CN1066332C - Hypoglycemic compound capsule - Google Patents

Abstract

The present invention relates to a Tangwei capsule for treating diabetes, which belongs to a Chinese and western compound medicine. The present invention applies a Chinese medicine theory, adopts a principle for treating both manifestation and root reasons of diseases, and achieves the purposes for rapidly relieving and eliminating symptoms of diabetes by regulating physiological functions of organs of a human body, and furthermore, the present invention reduces blood sugar and urine glucose, and the poison side effect is little. The present invention comprises the following proportions of the prescription (the weight percentages): 3 to 10% of American ginseng, 10 to 40% of coptis, 10 to 40% of astragalus roots, 10 to 40% of red sage roots, 5 to 30% of pueraria roots, 10 to 30% of solomonseal rhizome and 10 to 30% of radices trichosanthis, and furthermore, the present invention contains 2.5-15 mgglyburide (the dosage of a day). The treatment effect on reducing blood sugar of the medicine of the present invention is obviously superior to that of a comparison group of Youjiangtang and Xiaokewan by 120 cases of system clinical observation, the treatment display rate reaches 54.17%, and the total effective rate reaches 95%. The present invention has the characteristics of rapid effect, strong action, high treatment effect, less poison side effect and rapid symptom elimination.

Description

Hypoglycemic compound capsule

The present invention relates to a kind of hypoglycemic compound capsule for the treatment of diabetes, belong to the Chinese medicine and western medicine compound preparation.

Diabetes are a kind of common whole body chronic progressive disease.Because pancreatic is excreting insulin normally, cause insulin relative or absolute not enough, cause sugar, fat, proteinic metabolism disorder, hepatic glycogen and muscle glycogen can not be synthesized.Thereby occurred that blood glucose, glucose in urine raise and carbohydrate tolerance reduces, and typical clinical symptom is polydipsia, polyphagia, polyuria, lose weight etc., " three-many-one-little " symptom, the traditional Chinese medical science claim that diabetes are diabetes." more than three " are " three types of diabetes ".The damage of lung, stomach, kidney is the basis, sick position of diabetes, and the metabolism disorder of water liquid is the material base of diabetes.Diabetic duration length, easy concurrent whole body nerve, blood capillary, macroangiopathy are the more serious endocrine-metabolic diseases of harmful to human.Along with improving constantly of people's living standard, the change of dietary structure, the reduction of labor intensity is swashing increasing of state, and its sickness rate is rising gradually.The sickness rate of diabetes is 3-5% in the world, be about 0.7-1% according to China's incomplete statistics, the city is significantly higher than the rural area, interrelated data shows, at present the mortality rate that is caused by diabetes is higher, be only second to diseases such as cardiovascular, cerebrovascular and tumor, therefore positive prevention and treatment diabetes seem very important.The medicine for the treatment of at present diabetes clinically is a lot, can be divided into Western medicine and Chinese medicine two classes basically, and the oral western medicine majority can be than blood sugar lowering faster, but is prone to side effect such as hypoglycemic reaction, gastrointestinal reaction, and eliminates slower to the symptom of diabetes.The symptom of diabetes can be alleviated and eliminate to the Chinese medicine majority preferably, and toxic and side effects is less, but blood sugar lowering, glucose in urine are slower.Make a general survey of now clinical commonly used in, western drug, all do not reach promptly rapid-action, effect is strong, curative effect is high, toxic and side effects is little, symptom is eliminated fast characteristics.

The object of the present invention is to provide a kind ofly can reach rapid-action to treatment of diabetes, effect is strong, curative effect is high, toxic and side effects is little, symptom is eliminated fast Chinese medicine and western medicine compound preparation-hypoglycemic compound capsule.

The object of the present invention is achieved like this, and it is the application theory of Chinese medical science, adopts the principle for the treatment of both the principal and secondary aspects of a disease, and by adjusting the physiological function of each internal organs of body, reach rapid alleviation and eliminate diabetic symptom, blood sugar lowering, glucose in urine, and poison pair effect is little.

The present invention is made by raw material of Chinese medicine and Western medicine:

Wherein the percentage by weight of Chinese medicine is:

Radix Panacis Quinquefolii: 3-10 Rhizoma Coptidis: 10-40

The Radix Astragali: 10-40 Radix Salviae Miltiorrhizae: 10-40

Radix Puerariae: 5-30 Rhizoma Polygonati: 10-30

Radix Trichosanthis: 10-30

Glibenclamide by every day dosage be the 2.5-15 milligram

Each amounts of components for preparing 1000 capsules is:

Radix Panacis Quinquefolii 66.7g Radix Astragali 400g Rhizoma Coptidis 400g

Rhizoma Polygonati 200g Radix Trichosanthis 200g Radix Puerariae 200g

Radix Salviae Miltiorrhizae 200g glibenclamide 0.5g

Its processing and fabricating method following (prescription with above-mentioned preparation 1000 capsules is an example):

More than eight the flavor medicines, Radix Panacis Quinquefolii and part Rhizoma Coptidis powder are broken into fine powder, sieve, residue Rhizoma Coptidis and the Radix Astragali, Rhizoma Polygonati, Radix Trichosanthis, Radix Puerariae, Radix Salviae Miltiorrhizae Six-element decoct with water secondary, and each 1.5 hours, collecting decoction, filter, be concentrated into relative density 1.25-1.30 (50-60 ℃), add Radix Panacis Quinquefolii and Rhizoma Coptidis fine powder, mixing, drying, be ground into middle powder, add glibenclamide and appropriate amount of starch, mixing, the Capsules of packing into goes out 1000 promptly.

The pharmacology of each medicine of distinguishing the flavor of and act on as follows:

Radix Panacis Quinquefolii: the root of Araliaceae Radix Panacis Quinquefolii has lung benefiting the moon, the effect of asthenic fire, promoting the production of body fluid to quench thirst clearly.

The Radix Astragali: the dry root of leguminous plant Radix Astagali or Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, the effect of expelling pus and promoting granulation.

Rhizoma Coptidis: the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall.Has heat clearing and damp drying, the effect of eliminating fire and detoxication.

Rhizoma Polygonati: the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati, Rhizoma Polygonati or Polygonatum cyrtonema Hua.Effect with boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.

Radix Salviae Miltiorrhizae: labiate, the dry root and rhizome of Radix Salviae Miltiorrhizae.Have stasis-dispelling and pain-killing, the latus rectum of invigorating blood circulation, the effect of the relieving restlessness that clears away heart-fire.

Radix Puerariae: leguminous plant, the dry root of Herba Gelsemii Elegantis or Radix Puerariae rattan.Have expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, rash, the effect of yang invigorating antidiarrheal.

Radix Trichosanthis: the dry root of cucurbitaceous plant Fructus Trichosanthis.Effect with clearing away heat and promoting production of body fluid, detumescence and apocenosis.

Glibenclamide (glyburide)

N-[2-[4-[[[(hexamethylene amino) carbonyl] amino] sulfonyl] phenyl] ethyl]-2-methoxyl group-5-chlorobenzamide, have hypoglycemic activity.

In this capsule, Radix Panacis Quinquefolii, Rhizoma Polygonati giving young employees remedial-courses in general knowledge and vocational skills gas the moon, but Radix Panacis Quinquefolii replenishing body fluid and clearing away heat pathogen, Rhizoma Polygonati can the dry nourishing kidney essence of lung moistening.Radix Astragali invigorating the spleen and replenishing QI to be ending frequent micturition, and Radix Trichosanthis, Radix Puerariae Yin-nourishing and body fluid promoting protect Jin Yin with heat clearing away, Rhizoma Coptidis clearing away stomach-heat, and the Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling improves blood circulation and diabetes height and coagulates high smectic attitude.All medicines cooperate, play compatibility glibenclamide in the merit side of boosting qi and nourishing yin, clearing heat and moistening dryness, blood circulation promoting and blood stasis dispelling, blood sugar lowering altogether, can directly stimulate the beta Cell of islet excreting insulin, strengthen Insulin receptor INSR and postreceptor defects in the surrounding tissue, thereby the intensifier target histiocyte is to the sensitivity of insulin, i.e. the outer blood sugar reducing function of pancreas.The independent usefulness of glibenclamide easily causes side effect such as hypoglycemia, dyspepsia, diarrhea, cervicodynia, leukopenia.

This capsule is through 120 routine systematic observations, and its blood sugar lowering curative effect obviously is better than matched group glyburide and diabetes pill, and its obvious effective rate reaches 54.17%, total effective rate is 95%, and the glyburide obvious effective rate is 46.67%, and total effective rate is 86.67%, the diabetes pill obvious effective rate is 36.67%, and total effective rate is 80%.

This capsule only has an example than the hypopathia people comparatively slight hypoglycemic reaction to take place in 120 observed routine cases, and medicine decrement button recovers.And 2 routine hypoglycemic reactions appear in glyburide (glibenclamide) group 30 examples.One routine severe hypoglycemia reaction has appearred in diabetes pill group 30 examples.Prove that thus the probability of Tang Wei capsule generation hypoglycemic reaction and degree are well below glyburide (glibenclamide) and diabetes pill.

This capsule all can be alleviated or eliminate mouth rapidly and drinks polydipsia in 120 examples are observed, symptoms such as polyuria, polyphagia, weak, spontaneous sweating, dysphoria with feverish sensation in the chest palms and soles, and effect is lasting, and just tongue fur pulse condition improvement, its effect is better than diabetes pill and glyburide matched group.

Contain seven flavor Chinese medicine and Western medicine glyburide (glibenclamide) such as Radix Panacis Quinquefolii, Rhizoma Coptidis in this capsule.Clinical effectiveness proves that this medicine ratio is used Western medicine (glibenclamide) and Chinese medicine (removing the Chinese medicine part of glibenclamide) curative effect height separately, effect is fast, and side effect is little.Compare with similar kind diabetes pill, curative effect is higher than diabetes pill, and side effect is littler than diabetes pill.

This medicine is not found any infringement to internal organs such as patient's the heart, Liver and kidney in observed 120 examples.

Advantage of the present invention is that it is the specific drug of treatment type (type of deficiency of both QI and YIN), has characteristics rapid-action, that effect is strong, curative effect is high, toxic and side effects is little, the condition of illness elimination is fast.

Be embodiments of the invention below:

Embodiment 1:

Each amounts of components is: Radix Panacis Quinquefolii 1g, Rhizoma Coptidis 6g, Radix Astragali 6g, Radix Salviae Miltiorrhizae 6g, Radix Puerariae 3g, Rhizoma Polygonati 3g, Radix Trichosanthis 3g, glibenclamide 7.5mg.

Embodiment 2:

Each amounts of components is: Radix Panacis Quinquefolii 0.84g, Rhizoma Coptidis 2.8g, Radix Astragali 2.8g, Radix Salviae Miltiorrhizae 3.36g, Radix Puerariae 1.4g, Rhizoma Polygonati 8.4g, Radix Trichosanthis 8.4g, glibenclamide 7.5mg.

Claims (2)

1. hypoglycemic compound capsule for the treatment of diabetes is characterized in that being made by raw material of Chinese medicine and Western medicine:

Wherein the percentage by weight of Chinese medicine is:

Radix Panacis Quinquefolii: 3-10 Rhizoma Coptidis: 10-40

The Radix Astragali: 10-40 Radix Salviae Miltiorrhizae: 10-40

Radix Puerariae: 5-30 Rhizoma Polygonati: 10-30

Radix Trichosanthis: 10-30

Glibenclamide by every day dosage be the 2.5-15 milligram

2. hypoglycemic compound capsule according to claim 1 is characterized in that each amounts of components for preparing 1000 capsules is:

Radix Panacis Quinquefolii 66.7g Radix Astragali 400g Rhizoma Coptidis 400g

Rhizoma Polygonati 200g Radix Trichosanthis 200g Radix Puerariae 200g

Radix Salviae Miltiorrhizae 200g glibenclamide 0.5g