CN111588832A - Herbal purification liquid - Google Patents
Herbal purification liquid Download PDFInfo
- Publication number
- CN111588832A CN111588832A CN202010658014.8A CN202010658014A CN111588832A CN 111588832 A CN111588832 A CN 111588832A CN 202010658014 A CN202010658014 A CN 202010658014A CN 111588832 A CN111588832 A CN 111588832A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- blood
- herbal
- root
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000746 purification Methods 0.000 title claims abstract description 22
- 239000007788 liquid Substances 0.000 title claims abstract description 17
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract description 37
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 37
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 34
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 25
- 241000382455 Angelica sinensis Species 0.000 claims abstract description 24
- 241000903946 Clematidis Species 0.000 claims abstract description 24
- 241000132012 Atractylodes Species 0.000 claims abstract description 23
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 23
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 23
- 239000009136 dragon's blood Substances 0.000 claims abstract description 23
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 23
- 235000011477 liquorice Nutrition 0.000 claims abstract description 23
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229940116229 borneol Drugs 0.000 claims abstract description 22
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 22
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 22
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 21
- 241000112528 Ligusticum striatum Species 0.000 claims abstract description 21
- 240000004980 Rheum officinale Species 0.000 claims abstract description 21
- 235000008081 Rheum officinale Nutrition 0.000 claims abstract description 21
- 235000006533 astragalus Nutrition 0.000 claims abstract description 21
- 241000045403 Astragalus propinquus Species 0.000 claims abstract description 19
- 241001289529 Fallopia multiflora Species 0.000 claims abstract description 16
- 241000405911 Rehmannia glutinosa Species 0.000 claims abstract description 14
- 241000243684 Lumbricus Species 0.000 claims abstract description 12
- 240000004824 Trimezia steyermarkii Species 0.000 claims abstract description 7
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 5
- 235000008397 ginger Nutrition 0.000 claims abstract description 5
- 244000273928 Zingiber officinale Species 0.000 claims abstract 2
- 239000002245 particle Substances 0.000 claims description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 238000002156 mixing Methods 0.000 claims description 20
- 241000361919 Metaphire sieboldi Species 0.000 claims description 19
- 239000002994 raw material Substances 0.000 claims description 19
- 238000000605 extraction Methods 0.000 claims description 17
- 239000000706 filtrate Substances 0.000 claims description 16
- 229940102465 ginger root Drugs 0.000 claims description 14
- 239000001841 zingiber officinale Substances 0.000 claims description 14
- 238000001035 drying Methods 0.000 claims description 10
- 241000405414 Rehmannia Species 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 238000011068 loading method Methods 0.000 claims description 8
- 238000002791 soaking Methods 0.000 claims description 8
- 239000009286 sanguis draxonis Substances 0.000 claims description 7
- 241000205407 Polygonum Species 0.000 claims description 4
- 244000046146 Pueraria lobata Species 0.000 claims description 4
- 235000010575 Pueraria lobata Nutrition 0.000 claims description 4
- 239000006286 aqueous extract Substances 0.000 claims description 4
- 241000218158 Clematis Species 0.000 claims description 3
- 241000244365 Ligusticum sinense Species 0.000 claims description 3
- 240000001341 Reynoutria japonica Species 0.000 claims description 3
- 235000018167 Reynoutria japonica Nutrition 0.000 claims description 3
- 241000219061 Rheum Species 0.000 claims description 3
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims description 3
- 241001061264 Astragalus Species 0.000 claims description 2
- 241000510667 Conioselinum Species 0.000 claims description 2
- 235000002226 Ranunculus ficaria Nutrition 0.000 claims description 2
- 241001180876 Saposhnikovia Species 0.000 claims description 2
- 241000913745 Spatholobus Species 0.000 claims description 2
- 238000007605 air drying Methods 0.000 claims description 2
- 238000010981 drying operation Methods 0.000 claims description 2
- 210000004233 talus Anatomy 0.000 claims description 2
- 241000092665 Atractylodes macrocephala Species 0.000 claims 1
- 241001256368 Clematis chinensis Species 0.000 claims 1
- 240000008917 Glycyrrhiza uralensis Species 0.000 claims 1
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 claims 1
- 241000533388 Hansenia weberbaueriana Species 0.000 claims 1
- 241000237636 Pheretima Species 0.000 claims 1
- 241001530126 Scrophularia Species 0.000 claims 1
- 241001121987 Scrophularia ningpoensis Species 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract description 14
- 210000004369 blood Anatomy 0.000 abstract description 14
- 210000004185 liver Anatomy 0.000 abstract description 8
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract description 6
- 239000012530 fluid Substances 0.000 abstract description 6
- 210000003734 kidney Anatomy 0.000 abstract description 5
- 208000007536 Thrombosis Diseases 0.000 abstract description 3
- 230000036772 blood pressure Effects 0.000 abstract description 3
- 235000012000 cholesterol Nutrition 0.000 abstract description 3
- 230000036541 health Effects 0.000 abstract description 3
- 210000004204 blood vessel Anatomy 0.000 abstract description 2
- 230000037323 metabolic rate Effects 0.000 abstract description 2
- 230000000638 stimulation Effects 0.000 abstract description 2
- 210000001519 tissue Anatomy 0.000 abstract description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 12
- 239000000284 extract Substances 0.000 description 12
- 230000000694 effects Effects 0.000 description 10
- 239000009636 Huang Qi Substances 0.000 description 8
- 230000001737 promoting effect Effects 0.000 description 8
- 241000628997 Flos Species 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 239000008187 granular material Substances 0.000 description 6
- 238000010298 pulverizing process Methods 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 206010020772 Hypertension Diseases 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 241000234314 Zingiber Species 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 240000002234 Allium sativum Species 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000035487 diastolic blood pressure Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 201000005577 familial hyperlipidemia Diseases 0.000 description 2
- 235000004611 garlic Nutrition 0.000 description 2
- 208000034783 hypoesthesia Diseases 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 244000291564 Allium cepa Species 0.000 description 1
- 208000031229 Cardiomyopathies Diseases 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 208000002330 Congenital Heart Defects Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 201000006306 Cor pulmonale Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 241000212322 Levisticum officinale Species 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000004186 Pulmonary Heart Disease Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 244000081426 Ranunculus ficaria Species 0.000 description 1
- 206010063837 Reperfusion injury Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 201000007201 aphasia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 208000028831 congenital heart disease Diseases 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 208000012947 ischemia reperfusion injury Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000001645 levisticum officinale Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 208000004124 rheumatic heart disease Diseases 0.000 description 1
- 235000021259 spicy food Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses herbal purification liquid, and relates to the technical field of health care products, wherein the herbal purification liquid is prepared from the following components in parts by mass: 8-12 parts of salvia miltiorrhiza, 8-12 parts of ligusticum wallichii, 7-11 parts of radix puerariae, 4-6 parts of angelica sinensis, 7-9 parts of safflower, 3-5 parts of dragon's blood, 3-5 parts of rheum officinale, 3-5 parts of notopterygium roots, 3-5 parts of bighead atractylodes rhizome, 3-5 parts of radix clematidis, 8-12 parts of liquorice, 3-5 parts of caulis spatholobi, 2-4 parts of ginger roots, 7-9 parts of astragalus membranaceus, 7-9 parts of lumbricus, 2-4 parts of rehmannia glutinosa, 2-4 parts of radix scrophulariae, 3-5 parts of radix sileris, 6-8 parts of borneol and 3-5 parts of polygonum multiflorum, and the purifying liquid can be absorbed through skin to avoid stimulation; after entering a human body, the evolved fluid is exchanged to blood through tissue fluid, so that the evolved fluid can tonify the kidney, reduce liver fire and clear blood vessels, further improve the metabolic rate of blood fat and cholesterol in the blood, reduce blood viscosity and blood pressure and prevent thrombus.
Description
Technical Field
The invention relates to the technical field of health care products, in particular to herbal purification liquid.
Background
With the development and progress of economic level and the improvement of living standard of substances, people have great changes on life rules and dietary structure. Stay up, night, drinking, high cholesterol diet and the like are all the causes of cardiovascular diseases. The cardiovascular diseases include coronary heart disease, hypertension, hyperlipemia, cardiomyopathy, etc. Cardiovascular diseases are fast in onset, and if the cardiovascular diseases are not cured in time, paralysis, aphasia, hemiplegia and other serious consequences can be caused, and the serious people die directly. The investigation shows that the cardiovascular disease is the leading cause of death of urban and rural residents. Wherein cardiovascular diseases cause mortality of more than 30% in rural areas and mortality of more than 40% in cities. At present, more than 2.3 hundred million people in China suffer from cardiovascular diseases, wherein the proportion of patients with hypertension exceeds 87%, the proportion of patients with stroke exceeds 3.5%, the proportion of myocardial infarction exceeds 1%, the proportion of heart failure exceeds 2.2%, the proportion of pulmonary heart disease exceeds 2.2%, the proportion of rheumatic heart disease exceeds 1.2%, the proportion of congenital heart disease exceeds 1%, and even 1 person in every 5 adults suffers from cardiovascular diseases. Cardiovascular diseases are not only the first killer threatening personal health, but also have become a public health problem in China due to high mortality caused by cardiovascular diseases and the increasing number of patients with cardiovascular diseases.
Chinese patent with publication number CN102580024A discloses a composition for treating cardiovascular diseases, which is prepared from the following components in parts by weight: 1-20 parts of garlic, 1-15 parts of ginger, 1-10 parts of scallion, 30-70 parts of pseudo-ginseng, 10-40 parts of fleece-flower root, 10-40 parts of salvia miltiorrhiza, 10-40 parts of kudzuvine root, 4-20 parts of safflower and 4-20 parts of szechuan lovage rhizome, and the composition provided by the invention has obvious effects on treating hyperlipidemia, hyperglycemia and hypertension; however, the garlic and ginger contained in the medicine belong to spicy food and have irritation to intestinal tract, and the composition needs to be absorbed through the intestinal tract and has certain irritation to the intestinal tract.
Disclosure of Invention
The invention aims to provide a herbal purification solution to solve the technical problems.
The herbal purification solution is prepared from the following components in parts by mass: 8-12 parts of salvia miltiorrhiza, 8-12 parts of ligusticum wallichii, 7-11 parts of radix puerariae, 4-6 parts of angelica sinensis, 7-9 parts of safflower, 3-5 parts of dragon blood, 3-5 parts of rheum officinale, 3-5 parts of notopterygium roots, 3-5 parts of bighead atractylodes rhizome, 3-5 parts of radix clematidis, 8-12 parts of liquorice, 3-5 parts of caulis spatholobi, 2-4 parts of ginger roots, 7-9 parts of astragalus membranaceus, 7-9 parts of lumbricus, 2-4 parts of rehmannia glutinosa, 2-4 parts of radix scrophulariae, 3-5 parts of radix sileris, 6-8 parts of borneol and 3-5 parts of polygonum multiflo.
As a preferred scheme, the herbal purification solution is prepared from the following components in parts by mass: 10 parts of salvia miltiorrhiza, 10 parts of ligusticum wallichii, 8 parts of radix puerariae, 5 parts of angelica sinensis, 8 parts of safflower, 4 parts of dragon's blood, 3 parts of rheum officinale, 3 parts of notopterygium root, 3 parts of bighead atractylodes rhizome, 3 parts of radix clematidis, 10 parts of liquorice, 3 parts of caulis spatholobi, 3 parts of ginger root, 8 parts of astragalus mongholicus, 8 parts of earthworm, 3 parts of rehmannia glutinosa, 3 parts of radix scrophulariae, 4 parts of radix sileris, 5 parts of borneol and 4 parts of polygonum multiflo.
As a preferred embodiment, the herbal purification solution is prepared by the following steps:
step one, drying and crushing salvia miltiorrhiza, ligusticum chuanxiong hort, radix puerariae, angelica sinensis, safflower, dragon blood, rheum officinale, notopterygium root, bighead atractylodes rhizome, radix clematidis, liquorice, caulis spatholobi, ginger root, astragalus mongholicus, earthworm, rehmannia glutinosa, radix scrophulariae, radix sileris, borneol and polygonum multiflorum into particles;
step two, loading the salvia miltiorrhiza raw material particles into an extraction column, adding subcritical water, extracting twice, centrifuging at high speed to obtain filtrate, and combining the filtrates obtained twice to obtain the salvia miltiorrhiza aqueous extract;
step three, putting the particles of the hemlock parsley, the kudzuvine root, the Chinese angelica, the safflower, the dragon's blood, the rhubarb, the notopterygium root, the white atractylodes rhizome, the clematis root, the liquorice, the suberect spatholobus stem, the ginger root, the astragalus, the earthworm, the rehmannia root, the figwort root, the divaricate saposhnikovia root, the borneol and the tuber fleeceflower root into 50 percent alcohol by mass percent, soaking for 1 year at normal temperature;
and step four, mixing the salvia miltiorrhiza aqueous extract and the medicinal liquor solution, and concentrating under reduced pressure to 0.8-0.9g/ml to obtain the herbal purification solution. Preferably, the salvia miltiorrhiza is crushed into particles with the particle size of 0.1-0.2mm, and the ligusticum wallichii, the radix puerariae, the angelica sinensis, the safflower, the dragon's blood, the rheum officinale, the notopterygium root, the bighead atractylodes rhizome, the radix clematidis, the liquorice, the caulis spatholobi, the ginger root, the astragalus mongholicus, the earthworm, the rehmannia glutinosa, the radix scrophulariae, the radix sileris, the borneol and the polygonum multiflorum are crushed into particles with the particle size of 0.15-0.25 mm.
As a preferable scheme, in the second step, the column volume of the Salvia miltiorrhiza Bunge raw material particles is 1/3 of the extraction column volume, the subcritical water temperature is 185-.
As a preferable scheme, the drying operation in the first step is specifically as follows: placing the raw materials in a forced air drying oven, and drying at 45-65 deg.C for 8-10 h.
The therapeutic effects of the various components of the invention are as follows:
the salvia miltiorrhiza enters heart channels, liver channels and lung channels and has the function of treating ischemia-reperfusion injury; the ligusticum wallichii enters liver meridian and has the effects of promoting blood circulation, promoting qi circulation, dispelling wind and relieving pain; the angelica sinensis enters heart channel, liver channel and spleen channel and is mainly used for treating skin numbness and traumatic injury; safflower enters heart and liver meridians and is mainly used for treating blood stasis pain, traumatic injury and carbuncle swelling; dragon's blood enters lung channel, spleen channel and kidney channel, and has the functions of promoting blood circulation to disperse blood clots, stopping bleeding, healing sore and promoting granulation; rhubarb enters spleen channel, stomach channel, large intestine channel, liver channel and pericardium channel, and has the effects of clearing heat and purging fire, cooling blood and removing toxicity, and removing blood stasis and dredging channels; the notopterygium root enters bladder and kidney channels and has the functions of relieving exterior syndrome, dispelling cold, dispelling wind and eliminating dampness; the bighead atractylodes rhizome has the functions of invigorating spleen, tonifying qi, eliminating dampness and promoting diuresis; the clematis root enters bladder meridian and is mainly used for treating numbness of limbs and spasm of channels; the liquorice enters heart channel, spleen channel and stomach channel and is mainly used for treating carbuncle, cellulitis, wound and sore throat; caulis Spatholobi has effects of dispelling pathogenic wind, promoting blood circulation, relieving rigidity of muscles and activating collaterals; the ginger root has the effects of expelling pus, relieving pain and promoting blood circulation; lumbricus has effects of promoting diuresis, relieving pain, relieving asthma, lowering blood pressure, relieving fever, and relieving convulsion; rehmannia enters heart channel, liver channel and kidney channel, and has the effects of nourishing blood and enriching blood and cooling blood.
Compared with the prior art, the invention has the following beneficial effects:
through a large number of experiments, the invention provides a herbal purification liquid with scientific raw material ratio, and the purification liquid can be absorbed through skin, so that the stimulation to a digestive system caused by oral administration is avoided; after entering a human body, the evolved fluid is exchanged to blood through tissue fluid, so that the evolved fluid can tonify the kidney, reduce liver fire and clear blood vessels, further improve the metabolic rate of blood fat and cholesterol in the blood, reduce blood viscosity and blood pressure and prevent thrombus.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
Weighing 8g of salvia miltiorrhiza, 8g of ligusticum wallichii, 7g of radix puerariae, 4g of angelica sinensis, 7g of safflower, 3g of dragon blood, 3g of rheum officinale, 3g of notopterygium root, 3g of bighead atractylodes rhizome, 3g of radix clematidis, 8g of liquorice, 3g of caulis spatholobi, 2g of ginger root, 7g of astragalus mongholicus, 7g of earthworm, 2g of rehmannia glutinosa, 2g of radix scrophulariae, 3g of radix sileris, 6g of borneol and 3g of polygonum multiflorum, placing the salvia miltiorrhiza, ligusticum wallichii, radix puerariae, angelica sinensis, safflower carthamus tinctorius, dragon blood, the rheum officinale, notopterygium root, bighead atractylodes rhizome, radix clematidis, liquorice, caulis spatholobi, astragalus mongholicus, earthworm, rehmannia glutinosa, radix scrophulariae, radix sileris, borneol and polygonum multiflorum in a blast dryer, drying for 9 hours at 45 ℃, then crushing the salvia miltiorrhiza into particles with the particle size of 0.1-0., Mixing rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix, and pulverizing into granules with particle diameter of 0.15-0.25 mm;
loading Saviae Miltiorrhizae radix raw material particles into an extraction column, wherein the column volume of the raw material particles is 1/3 of the extraction column volume, adding subcritical water at 190 deg.C, extracting twice, centrifuging at high speed to obtain filtrate, and mixing the filtrates to obtain Saviae Miltiorrhizae radix water extract;
soaking rhizoma Ligustici Chuanxiong, radix Puerariae, radix Angelicae sinensis, Carthami flos, sanguis Draxonis, radix et rhizoma Rhei, Notopterygii rhizoma, Atractylodis rhizoma, radix Clematidis, Glycyrrhrizae radix, caulis Spatholobi, rhizoma Zingiberis recens, radix astragali, Lumbricus, rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix in 50% alcohol at normal temperature for 1 year, and filtering with gauze to obtain medicated liquor solution;
mixing the Saviae Miltiorrhizae radix water extract and the medicated liquor solution, and concentrating under reduced pressure to 0.5g/ml to obtain herbal purified solution.
Example two
Weighing 12g of salvia miltiorrhiza, 12g of ligusticum wallichii, 11g of radix puerariae, 6g of angelica sinensis, 9g of safflower, 5g of dragon blood, 5g of rheum officinale, 5g of notopterygium root, 5g of bighead atractylodes rhizome, 5g of radix clematidis, 12g of liquorice, 5g of caulis spatholobi, 4g of ginger root, 9g of astragalus mongholicus, 9g of earthworm, 4g of rehmannia, 4g of radix scrophulariae, 5g of radix sileris, 8g of borneol and 5g of polygonum multiflorum, placing the salvia miltiorrhiza, ligusticum wallichii, radix puerariae, angelica sinensis, safflower carthamus tinctorius, dragon blood, the rheum officinale, notopterygium root, bighead atractylodes rhizome, radix clematidis, liquorice, caulis spatholobi, astragalus mongholicus, earthworm, rehmannia, radix scrophulariae, radix sileris, borneol and polygonum multiflorum in a blast drier, drying for 9 hours at 55 ℃, then crushing the salvia miltiorrhiza into particles with the particle size of 0.1-0.2mm, and, Mixing rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix, and pulverizing into granules with particle diameter of 0.15-0.25 mm;
loading Saviae Miltiorrhizae radix raw material particles into an extraction column, wherein the column volume of the raw material particles is 1/3 of the extraction column volume, adding subcritical water at 190 deg.C, extracting twice, centrifuging at high speed to obtain filtrate, and mixing the filtrates to obtain Saviae Miltiorrhizae radix water extract;
soaking rhizoma Ligustici Chuanxiong, radix Puerariae, radix Angelicae sinensis, Carthami flos, sanguis Draxonis, radix et rhizoma Rhei, Notopterygii rhizoma, Atractylodis rhizoma, radix Clematidis, Glycyrrhrizae radix, caulis Spatholobi, rhizoma Zingiberis recens, radix astragali, Lumbricus, rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix in 50% alcohol at normal temperature for 1 year, and filtering with gauze to obtain medicated liquor solution;
mixing the Saviae Miltiorrhizae radix water extract and the medicated liquor solution, and concentrating under reduced pressure to 0.85g/ml to obtain herbal purified solution.
EXAMPLE III
Weighing 8g of salvia miltiorrhiza, 12g of ligusticum wallichii, 7g of radix puerariae, 6g of angelica sinensis, 7g of safflower, 5g of dragon blood, 3g of rheum officinale, 5g of notopterygium root, 3g of bighead atractylodes rhizome, 5g of radix clematidis, 8g of liquorice, 5g of caulis spatholobi, 2g of ginger root, 9g of astragalus mongholicus, 7g of earthworm, 4g of rehmannia, 2g of radix scrophulariae, 5g of radix sileris, 6g of borneol and 5g of polygonum multiflorum, placing the salvia miltiorrhiza, ligusticum wallichii, radix puerariae, angelica sinensis, safflower carthamus tinctorius, dragon blood, rheum officinale, notopterygium root, bighead atractylodes rhizome, radix clematidis, liquorice, caulis spatholobi, astragalus mongholicus, earthworm, rehmannia, radix scrophulariae, radix sileris, borneol and polygonum multiflorum in a blast drier, drying for 9 hours at 55 ℃, then crushing the salvia miltiorrhiza into particles with the particle size of 0.1-0.2mm, and placing, Mixing rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix, and pulverizing into granules with particle diameter of 0.15-0.25 mm;
loading Saviae Miltiorrhizae radix raw material particles into an extraction column, wherein the column volume of the raw material particles is 1/3 of the extraction column volume, adding subcritical water at 190 deg.C, extracting twice, centrifuging at high speed to obtain filtrate, and mixing the filtrates to obtain Saviae Miltiorrhizae radix water extract;
soaking rhizoma Ligustici Chuanxiong, radix Puerariae, radix Angelicae sinensis, Carthami flos, sanguis Draxonis, radix et rhizoma Rhei, Notopterygii rhizoma, Atractylodis rhizoma, radix Clematidis, Glycyrrhrizae radix, caulis Spatholobi, rhizoma Zingiberis recens, radix astragali, Lumbricus, rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix in 50% alcohol at normal temperature for 1 year, and filtering with gauze to obtain medicated liquor solution;
mixing the Saviae Miltiorrhizae radix water extract and the medicated liquor solution, and concentrating under reduced pressure to 0.84g/ml to obtain herbal purified solution.
Example four
Weighing 9g of salvia miltiorrhiza, 9g of ligusticum wallichii, 8g of radix puerariae, 5g of angelica sinensis, 8g of safflower, 4g of dragon blood, 4g of rheum officinale, 4g of notopterygium root, 4g of bighead atractylodes rhizome, 4g of radix clematidis, 9g of liquorice, 4g of caulis spatholobi, 3g of ginger root, 8g of astragalus mongholicus, 8g of earthworm, 3g of rehmannia glutinosa, 3g of radix scrophulariae, 4g of radix sileris, 7g of borneol and 4g of polygonum multiflorum, placing the salvia miltiorrhiza, ligusticum wallichii, radix puerariae, angelica sinensis, safflower, dragon blood, the rheum officinale, notopterygium officinale, bighead atractylodes rhizome, liquorice, caulis spatholobi, radix astragali, earthworm, rehmannia glutinosa, radix scrophulariae, radix sileris, borneol and polygonum multiflorum in a blast drier, drying for 8-10 hours at 55 ℃, then crushing the salvia miltiorrhiza into particles with the particle size of 0.1-0.2mm, and placing the ligusticum wallichii, the, Mixing Lumbricus, rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix, and pulverizing into granules with particle diameter of 0.15-0.25 mm;
loading Saviae Miltiorrhizae radix raw material particles into an extraction column, wherein the column volume of the raw material particles is 1/3 of the extraction column volume, adding subcritical water at 190 deg.C, extracting twice, centrifuging at high speed to obtain filtrate, and mixing the filtrates to obtain Saviae Miltiorrhizae radix water extract;
soaking rhizoma Ligustici Chuanxiong, radix Puerariae, radix Angelicae sinensis, Carthami flos, sanguis Draxonis, radix et rhizoma Rhei, Notopterygii rhizoma, Atractylodis rhizoma, radix Clematidis, Glycyrrhrizae radix, caulis Spatholobi, rhizoma Zingiberis recens, radix astragali, Lumbricus, rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix in 50% alcohol at normal temperature for 1 year, and filtering with gauze to obtain medicated liquor solution;
mixing the Saviae Miltiorrhizae radix water extract and the medicated liquor solution, and concentrating under reduced pressure to 0.86g/ml to obtain herbal purified solution.
EXAMPLE five
Weighing 11g of salvia miltiorrhiza, 11g of ligusticum wallichii, 10g of radix puerariae, 5g of angelica sinensis, 8g of safflower, 4g of dragon blood, 4g of rheum officinale, 4g of notopterygium root, 4g of bighead atractylodes rhizome, 4g of radix clematidis, 11g of liquorice, 4g of caulis spatholobi, 3g of ginger root, 8g of astragalus mongholicus, 8g of earthworm, 3g of rehmannia glutinosa, 3g of radix scrophulariae, 4g of radix sileris, 7g of borneol and 4g of polygonum multiflorum, placing the salvia miltiorrhiza, ligusticum wallichii, radix puerariae, angelica sinensis, safflower, dragon blood, the rheum officinale, notopterygium officinale, bighead atractylodes rhizome, liquorice, caulis spatholobi, radix astragali, earthworm, rehmannia glutinosa, radix scrophulariae, radix sileris, borneol and polygonum multiflorum in a blast drier, drying for 8-10 hours at 55 ℃, then crushing the salvia miltiorrhiza into particles with the particle size of 0.1-0.2mm, and placing the ligusticum wallichii, the, Mixing Lumbricus, rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix, and pulverizing into granules with particle diameter of 0.15-0.25 mm;
loading Saviae Miltiorrhizae radix raw material particles into an extraction column, wherein the column volume of the raw material particles is 1/3 of the extraction column volume, adding subcritical water at 190 deg.C, extracting twice, centrifuging at high speed to obtain filtrate, and mixing the filtrates to obtain Saviae Miltiorrhizae radix water extract;
soaking rhizoma Ligustici Chuanxiong, radix Puerariae, radix Angelicae sinensis, Carthami flos, sanguis Draxonis, radix et rhizoma Rhei, Notopterygii rhizoma, Atractylodis rhizoma, radix Clematidis, Glycyrrhrizae radix, caulis Spatholobi, rhizoma Zingiberis recens, radix astragali, Lumbricus, rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix in 50% alcohol at normal temperature for 1 year, and filtering with gauze to obtain medicated liquor solution;
mixing the Saviae Miltiorrhizae radix water extract and the medicated liquor solution, and concentrating under reduced pressure to 0.86g/ml to obtain herbal purified solution.
EXAMPLE six
Weighing 10g of salvia miltiorrhiza, 10g of ligusticum wallichii, 9g of radix puerariae, 5g of angelica sinensis, 8g of safflower, 4g of dragon blood, 4g of rheum officinale, 4g of notopterygium root, 4g of bighead atractylodes rhizome, 4g of radix clematidis, 9g of liquorice, 4g of caulis spatholobi, 3g of ginger root, 8g of astragalus mongholicus, 8g of earthworm, 3g of rehmannia, 3g of radix scrophulariae, 4g of radix sileris, 7g of borneol and 4g of polygonum multiflorum, placing the salvia miltiorrhiza, ligusticum wallichii, radix puerariae, angelica sinensis, safflower carthamus tinctorius, dragon blood, the rheum officinale, notopterygium root, bighead atractylodes rhizome, radix clematidis, liquorice, caulis spatholobi, astragalus mongholicus, earthworm, rehmannia, radix scrophulariae, radix sileris, borneol and polygonum multiflorum in a blast drier, drying for 9 hours at 55 ℃, then crushing the salvia miltiorrhiza into particles with the particle size of 0.1-0.2mm, and, Mixing rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix, and pulverizing into granules with particle diameter of 0.15-0.25 mm;
loading Saviae Miltiorrhizae radix raw material particles into an extraction column, wherein the column volume of the raw material particles is 1/3 of the extraction column volume, adding subcritical water at 190 deg.C, extracting twice, centrifuging at high speed to obtain filtrate, and mixing the filtrates to obtain Saviae Miltiorrhizae radix water extract;
soaking rhizoma Ligustici Chuanxiong, radix Puerariae, radix Angelicae sinensis, Carthami flos, sanguis Draxonis, radix et rhizoma Rhei, Notopterygii rhizoma, Atractylodis rhizoma, radix Clematidis, Glycyrrhrizae radix, caulis Spatholobi, rhizoma Zingiberis recens, radix astragali, Lumbricus, rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix in 50% alcohol at normal temperature for 1 year, and filtering with gauze to obtain medicated liquor solution;
mixing the Saviae Miltiorrhizae radix water extract and the medicated liquor solution, and concentrating under reduced pressure to 0.87g/ml to obtain herbal purified solution.
Selecting patients with hypertension and hyperlipemia, dividing the patients into 10 groups, wherein the number of each group is 100, and the patients are respectively a placebo group, a current commercial product group, an experimental high-dose group (administration example 1 purified liquid), a medium-dose group (administration example 1 purified liquid), a low-dose group (administration example 1 purified liquid), an experimental 1 group (administration example 2 purified liquid), an experimental 2 group (administration example 3 purified liquid), an experimental 3 group (administration example 4 purified liquid), an experimental 4 group (administration example 5 purified liquid) and an experimental 5 group (administration example 6 purified liquid), wherein the dosage of the high-dose group is 20ml each time, 3 times each day, the medium-dose group is 10ml each time, 3 times each day, the low-dose group is 10ml each time, 1 time each day, the experimental 1 group, the experimental 2 group, the experimental 3 group, the experimental 4 group and the experimental 5 group have the same dosage and frequency as the medium-dose group, 10ml for each time, 3 times per day, the hypertension patients show effect of diastolic pressure reduction of 10-20mmHg, and show no effect of diastolic pressure reduction of 10 mmHg; patients with hyperlipidemia have effects of TG reduction more than or equal to 20%, effective in 10-20%, and ineffective in less than 10%. The results are shown in the following table, and it can be seen from the table that the herbal purification solution provided by the invention has obviously improved significant efficiency and efficiency compared with the existing product.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. The herbal purification liquid is characterized by being prepared from the following components in parts by mass: 8-12 parts of salvia miltiorrhiza, 8-12 parts of ligusticum wallichii, 7-11 parts of radix puerariae, 4-6 parts of angelica sinensis, 7-9 parts of safflower, 3-5 parts of dragon blood, 3-5 parts of rheum officinale, 3-5 parts of notopterygium roots, 3-5 parts of bighead atractylodes rhizome, 3-5 parts of radix clematidis, 8-12 parts of liquorice, 3-5 parts of caulis spatholobi, 2-4 parts of ginger roots, 7-9 parts of astragalus membranaceus, 7-9 parts of lumbricus, 2-4 parts of rehmannia glutinosa, 2-4 parts of radix scrophulariae, 3-5 parts of radix sileris, 6-8 parts of borneol and 3-5 parts of polygonum multiflo.
2. The herbal purification solution as claimed in claim 1, wherein the herbal purification solution is prepared from the following components in parts by mass: 10 parts of salvia miltiorrhiza, 10 parts of ligusticum wallichii, 8 parts of radix puerariae, 5 parts of angelica sinensis, 8 parts of safflower, 4 parts of dragon's blood, 3 parts of rheum officinale, 3 parts of notopterygium root, 3 parts of bighead atractylodes rhizome, 3 parts of radix clematidis, 10 parts of liquorice, 3 parts of caulis spatholobi, 3 parts of ginger root, 8 parts of astragalus mongholicus, 8 parts of earthworm, 3 parts of rehmannia glutinosa, 3 parts of radix scrophulariae, 4 parts of radix sileris, 5 parts of borneol and 4 parts of polygonum multiflo.
3. The herbal purification solution as claimed in claim 1, wherein the herbal purification solution is prepared by the following steps:
step one, drying and crushing salvia miltiorrhiza, ligusticum chuanxiong hort, radix puerariae, angelica sinensis, safflower, dragon blood, rheum officinale, notopterygium root, bighead atractylodes rhizome, radix clematidis, liquorice, caulis spatholobi, ginger root, astragalus mongholicus, earthworm, rehmannia glutinosa, radix scrophulariae, radix sileris, borneol and polygonum multiflorum into particles;
step two, loading the salvia miltiorrhiza raw material particles into an extraction column, adding subcritical water, extracting twice, centrifuging at high speed to obtain filtrate, and combining the filtrates obtained twice to obtain the salvia miltiorrhiza aqueous extract;
step three, putting the particles of the hemlock parsley, the kudzuvine root, the Chinese angelica, the safflower, the dragon's blood, the rhubarb, the notopterygium root, the white atractylodes rhizome, the clematis root, the liquorice, the suberect spatholobus stem, the ginger root, the astragalus, the earthworm, the rehmannia root, the figwort root, the divaricate saposhnikovia root, the borneol and the tuber fleeceflower root into 50 percent alcohol by mass percent, soaking for 1 year at normal temperature;
and step four, mixing the salvia miltiorrhiza aqueous extract and the medicinal liquor solution, and concentrating under reduced pressure to 0.8-0.9g/ml to obtain the herbal purification solution.
4. The herbal purification solution as claimed in claim 3, wherein the Salvia miltiorrhiza Bunge is pulverized into particles with a particle size of 0.1-0.2mm, and the Ligusticum chuanxiong Hort, Pueraria lobata Ohwi, Angelica sinensis Kitagawa, Carthamus tinctorius, sanguis Draxonis, Rheum officinale, Notopterygium incisum, Atractylodes macrocephala, Clematis chinensis, Glycyrrhiza uralensis Fisch, caulis Spatholobi, rhizoma Zingiberis recens, Astragalus membranaceus, Pheretima, rehmanniae radix, Scrophularia ningpoensis, Saposhnikovi.
5. The herbal purification solution as claimed in claim 3, wherein in step two, the column volume of the Salvia miltiorrhiza Bunge raw material particles is 1/3 of the extraction column volume, the subcritical water temperature is 185-195 ℃, the pressure is 5.5-6.5MPa, and the extraction time is 60-90 min.
6. The herbal purification solution as claimed in claim 3, wherein the drying operation in the first step is as follows: placing the raw materials in a forced air drying oven, and drying at 45-65 deg.C for 8-10 h.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010658014.8A CN111588832A (en) | 2020-07-09 | 2020-07-09 | Herbal purification liquid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010658014.8A CN111588832A (en) | 2020-07-09 | 2020-07-09 | Herbal purification liquid |
Publications (1)
Publication Number | Publication Date |
---|---|
CN111588832A true CN111588832A (en) | 2020-08-28 |
Family
ID=72188265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010658014.8A Pending CN111588832A (en) | 2020-07-09 | 2020-07-09 | Herbal purification liquid |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111588832A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114558073A (en) * | 2022-03-28 | 2022-05-31 | 陈伟 | Essential oil with dehumidifying function |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1411830A (en) * | 2001-10-17 | 2003-04-23 | 宋大文 | Medicine for curing hypertension and its preparation method |
CN104857277A (en) * | 2015-06-01 | 2015-08-26 | 青岛友诚高新技术有限公司 | Thrombolytic pure Chinese drug preparation and preparation method thereof |
-
2020
- 2020-07-09 CN CN202010658014.8A patent/CN111588832A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1411830A (en) * | 2001-10-17 | 2003-04-23 | 宋大文 | Medicine for curing hypertension and its preparation method |
CN104857277A (en) * | 2015-06-01 | 2015-08-26 | 青岛友诚高新技术有限公司 | Thrombolytic pure Chinese drug preparation and preparation method thereof |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114558073A (en) * | 2022-03-28 | 2022-05-31 | 陈伟 | Essential oil with dehumidifying function |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104998017A (en) | Traditional Chinese medicine for expelling toxin and nourishing liver and kidney and preparation method thereof | |
CN101940733B (en) | Traditional Chinese medicinal composition for curing nephritis diseases and preparation method thereof | |
CN101987138A (en) | Chinese medicinal preparation for treating impotence | |
CN102327452A (en) | Chinese patent medicament and Chinese decoction for treating initial carbuncle | |
CN102048899A (en) | Traditional Chinese medicine preparation for treating impotence | |
CN111588832A (en) | Herbal purification liquid | |
CN1049827C (en) | Anti-cancer powder | |
CN115282229B (en) | Traditional Chinese medicine composition for treating qi deficiency and blood stasis type coronary heart disease and preparation method thereof | |
CN110624033A (en) | Traditional Chinese medicine for reunion of bone and tendon and preparation method thereof | |
CN1506098A (en) | Medicine composition for treating liver fibrillation and liver cirrhosis and its prepn process | |
CN103520421A (en) | Chinese medicinal composition for treating armpit odor | |
CN1190214C (en) | Traditional Chinese granule medicine for preventing and caring prawn viral and bacterial disease | |
CN106110096A (en) | A kind of pharmaceutical composition treating post gynecologic operation low fever | |
CN112870267A (en) | New medicine for treating tumor and preparation method thereof | |
CN110638955A (en) | Chinese medicinal composition for treating arthralgia | |
CN1293908C (en) | Cancer preventing and curing Chinese medicine of two snakes and Ganoderma Lucidum seu Japonicum | |
CN111084842B (en) | External traditional Chinese medicine composition for treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation and osteoarthritis | |
CN116270830B (en) | Anti-radiation traditional Chinese medicine composition and application thereof | |
CN114129684B (en) | Traditional Chinese medicine composition and preparation method and application thereof | |
CN113384633B (en) | Traditional Chinese medicine composition for treating eczema | |
CN111214584B (en) | Traditional Chinese medicine composition for tonifying kidney and benefiting liver as well as preparation method and application thereof | |
CN109464606B (en) | Traditional Chinese medicine composition for treating hypertensive proteinuria | |
CN102038834A (en) | Traditional Chinese medicine preparation for preventing and treating cancers | |
CN114869983A (en) | Traditional Chinese medicine composition and preparation for treating rheumatism as well as preparation method and application of traditional Chinese medicine composition and preparation | |
CN1144115A (en) | Gantai tablet for curing hepatic disease |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200828 |
|
RJ01 | Rejection of invention patent application after publication |