CN101167876B - Medicinal composition for treating high blood pressure and its complication and preparation method thereof - Google Patents
Medicinal composition for treating high blood pressure and its complication and preparation method thereof Download PDFInfo
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- CN101167876B CN101167876B CN2007101770507A CN200710177050A CN101167876B CN 101167876 B CN101167876 B CN 101167876B CN 2007101770507 A CN2007101770507 A CN 2007101770507A CN 200710177050 A CN200710177050 A CN 200710177050A CN 101167876 B CN101167876 B CN 101167876B
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Abstract
The invention discloses a medicament composition for curing headache, vertigo, acoasm, and limb numbness and the like which are caused by high blood pressure, and process for preparation. The invention is constituted by raw material drugs which adopt part by weight to be a unit, and the raw material comprises 35 parts of cassia seeds, 30 parts of loranthus parasiticus, 30 parts of haws, 20 parts of lotus plumules, 20 parts of scrophularia roots, 15 parts of wild chrysanthemum flower, 15 parts of seabuckthorn fruit, 10 parts of kudzu roots, and 10 parts of cimicifuga foetida. The invention has the efficacies of calming liver and suppressing liver-yang, elevating Yang and relieving heart, and clearing heat and activating blood, which is used for curing headache, vertigo, acoasm, and limb numbness and the like which are caused by high blood pressure. The invention has the advantages of simple formulas, simple and convenient production, distinct curative effect, poisonless, excellent stability, and easy taking, which has an extensive application value.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, belong to the technical field of pharmaceuticals of treatment hypertension and complication thereof.Be used for the treatment of hypertension and due to headache, dizzy, tinnitus, diseases such as numb limbs and tense tendons.
Background technology
Hypertension is commonly encountered diseases, frequently-occurring disease, and the cause of disease is that blood vessel wall makes the blood vessel wall constriction owing to haemolysate in blood fat rising or the blood reduces, and forms thrombosis; Perhaps because subcutaneous fat is too much, the compressing blood vessel causes the vascular flow amount superfluous and cause that it seriously endangers healthy, particularly the important risk factor of cardiovascular and cerebrovascular diseases such as apoplexy, coronary heart disease, renal failure and retinopathy.Present cardiovascular and cerebrovascular complication mortality rate because of caused by hypertension occupies first of China's disease death rate.Therefore early stage active prevention treatment hypertension is impaired to alleviating organ, and it is significant to reduce complication.
The treatment hypertension is based on Western medicine at present, normal sympathetic inhibitor, antipsychotic drugs, expansion blood vessel medicine and the maincenter depressor etc. of using comprise diuretic, beta-blocker, calcium ion channel blocker, the inhibitor of Angiotensin-Converting and the antagonist of angiotensin receptor etc.But these medicines all can not effect a permanent cure, and significant side effects is arranged, and also need to take for a long time.Though the Chinese patent medicine of some treatment hypertension is also arranged, because effect is very not remarkable, the patient still has to rely on some Western medicine.
The traditional Chinese medical science thinks that hypertension belongs to vertigo, is the excess of the liver kidney deficiency, and hyperactivity of deficient fire is worked as replenishing the kidney(water)to nourish the liver(wood), suppressing the hyperactive liver and subsiding YANG, and yang invigorating clears away heart-fire, and heat clearing and blood circulation promoting just can be treated diseases such as headache that hypertension causes, dizzy, cardiopalmus, insomnia, tinnitus, numb limbs and tense tendons.Through clinical observation, find that this Chinese medicine preparation has alleviated the symptom of various discomforts when obviously reducing patient's blood pressure, do not find untoward reaction simultaneously.
Summary of the invention
The object of the present invention is to provide a kind of evident in efficacy, taking convenience, side effect little, can be fit to the treatment hypertension of taking for a long time and the pharmaceutical composition of complication thereof.
The present invention also provides this preparation of drug combination method.
Pharmaceutical composition of the present invention can be used for treating diseases such as headache that hypertension causes, dizzy, cardiopalmus, insomnia, tinnitus, numb limbs and tense tendons.
Pharmaceutical composition of the present invention is prepared from by the following weight parts proportion raw material:
1～30 part of 10～100 parts of Semen Cassiaes, 10～80 parts of Herba Taxillis, 10～80 parts of Fructus Crataegis, 5～60 parts of Plumula Nelumbiniss, 5～60 parts of Radix Scrophulariaes, 5～50 parts of Flos Chrysanthemi Indicis, 5～50 parts of Fructus Hippophaes, 1～30 part of Radix Puerariae and Rhizoma Cimicifugae.
Pharmaceutical composition of the present invention is prepared from by following preferred weight part proportion raw material:
5～20 parts of 20～50 parts of Semen Cassiaes, 20～50 parts of Herba Taxillis, 20～50 parts of Fructus Crataegis, 10～40 parts of Plumula Nelumbiniss, 10～40 parts of Radix Scrophulariaes, 10～30 parts of Flos Chrysanthemi Indicis, 10～30 parts of Fructus Hippophaes, 5～20 parts of Radix Puerariaes and Rhizoma Cimicifugaes.
Pharmaceutical composition of the present invention is prepared from by following optimum weight part proportion raw material:
10 parts of 35 parts of Semen Cassiaes, 30 parts of Herba Taxillis, 30 parts of Fructus Crataegis, 20 parts of Plumula Nelumbiniss, 20 parts of Radix Scrophulariaes, 15 parts of Flos Chrysanthemi Indicis, 15 parts of Fructus Hippophaes, 10 parts of Radix Puerariaes and Rhizoma Cimicifugaes.
Pharmaceutical composition of the present invention can be prepared from by following method:
1, Semen Cassiae, Herba Taxilli, Fructus Hippophae and the powder of Radix Puerariae with described weight portion is broken into coarser powder, and with 80% alcohol heating reflux 2 times, 2 hours for the first time, 1 hour for the second time, merging filtrate reclaimed ethanol, spray drying, and medicated powder is standby;
2, residue and Fructus Crataegi and Flos Chrysanthemi Indici decoct with water 2 times, and each 1 hour, filter, merging filtrate concentrates the back spray drying, and medicated powder is standby;
3, Radix Scrophulariae and Rhizoma Cimicifugae etc. are ground into fine powder, and 70% alcohol dipping percolation after 48 hours leaves standstill after-filtration then, get supernatant concentration after spray drying standby;
4, Plumula Nelumbinis is extracted with 2 ‰ hydrochloric acid solution percolation, the alkalization of 10% ammonia, the leaching precipitation, dry back is standby.With four part medicated powder mix homogeneously, incapsulate and get final product.
Prescription of the present invention is made up of nine flavor Chinese medicines such as Semen Cassiae, Herba Taxilli, Fructus Crataegi, Plumula Nelumbinis, Radix Scrophulariae, Flos Chrysanthemi Indici, Fructus Hippophae, Radix Puerariae and Rhizoma Cimicifugae.Modern pharmacological research shows: Semen Cassiae liver heat removing and eyesight improving in the side, and dispersing swelling and dissipating binds has good blood pressure lowering, blood fat reducing and relieving constipation by purgation effect, and it boils agent, water leaching agent, ethanol preserved material and ethanol water logging agent and all has tangible hypotensive activity; The Herba Taxilli wind-damp dispelling, liver and kidney tonifying nourishes blood, and bone and muscle strengthening has blood fat reducing, blood pressure lowering, calmness and diuresis, and is shared with Semen Cassiae, and curative effect more has raising; The hawthorn digesting eliminate indigestion, the circulation of qi promoting dissipating blood stasis is used for stasis of blood resistance and swells and ache, and Fructus Crataegi extract has heart tonifying, blood pressure lowering, increase coronary flow and antiarrhythmic effect, and its total flavones and triterpene acids all have blood pressure lowering, blood fat reducing and antiatherogenic effect; Plumula Nelumbinis energy clearing away heart-fire for tranquillization, unsmoothing the sperm and stopping bleeding is controlled the insomnia of disarmony between the heart and kidney, clearing away heat and cooling blood, its water decoction has hypotensive effect; Radix Scrophulariae energy clearing away heat and cooling blood, the YIN nourishing detoxifcation is promoted the production of body fluid and is moisturized, and its infusion or decoct can make blood pressure drops, and pure extractum aqueous solution is coronary blood flow increasing obviously; Flos Chrysanthemi Indici can be dispersed wind heat, liver heat removing and eyesight improving, suppressing liver-YANG, heat-clearing and toxic substances removing, main improving sight and hearing had both removed irritable feverish sensation in the chest, controlled the dizziness headache again, and its decoct is coronary artery dilator significantly, coronary blood flow increasing and improve myocardial oxygen consumption, itself and Fructus Crataegi compatibility, decocting can be controlled hyperlipemia and hypertension; Fructus Hippophae nourishing stomach and spleen, activating blood circulation to dissipate blood stasis, calm the nerves, be rich in bioactive substances such as vitamin C, multivitamin SOD, trace element and flavone compound; Radix Puerariae and Rhizoma Cimicifugae expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, living positive antidiarrheal, its contained total flavones energy coronary artery dilator and cerebrovascular, blood flow increasing has obvious hypotensive effect; That Rhizoma Cimicifugae extract has is analgesic, spasmolytic, analgesia, calmness and anticonvulsant action, can decreased heart rate and blood pressure lowering.
The pharmaceutical composition that the present invention is used for the treatment of hypertension and complication thereof shows through pharmacodynamic experiment, toxicological test and stability experiment, and is evident in efficacy, nontoxic, good stability, patient's taking convenience.
Through clinical experiment, we can be used for treating hypertension and complication thereof, this Chinese medicinal capsule carries out observation of curative effect to 317 routine cases, take the back discovery of 2 weeks and 167 routine patient's blood pressure drops are arranged to normal condition, 129 routine patient's blood pressures descend to some extent, other has 21 people invalid, and total effective rate reaches 93.38%, therefore is with a wide range of applications.
Claims (4)
1. pharmaceutical composition for the treatment of hypertension and complication thereof is characterized in that this pharmaceutical composition is formed by the feedstock production of following weight parts: 1～30 part of 10～100 parts of Semen Cassiaes, 10～80 parts of Herba Taxillis, 10～80 parts of Fructus Crataegis, 5～60 parts of Plumula Nelumbiniss, 5～60 parts of Radix Scrophulariaes, 5～50 parts of Flos Chrysanthemi Indicis, 5～50 parts of Fructus Hippophaes, 1～30 part of Radix Puerariae and Rhizoma Cimicifugae.
2. pharmaceutical composition according to claim 1 is characterized in that this pharmaceutical composition is formed by the feedstock production of following weight parts: 5～20 parts of 20～50 parts of Semen Cassiaes, 20～50 parts of Herba Taxillis, 20～50 parts of Fructus Crataegis, 10～40 parts of Plumula Nelumbiniss, 10～40 parts of Radix Scrophulariaes, 10～30 parts of Flos Chrysanthemi Indicis, 10～30 parts of Fructus Hippophaes, 5～20 parts of Radix Puerariaes and Rhizoma Cimicifugaes.
3. according to the pharmaceutical composition of claim 1 or 2 described treatment hypertension and complication thereof, it is characterized in that this pharmaceutical composition is formed by the feedstock production of following weight parts: 10 parts of 35 parts of Semen Cassiaes, 30 parts of Herba Taxillis, 30 parts of Fructus Crataegis, 20 parts of Plumula Nelumbiniss, 20 parts of Radix Scrophulariaes, 15 parts of Flos Chrysanthemi Indicis, 15 parts of Fructus Hippophaes, 10 parts of Radix Puerariaes and Rhizoma Cimicifugaes.
4. pharmaceutical composition according to claim 3 is broken into coarser powder with Semen Cassiae, Herba Taxilli, Fructus Hippophae and the powder of Radix Puerariae of described weight portion, with 80% alcohol heating reflux 2 times, 2 hours for the first time, 1 hour for the second time, merging filtrate reclaimed ethanol, spray drying, medicated powder is standby; Residue and Fructus Crataegi and Flos Chrysanthemi Indici decoct with water 2 times, and each 1 hour, filter, merging filtrate concentrates the back spray drying, and medicated powder is standby; Radix Scrophulariae and Rhizoma Cimicifugae are ground into fine powder, and 70% alcohol dipping percolation after 48 hours leaves standstill after-filtration then, get supernatant concentration after spray drying standby; Plumula Nelumbinis is extracted with 2 ‰ hydrochloric acid solution percolation, the alkalization of 10% ammonia, the leaching precipitation, dry back is standby; With four part medicated powder mix homogeneously, incapsulate and get final product; Every capsules 0.5g.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007101770507A CN101167876B (en) | 2007-11-09 | 2007-11-09 | Medicinal composition for treating high blood pressure and its complication and preparation method thereof |
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| CN2007101770507A CN101167876B (en) | 2007-11-09 | 2007-11-09 | Medicinal composition for treating high blood pressure and its complication and preparation method thereof |
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| CN101167876A CN101167876A (en) | 2008-04-30 |
| CN101167876B true CN101167876B (en) | 2011-04-06 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1411830A (en) * | 2001-10-17 | 2003-04-23 | 宋大文 | Medicine for curing hypertension and its preparation method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1411830A (en) * | 2001-10-17 | 2003-04-23 | 宋大文 | Medicine for curing hypertension and its preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 马春武等.中药治疗高血压的研究现状及进展.中国现代药物应用1 1.2007,1(1),61-62. |
| 马春武等.中药治疗高血压的研究现状及进展.中国现代药物应用1 1.2007,1(1),61-62. * |
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| CN101167876A (en) | 2008-04-30 |
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Owner name: SHANGHAI ZHONGJINGTANG INDUSTRIAL CO., LTD. Free format text: FORMER OWNER: BEIJING ZHONGKE YONGHE MEDICAL TECHNOLOGY CO., LTD. Effective date: 20140714 |
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Effective date of registration: 20140714 Address after: 200135, No. 1576, Zhang Yang Road, 3, Shanghai Patentee after: Shanghai Zhongjingtang Industrial Co.,Ltd. Address before: 100027 Beijing City, Dongcheng District Andingmen East Street, No. 28, East Building 1 unit 508 Patentee before: Beijing Zhongke Yonghe Medical Technology Co., Ltd. |