CN1086586C - Medicine for treating cardiac and cerebral vascular diseases and its preparation - Google Patents
Medicine for treating cardiac and cerebral vascular diseases and its preparation Download PDFInfo
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- CN1086586C CN1086586C CN98126131A CN98126131A CN1086586C CN 1086586 C CN1086586 C CN 1086586C CN 98126131 A CN98126131 A CN 98126131A CN 98126131 A CN98126131 A CN 98126131A CN 1086586 C CN1086586 C CN 1086586C
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Abstract
The present invention discloses novel medicine for treating cardiovascular and cerebrovascular diseases. The medicine is mainly used for treating and preventing various types of cardiovascular and cerebrovascular diseases. The present invention is a pure traditional Chinese medicine preparation. The present invention is proportionally prepared from the following raw material: angelica, hemlock parsley, red peony root, safflower, herba schizonepetae, ephedra, radix sileris, Chinese atractylodes, forsythia fruit, balloonflower root, liquorice, mint, scutellaria root, kudzu root, shaved moutan, raw flowery knotweed, rhubarb, sodium sulphate, gardenia, rehmannia root, radix rubiae, nutgrass galingale rhizome, scrophularia, talcum gypsum and carina. According to the characteristics of each type of medicine, the raw material is processed in a step-by-step mode, and various preparations, such as capsules, etc., are prepared. The formulation and the preparation method of the present invention are unique; the present invention can be used for treating both manifestation and root cause of diseases; the therapeutic effect is obvious.
Description
The present invention relates to a kind of medicine for the treatment of cardiovascular and cerebrovascular disease, specifically a kind of is the pure Chinese medicinal preparation of the treatment cardiovascular and cerebrovascular disease made of raw material with the natural Chinese medicinal herb, the invention still further relates to the preparation method of this medicine.
Cardio-cerebralvascular diseases is a kind of common multiple disease, and such disease seriously influences patient's physical and mental health and daily life.Cardiovascular and cerebrovascular disease mainly comprises diseases such as hypertension, hyperlipidemia, heart disease, hemiplegia and epilepsy.
The major defect of the medicine of the above-mentioned disease of present existing treatment is as follows:
● most of depressor all is by regulating nerve, suppressing adrenaline secretion or expansion
Blood vessels etc. play the effect of temporary transient blood pressure lowering.And to unnecessary fifth wheel in the blood
Disadvantage factor in matter or the body tissue can not in time be got rid of, so can only play
Temporary transient effect.
● the medicine of cerebral hemorrhage can be treated at present, cerebral embolism can not be treated; And can treat
The medicine of cerebral embolism can not be treated cerebral hemorrhage again.
● heart disease is divided pulmonary heart disease, rheumatic heart disease, the coronary artery type heart at present
Polytypes such as disease of ZANG-organs, mitral incompetence type heart disease.Existing treatment side
Formula all is by temporary transient symptomatic treatment such as heart tonifying, coronary artery dilator, can only play
Mitigation.
All there is not person's variety of issue in existing various form of Chinese drug, and, effective ingredient big as dosage can not full use, take inconvenience etc.The chemical purification method utilizes the efficacy of a drug single, and the chemical constitution of some medicine is destroyed, and unknown composition is not suggested, and is difficult to represent the medical material overall picture.
The object of the present invention is to provide a kind of pure Chinese drugs agentia for the treatment of various types of cardiovascular and cerebrovascular disease, scalable bodily fuctions, drives six climate exopathogens outward at promoting blood circulation to remove obstruction in the collateral, promoting tissue regeneration by removing blood stasis, interior accent seven emotions, can reach prevention and effect a radical cure the effect of all kinds of heart and brain diseases.Directly, take effect fast, treat wide spectrum, effect lastingly, have no side effect at the cause of disease.
Another object of the present invention provides the preparation method of this cardiovascular and cerebrovascular vessel Remedies for diseases in association.The said preparation method can be utilized the effective elements of the medicine of respectively distinguishing the flavor of fully and effectively, has both dwindled the medication volume, can improve drug effect again.
Solution of the present invention is based on pathogenetic understanding and the Therapeutic Principle of motherland's medical science to cardiovascular and cerebrovascular disease, with reference to the modern pharmacological research achievement, from motherland's medicine treasure-house, filter out the natural drug of promoting blood circulation to remove obstruction in the collateral, promoting tissue regeneration by removing blood stasis, heart tonifying and brain strengthening, expelling wind and removing dampness, according to the theory of Chinese medical science prescription.Each medicine synergism of distinguishing the flavor of is to reach curative effect.
The present invention treats the medicine of cardiovascular and cerebrovascular disease and is made by following component: (consumption is a weight portion)
Radix Angelicae Sinensis 21-37 Rhizoma Chuanxiong 25-35 Radix Paeoniae Rubra 17-30
Flos Carthami 19-28 Herba Schizonepetae 25-40 Herba Ephedrae 26-35
Radix Saposhnikoviae 25-35 Rhizoma Atractylodis 31-50 Fructus Forsythiae 26-40
Radix Platycodonis 17-26 Radix Glycyrrhizae 17-26 Herba Menthae 15-25
Radix Scutellariae 23-37 Radix Puerariae 25-45 unpeeled CORTEX MOUTAN 25-40
Radix Polygoni Multiflori 32-51 Radix Et Rhizoma Rhei 110-155 Natrii Sulfas 105-160
Fructus Gardeniae 26-45 Radix Rehmanniae 15-40 Radix Rubiae 21-43
Rhizoma Cyperi 26-55 Radix Scrophulariae 20-35 Talcum 60-90
Gypsum Fibrosum 65-90 Os Draconis 25-50
Formula optimization weight (part) ratio range of preparation medicine of the present invention is:
Radix Angelicae Sinensis 30 Rhizoma Chuanxiongs 30 Radix Paeoniae Rubra 20
Flos Carthami 20 Herba Schizonepetae 30 Herba Ephedraes 30
Radix Saposhnikoviae 30 Rhizoma Atractylodis 40 Fructus Forsythiaes 30
Radix Platycodonis 20 Radix Glycyrrhizaes 20 Herba Menthaes 20
Radix Scutellariae 30 Radix Puerariaes 40 unpeeled CORTEX MOUTANs 30
Radix Polygoni Multiflori 40 Radix Et Rhizoma Rhei 150 Natrii Sulfas 150
Fructus Gardeniae 30 Radix Rehmanniae 30 Radix Rubiaes 30
Rhizoma Cyperi 40 Radix Scrophulariae 30 Talcums 80
Gypsum Fibrosum 80 Os Draconis 40
Each flavor is crude drug in the medicine of the present invention, starts with from the cause of disease of heart and brain disease, according to cause of disease medication, regulates the bodily fuctions, promoting blood circulation to remove obstruction in the collateral, promoting tissue regeneration by removing blood stasis, interior accent seven emotions is arranged, drive the effect of six climate exopathogens outward.With the disease-relieving and physique enhancing is purpose, improves the body circulation, and the mediation microcirculation utilizes metabolic pathway, just reach sweat gland from two and excrete, remove body inner product reservation or revocation material, alleviate internal organs load resistance, the recovery organization normal function, safeguard the intravital ecological balance of people, eradicate source of disease, cure the heart and brain disease.
Medicine of the present invention also can prevent cardiovascular and cerebrovascular disease, if headache, symptom such as dizzy, nervous are arranged, taking medicine one gets final product for twice.
Medicine of the present invention can be made various dosage forms according to a conventional method.
Preferred a kind of capsule formulation of making by special process in various dosage forms.Preparation method is as follows:
Take by weighing the crude drug of respectively distinguishing the flavor of by prescription, drying is pulverized, and sieves.Residual medicine dreg is decocted with water, after the filtration filtrate is concentrated the back and add medicated powder, spread medicine out drying after stirring, incapsulate after the pulverizing and get final product.
Utilize the medicament of formulation method preparation of the present invention, be different from various traditional formulation methods.As decoction, dosage is big, and effective ingredient can not be all fried next, and the medical material waste is serious; Honeyed pill need adopt excipient over half during preparation, if dose is little, and efficacy of a drug deficiency, dose is big, then is difficult to swallow; The watered pill is the same with powder, and the medicinal residues waste material is all taken, and measures little uselessly, and it is poor to measure big mouthfeel; Chemical purification utilizes the efficacy of a drug single, and some drug chemistry is destructurized, and unknown composition is not suggested, and is difficult to represent the medical material overall picture, just can not embody the principle that treatment by Chinese herbs cooperatively interacts and coordinates.The length of desirable each dosage form of formulation method of the present invention is gone its deficiency again, has both improved the utilization rate of medical material, has dwindled volume again.The capsule preparations of the medicine of the present invention that per 5 balls employing formulation method of the present invention is made (every ball 0.5 gram) is equivalent to the potion decoction, or pill 36 restrains, the efficacy of a drug of powder 10 grams.So taking convenience, take effect fast, effect is lasting, has no side effect.
For showing the therapeutic effect of medicine of the present invention to cardiovascular and cerebrovascular disease, systematically selected all ages and classes, sex and dissimilar cardiovascular and cerebrovascular disease cases, comprise hypertension, hyperlipidemia, coronary heart disease, cerebral ischemia, apoplexy sequela and epilepsy etc.Symptom is:
Hypertension: diastolic pressure surpasses 90mmHg;
Hyperlipidemia: cholesterol level surpasses 5.7mmol/L in the blood, and three fat content surpass 1.7mmol/L, and the high-density protein man is lower than 1.53mmol/L, and the woman is lower than 2.00mmol/L (in 1991 version of national Clinical Laboratory rule of operation);
Coronary heart disease: mainly according to clinical response, the various performances of acute or chronic myocardial ischemia, as uncomfortable in chest, pareordia paroxysmal pain, die Blausucht, agitation etc. frequently, and relevant therewith age, hypertension, hyperlipidemia and ECG T wave are inverted auxiliary examinations such as Q, R, S brownout;
Apoplexy sequela: mainly according to the morbidity history, the side limb is dumb or attach undue importance to one thing to the neglect of the other, and relevant CT Doppler, blood fat chemical examination measure etc. check unusual etc.;
Epilepsy: mainly according to medical history performance,, spit out white foams, wake up and do not know or electroencephalogram is found auxiliary examinations such as focus as the paroxysmal stupor of twitching.
In the case according to above symptom selection, male 185 people, women 159 people.Maximum 76 years old age, minimal ages 10 years old, 47 years old mean age.
Use medicine of the present invention to treat, be 30 days a course of treatment.
Instructions of taking: each 5 balls (every ball 0.5 gram), children's's decrement, every day secondary.Treatment cycle is three courses of treatment.
The curative effect statistical standard is as shown in the table:
Its therapeutic effect can be added up referring to table 1 curative effect clinical data.
Table 1 curative effect clinical data statistics
| Disease | Case load (people) | Produce effects | Enabledisable | Effective percentage (%) |
| Hypertension | 123 | 67 | 51 5 | 95.9 |
| Hyperlipidemia | 117 | 79 | 35 3 | 97.4 |
| Coronary heart disease | 91 | 35 | 52 4 | 95.5 |
| Apoplexy sequela | 6 | 2 | 3 1 | 83 |
| Epilepsy | 7 | 6 | 1 | 85 |
By above-mentioned clinical data as seen, medicine of the present invention all has curative effect preferably, treating both the principal and secondary aspects of a disease for polytype cardiovascular and cerebrovascular disease.Thoroughly remove pathogen, alleviate internal organs load resistance, the recovery organization function, thus improve blood circulation.Utilize the special nature of natural animal-plant, safeguard the intravital ecological balance of people, reach the purpose of disease-relieving and physique enhancing.Make disease spontaneous recovery by regulating and strengthening patient self function.Not only can eliminate and alleviate the symptom of cardiovascular and cerebrovascular disease quickly, can improve patient's various states preferably simultaneously, reach the effect of effecting a permanent cure.Therapeutic effect has stability, certainty.Taking convenience, patient easily accepts, and side effect is little.
The length of desirable each dosage form of formulation method of the present invention is gone its deficiency again, has both improved the utilization rate of medical material, has dwindled volume again.So taking convenience, take effect fast, effect is lasting, has no side effect.
Embodiment
Take by weighing raw material (kilogram) by following proportioning:
Radix Angelicae Sinensis 30 Rhizoma Chuanxiongs 30 Radix Paeoniae Rubra 20
Flos Carthami 20 Herba Schizonepetae 30 Herba Ephedraes 30
Radix Saposhnikoviae 30 Rhizoma Atractylodis 40 Fructus Forsythiaes 30
Radix Platycodonis 20 Radix Glycyrrhizaes 20 Herba Menthaes 20
Radix Scutellariae 30 Radix Puerariaes 40 unpeeled CORTEX MOUTANs 30
Radix Polygoni Multiflori 40 Radix Et Rhizoma Rhei 150 Natrii Sulfas 150
Fructus Gardeniae 30 Radix Rehmanniae 30 Radix Rubiaes 30
Rhizoma Cyperi 40 Radix Scrophulariae 30 Talcums 80
Gypsum Fibrosum 80 Os Draconis 40
Preparation method:
Take by weighing the crude drug of respectively distinguishing the flavor of by prescription, drying is pulverized, and crosses 120 mesh sieves, obtains the medicated powder of crude drug amount about 55%.Residual medicine dreg is decocted with water 2 times, after the filtration filtrate is concentrated into when equating with the medicated powder volume and adds medicated powder immediately, spread medicine out drying after stirring, incapsulate after the pulverizing, every ball is adorned 0.5 gram.
Model case:
1. Jiao, area just outside a city gate, Dengfeng town Da Yan people from village, man, 59 years old.Have hypertension, the time
Normal dizzy, the Spring Festival in 1996 got sun in institute, felt general weakness suddenly, the extremity fiber crops
Wood, can not from.Measure blood pressure 180/100mmHg, apathetic expression, slurred speech,
Bradykinesia, pulse condition flood number is diagnosed as apoplectic stroke, takes this
Bright medicine after five days disease take a turn for the better, can from the action, rehabilitation after taking medicine again ten days.
Followed up a case by regular visits to through 1 year and not see recurrence, can normally work down.
2. grandson, man, Yuzhou City mesa town Zhuan Gou people from village.Its female 67 years old, suffered from cerebral thrombosis
3 years, the medicine of the present invention crutch of can leaving away after ten days was taken in right hand foot inconvenience,
Take January again and rehabilitation.After more than a year, follow up a case by regular visits to, do not see recurrence.
3. permitted certain, woman, 17 years old, Da Jin shop, Dengfeng City Bi Cun people, student.Excuse before 3 years
Portion is injured goes back to school after treatment.But hypomnesis is dizzy frequently.In 1994
December was fallen in a swoon suddenly in the school on the 6th, and syncope is spat out white foams, tic of the limbs.
Teachers and students are all frightened, wake up in about ten minutes, ask and do not know.Went to school again in second day, the time
Permitted again same morbidity every other month once.Be diagnosed as epileptics, get it filled and take, do not reach
First quarter moon, disease is shown effect again, though treatment does not stop, attack times is gradually many, Chinese medicine and western medicine is equal
Do not take effect.Therefore suspend schooling.Nineteen ninety-five has been the number of falling ill every day when March 4 examined
Inferior.Analyze according to state of an illness medical history, this should be brain injury sequela, because brain decreases
Hindering influences cerebral blood supply, and cerebral hypoxia loses vigor during to the limit, promptly takes place insane
Epilepsy.Because of every outbreak once all has damage to brain, so attack times is gradually many.Treatment
The time answer the kidney invigorating and brain-strengthening to carry out simultaneously, rise and promptly do not see outbreak through taking medicine of the present invention,
Spirit also take a favorable turn, and like rehabilitation, requires to go to school, in the school again after taking medicine 10 days
Take medicine and consolidated curative effect in 10 days.Through following up a case by regular visits to more than a year, do not see recurrence.
Claims (8)
1. medicine for the treatment of cardiovascular and cerebrovascular disease is characterized in that it is the medicament of being made by the following weight proportion raw material:
Radix Angelicae Sinensis 21-37 Rhizoma Chuanxiong 25-35 Radix Paeoniae Rubra 17-30
Flos Carthami 19-28 Herba Schizonepetae 25-40 Herba Ephedrae 26-35
Radix Saposhnikoviae 25-35 Rhizoma Atractylodis 31-50 Fructus Forsythiae 26-40
Radix Platycodonis 17-26 Radix Glycyrrhizae 17-26 Herba Menthae 15-25
Radix Scutellariae 23-37 Radix Puerariae 25-45 unpeeled CORTEX MOUTAN 25-40
Radix Polygoni Multiflori 32-51 Radix Et Rhizoma Rhei 110-155 Natrii Sulfas 105-160
Fructus Gardeniae 26-45 Radix Rehmanniae 15-40 Radix Rubiae 21-43
Rhizoma Cyperi 26-55 Radix Scrophulariae 20-35 Talcum 60-90
Gypsum Fibrosum 65-90 Os Draconis 25-50
2. the medicine of treatment cardiovascular and cerebrovascular disease according to claim 1, wherein the weight proportion of each raw material is:
Radix Angelicae Sinensis 30 Rhizoma Chuanxiongs 30 Radix Paeoniae Rubra 20
Flos Carthami 20 Herba Schizonepetae 30 Herba Ephedraes 30
Radix Saposhnikoviae 30 Rhizoma Atractylodis 40 Fructus Forsythiaes 30
Radix Platycodonis 20 Radix Glycyrrhizaes 20 Herba Menthaes 20
Radix Scutellariae 30 Radix Puerariaes 40 unpeeled CORTEX MOUTANs 30
Radix Polygoni Multiflori 40 Radix Et Rhizoma Rhei 150 Natrii Sulfas 150
Fructus Gardeniae 30 Radix Rehmanniae 30 Radix Rubiaes 30
Rhizoma Cyperi 40 Radix Scrophulariae 30 Talcums 80
Gypsum Fibrosum 80 Os Draconis 40
3. the medicine of treatment cardiovascular and cerebrovascular disease according to claim 1 and 2 is characterized in that said medicament is a said dosage form on any pharmaceutics.
4. the medicine of treatment cardiovascular and cerebrovascular disease according to claim 3 is characterized in that said medicament is a capsule.
5. the preparation method of the medicine of treatment cardiovascular and cerebrovascular disease according to claim 4, it is characterized in that taking by weighing the crude drug of respectively distinguishing the flavor of, dry, pulverize, sieve, residual medicine dreg is decocted with water, after the filtration filtrate is concentrated the back and add medicated powder, spread medicine out drying after stirring, incapsulate after the pulverizing and get final product.
6. the make a living 50%-60% of dose of the preparation method of the medicine of treatment cardiovascular and cerebrovascular disease according to claim 5, the medicated powder amount of the gained that it is characterized in that sieving.
7. the preparation method of the medicine of treatment cardiovascular and cerebrovascular disease according to claim 5 is characterized in that filtrate concentrated and adds medicated powder when equating as for the medicated powder volume immediately.
8. the preparation method of the medicine of treatment cardiovascular and cerebrovascular disease according to claim 5, it is characterized in that every pill capsule adorn 0.5 the gram medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98126131A CN1086586C (en) | 1998-12-25 | 1998-12-25 | Medicine for treating cardiac and cerebral vascular diseases and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98126131A CN1086586C (en) | 1998-12-25 | 1998-12-25 | Medicine for treating cardiac and cerebral vascular diseases and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1258521A CN1258521A (en) | 2000-07-05 |
| CN1086586C true CN1086586C (en) | 2002-06-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98126131A Expired - Fee Related CN1086586C (en) | 1998-12-25 | 1998-12-25 | Medicine for treating cardiac and cerebral vascular diseases and its preparation |
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| Country | Link |
|---|---|
| CN (1) | CN1086586C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100366277C (en) * | 2005-09-21 | 2008-02-06 | 李永发 | Medicine composition for treating cardiac and cerebral vascular diseases and its prepn |
| CN1319557C (en) * | 2005-09-27 | 2007-06-06 | 鲁南制药集团股份有限公司 | Chinese medicine composition for treating cardiac and cerebral vascular diseases and its prepn |
| CN102274337B (en) * | 2011-08-07 | 2012-11-28 | 郭静 | Chinese medicinal medicament for treating angioneurotic headache |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096697A (en) * | 1993-06-24 | 1994-12-28 | 乐清健生保健品有限公司 | A kind of Chinese medicine electuary of preventing and treating cardiovascular and cerebrovascular disease |
| CN1195556A (en) * | 1997-04-08 | 1998-10-14 | 刘志恒 | Method for preparing medicinal liquor with heart and brain recovery function |
-
1998
- 1998-12-25 CN CN98126131A patent/CN1086586C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096697A (en) * | 1993-06-24 | 1994-12-28 | 乐清健生保健品有限公司 | A kind of Chinese medicine electuary of preventing and treating cardiovascular and cerebrovascular disease |
| CN1195556A (en) * | 1997-04-08 | 1998-10-14 | 刘志恒 | Method for preparing medicinal liquor with heart and brain recovery function |
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| Publication number | Publication date |
|---|---|
| CN1258521A (en) | 2000-07-05 |
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