CN1298715A - Hematopoietic oral liquid and its preparing process - Google Patents
Hematopoietic oral liquid and its preparing process Download PDFInfo
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- CN1298715A CN1298715A CN00113468A CN00113468A CN1298715A CN 1298715 A CN1298715 A CN 1298715A CN 00113468 A CN00113468 A CN 00113468A CN 00113468 A CN00113468 A CN 00113468A CN 1298715 A CN1298715 A CN 1298715A
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Abstract
An oral liquid for tonifying blood is prepared from black fungus, red date, black soybean, donkey hide gelatin, rhizome polygonati, astragalus root, brown sugar, red ginseng, radix angelicae sinensis, etc. through infusion, decoction thrice, filtration to obtain filtrate, merging the filtrates, concentration, filling to obtain product. The invented blood tonifying oral liquid, is easy to be absorbed by human body, no irritation to stomach and intestine, and can raise the content of human body's red blood cell and ferrohemoglobin.
Description
The present invention relates to a kind of blood-enriching oral liquid, specifically is a kind of blood-enriching oral liquid that is suitable for the anemia edible for patients, the invention still further relates to the preparation method of this blood-enriching oral liquid.
The treatment anemia, many with the method for replenishing chalybeate and vitamin, as Chinese invention patent application specification CN1077124 (93100931.6) disclosed a kind of be the hematinic of Main Ingredients and Appearance with Melanteritum (being that puritan filler is ferrous), can make the Chinese medicine preparation of capsule or close ball, also just like Chinese invention patent application specification CN1049788 (89105151.1) disclosed a kind of be the children's antanemic syrup of main component with the ferrous sulfate, its iron supplement agent all belongs to inorganic mineral ferrum, their common drawback is absorption of human body utilization rate lower (being about 5%-10%), gastrointestinal tract is had certain zest, and the patient is difficult to adhere to taking for a long time.
The objective of the invention is to overcome above shortcoming, provide a kind of and easily be absorbed by the body, the stimulating gastrointestinal road can not adhered to for a long time taking, and can be significantly improved the blood-enriching oral liquid of human erythrocyte and content of hemoglobin.
Another object of the present invention provides the preparation method of this blood-enriching oral liquid.
The purpose of this utility model is achieved in that a kind of blood-enriching oral liquid, and it is to be made by the raw material of following weight proportioning (umber):
Auricularia 8～38 Fructus Jujubaes 10～50 Semen sojae atricolors 4～26 Colla Corii Asini 1～9 Rhizoma Polygonati 2～13
The Radix Astragali 2～13 brown sugar 2～26
Radix Ginseng Rubra 0～5 Radix Angelicae Sinensis 0～5 Rhizoma Chuanxiong 0～5 Radix Paeoniae Alba 0～5 Radix Polygoni Multiflori 0～6 Radix Rehmanniae Preparata 0～10
Its preparation method and technical process are as follows:
After the raw material except that brown sugar that takes by weighing cleaned up, extracting red date stone, with 3～5 times of cold water with raw material soaking 40 minutes.Decoct with water three times again, earlier raw material is boiled to boiling before each the decoction, reuse slow fire slowly decocts.Add for the first time the water yield and be 6～8 times of raw material, decocted 50～70 minutes; Add for the second time the water yield and be 4～6 times of raw material, decocted 40～60 minutes; Add the water yield for the third time and be 3～5 times of raw material, decocted 30～50 minutes.
Each decoction liquor is filtered extracting juice, merges three times filtrate, concentrate 3～4 hours according to a conventional method, taking the dish out of the pot precedingly adds concentrated solution with brown sugar, dissolves and stirs.
Fill: concentrated solution is become 10 milliliters/with the fill of vial filling machine, make finished product.
Following advantage of blood-enriching oral liquid tool of the present invention and good effect:
1, the raw material with food such as Auricularia, Fructus Jujubae, Semen sojae atricolor or medicine-food two-purpose is the material of enriching blood of main component, has overcome the inorganic mineral chalybeate of enriching blood and has been difficult for the shortcoming that is absorbed by the body and utilizes.
2, show this blood-enriching oral liquid after taking 10 days according to animal experiment, but the utmost point significantly improves the content (P＜0.01) of erythrocyte and hemoglobin, stronger blood nourishing function (animal experiment sees the report of literary composition back for details) is arranged.
3, oral liquid taking convenience has been avoided the trouble that needs boiled water to brew or take.
This blood-enriching oral liquid that adopts this preparation method to produce, its former material nutrient extracts fully, and product quality is guaranteed.
The invention will be further described below in conjunction with drawings and Examples, but the present invention is not limited only to these examples.
Accompanying drawing is the preparation method process chart of blood-enriching oral liquid of the present invention.
Embodiment 1:
Take by weighing raw material (kilogram) in following ratio:
Auricularia 36, Fructus Jujubae 24, Semen sojae atricolor 12, brown sugar 7, Colla Corii Asini 5, Rhizoma Polygonati 5, the Radix Astragali 11.
The production method of above raw material being made blood-enriching oral liquid of the present invention is as follows:
After raw material (except that brown sugar) water cleaned up, extracting red date stone, decocted with water three times raw material soaking 40 minutes with 300 kilograms of cold water again, earlier raw material is boiled to boiling before each the decoction, and reuse slow fire slowly decocts.For the first time adding the water yield is 600 kilograms, decocts 60 minutes; Amount of water is 600 kilograms for the second time, decocts 50 minutes; Adding the water yield for the third time is 500 kilograms, decocts 40 minutes.Each decoction liquor is filtered extracting juice, merges three times filtrate, concentrate 3 hours according to a conventional method, taking the dish out of the pot precedingly adds concentrated solution with brown sugar, dissolves and stirs.Again concentrated solution is become 10 milliliters/with the fill of vial filling machine, make finished product.
Embodiment 2:
Take by weighing raw material (kilogram) in following ratio:
Auricularia 9, Fructus Jujubae 12, Semen sojae atricolor 24, brown sugar 24, Radix Angelicae Sinensis 0.8, Rhizoma Chuanxiong 1, the Radix Paeoniae Alba 1, Radix Polygoni Multiflori 1.2, Radix Rehmanniae Preparata 2, Rhizoma Polygonati 12, the Radix Astragali 4, Colla Corii Asini 8, Radix Ginseng Rubra 1.
Its production method and processing step are with embodiment 1, just some parameters change: immersion adds 500 kilograms in water, soak time 40 minutes, and three times the decoction amount of water is respectively 500 kilograms, 500 kilograms, 600 kilograms, decocting time was respectively 50 minutes, 50 minutes, 50 minutes, and concentration time is 5 hours.
Embodiment 3:
Take by weighing raw material (kilogram) in following ratio:
Auricularia 21, Fructus Jujubae 27, Semen sojae atricolor 10, brown sugar 12, Radix Angelicae Sinensis 3.2, Rhizoma Chuanxiong 2, the Radix Paeoniae Alba 2, Radix Polygoni Multiflori 4.8, Radix Rehmanniae Preparata 4, Rhizoma Polygonati 4, the Radix Astragali 4, Colla Corii Asini 4, Radix Ginseng Rubra 3.
Its production method and processing step are with embodiment 1, just some parameters change, immersion adds 400 kilograms in water, soak time 40 minutes, three amount of water are respectively 700 kilograms, 500 kilograms, 400 kilograms during decoction, and it is 3.5 hours that three decocting times are respectively 60 minutes, 50 minutes, 40 minutes, concentration time.
Embodiment 4:
Take by weighing raw material (kilogram) in following ratio:
Auricularia 13, Fructus Jujubae 48, Semen sojae atricolor 18, brown sugar 15, Colla Corii Asini 2, Rhizoma Polygonati 6, the Radix Astragali 6.
Production method and processing step and parameter are with embodiment 3.
Embodiment 5:
Take by weighing raw material (kilogram) in following ratio:
Auricularia 18, Fructus Jujubae 18, Semen sojae atricolor 15, brown sugar 11, Radix Angelicae Sinensis 2.6, Rhizoma Chuanxiong 3, the Radix Paeoniae Alba 4, Radix Polygoni Multiflori 3.4, Radix Rehmanniae Preparata 5, Rhizoma Polygonati 6, the Radix Astragali 8, Colla Corii Asini 8, Radix Ginseng Rubra 2.
Production method and processing step and parameter are with embodiment 3
Attached: zoopery report (institute of Chinese materia medica, Hunan Inst of Traditional Chinese Medicine, on February 23rd, 2000)
The experimentation of 1 sample I, II blood tonification effect
Sample I, II number all have the effect of the tonify deficiency that nourishes blood, but the sample I is excellent than the sample II, existing result of the test are reported as follows:
1.1 test material
1.1.1 sample: I number, concentration are 0.23 gram crude drug/milliliter; II number, concentration are 0.3 gram crude drug/milliliter; Limited company provides lot number by Jinjian, Hunan Province rice industry: 991027.With I sample concentration to 0.5 gram crude drug/milliliter, II sample concentration to 0.6 restrains crude drug/milliliter during experiment.Heart K blood-forming agent is produced by Wuhan heart karat gold spring pharmaceutcal corporation, Ltd, lot number: 990812.The prison time spent is made into 13 ml/kg.
1.1.2 animal: BALB/C mice, male and female half and half, body weight 19-22 gram is provided by institute for drug control, Hunan Province Animal House.
1.2 method and result
Animal all is divided into seven groups immediately, is respectively the normal control group, model control group, positive controls, sample I number 7.5 gram/kilograms group and 15 gram/kilograms group, sample II number 10 gram/kilograms group and 20 gram/kilograms group, every group of 10 animals, male and female half and half.At first get blood and survey the normal value of mouse red blood cell (RBC) and hemoglobin (Hb), except that the normal control group, every of other group are got blood survey RBC and Hb value again from 0.5 milliliter of eye socket venous plexus blood-letting after 24 hours then, and gastric infusion immediately.Normal control group and model control group gavage isopyknic distilled water (30 ml/kg), and successive administration 10 days was got blood in the 11st day from the eye socket venous plexus and surveyed RBC and Hb value, the results are shown in Table 1,2.
The result shows that its RBC and Hb value significantly were lower than before the blood-letting and the normal control group after mice lost blood.The blood-letting mice is through taking the treatment of sample number and heart K blood-forming agent after 10 days, 5 administration groups and model group are relatively, its RBC and Hb value all are significantly higher than model group, the effect of sample I number 15 gram/kilograms group is better than 7.5 gram/kilograms group, two dosage groups of positive drug group and sample II number, and return to before the blood-letting substantially and normal control group mice level.
1.3 brief summary
More than experiment shows, sample I, II number can both obviously improve the RBC and the Hb value of anemia mice, but the sample I is better than the sample II, and makes the RBC of anemia mice and Hb value return to normal level substantially.According to experimental result, recommending the clinical optimum amount of I sample is 115 gram crude drug/day/people.
Table 1 sample I, II number are to the influence of blood deficiency mice RBC number (X ± SD)
Dosage number of animals RBC (* 10
12/ l)
Group (g/kg) (n) is lost blood before losing blood after the treatment of back
Normal control 30ml/kg 10 7.69 ± 0.53 7.60 ± 0.61 7.50 ± 036
Model group 30ml/kg 10 7.68 ± 0.70 4.27 ± 0.49 △, 5.87 ± 1.13 △
Heart k blood-forming agent 13ml/kg 10 7.68 ± 0.82 4.50 ± 1.02 △ 7.0 ± 0.90
*
Sample I 7.5 10 7.73 ± 0.58 5.15 ± 0.80 △ 7.0 ± 0.85
*
Sample I 15 10 7.88 ± 0.76 4.14 ± 0.49 △ 7.74 ± 1.13
*
Sample II 10 10 7.81 ± 0.66 4.92 ± 0.78 △ 6.58 ± 0.78
Sample II 20 10 7.81 ± 0.72 4.37 ± 0.62 △ 7.10 ± 1.13
*
Annotate: compare △ P＜0.001 with normal control group ratio with before losing blood; With the model group ratio,
*P＜0.05,
*P＜0.01
Table 2 sample I, II number are to the influence of blood deficiency mice Hb number (X ± SD)
Dosage number of animals Hb (g/dl)
Group (g/kg) (n) is lost blood before losing blood after the treatment of back
Normal control 30ml/kg 10 18.54 ± 0.88 18.91 ± 1.29 18.35 ± 0.99
Model group 30ml/kg 10 18.74 ± 0.91 11.76 ± 1.17 △, 14.87 ± 1.86 △
Heart k blood-forming agent 13ml/kg 10 18.21 ± 1.33 12.62 ± 1.19 △ 17.17 ± 1.86
*
Sample I 7.5 10 18.51 ± 0.97 12.55 ± 1.74 △ 17.09 ± 2.21
*
Sample I 15 10 19.11 ± 1.49 11.17 ± 1.18 △ 18.48 ± 2.34
*
Sample II 10 10 18.62 ± 1.07 11.92 ± 1.46 △ 16.03 ± 2.09
Sample II 20 10 18.57 ± 0.91 11.36 ± 1.06 △ 17.71 ± 1.57
*
Annotate: compare △ P＜0.001 with normal control group ratio with before losing blood; With the model group ratio,
*P＜0.05,
*P＜0.01
Claims (5)
1, a kind of blood-enriching oral liquid is characterized in that, it is to be made by the raw material of following weight proportioning (umber):
Auricularia 8～38 Fructus Jujubaes 10～50 Semen sojae atricolors 4～26 Colla Corii Asini 1～9 Rhizoma Polygonati 2～13
The Radix Astragali 2～13 brown sugar 2～26
Radix Ginseng Rubra 0～5 Radix Angelicae Sinensis 0～5 Rhizoma Chuanxiong 0～5 Radix Paeoniae Alba 0～5 Radix Polygoni Multiflori 0～6 Radix Rehmanniae Preparata 0～10
2, blood-enriching oral liquid according to claim 1 is characterized in that the weight proportion (umber) of its raw material is:
Auricularia 10～34 Fructus Jujubaes 14～40 Semen sojae atricolors 8～20 Colla Corii Asini 3～7 Rhizoma Polygonatis 4～10
The Radix Astragali 4～10 brown sugar 6～20
Radix Ginseng Rubra 1～4 Radix Angelicae Sinensis 1～4 Rhizoma Chuanxiong 1～4 Radix Paeoniae Alba 1～4 Radix Polygoni Multiflori 1.2～4.8 Radix Rehmanniaes Preparata 2～8
3, blood-enriching oral liquid according to claim 1 is characterized in that, the weight proportion of its raw material (umber) is:
Auricularia 15～30 Fructus Jujubaes 16～30 Semen sojae atricolors 10～18 Colla Corii Asini 4～6 Rhizoma Polygonatis 5～8
The Radix Astragali 5～8 brown sugar 8～16
Radix Ginseng Rubra 2～3 Radix Angelicae Sinensis 2～3 Rhizoma Chuanxiongs 2～3 Radix Paeoniae Albas 2～3 Radix Polygoni Multiflori 1.2～3.6 Radix Rehmanniaes Preparata 3～6
4, the preparation method of the described blood-enriching oral liquid of a kind of claim 1 is characterized in that, this preparation method and technical process are as follows:
After raw material that will be except that brown sugar cleaned, extracting red date stone was with 3～5 times of cold water soak of raw material gross weight;
Decoct with water three times again, boil earlier to boiling before each the decoction, reuse slow fire slowly decocts; The water yield that adds water for the first time, for the second time, for the third time is respectively 6～8 times of raw material gross weight, 4～6 times, 3～5 times, and the time that decocts for three times was respectively 50～70 minutes, 40～60 minutes, 30～50 minutes;
Each decoction liquor is filtered extracting juice, merges three times filtrate, concentrate 2～5 hours, before taking the dish out of the pot brown sugar added concentrated solution and dissolve and stir;
Fill.
5, the preparation method of blood-enriching oral liquid according to claim 4 is characterized in that:
Described immersion amount of water is 4 times of raw material total amount, and soak time is 40 minutes: decoct for described three times, amount of water is 7 times of raw material gross weight for the first time, decocts 60 minutes; For the second time amount of water is 5 times of raw material gross weight, decocts 50 minutes, and amount of water is 4 times of raw material gross weight for the third time, decocts 40 fens;
Described fill refers to concentrated solution is become 10 milliliters/with the fill of vial filling machine, makes finished product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00113468A CN1101206C (en) | 2000-05-26 | 2000-05-26 | Hematopoietic oral liquid and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00113468A CN1101206C (en) | 2000-05-26 | 2000-05-26 | Hematopoietic oral liquid and its preparing process |
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| CN1298715A true CN1298715A (en) | 2001-06-13 |
| CN1101206C CN1101206C (en) | 2003-02-12 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393182A (en) * | 2013-07-31 | 2013-11-20 | 马健 | Health-care fruit oral liquid for pregnant women |
| CN103461879A (en) * | 2013-08-13 | 2013-12-25 | 当涂县瑞龙果树种植专业合作社 | Blood replenishing canned litchis |
| CN104498282A (en) * | 2014-12-10 | 2015-04-08 | 常州兆阳光能科技有限公司 | Health wine for benefiting qi and nourishing blood |
| CN106074764A (en) * | 2016-08-15 | 2016-11-09 | 王开丽 | A kind of Aetanemic powder medicine and preparation method thereof |
| CN116210901A (en) * | 2023-01-09 | 2023-06-06 | 贵州医科大学 | Health product for tonifying qi and nourishing blood, preparation method and content measurement |
-
2000
- 2000-05-26 CN CN00113468A patent/CN1101206C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393182A (en) * | 2013-07-31 | 2013-11-20 | 马健 | Health-care fruit oral liquid for pregnant women |
| CN103461879A (en) * | 2013-08-13 | 2013-12-25 | 当涂县瑞龙果树种植专业合作社 | Blood replenishing canned litchis |
| CN104498282A (en) * | 2014-12-10 | 2015-04-08 | 常州兆阳光能科技有限公司 | Health wine for benefiting qi and nourishing blood |
| CN106074764A (en) * | 2016-08-15 | 2016-11-09 | 王开丽 | A kind of Aetanemic powder medicine and preparation method thereof |
| CN116210901A (en) * | 2023-01-09 | 2023-06-06 | 贵州医科大学 | Health product for tonifying qi and nourishing blood, preparation method and content measurement |
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| Publication number | Publication date |
|---|---|
| CN1101206C (en) | 2003-02-12 |
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