CN102462787A - Chinese medicine composition for treating hypertension and improving hyperlipidemia and preparation method of Chinese medicine composition - Google Patents
Chinese medicine composition for treating hypertension and improving hyperlipidemia and preparation method of Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a Chinese medicine composition for treating hypertension and improving hyperlipidemia and a preparation method of the Chinese medicine composition. The Chinese medicine composition comprises the following components in parts by weight: 10 to 20 parts of semen cassia, 8 to 16 parts of fleece-flower root, 10 to 20 pars of pheretima, 10 to 20 parts of raw haws, 10 to 20 parts of wild tea, 10 to 20 parts of kudzuvine root powder, 8 to 16 parts of rhizoma alismatis, 8 to 16 parts of white mulberry root bark and 10 to 20 parts of young uncaria. The preparation method comprises the following steps of: a, weighing the semen cassia, the fleece-flower root, the pheretima, the raw haws and the kudzuvine root powder according to the parts in weight; after pulverizing, screening with a sieve of 300 meshes to form medicinal powder; b, weighing the wild tea, the rhizoma alismatis, the white mulberry root bark and the young uncaria according to the parts in weight; adding water; decocting to form thick juice; and c, mixing and uniformly stirring the medicinal powder and the medicinal juice; drying; and preparing into a desired medicinal dosage form. The Chinese medicine composition provided by the invention has a smoother hypotensive effect in comparison with western medicines, does not have any toxic or side effect, and has efficacy of enhancing organism immunity and senescence resistance.
Description
One. technical field
The present invention relates to a kind of Chinese medicine, particularly relate to a kind of Chinese medicine composition and formulation method thereof of treating hypertension, improving hyperlipidemia.
Two. background technology
Since growth in the living standard, the quickening of work rhythm, the personnel that suffer from hypertension, hyperlipidemia, high triglyceride are a lot, and this not only brings disease and misery to afflicted, also family and society is caused burden.At present, the method for existing treatment hypertension, hyperlipidemia adopts injection and Western medicine more; It is on the high side that Western medicine contains chemical constituent, and its toxic and side effects is bigger, have in addition take to take a large amount of chemohormonal Therapeutic Method; Often cause bringing out complication, the patient's body organ has been caused infringement, owing to belonging to treatment method; Can't reach the equilibrium between yin and yang of the person and the effect of radical cure, to this situation, people develop some Chinese medicines; But adopt the Chinese medicine prescription, need normal extension to examine and make up a prescription and the decoct medicinal herbs medicine of a warm nature, bring inconvenience to the patient.
Three. summary of the invention
Technical problem to be solved by this invention is: provide a kind of and fill a prescription rationally, clinical efficacy obviously, the treatment hypertension of taking convenience, improve the Chinese medicine composition of hyperlipidemia, and a kind of formulation method of this Chinese medicine composition is provided.
Technical scheme of the present invention is: a kind of Chinese medicine composition of treating hypertension, improving hyperlipidemia; Comprise: be unit with the weight portion; By Semen Cassiae 10-20 part, Radix Polygoni Multiflori 8-16 part, LUMBRICUS 10-20 part, Fructus Crataegi 10-20 part, wild tea 10-20 part, RADIX PUERARIAE 10-20 part, Rhizoma Alismatis 8-16 part, Cortex Mori 8-16 part, tender Ramulus Uncariae Cum Uncis 10-20 part is formed.
Treatment hypertension, improve the formulation method of the Chinese medicine composition of hyperlipidemia, may further comprise the steps:
A, according to said weight portion get it filled Semen Cassiae, Radix Polygoni Multiflori, LUMBRICUS, Fructus Crataegi and RADIX PUERARIAE, pulverize the back and cross 300 mesh sieves, form medicated powder;
B, get wild tea, Rhizoma Alismatis, Cortex Mori according to said weight portion. tender Ramulus Uncariae Cum Uncis, add water and boil, fry in shallow oil into extract, filter the back and form medicine juice;
C, said medicated powder (a) and medicine juice (b) mixed mix the back oven dry thoroughly, process required pharmaceutical dosage form again.
Said medicated powder and medicine juice mix mixes back tabletting oven dry thoroughly, forms tablet.
Said medicated powder and medicine juice mix mixes the back oven dry thoroughly, pulverizes the back and forms granule.
Add an amount of sucrose in said medicated powder and the medicine juice.
Positive beneficial effect of the present invention is:
1. step-down ratio of the present invention is steady with the Western medicine blood pressure lowering, can improve blood viscosity again, has no side effect, and can take for a long time, does not damage any function, and immunity of the human body of enhancing and antidotal effect are arranged.
2. the present invention can carry, taking convenience, and general patient need not be in hospital, and can reduce patient's spending significantly, reduces medical expense.
3, the present invention has the effect of liver heat removing and eyesight improving blood pressure lowering, diffusing silt function of invigorating circulation and reducing blood fat; Cure mainly: have a dizzy spell, insomnia and dreamful sleep, uncomfortable in chestly nervous breathe hard, the whole body feels sleepy weak etc. (hypertension, hyperlipidemia, hypercholesterolemia, high triglyceride, strengthen coronary flow circulation, arrhythmia etc.) good effect.
The pharmacological action of Chinese medicine composition of the present invention is:
1, Semen Cassiae: meridian distribution of property and flavor; Sweet, bitter, be slightly cold, return liver, large intestine channel.Effect: liver heat removing and eyesight improving, loosening bowel to relieve constipation.Cure mainly: hypertension, hyperlipidemia.These article reduce the effect of serum cholesterol and blood pressure lowering, and sclerosis has certain curative effect with hypertension to treatment of vascular.
Hypotensive effect: Semen Cassiae infusion, pure water-leach liquor, alcohol leaching liquid, give anesthesia Canis familiaris L., cat, rabbit, the effect of blood pressure lowering is arranged.Semen Cassiae can make SHH rat systolic pressure, diastolic pressure, obviously reduce, and heart rate and breathing are not made significant difference, and blood pressure lowering intensity significantly is better than reserpine, and the persistent period also significantly is longer than reserpine.
The effect of blood fat reducing; The effect that Semen Cassiae has low total plasma cholesterol (TC) and triglyceride makes it to reduce by 19% and 73% than tentative serum lipids in rats group respectively; Reduce the effect of triglyceride and anticoagulant in the liver in addition.Its value reduces by 49% and 50% than tentative hyperlipemia group respectively.These article increase immune, antibacterial, anticancer function.
2, Radix Polygoni Multiflori: meridian distribution of property and flavor; Bitter, sweet, puckery, little hardship is returned liver, the heart, kidney channel.Effect: enrich and benefit essence and blood, detoxifcation preventing the attack (or recurrence) of malaria, loosening bowel to relieve constipation.Cure mainly: both liver and kidney deficiency, asthenia of essence and blood, diseases such as dizziness and blurred vision, vertical tin of tinnitus, forgetful insomnia, early whitening of beard and hair.
Radix Polygoni Multiflori can be treated hyperlipemia and arteriosclerosis from absorption of cholesterol, metabolism etc. are many-sided, and can reduce the hypercoagulability of blood, and defying age, enhance immunity are had obvious effect.
3, Fructus Crataegi: meridian distribution of property and flavor; Sour, sweet, tepor.Return spleen, stomach, Liver Channel.Effect; Promoting digestion and removing stagnation, promoting blood circulation to remove blood stasis.
Fructus Crataegi has blood vessel dilating, increases coronary flow, the effect of heart tonifying and blood pressure lowering, and the ethanol soluble extraction of Fructus Crataegi is given the anesthetized rabbit intravenous injection, and blood pressure is slowly descended.The Fructus Crataegi extract has the myocardial ischemia of alleviating and downright bad effect to experimental animal models, reduces viscosity of blood.
4, Pheretima: meridian distribution of property and flavor is salty, cold.Return liver, spleen, urinary bladder channel.Effect; Clearing heat for calming endogenous wind arranged, relieving asthma, promote blood circulation, diuresis.Use; My hypotensive effect, can treat the vascular hypertension of first type on the liver-yang.
Experiment and clinical confirmation; The Lumbricus tincture has hypotensive effect, and its characteristics are lasting for effect relaxes.The active ingredient of LUMBRICUS blood pressure lowering is Pheretima B1 and time yellow foxtail millet cry of certain animals.The blood pressure lowering blood pressure drops of Pheretima B1.Pheretima has improves body immunity to face upward the growth of system oncocyte, and antitumaous effect is arranged.Effective percentage is 90.9%, and the decline of systolic pressure and diastolic pressure is all shown good effect.Along with the decline of blood pressure, symptom is alleviated gradually or is disappeared.Pheretima B1 does not have untoward reaction to the heart, Liver and kidney hemopoietic system, and brain and endocrine dysfunction are not found any untoward reaction yet.The blood pressure lowering mechanism of Pheretima possibly be the central nervous system that influences who directly acts on the above central nervous system of spinal cord or pass through some visceroceptor reflection, causes the expansion of part visceral vessel, and volume increases, and causes
5, wild tea: meridian distribution of property and flavor; Puckery, be slightly cold.Return Liver Channel.Effect; Suppressing the hyperactive liver is calmed the nerves, heat clearing away blood pressure lowering, heart tonifying diuresis.Disease is seen headache, dizzy and irritated insomnia etc.These article have that suppressing the hyperactive liver expels the heat-evil, the effect of blood pressure lowering.
Hypotensive effect, behind anesthetized dog vein constant speed injection Folium Apocyni Veneti extractum filter liquor, blood pressure drops continues more than 7 minutes.Decline up 22.3%.The Folium Apocyni Veneti decoct irritated stomach 2 hours for kidney type hypertension dog; Blood pressure is stabilized in reduced levels always; Rise was just arranged after 3 days, and its hypotensive effect possibly weakened by antihistaminic Ben Hai Lamine, and the hypotensive effect that Herba Apocyni veneti is described mainly is to realize through histamine's receptor.Other has the hypotensive effect that experiment showed, Herba Apocyni veneti also relevant in direct vasodilation.These article have cardiac muscle and coronary vasodilator sclerosis, immunity of enhancing human body and the antidotal effect of preventing.
Effect for reducing blood fat, Folium Apocyni Veneti extractum can significantly reduce the serum total cholesterol value that TVITON causes the rat of hyperlipidemia, serum triglyceride value, but fail to reduce mice forms hypercholesterolemia because of high lipid food cholesterol value.Experiment shows; The Folium Apocyni Veneti aqueous extract falls the effect of serum total cholesterol greater than clofibrate.
6, Radix Puerariae: meridian distribution of property and flavor; Sweet. suffering. cold.Return spleen, stomach warp.Effect; Relieving muscles diaphoresis, invigorating YANG QI to promote eruption, promoting the production of body fluid to quench thirst.Cure mainly; Headache due to the affection due to external wind and heat, stiff nape and back and hypertensive encephalopathy etc.
Hypotensive effect, Radix Puerariae all has certain hypotensive effect to normal and hypertension animal.Use kudzuvine root wine extractum, total flavones, the puerarin intravenous injection can make the blood pressure of anesthesia normal dogs obviously reduce immediately, and metering increase effect is strengthened.Oral Radix Puerariae decoct or spill extractum also has certain hypotensive effect to the hypertension dog of not anaesthetizing.These article can the cerebral blood flow increasing amount to cerebral circulation.There is the effect of tangible expansion coronary vasodilator that relaxing smooth muscle is also arranged to heart, falls the effect that blood expands.
7, Rhizoma Alismatis: meridian distribution of property and flavor; Sweet, light, cold.Return kidney, urinary bladder channel.Effect; The diuresis eliminating dampness by diuresis expels the heat-evil.Be used for diseases such as edema, dysuria, diarrhea stranguria with turbid discharge, leukorrhagia phlegm retention.
Diuresis, Rhizoma Alismatis have remarkable diuresis and blood pressure is reduced.A little less than Rhizoma Alismatis decoct and extractum gave the rabbit oral result extremely, Rhizoma Alismatis stream was invaded the cream lumbar injection and then is remarkable diuresis.Rat diuresis experimental result shows, the Rhizoma Alismatis of different acquisition season and different parts, and effect is different.With winter the person's of adopting diuresis the strongest, the spring Rhizoma Alismatis render a service poor slightly, the winter Rhizoma Alismatis must act on slightly, Rhizoma Alismatis grass roots and Rhizoma Alismatis must all not have diuresis.
Effect for reducing fat; Rhizoma Alismatis extract has tangible cholesterol reducing effect and study of anti-atherogenic effect to rabbit experiment property hypercholesterolemia; Alisol A and Alisol A, B, C, acetate all have cholesterol reducing effect, the strongest with Alisol A-24-acetate effect especially, and clinical practice is found; In the time of Rhizoma Alismatis and reduction serum cholesterol, also triglyceride reducing improves the content of density lipoprotein and the ratio of HDL-C/T-CHOL.The water-soluble part of alisol extract is by the effect of remarkable coronary artery dilator, and to AFL. and fall blood and expand special effect is also arranged.
8, Cortex Mori: meridian distribution of property and flavor. sweet, cold.Return lung meridian.Effect; Eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.Be used for dyspnea and cough due to lung-heat, the edema of edema, dysuria.And certain hypotensive effect is arranged, can treat hypertension.
Mulberry root and root bark have hypotensive effect, and ether, water, warm methanolic extract all have hypotensive effect, and Cortex Mori contains ethanol choline-like material.And diuresis is arranged, the effect of calmness.
9, tender Ramulus Uncariae Cum Uncis; Meridian distribution of property and flavor, sweet, be slightly cold.Return liver, pericardium channel.Effect; The endogenous wind stopping relieving convulsion, the heat clearing away suppressing the hyperactive liver.Being used for infantile convulsion and twitching, the liver-heat headache. head rises, and excessive rising of liver-YANG, the liver-fire of having a dizzy spell is flourishing and the liver-Yang sthenia type hypertension.
The various preparations of Ramulus Uncariae Cum Uncis to anesthetized animal or not anesthetized animal, intact animal or hypertension animal, no matter intravenous injection or gastric infusion all have the effect of blood pressure lowering.Ramulus Uncariae Cum Uncis decoct, Rhomotoxine Ramulus Uncariae cum Uncis alkali also have the effect of blood pressure lowering to the hypertensive rat of nephropathy.Ramulus Uncariae Cum Uncis blood pressure lowering mechanism result of study is shown that its site of action is extensive; Relate to nerve centre, neuroganglion, peripheral nerve, different effects such as heart and peripheral blood vessel.Ramulus Uncariae Cum Uncis also has effects such as anticoagulant and antithrombotic formation.
Usage of the present invention: obey three times, each 6 grams every day, be a course of treatment January.Taboo: period in a medicine, taboo are eaten Semen phaseoli radiati.Eat article higher fatty acid, high protein less.
Model case:
Medical record one: Lee: man, 56 years old, first visit on April 22 in 2006.Have hypertension history and familial history of hypertension; Blood pressure is high sometimes; Sometimes normally irregular, nearly first quarter moon is because of being busy with one's work, and adds again that family's thing causes to feel bad; Cause dizzy feeling of fullness in the head, insomnia, flushing conjunctival congestion, cardiopalmus, the whole body are weak, xerostomia, red tip of the tongue, two are just transferred suitable, thin lingual fur, stringy and thready pulse.Blood pressure 220/105mmHg [29/14kpa].Disease belongs to: the heart-yin is hyperactivity of hesrt-fire and liver-fire due to consumption, lack of preservation of spirit, the emotion secretly.Smelting is suitable; Heat clearing away is nourished heart, suppressing the hyperactive liver and subsiding YANG.Take medicine of the present invention, obey three times, each 6 grams every day, be a course of treatment January.26 days two May in 2006 examined: oneself takes a turn for the better dizzy feeling of fullness in the head, flushing conjunctival congestion, and blood pressure reduces to that 150/90mmHg (20/12kPa) insomnia, cardiopalmus obviously improve, the whole body does not weakly subtract, anorexia.Continue to take medicine, follow up a case by regular visits to blood pressure stabilization after two months about 145/85mmHg (19/11Kpa).
Medical record two: suddenly so-and-so; The woman, 54 years old, people from Weizhi County.First visit on January 16 in 2008, have dizzy spells all day, the whole body is weak, walking the time is One's legs gave way, indigestion and loss of appetite, nausea, xerostomia are not desired BP general; 200/100mmHg (26.5/13.5Kpa), clinic's transfusion once in the village, oral KADUOPULI, reserpine etc., blood pressure is reduced to 180/95mmHg (24/13kpa).Inscribe: dizziness and blurred vision, nausea and vomiting, unable all over the body, through county people's hospital (full-automatic blood rheology measurement report); The whole blood height is cut (200/s). and reference value is 3.51-4.82, and measured value is 5.35, and is higher by 0.53 than normal.Cutting (30/s) reference value in the whole blood is 4.08-6.14, and measured value is that 6.52. is higher by 0.38 than normal value.Low cut (1/s) of whole blood. reference value is 7.02-12.10, and measured value is that 13.03. is higher by 0.93 than normal value.Anorexia, two just transfer, and thick fur is greasy. stringy and rolling pulse.Disease belongs to: the phlegm-damp spleen is stranded, clear YANG failing to ascend.Take medicine of the present invention, obey three times, each 6 grams every day, be a course of treatment January.
Further consultation on February 24 in 2008: dizzy dizzy improvement, spirit can, be received and eaten increase; At the full-automatic blood rheology measurement of 23 Nikkei county hospitals in February, it is 3.63 that the whole blood height is cut (200/S) measured value, and cutting (30S) measured value in the whole blood is 4.73, and whole blood is low, and to cut (1/S) measured value be 1.59, and the hemorheology check the value is all in normal range.Continue to obey January, strengthen consolidating curative effect.Follow up a case by regular visits to blood pressure over 3 years all about 145/90mmHg at every turn.
Four. the specific embodiment
Embodiment one: treatment hypertension, improve the Chinese medicine composition of hyperlipidemia; With the weight portion is unit (g), is made up of Semen Cassiae 10g, Radix Polygoni Multiflori 8g, LUMBRICUS 10g, Fructus Crataegi 10g, wild tea 10g, RADIX PUERARIAE 10g, Rhizoma Alismatis 8g, Cortex Mori 8g and tender Ramulus Uncariae Cum Uncis 10g.
Its formulation method may further comprise the steps:
A, take by weighing medicine Semen Cassiae, Radix Polygoni Multiflori, LUMBRICUS, Fructus Crataegi and RADIX PUERARIAE, pulverize the back and cross 300 mesh sieves, form medicated powder according to weight portion;
B, take by weighing wild tea, Rhizoma Alismatis, Cortex Mori and tender Ramulus Uncariae Cum Uncis, add water and boil, fry in shallow oil into extract 40g, filter the back and form medicine juice according to weight portion;
C, medicated powder and medicine juice mixed mix the back oven dry thoroughly, process required pharmaceutical dosage form again.
Medicated powder and medicine juice mix mixes back tabletting oven dry thoroughly, forms tablet.Perhaps, medicated powder and medicine juice mix mixes the back oven dry thoroughly, pulverizes the back and forms granule.Add an amount of sucrose in medicated powder and the medicine juice, regulate taste.
Usage of the present invention: obey three times, each 6 grams every day, be a course of treatment January.Taboo: period in a medicine, taboo are eaten Semen phaseoli radiati.Eat article higher fatty acid, high protein less.
Embodiment two: present embodiment and embodiment one are basic identical; Something in common does not repeat, and difference is: treatment hypertension, the Chinese medicine composition that improves hyperlipidemia are made up of Semen Cassiae 15g, Radix Polygoni Multiflori 12g, LUMBRICUS 15g, Fructus Crataegi 15g, wild tea 15g, RADIX PUERARIAE 15g, Rhizoma Alismatis 12g, Cortex Mori 12g and tender Ramulus Uncariae Cum Uncis 15g.
Embodiment three: present embodiment and embodiment one are basic identical; Something in common does not repeat, and difference is: treatment hypertension, the Chinese medicine composition that improves hyperlipidemia are made up of Semen Cassiae 20g, Radix Polygoni Multiflori 16g, LUMBRICUS 20g, Fructus Crataegi 120g, wild tea 20g, RADIX PUERARIAE 20g, Rhizoma Alismatis 16g, Cortex Mori 16g and tender Ramulus Uncariae Cum Uncis 20g.
Change the concrete value of each component, can form a plurality of embodiment, do not detail one by one, be protection scope of the present invention at this.
Claims (5)
1. Chinese medicine composition of treating hypertension, improving hyperlipidemia; It is characterized in that: be unit with the weight portion; By Semen Cassiae 10-20 part, Radix Polygoni Multiflori 8-16 part, LUMBRICUS 10-20 part, Fructus Crataegi 10-20 part, wild tea 10-20 part, RADIX PUERARIAE 10-20 part, Rhizoma Alismatis 8-16 part, Cortex Mori 8-16 part, tender Ramulus Uncariae Cum Uncis 10-20 part is formed.
The described treatment hypertension of claim 1, improve the formulation method of the Chinese medicine composition of hyperlipidemia, may further comprise the steps:
A, according to said weight portion get it filled Semen Cassiae, Radix Polygoni Multiflori, LUMBRICUS, Fructus Crataegi and RADIX PUERARIAE, pulverize the back and cross 300 mesh sieves, form medicated powder;
B, get wild tea, Rhizoma Alismatis, Cortex Mori according to said weight portion. tender Ramulus Uncariae Cum Uncis, add water and boil, fry in shallow oil into extract, filter the back and form medicine juice;
C, said medicated powder (a) and medicine juice (b) mixed mix the back oven dry thoroughly, process required pharmaceutical dosage form again.
3. formulation method according to claim 2 is characterized in that: said medicated powder and medicine juice mix mixes back tabletting oven dry thoroughly, forms tablet.
4. formulation method according to claim 2 is characterized in that: said medicated powder and medicine juice mix mixes the back oven dry thoroughly, pulverizes the back and forms granule.
5. formulation method according to claim 4 is characterized in that: add an amount of sucrose in said medicated powder and the medicine juice.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103071063A (en) * | 2013-02-27 | 2013-05-01 | 崔合芳 | Traditional Chinese medicinal composition for treating hyperlipidemia and preparation method thereof |
| CN105031038A (en) * | 2015-09-10 | 2015-11-11 | 任德旺 | Traditional Chinese medicine preparation for treating hypertension |
| CN110693979A (en) * | 2019-09-05 | 2020-01-17 | 罗琢滨 | Traditional Chinese medicine composition for reducing blood fat and blood pressure and preparation method thereof |
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| CN1104040A (en) * | 1993-12-22 | 1995-06-28 | 苏州市轻工业品设计研究所 | Pure natural ABC nutrient and health-care product for reducing blood pressure and blood fat |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071063A (en) * | 2013-02-27 | 2013-05-01 | 崔合芳 | Traditional Chinese medicinal composition for treating hyperlipidemia and preparation method thereof |
| CN105031038A (en) * | 2015-09-10 | 2015-11-11 | 任德旺 | Traditional Chinese medicine preparation for treating hypertension |
| CN110693979A (en) * | 2019-09-05 | 2020-01-17 | 罗琢滨 | Traditional Chinese medicine composition for reducing blood fat and blood pressure and preparation method thereof |
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