CN1240416C - Medicine for curing hypertension and its preparation method - Google Patents
Medicine for curing hypertension and its preparation method Download PDFInfo
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- CN1240416C CN1240416C CNB011289783A CN01128978A CN1240416C CN 1240416 C CN1240416 C CN 1240416C CN B011289783 A CNB011289783 A CN B011289783A CN 01128978 A CN01128978 A CN 01128978A CN 1240416 C CN1240416 C CN 1240416C
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Abstract
The present invention relates to a medicinal composition for treating hypertension. The medicinal composition has the scheme based on the recognition and the therapeutic principle of traditional Chinese medicines to hypertension, uses the compound pharmacological property of the traditional Chinese medicines and pharmacy to regulate yin and yang, qi and blood, zang-fu viscera, channels, cold and heat, etc. for human bodies, uses medicines for invigorating blood circulation and removing stasis to remove the stasis in the channels and to smooth the circulation of the blood vessels and the channels, uses medicines for regulating vital energy and promoting blood circulation to improve the relation of nutrient qi and blood and defensive qi and blood, and uses the active ingredients of the traditional Chinese medicines to decompose the lipoprotein in blood and reduce blood pressure. Thereby, the medicine has obvious drug effects for treating hypertension, cardiovascular/cerebrovascular diseases caused by hypertension, coronary heart diseases, atherosclerosis, cardiovascular/cerebrovascular abnormity and pulmonary diseases.
Description
The present invention relates to the hypertensive pharmaceutical composition of a kind of treatment, particularly a kind of is the hypertensive medicine of treatment that raw material is made with the animals and plants Chinese herbal medicine.
Hypertension is a kind of clinical common diseases, based on the syndrome of systemic arterial blood pressure rising.No matter can be divided into essential hypertension and secondary hypertension disease, be former or secondary, can both cause peripheral vessels, and the organic change of internal organs can cause the pathological changes of organs such as blood vessel, brain, the heart, kidney to cause coronary heart disease, heart failure etc.It is higher that hypertension causes human mortality rate, and according to statistics to 1997, hypertension accounts for 40% of China people death, so hypertension and caused cardiovascular and cerebrovascular disease thereof are human No.1 killers.
Hypertension will be treated throughout one's life, treats hypertensive medicine and not only will bring high blood pressure down, and will reduce the morbidity and the dead danger of cardiovascular and cerebrovascular disease, and in general, treatment hypertension mainly adopts Western medicine, but the Western medicine toxic side effect is big, and curative effect is single, and cure rate is low.Have some Chinese medicines to be used for the treatment of hypertension, but Chinese medicine prevention hypertension characteristic is not outstanding for many years, clinical actual effect is not high yet, and treatment means is single, so also do not obtain good effect.This is not that Chinese medicine can't be used for treating hypertension, but existing means fail from the viewpoint serious analysis pathogeny of motherland's medical science, thereby writes out a prescription medication targetedly.
The object of the present invention is to provide a kind of energy blood fat reducing, promote the internal body balance, and reduce, alleviate the treatment hypertension drug of the cardiovascular and cerebrovascular disease that causes by hypertension.
Another object of the present invention provides the preparation method of treatment hypertension drug.
Solution of the present invention is based on motherland's medical science to hypertensive understanding and Therapeutic Principle, be suitable for the compound recipe pharmacological property of Chinese medicine, adjust human body negative and positive, QI and blood, internal organs, meridians, cold and heat etc. are whole, it is long-pending that the utilization drug for invigorating blood circulation and eliminating stasis picks the stasis of blood of scraping meridians, it is unimpeded to improve the blood vessel meridians, the employing current meridian qi and blood of promoting the circulation of blood medicine of regulating the flow of vital energy, improve the four stages in the course of an epidemic febrile disease relation, the effective ingredient of utilization traditional Chinese medical science medicine, force the decomposition of lipoprotein in the blood, bring high blood pressure down, thus the cardiovascular and cerebrovascular disease of effectively treating hypertension and causing by hypertension.
Treat hypertensive medicine and make (consumption is a weight portion) by following component.
Radix Polygoni Multiflori 5-13 Rhizoma Chuanxiong 1-10 Radix Angelicae Sinensis 1-10 Bulbus Fritillariae Cirrhosae 1-10
Radix Rehmanniae 1-5 Flos Carthami 1-10 Bombyx Batryticatus 1-5 Radix Scrophulariae 1-10
Pericarpium Citri Reticulatae Viride 1-3 Concha Ostreae 1-10 Herba Taxilli 5-13 Radix Salviae Miltiorrhizae 5-13
Radix Et Rhizoma Rhei 1-3 Radix Ginseng 1-5 Radix Notoginseng 1-5 Scorpio 1-5
Herba Cistanches 1-5 Zaocys 1-5 Concha Haliotidis 1-5 Semen Cassiae 5-13
The reddish brown 1-5 Fructus Tribuli of Radix Puerariae 1-10 1-5 Spica Prunellae 5-13
Caulis Spatholobi 1-10 Ramulus Uncariae Cum Uncis 5-13 Radix Astragali 5-13 Rhizoma Acori Graminei 1-5
Pheretima 1-10
Optimum weight part proportioning of treatment hypertension drug is:
Radix Polygoni Multiflori 7 Rhizoma Chuanxiongs 3 Radix Angelicae Sinensis 3 Bulbus Fritillariae Cirrhosaes 3
The Radix Rehmanniae 1 Flos Carthami 3 Bombyx Batryticatus 1 Radix Scrophulariae 3
Pericarpium Citri Reticulatae Viride 1 Concha Ostreae 3 Herba Taxillis 7 Radix Salviae Miltiorrhizaes 7
Radix Et Rhizoma Rhei 1 Radix Ginseng 1 Radix Notoginseng 1 Scorpio 1
Herba Cistanches 1 Zaocys 1 Concha Haliotidis 1 Semen Cassiae 7
Radix Puerariae 7 Haematitums 1 Fructus Tribuli 1 Spica Prunellae 7
Caulis Spatholobi 3 Ramulus Uncariae Cum Uncis 7 Radixs Astragali 7 Rhizoma Acori Gramineis 1
Pheretima 3
The method of above-mentioned each component being made the treatment hypertension drug is:
1, it is an amount of black saturating with boiling Radix Polygoni Multiflori to be added water with Semen sojae atricolor, drying and crushing to 120 order fine powder;
2, with Rhizoma Chuanxiong drying and crushing to 120 order fine powder;
3, Radix Angelicae Sinensis is added loess and fry usefulness, drying and crushing to 120 order fine powder;
4, with giving birth to usefulness after the Bulbus Fritillariae Uninbracteatae drying, be crushed to 120 order fine powders;
5, Bombyx Batryticatus and Testa Tritici are fried together, be crushed to thin part of 120 orders;
6, vinegar is gone up in the Pericarpium Citri Reticulatae Viride section and fried usefulness, be crushed to 120 order fine powders;
7, the Radix Et Rhizoma Rhei section is fried usefulness with wine, be crushed to 120 order fine powders;
8, Radix Ginseng is given birth to usefulness after concocting, and is crushed to 120 order fine powders;
9, Scorpio is concocted the back and give birth to usefulness, be crushed to 120 order fine powders;
10, Herba Cistanches is added yellow wine and steam thoroughly crushed after being dried to 120 order fine powder;
11, Zaocys is decaptitated add the stewing back of yellow wine and fry usefulness, be crushed to 120 order fine powders;
12, Haematitum is smashed to pieces fire and forged and quench, be crushed to 120 order fine powders;
13, Fructus Tribuli is added saline and fry usefulness, be crushed to 120 order fine powders;
14, will fry smelling removal behind the Pheretima steeping in wine, be crushed to 120 order fine powders;
15, with Flos Carthami, Radix Scrophulariae, Concha Ostreae, Herba Taxilli, Radix Salviae Miltiorrhizae, Radix Notoginseng, Concha Haliotidis, Semen Cassiae, Radix Puerariae, Spica Prunellae, Caulis Spatholobi, Ramulus Uncariae Cum Uncis, the Radix Astragali, Rhizoma Acori Graminei, the Radix Rehmanniae is given birth to usefulness, crushed after being dried to 120 order fine powder;
16, with above-mentioned whole medicament components by after the described mixed, carry out ripening at 100-110 ℃, sterilization treatment 10-30 minute, get final product the powder medicine.
Powder after the maturation process can be made ball, loose or capsule, to meet patient's the custom of taking by the conventional treatment method of Chinese medicine.
Medicament of the present invention contains the various active ingredients that human body is played an important role, and its effect concludes to get up roughly to have:
1, medicament of the present invention has stronger blood pressure lowering, blood fat reducing, diuretic, kalium replenishment, synergism such as replenish the calcium.By drug influence power, in diuretic and increase the absorption of potassium, potassium, sugar, calcium, water, electrolyte metabolism are had no adverse effects.Brain, the heart, kidney, target organ there is protective effect, reversing left ventricular hypertrophy, the incidence rate of minimizing apoplexy, coronary heart disease.
2, effects such as stronger blood circulation promoting and blood stasis dispelling, dredge the meridian passage, heat reliving and toxin-eliminating, clearing away phlegm are sensible, refreshment are arranged, can improve the blood vessel microcirculation, reduce fibrin stabilizing factor and improve blood inner fibrin lytic activity, shorten the dissolution time of euglobulin, reduce surface activity of blood platelet and aggregation, blood viscosity lowering prevents thrombosis.To feritin--hypertensin system (RAS) can be regulated water-electrolyte metabolism in vivo, antiotasis and sympathetic nervous system activity, by suppressing the effect of angiotensin converting enzyme inhibitor (ACEI), produce stronger blood pressure lowering performance, reverse blood vessel wall and the bad of heart and reinvent, recover 26S Proteasome Structure and Function.
3, the characteristic of the compound recipe pharmacology of utilization Chinese herbal medicine influences the transhipment of calcium ion, makes smooth muscle loose, and expansion small artery and vein blood vessel reduce vascular resistance, increase brain, heart coronary flow, prevent the myocardial ischemia necrosis.
4, animal and plant class medicine is regulated equilibrium between yin and yang after acting on human body, homoiostasis, and it is longer to keep effective drug duration, and blood pressure lowering is lasting, protection cardiorenal function, slow down aging.
Medicament of the present invention particularly has the obvious treatment effect to following disease in view of above-mentioned functions is arranged:
1, hypertensive patients left ventricular hypertrophy, patients with coronary heart disease;
2, hypertensive patients nephropathy, urine protein 24 hours 〉=1 gram person;
3, hypertension complicated with diabetes mellitus or impaired glucose tolerance and the person that has the insulin resistant;
4, hypertensive patients atherosclerosis, the unusual person of cardiovascular and cerebrovascular vessel;
5, hypertensive patients bronchus and pulmonary disease person.
For showing the effect of this hypertension therapy, specially make more careful clinical statistics.Select typical hyperpietic's 100 examples, wherein male 64 examples, women 36 examples, the age minimum be 40 years old, maximum is 87 years old, blood pressure soprano systolic pressure 240 millimetress of mercury, diastolic pressure 140 millimetress of mercury, minimum systolic pressure 190 millimetress of mercury, diastolic pressure 100 millimetress of mercury, the lipoprotein index all has in various degree and increases in the blood samples of patients, and left ventricle is plump in various degree, wherein hypertension stroke hemiplegia patient 48 examples.
Above-mentioned object of statistics is after taking medicament of the present invention, and what medicine time was the longest is 14 months, the shortest 3 months, following up a case by regular visits to after the healing of taking medicine, blood pressure remains on systolic pressure 140 millimetress of mercury always, and below diastolic pressure 90 millimetress of mercury, the lipoprotein index is all in normal range in the blood.Recurrence patient 4 examples, treatment rate reaches 96%.
Now enumerate the curative effect of some indivedual case explanation medicines again.
Case 1: bright certain, man, 76 years old now, South Sichuan people from county, patient fall down to the ground suddenly in July, 84 and faint the left side hemiplegia, be diagnosed as cerebral thrombosis through the locality, treatment is invalid after half a year, comes the inventor to locate to seek medical advice, hemiplegia on inspection, the walking of can not standing, dysphonia, blood pressure systolic pressure 210mmHg, diastolic pressure 110mmHg, TV x-ray fluoroscopy left ventricular hypertrophy, the blood lipoprotein is not looked into because of the unconditional inspection of hospital, diagnosis hypertension stroke hemiplegia, coronary heart disease, be in take this medicament after, the walking of leaving the bed voluntarily in 2 months, blood pressure is normal, and walking is normal substantially after taking medicine four months, competent slight housework was taken medicine 8 months altogether after 6 months.Followed up a case by regular visits to the patient 15 years, patient's blood pressure remains at systolic pressure 120mmHg, and diastolic pressure 70mmHg can participate in any physical work.
Case 2: Lee, man, 65 years old now, the patient fell down to the ground suddenly in February, 94, was diagnosed the left side hemiplegia after 4 hours by the inventor, can not sit up, rapid breathing, pulse is strong greatly, 38 ℃ of body temperature, dysphonia, blood pressure: systolic pressure 220mmHg, diastolic pressure 115mmHg, TV X perspective: left ventricular hypertrophy is diagnosed as hypertension apoplexy hemiplegia, coronary heart disease, after rescuing a week, take medicine of the present invention with Western medicine, two weeks held up down and turn walking, and three weeks were walked out hospital, went home to take medicine, the county hospital check is gone in drug withdrawal after February, change clothes Western medicine February, stroke hemiplegia recurrence for the second time after three months, secondary is sent the diagnosis and treatment by the inventor here, clinical state and last time are basic identical on inspection, after go home to take medicament of the present invention continuously 10 months, followed up a case by regular visits to 8 years, blood pressure is normal substantially, the fat disappearance now can normally be done some housework.
More than the above case, too numerous to enumerate.
Embodiment:
Take by weighing material by following proportioning:
4 kilograms of 4 kilograms of Bulbus Fritillariae Cirrhosaes of 4 kilograms of Radix Angelicae Sinensis of 8 kilograms of Rhizoma Chuanxiongs of Radix Polygoni Multiflori
4 kilograms of 2 kilograms of Radix Scrophulariaes of 4 kilograms of Bombyx Batryticatus of 1.2 kilograms of Flos Carthamis of the Radix Rehmanniae
8 kilograms of 8 kilograms of Radix Salviae Miltiorrhizaes of 4 kilograms of Herba Taxillis of 1.2 kilograms of Concha Ostreaes of Pericarpium Citri Reticulatae Viride
2 kilograms of 2 kilograms of Scorpios of 2 kilograms of Radix Notoginseng of 1.2 kilograms of Radix Ginsengs of Radix Et Rhizoma Rhei
8 kilograms of 2 kilograms of Semen Cassiaes of 2 kilograms of Concha Haliotidis of 2 kilograms of Zaocyss of Herba Cistanches
8 kilograms of 2 kilograms of Spica Prunellaes of 2 kilograms of Fructus Tribulis of 8 kilograms of Haematitums of Radix Puerariae
2 kilograms of 8 kilograms of Rhizoma Acori Gramineis of 8 kilograms of Radixs Astragali of 4 kilograms of Ramulus Uncariae Cum Uncis of Caulis Spatholobi
4 kilograms of Pheretimas
Claims (4)
1, the hypertensive medicine of a kind of treatment, it is characterized in that: it is the medicament of being made by the following weight proportion raw material:
Radix Polygoni Multiflori 5-13 Rhizoma Chuanxiong 1-10 Radix Angelicae Sinensis 1-10 Bulbus Fritillariae Cirrhosae 1-10
Radix Rehmanniae 1-5 Flos Carthami 1-10 Bombyx Batryticatus 1-5 Radix Scrophulariae 1-10
Pericarpium Citri Reticulatae Viride 1-3 Concha Ostreae 1-10 Herba Taxilli 5-13 Radix Salviae Miltiorrhizae 5-13
Radix Et Rhizoma Rhei 1-3 Radix Ginseng 1-5 Radix Notoginseng 1-5 Scorpio 1-5
Herba Cistanches 1-5 Zaocys 1-5 Concha Haliotidis 1-5 Semen Cassiae 5-13
Radix Puerariae 1-10 Haematitum 1-5 Fructus Tribuli 1-5 Spica Prunellae 5-13
Caulis Spatholobi 1-10 Ramulus Uncariae Cum Uncis 5-13 Radix Astragali 5-13 Rhizoma Acori Graminei 1-5
Pheretima 1-10.
2, the hypertensive medicine of treatment according to claim 1, it is characterized in that: it is made by the following weight proportion raw material:
Radix Polygoni Multiflori 7 Rhizoma Chuanxiongs 3 Radix Angelicae Sinensis 3 Bulbus Fritillariae Cirrhosaes 3
The Radix Rehmanniae 1 Flos Carthami 3 Bombyx Batryticatus 1 Radix Scrophulariae 3
Pericarpium Citri Reticulatae Viride 1 Concha Ostreae 3 Herba Taxillis 7 Radix Salviae Miltiorrhizaes 7
Radix Et Rhizoma Rhei 1 Radix Ginseng 1 Radix Notoginseng 1 Scorpio 1
Herba Cistanches 1 Zaocys 1 Concha Haliotidis 1 Semen Cassiae 7
Radix Puerariae 7 Haematitums 1 Fructus Tribuli 1 Spica Prunellae 7
Caulis Spatholobi 3 Ramulus Uncariae Cum Uncis 7 Radixs Astragali 7 Rhizoma Acori Gramineis 1
Pheretima 3.
3, the hypertensive medicine of treatment according to claim 1 and 2 is characterized in that: said medicament is ball, looses or capsule.
4, a kind of preparation method for the treatment of hypertension drug according to claim 1 and 2, it is characterized in that: described preparation method is:
(1) it is an amount of black saturating with boiling Radix Polygoni Multiflori to be added water with Semen sojae atricolor, drying and crushing to 120 order fine powder;
(2) with Rhizoma Chuanxiong drying and crushing to 120 order fine powder;
(3) Radix Angelicae Sinensis is added loess and fry usefulness, drying and crushing to 120 order fine powder;
(4) with giving birth to usefulness after the Bulbus Fritillariae Uninbracteatae drying, be crushed to 120 order fine powders;
(5) Bombyx Batryticatus and Testa Tritici are fried together, be crushed to thin part of 120 orders;
(6) the Pericarpium Citri Reticulatae Viride section is gone up vinegar and is fried usefulness, is crushed to 120 order fine powders;
(7) the Radix Et Rhizoma Rhei section is fried usefulness with wine, be crushed to 120 order fine powders;
(8) Radix Ginseng is given birth to usefulness after concocting, and is crushed to 120 order fine powders;
(9) Scorpio is concocted the back and give birth to usefulness, be crushed to 120 order fine powders;
(10) Herba Cistanches is added yellow wine and steam thoroughly crushed after being dried to 120 order fine powder;
(11) Zaocys is decaptitated add yellow wine and dry after stewing, be crushed to 120 order fine powders;
(12) Haematitum is smashed to pieces fire and forged and quench, be crushed to 120 order fine powders;
(13) Fructus Tribuli is added saline and fry usefulness, be crushed to 120 order fine powders;
(14) will fry smelling removal behind the Pheretima steeping in wine, be crushed to 120 order fine powders;
(15) with Flos Carthami, Radix Scrophulariae, Concha Ostreae, Herba Taxilli, Radix Salviae Miltiorrhizae, Radix Notoginseng, Concha Haliotidis, Semen Cassiae, Radix Puerariae, Spica Prunellae, Caulis Spatholobi, Ramulus Uncariae Cum Uncis, the Radix Astragali, Rhizoma Acori Graminei. the Radix Rehmanniae is given birth to and is used, crushed after being dried to 120 order fine powder, with above-mentioned whole medicament components by after the described mixed, carry out ripening at 100-110 ℃, sterilization treatment 10-30 minute, get final product the powder medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011289783A CN1240416C (en) | 2001-10-17 | 2001-10-17 | Medicine for curing hypertension and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB011289783A CN1240416C (en) | 2001-10-17 | 2001-10-17 | Medicine for curing hypertension and its preparation method |
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| CN1411830A CN1411830A (en) | 2003-04-23 |
| CN1240416C true CN1240416C (en) | 2006-02-08 |
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| CNB011289783A Expired - Fee Related CN1240416C (en) | 2001-10-17 | 2001-10-17 | Medicine for curing hypertension and its preparation method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102614279A (en) * | 2012-04-20 | 2012-08-01 | 北京绿源求证科技发展有限责任公司 | Chinese medicine for treating diabetic hypertension |
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| US7258877B2 (en) * | 2001-12-21 | 2007-08-21 | Sunten Phytotech Co., Ltd. | Herbal pharmaceutical composition for treatment of cardiovascular disease |
| CN1298340C (en) * | 2004-10-29 | 2007-02-07 | 南京生物工程与医药科技发展有限公司 | Chinese traditional medicine composition for treating blood stasis qi-stagnation type cardiodynia and preparation method thereof |
| CN1296080C (en) * | 2004-12-21 | 2007-01-24 | 贾洪章 | Liver clearing blood pressure lowering capsule nd its preparation method |
| CN101024002B (en) * | 2007-03-29 | 2010-08-11 | 牟善芳 | Oral Chinese medicine composition for treating hypertension |
| CN101167876B (en) * | 2007-11-09 | 2011-04-06 | 北京中科雍和医药技术有限公司 | Medicinal composition for treating high blood pressure and its complication and preparation method thereof |
| CN101554434B (en) * | 2008-04-09 | 2011-02-09 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating clinical hypertension |
| CN101264189B (en) * | 2008-05-05 | 2010-06-16 | 胡建新 | Cardiac disease rehabilitation proprietary Chinese medicine |
| CN101422241B (en) * | 2008-12-10 | 2011-12-21 | 许宗磊 | Antihypertensive health-care porridge |
| CN102091291B (en) * | 2010-12-06 | 2012-05-09 | 李新焕 | Chinese medicine composition for treating cerebral arteriosclerosis |
| CN102151326B (en) * | 2011-04-18 | 2012-07-18 | 苑学 | Chinese medicine composition for curing hypertension and hyperlipaemia |
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| CN102784273B (en) * | 2012-08-01 | 2014-01-15 | 周晓生 | Method for preparing traditional Chinese medicine for treating insomnia caused by high blood pressure |
| CN102920899B (en) * | 2012-10-23 | 2014-03-26 | 四川元安药业有限公司 | Medicine for treating coronary heart diseases and preparation method thereof |
| CN103041361B (en) * | 2013-01-17 | 2014-04-30 | 广西东兴市创新特色医药科技发展有限公司 | Medicament for treating three-high disease (high cholesterol, high blood pressure, high blood sugar) and preparation method thereof |
| CN103301270A (en) * | 2013-07-08 | 2013-09-18 | 陈明 | Medicine for preventing and treating coronary heart disease and preparation method thereof |
| CN106421564A (en) * | 2016-12-09 | 2017-02-22 | 李建才 | Traditional Chinese medicine for treating essential hypertension |
| CN111588832A (en) * | 2020-07-09 | 2020-08-28 | 文秋方 | Herbal purification liquid |
-
2001
- 2001-10-17 CN CNB011289783A patent/CN1240416C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614279A (en) * | 2012-04-20 | 2012-08-01 | 北京绿源求证科技发展有限责任公司 | Chinese medicine for treating diabetic hypertension |
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