rhei insufficiency of the spleen group (water), as seen normal rat gives crown prince's treasured of the present invention can obviously increase the discharge rate of rat to the D-xylose, show that crown prince's Bao oral liquid of the present invention has the small intestinal of raising absorption function, the continuous ig Rhei Decoction of rat 25g/kg can form model of spleen deficiency, the discharge rate that shows as the D-xylose obviously reduces, the small intestinal absorption function is poor, give crown prince's Bao oral liquid of the present invention or decoction of four noble drugs, the discharge rate of D-xylose obviously is increased to normal level, has shown that crown prince's treasured of the present invention has preventive and therapeutic effect with decoction of four noble drugs to model of spleen deficiency.
Example 13, apositia of children clinical efficacy test example.
Apositia of children is totally 142 examples (wherein: test group 100 examples, matched group 42 examples), male 76 examples, and women 66 examples, 3～5 years old age was many, lost strong type and qi-deficiency of spleen and stomach is seen more with spleen fortune, the course of disease is to account for 84% in 1 month to 5 years.
Test group is taken example 1 of the present invention " crown prince's Bao oral liquid ", and every day 3 times, each 1, every 10ml serve on for 2 weeks.
Matched group is taken " the precious youngster's health-care oral liquid " that Hangzhou second pharmaceutical factory of traditional Chinese medicine produces, and every day 3 times, each 1, every 10ml serve on for 2 weeks.
Clinical total effects evaluation (by 2: 1 at random) sees table 11 for details.Analyze through Ridit, the curative effect of test group is better than matched group, P＜0.01.After the test group 52 example treatments, blood zinc increases 46 examples (88%); After the matched group 22 example treatments, blood zinc increases 11 examples (50%); Two groups of differences (through Ridit check, P＜0.01).
Example 14, infantile dyspepsia disease clinical efficacy test example.
Infantile dyspepsia disease 140 examples (wherein: test group 100 examples, matched group 40 examples), male 97 examples, women 43 examples, age＜3 year old account for the overwhelming majority, rush down type and the diarrhea due to improper diet type is many with wind and cold, and the average number of days of the course of disease is 5.81 days.
Test group is taken example 1 of the present invention " crown prince's Bao oral liquid ", and every day 3 times, each 1, every 10ml serve on for 2 weeks.
Matched group is taken " the precious youngster's health-care oral liquid " that Hangzhou second pharmaceutical factory of traditional Chinese medicine produces, and every day 3 times, each 1, every 10ml serve on for 2 weeks.
Clinical total effects evaluation: test group 100 examples, 60 examples of fully recovering, 30 examples that take a turn for the better, invalid 10 examples.The Comparison of therapeutic of each 40 example of matched group and test group sees Table 12 at random.Analyze through Ridit, the curative effect of test group is better than matched group, P＜0.05.The average antidiarrheal number of days of test group 4.04 ± 2.54 days, and average 6.17 ± 2.04 days of matched group.Check through t: test group is fast than matched group antidiarrheal, and there were significant differences, P＜0.05.
Example 15, iron deficiency anemia clinical efficacy test example.
Iron deficiency anemia 131 examples (wherein: test group 91 examples, matched group 40 examples), male 88 examples, women 43 examples at 3～7 years old age, are seen with qi and blood deficiency and due to weakness of spleen and stomach more.
Test group is taken example 1 of the present invention " crown prince's Bao oral liquid ", and every day 3 times, each 1, every 10ml serve on 2 months.
Matched group is taken " Chinese angelica blood supplementing essence " (syrup) that Quanzhou, Fujian Province pharmaceutical factory produces, and every day 3 times, each 3ml(is 100ml for every bottle), serve on 2 months.
Clinical total effects evaluation: test group 91 examples, produce effects 58 examples (64%), effective 29 examples (32%), invalid 4 examples (4%), total effective rate 96%; Each the 40 routine randomized controlled trial contrast of test group and matched group see Table 13.Analyze through Ridit, the curative effect of test group is better than matched group, P＜0.01; The index of SF, hemoglobin changes before and after the curative effect; Test group treatment back SF and hemoglobin all have obvious rising, and (the former η=40 rise to 50.9 ± 30.7 from 42.3 ± 22.8 μ g/L, raise 8.6 ± 20.9, in pairs t check P＜0.05 with relatively there were significant differences before the treatment; After boil from 103.9 ± 5.9g/L and rise to 113.2 ± 12.0, raise 9.3 ± 10.8, t check in pairs, P＜0.01).And SF does not have obvious rising before and after the treatment of control group, P＞0.05, and hemoglobin rising 1.5 ± 3.2g/L, the rising amplitude is more very different than test group, P＜0.05.
Subordinate list is as follows:
(table 1) (X ± SD)
Claims (5)
1, a kind of precious health care medicine of crown prince that is used for the treatment of child's anorexia, infantile dyspepsia and iron Deficiency Anemia, the medicinal component that it is characterized in that this medicine by: Radix Pseudostellariae, Poria, Fructus Hordei Germinatus, Fructus Setariae Germinatus, Fructus Crataegi, Ganoderma extract, calcium gluconate, ferric ammonium citrate and zinc sulfate are formed, the content of each medicinal component (by wt%) is: Radix Pseudostellariae 40～50, Poria 20～30, Fructus Hordei Germinatus 10～15, Fructus Setariae Germinatus 10～15, Fructus Crataegi 5～10, Ganoderma extract 1～3, calcium gluconate 0.5～2, ferric ammonium citrate 0.01～0.03 and zinc sulfate 0.01～0.03.
2, according to the precious health care medicine of the described crown prince of claim, it is characterized in that this health care medicine comprises: oral liquid, electuary, tablet, beverage.
3, a kind of method that is used for the precious health care medicine of the described crown prince of production claim 1 is characterized in that the production technology of this pharmaceutical oral liquid is:
3,1, get crown prince and participate in decocting in water and carry 3～4 times, merge each time extracting solution, cross liquid, filtrate concentrates and adds ethanol to ethanol content and reaches 70% and carry out alcohol and precipitate, and gets supernatant after leaving standstill;
3,2, get Poria, Fructus Hordei Germinatus, Fructus Setariae Germinatus, Fructus Crataegi and merge and add decocting in water and carry 2～3 times, merge each time extracting solution, filter, filtrate concentrates and adds ethanol to ethanol content and reaches 70% and carry out alcohol and precipitate, and gets supernatant after leaving standstill;
3,3, two kinds of supernatant getting above-mentioned " 3,1 " and " 3,2 " gained merge, reclaim ethanol, concentrate, make with extra care, add Ganoderma extract, calcium gluconate, ferric ammonium citrate, zinc sulfate and suitable amount of sucrose, the dissolving after-filtration, add water and adjust, packing, sterilization are promptly.
4, a kind of method that is used for the precious health care medicine of the described crown prince of production claim 1 is characterized in that the production technology of this medicine tablet is:
4,1, get crown prince and participate in decocting in water and carry 3～4 times, merge each time extracting solution, filter, filtrate concentrates and adds ethanol and makes ethanol content reach 70% to carry out alcohol and precipitate, get supernatant after leaving standstill;
4,2, get Poria, Fructus Hordei Germinatus, Fructus Setariae Germinatus, Fructus Crataegi and merge and add decocting in water and carry 2～3 times, merge each time extracting solution, filter, filtrate concentrates and adds ethanol and makes ethanol content reach 70% to carry out alcohol and precipitate, get supernatant after leaving standstill;
4,3, two kinds of supernatant getting above-mentioned " 4,1 " and " 4,2 " gained merge, reclaim ethanol, concentrate, add the Ganoderma extracting solution, calcium gluconate, ferric ammonium citrate, zinc sulfate and an amount of food coloring, the sucrose that grind into fine powder in advance, stir evenly, the granulation of sieving, in dry below 70 ℃, granulate adds stearyl ester magnesium, mixing, compacting are in flakes.
5, a kind of method that is used for the precious health care medicine of the described crown prince of production claim 1 is characterized in that the production technology of this medicine electuary is:
5,1, get crown prince and participate in decocting in water and carry 3～4 times, merge each time extracting solution, filter, filtrate concentrating adds ethanol to ethanol content and reaches 70% and carry out alcohol and precipitate, and gets supernatant after leaving standstill;
5,2, get Poria, Fructus Hordei Germinatus, Fructus Setariae Germinatus, Fructus Crataegi and merge and add decocting in water and carry 2～3 times, merge each time extracting solution, filter, filtrate concentrates and adds ethanol to ethanol content and reaches 70% and carry out alcohol and precipitate, and gets supernatant after leaving standstill;
5,3, two kinds of supernatant getting above-mentioned " 5,1 " and " 5,2 " gained merge, reclaim ethanol, concentrate, add the Ganoderma extract, calcium gluconate, ferric ammonium citrate, zinc sulfate and the suitable amount of sucrose that grind into fine powder in advance, mixing, the granulation of sieving, in dry below 70 ℃, granulate, mixing is distributed into bag.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92115281 CN1088793A (en) | 1992-12-28 | 1992-12-28 | Health Pseudostellaria medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92115281 CN1088793A (en) | 1992-12-28 | 1992-12-28 | Health Pseudostellaria medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1088793A true CN1088793A (en) | 1994-07-06 |
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ID=4947323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 92115281 Pending CN1088793A (en) | 1992-12-28 | 1992-12-28 | Health Pseudostellaria medicine |
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| Country | Link |
|---|---|
| CN (1) | CN1088793A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078076C (en) * | 1996-08-24 | 2002-01-23 | 陈金元 | Instant powder to invigorate the function of spleen and preparation thereof |
| CN1304044C (en) * | 2004-10-12 | 2007-03-14 | 李本治 | Traditional Chinese medicine composition for treating iron-deficiency anemia |
| CN102960817A (en) * | 2012-12-05 | 2013-03-13 | 安徽燕之坊食品有限公司 | Mind tranquilizing and heart nourishing solid beverage and preparation method thereof |
| CN103027298A (en) * | 2013-01-15 | 2013-04-10 | 袁华 | Compound radix pseudostellariae oral liquid and preparation method thereof |
| CN103039990A (en) * | 2013-01-15 | 2013-04-17 | 袁华 | Compound radix pseudostellariae granules and preparation method thereof |
| CN105767801A (en) * | 2016-03-12 | 2016-07-20 | 贵州省生物研究所 | Immune regulation type radix pseudostellariae functional beverage and preparation method thereof |
-
1992
- 1992-12-28 CN CN 92115281 patent/CN1088793A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078076C (en) * | 1996-08-24 | 2002-01-23 | 陈金元 | Instant powder to invigorate the function of spleen and preparation thereof |
| CN1304044C (en) * | 2004-10-12 | 2007-03-14 | 李本治 | Traditional Chinese medicine composition for treating iron-deficiency anemia |
| CN102960817A (en) * | 2012-12-05 | 2013-03-13 | 安徽燕之坊食品有限公司 | Mind tranquilizing and heart nourishing solid beverage and preparation method thereof |
| CN103027298A (en) * | 2013-01-15 | 2013-04-10 | 袁华 | Compound radix pseudostellariae oral liquid and preparation method thereof |
| CN103039990A (en) * | 2013-01-15 | 2013-04-17 | 袁华 | Compound radix pseudostellariae granules and preparation method thereof |
| CN105767801A (en) * | 2016-03-12 | 2016-07-20 | 贵州省生物研究所 | Immune regulation type radix pseudostellariae functional beverage and preparation method thereof |
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