CN111588832A

CN111588832A - Herbal purification liquid

Info

Publication number: CN111588832A
Application number: CN202010658014.8A
Authority: CN
Inventors: 文秋方
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-07-09
Filing date: 2020-07-09
Publication date: 2020-08-28

Abstract

The invention discloses herbal purification liquid, and relates to the technical field of health care products, wherein the herbal purification liquid is prepared from the following components in parts by mass: 8-12 parts of salvia miltiorrhiza, 8-12 parts of ligusticum wallichii, 7-11 parts of radix puerariae, 4-6 parts of angelica sinensis, 7-9 parts of safflower, 3-5 parts of dragon's blood, 3-5 parts of rheum officinale, 3-5 parts of notopterygium roots, 3-5 parts of bighead atractylodes rhizome, 3-5 parts of radix clematidis, 8-12 parts of liquorice, 3-5 parts of caulis spatholobi, 2-4 parts of ginger roots, 7-9 parts of astragalus membranaceus, 7-9 parts of lumbricus, 2-4 parts of rehmannia glutinosa, 2-4 parts of radix scrophulariae, 3-5 parts of radix sileris, 6-8 parts of borneol and 3-5 parts of polygonum multiflorum, and the purifying liquid can be absorbed through skin to avoid stimulation; after entering a human body, the evolved fluid is exchanged to blood through tissue fluid, so that the evolved fluid can tonify the kidney, reduce liver fire and clear blood vessels, further improve the metabolic rate of blood fat and cholesterol in the blood, reduce blood viscosity and blood pressure and prevent thrombus.

Description

Herbal purification liquid

Technical Field

The invention relates to the technical field of health care products, in particular to herbal purification liquid.

Background

With the development and progress of economic level and the improvement of living standard of substances, people have great changes on life rules and dietary structure. Stay up, night, drinking, high cholesterol diet and the like are all the causes of cardiovascular diseases. The cardiovascular diseases include coronary heart disease, hypertension, hyperlipemia, cardiomyopathy, etc. Cardiovascular diseases are fast in onset, and if the cardiovascular diseases are not cured in time, paralysis, aphasia, hemiplegia and other serious consequences can be caused, and the serious people die directly. The investigation shows that the cardiovascular disease is the leading cause of death of urban and rural residents. Wherein cardiovascular diseases cause mortality of more than 30% in rural areas and mortality of more than 40% in cities. At present, more than 2.3 hundred million people in China suffer from cardiovascular diseases, wherein the proportion of patients with hypertension exceeds 87%, the proportion of patients with stroke exceeds 3.5%, the proportion of myocardial infarction exceeds 1%, the proportion of heart failure exceeds 2.2%, the proportion of pulmonary heart disease exceeds 2.2%, the proportion of rheumatic heart disease exceeds 1.2%, the proportion of congenital heart disease exceeds 1%, and even 1 person in every 5 adults suffers from cardiovascular diseases. Cardiovascular diseases are not only the first killer threatening personal health, but also have become a public health problem in China due to high mortality caused by cardiovascular diseases and the increasing number of patients with cardiovascular diseases.

Chinese patent with publication number CN102580024A discloses a composition for treating cardiovascular diseases, which is prepared from the following components in parts by weight: 1-20 parts of garlic, 1-15 parts of ginger, 1-10 parts of scallion, 30-70 parts of pseudo-ginseng, 10-40 parts of fleece-flower root, 10-40 parts of salvia miltiorrhiza, 10-40 parts of kudzuvine root, 4-20 parts of safflower and 4-20 parts of szechuan lovage rhizome, and the composition provided by the invention has obvious effects on treating hyperlipidemia, hyperglycemia and hypertension; however, the garlic and ginger contained in the medicine belong to spicy food and have irritation to intestinal tract, and the composition needs to be absorbed through the intestinal tract and has certain irritation to the intestinal tract.

Disclosure of Invention

The invention aims to provide a herbal purification solution to solve the technical problems.

The herbal purification solution is prepared from the following components in parts by mass: 8-12 parts of salvia miltiorrhiza, 8-12 parts of ligusticum wallichii, 7-11 parts of radix puerariae, 4-6 parts of angelica sinensis, 7-9 parts of safflower, 3-5 parts of dragon blood, 3-5 parts of rheum officinale, 3-5 parts of notopterygium roots, 3-5 parts of bighead atractylodes rhizome, 3-5 parts of radix clematidis, 8-12 parts of liquorice, 3-5 parts of caulis spatholobi, 2-4 parts of ginger roots, 7-9 parts of astragalus membranaceus, 7-9 parts of lumbricus, 2-4 parts of rehmannia glutinosa, 2-4 parts of radix scrophulariae, 3-5 parts of radix sileris, 6-8 parts of borneol and 3-5 parts of polygonum multiflo.

As a preferred scheme, the herbal purification solution is prepared from the following components in parts by mass: 10 parts of salvia miltiorrhiza, 10 parts of ligusticum wallichii, 8 parts of radix puerariae, 5 parts of angelica sinensis, 8 parts of safflower, 4 parts of dragon's blood, 3 parts of rheum officinale, 3 parts of notopterygium root, 3 parts of bighead atractylodes rhizome, 3 parts of radix clematidis, 10 parts of liquorice, 3 parts of caulis spatholobi, 3 parts of ginger root, 8 parts of astragalus mongholicus, 8 parts of earthworm, 3 parts of rehmannia glutinosa, 3 parts of radix scrophulariae, 4 parts of radix sileris, 5 parts of borneol and 4 parts of polygonum multiflo.

As a preferred embodiment, the herbal purification solution is prepared by the following steps:

step one, drying and crushing salvia miltiorrhiza, ligusticum chuanxiong hort, radix puerariae, angelica sinensis, safflower, dragon blood, rheum officinale, notopterygium root, bighead atractylodes rhizome, radix clematidis, liquorice, caulis spatholobi, ginger root, astragalus mongholicus, earthworm, rehmannia glutinosa, radix scrophulariae, radix sileris, borneol and polygonum multiflorum into particles;

step two, loading the salvia miltiorrhiza raw material particles into an extraction column, adding subcritical water, extracting twice, centrifuging at high speed to obtain filtrate, and combining the filtrates obtained twice to obtain the salvia miltiorrhiza aqueous extract;

step three, putting the particles of the hemlock parsley, the kudzuvine root, the Chinese angelica, the safflower, the dragon's blood, the rhubarb, the notopterygium root, the white atractylodes rhizome, the clematis root, the liquorice, the suberect spatholobus stem, the ginger root, the astragalus, the earthworm, the rehmannia root, the figwort root, the divaricate saposhnikovia root, the borneol and the tuber fleeceflower root into 50 percent alcohol by mass percent, soaking for 1 year at normal temperature;

and step four, mixing the salvia miltiorrhiza aqueous extract and the medicinal liquor solution, and concentrating under reduced pressure to 0.8-0.9g/ml to obtain the herbal purification solution. Preferably, the salvia miltiorrhiza is crushed into particles with the particle size of 0.1-0.2mm, and the ligusticum wallichii, the radix puerariae, the angelica sinensis, the safflower, the dragon's blood, the rheum officinale, the notopterygium root, the bighead atractylodes rhizome, the radix clematidis, the liquorice, the caulis spatholobi, the ginger root, the astragalus mongholicus, the earthworm, the rehmannia glutinosa, the radix scrophulariae, the radix sileris, the borneol and the polygonum multiflorum are crushed into particles with the particle size of 0.15-0.25 mm.

As a preferable scheme, in the second step, the column volume of the Salvia miltiorrhiza Bunge raw material particles is 1/3 of the extraction column volume, the subcritical water temperature is 185-.

As a preferable scheme, the drying operation in the first step is specifically as follows: placing the raw materials in a forced air drying oven, and drying at 45-65 deg.C for 8-10 h.

The therapeutic effects of the various components of the invention are as follows:

the salvia miltiorrhiza enters heart channels, liver channels and lung channels and has the function of treating ischemia-reperfusion injury; the ligusticum wallichii enters liver meridian and has the effects of promoting blood circulation, promoting qi circulation, dispelling wind and relieving pain; the angelica sinensis enters heart channel, liver channel and spleen channel and is mainly used for treating skin numbness and traumatic injury; safflower enters heart and liver meridians and is mainly used for treating blood stasis pain, traumatic injury and carbuncle swelling; dragon's blood enters lung channel, spleen channel and kidney channel, and has the functions of promoting blood circulation to disperse blood clots, stopping bleeding, healing sore and promoting granulation; rhubarb enters spleen channel, stomach channel, large intestine channel, liver channel and pericardium channel, and has the effects of clearing heat and purging fire, cooling blood and removing toxicity, and removing blood stasis and dredging channels; the notopterygium root enters bladder and kidney channels and has the functions of relieving exterior syndrome, dispelling cold, dispelling wind and eliminating dampness; the bighead atractylodes rhizome has the functions of invigorating spleen, tonifying qi, eliminating dampness and promoting diuresis; the clematis root enters bladder meridian and is mainly used for treating numbness of limbs and spasm of channels; the liquorice enters heart channel, spleen channel and stomach channel and is mainly used for treating carbuncle, cellulitis, wound and sore throat; caulis Spatholobi has effects of dispelling pathogenic wind, promoting blood circulation, relieving rigidity of muscles and activating collaterals; the ginger root has the effects of expelling pus, relieving pain and promoting blood circulation; lumbricus has effects of promoting diuresis, relieving pain, relieving asthma, lowering blood pressure, relieving fever, and relieving convulsion; rehmannia enters heart channel, liver channel and kidney channel, and has the effects of nourishing blood and enriching blood and cooling blood.

Compared with the prior art, the invention has the following beneficial effects:

through a large number of experiments, the invention provides a herbal purification liquid with scientific raw material ratio, and the purification liquid can be absorbed through skin, so that the stimulation to a digestive system caused by oral administration is avoided; after entering a human body, the evolved fluid is exchanged to blood through tissue fluid, so that the evolved fluid can tonify the kidney, reduce liver fire and clear blood vessels, further improve the metabolic rate of blood fat and cholesterol in the blood, reduce blood viscosity and blood pressure and prevent thrombus.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example one

Weighing 8g of salvia miltiorrhiza, 8g of ligusticum wallichii, 7g of radix puerariae, 4g of angelica sinensis, 7g of safflower, 3g of dragon blood, 3g of rheum officinale, 3g of notopterygium root, 3g of bighead atractylodes rhizome, 3g of radix clematidis, 8g of liquorice, 3g of caulis spatholobi, 2g of ginger root, 7g of astragalus mongholicus, 7g of earthworm, 2g of rehmannia glutinosa, 2g of radix scrophulariae, 3g of radix sileris, 6g of borneol and 3g of polygonum multiflorum, placing the salvia miltiorrhiza, ligusticum wallichii, radix puerariae, angelica sinensis, safflower carthamus tinctorius, dragon blood, the rheum officinale, notopterygium root, bighead atractylodes rhizome, radix clematidis, liquorice, caulis spatholobi, astragalus mongholicus, earthworm, rehmannia glutinosa, radix scrophulariae, radix sileris, borneol and polygonum multiflorum in a blast dryer, drying for 9 hours at 45 ℃, then crushing the salvia miltiorrhiza into particles with the particle size of 0.1-0., Mixing rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix, and pulverizing into granules with particle diameter of 0.15-0.25 mm;

loading Saviae Miltiorrhizae radix raw material particles into an extraction column, wherein the column volume of the raw material particles is 1/3 of the extraction column volume, adding subcritical water at 190 deg.C, extracting twice, centrifuging at high speed to obtain filtrate, and mixing the filtrates to obtain Saviae Miltiorrhizae radix water extract;

soaking rhizoma Ligustici Chuanxiong, radix Puerariae, radix Angelicae sinensis, Carthami flos, sanguis Draxonis, radix et rhizoma Rhei, Notopterygii rhizoma, Atractylodis rhizoma, radix Clematidis, Glycyrrhrizae radix, caulis Spatholobi, rhizoma Zingiberis recens, radix astragali, Lumbricus, rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix in 50% alcohol at normal temperature for 1 year, and filtering with gauze to obtain medicated liquor solution;

mixing the Saviae Miltiorrhizae radix water extract and the medicated liquor solution, and concentrating under reduced pressure to 0.5g/ml to obtain herbal purified solution.

Example two

Weighing 12g of salvia miltiorrhiza, 12g of ligusticum wallichii, 11g of radix puerariae, 6g of angelica sinensis, 9g of safflower, 5g of dragon blood, 5g of rheum officinale, 5g of notopterygium root, 5g of bighead atractylodes rhizome, 5g of radix clematidis, 12g of liquorice, 5g of caulis spatholobi, 4g of ginger root, 9g of astragalus mongholicus, 9g of earthworm, 4g of rehmannia, 4g of radix scrophulariae, 5g of radix sileris, 8g of borneol and 5g of polygonum multiflorum, placing the salvia miltiorrhiza, ligusticum wallichii, radix puerariae, angelica sinensis, safflower carthamus tinctorius, dragon blood, the rheum officinale, notopterygium root, bighead atractylodes rhizome, radix clematidis, liquorice, caulis spatholobi, astragalus mongholicus, earthworm, rehmannia, radix scrophulariae, radix sileris, borneol and polygonum multiflorum in a blast drier, drying for 9 hours at 55 ℃, then crushing the salvia miltiorrhiza into particles with the particle size of 0.1-0.2mm, and, Mixing rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix, and pulverizing into granules with particle diameter of 0.15-0.25 mm;

mixing the Saviae Miltiorrhizae radix water extract and the medicated liquor solution, and concentrating under reduced pressure to 0.85g/ml to obtain herbal purified solution.

EXAMPLE III

Weighing 8g of salvia miltiorrhiza, 12g of ligusticum wallichii, 7g of radix puerariae, 6g of angelica sinensis, 7g of safflower, 5g of dragon blood, 3g of rheum officinale, 5g of notopterygium root, 3g of bighead atractylodes rhizome, 5g of radix clematidis, 8g of liquorice, 5g of caulis spatholobi, 2g of ginger root, 9g of astragalus mongholicus, 7g of earthworm, 4g of rehmannia, 2g of radix scrophulariae, 5g of radix sileris, 6g of borneol and 5g of polygonum multiflorum, placing the salvia miltiorrhiza, ligusticum wallichii, radix puerariae, angelica sinensis, safflower carthamus tinctorius, dragon blood, rheum officinale, notopterygium root, bighead atractylodes rhizome, radix clematidis, liquorice, caulis spatholobi, astragalus mongholicus, earthworm, rehmannia, radix scrophulariae, radix sileris, borneol and polygonum multiflorum in a blast drier, drying for 9 hours at 55 ℃, then crushing the salvia miltiorrhiza into particles with the particle size of 0.1-0.2mm, and placing, Mixing rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix, and pulverizing into granules with particle diameter of 0.15-0.25 mm;

mixing the Saviae Miltiorrhizae radix water extract and the medicated liquor solution, and concentrating under reduced pressure to 0.84g/ml to obtain herbal purified solution.

Example four

Weighing 9g of salvia miltiorrhiza, 9g of ligusticum wallichii, 8g of radix puerariae, 5g of angelica sinensis, 8g of safflower, 4g of dragon blood, 4g of rheum officinale, 4g of notopterygium root, 4g of bighead atractylodes rhizome, 4g of radix clematidis, 9g of liquorice, 4g of caulis spatholobi, 3g of ginger root, 8g of astragalus mongholicus, 8g of earthworm, 3g of rehmannia glutinosa, 3g of radix scrophulariae, 4g of radix sileris, 7g of borneol and 4g of polygonum multiflorum, placing the salvia miltiorrhiza, ligusticum wallichii, radix puerariae, angelica sinensis, safflower, dragon blood, the rheum officinale, notopterygium officinale, bighead atractylodes rhizome, liquorice, caulis spatholobi, radix astragali, earthworm, rehmannia glutinosa, radix scrophulariae, radix sileris, borneol and polygonum multiflorum in a blast drier, drying for 8-10 hours at 55 ℃, then crushing the salvia miltiorrhiza into particles with the particle size of 0.1-0.2mm, and placing the ligusticum wallichii, the, Mixing Lumbricus, rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix, and pulverizing into granules with particle diameter of 0.15-0.25 mm;

mixing the Saviae Miltiorrhizae radix water extract and the medicated liquor solution, and concentrating under reduced pressure to 0.86g/ml to obtain herbal purified solution.

EXAMPLE five

Weighing 11g of salvia miltiorrhiza, 11g of ligusticum wallichii, 10g of radix puerariae, 5g of angelica sinensis, 8g of safflower, 4g of dragon blood, 4g of rheum officinale, 4g of notopterygium root, 4g of bighead atractylodes rhizome, 4g of radix clematidis, 11g of liquorice, 4g of caulis spatholobi, 3g of ginger root, 8g of astragalus mongholicus, 8g of earthworm, 3g of rehmannia glutinosa, 3g of radix scrophulariae, 4g of radix sileris, 7g of borneol and 4g of polygonum multiflorum, placing the salvia miltiorrhiza, ligusticum wallichii, radix puerariae, angelica sinensis, safflower, dragon blood, the rheum officinale, notopterygium officinale, bighead atractylodes rhizome, liquorice, caulis spatholobi, radix astragali, earthworm, rehmannia glutinosa, radix scrophulariae, radix sileris, borneol and polygonum multiflorum in a blast drier, drying for 8-10 hours at 55 ℃, then crushing the salvia miltiorrhiza into particles with the particle size of 0.1-0.2mm, and placing the ligusticum wallichii, the, Mixing Lumbricus, rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix, and pulverizing into granules with particle diameter of 0.15-0.25 mm;

EXAMPLE six

Weighing 10g of salvia miltiorrhiza, 10g of ligusticum wallichii, 9g of radix puerariae, 5g of angelica sinensis, 8g of safflower, 4g of dragon blood, 4g of rheum officinale, 4g of notopterygium root, 4g of bighead atractylodes rhizome, 4g of radix clematidis, 9g of liquorice, 4g of caulis spatholobi, 3g of ginger root, 8g of astragalus mongholicus, 8g of earthworm, 3g of rehmannia, 3g of radix scrophulariae, 4g of radix sileris, 7g of borneol and 4g of polygonum multiflorum, placing the salvia miltiorrhiza, ligusticum wallichii, radix puerariae, angelica sinensis, safflower carthamus tinctorius, dragon blood, the rheum officinale, notopterygium root, bighead atractylodes rhizome, radix clematidis, liquorice, caulis spatholobi, astragalus mongholicus, earthworm, rehmannia, radix scrophulariae, radix sileris, borneol and polygonum multiflorum in a blast drier, drying for 9 hours at 55 ℃, then crushing the salvia miltiorrhiza into particles with the particle size of 0.1-0.2mm, and, Mixing rehmanniae radix, radix scrophulariae, radix Saposhnikoviae, Borneolum Syntheticum and Polygoni Multiflori radix, and pulverizing into granules with particle diameter of 0.15-0.25 mm;

mixing the Saviae Miltiorrhizae radix water extract and the medicated liquor solution, and concentrating under reduced pressure to 0.87g/ml to obtain herbal purified solution.

Selecting patients with hypertension and hyperlipemia, dividing the patients into 10 groups, wherein the number of each group is 100, and the patients are respectively a placebo group, a current commercial product group, an experimental high-dose group (administration example 1 purified liquid), a medium-dose group (administration example 1 purified liquid), a low-dose group (administration example 1 purified liquid), an experimental 1 group (administration example 2 purified liquid), an experimental 2 group (administration example 3 purified liquid), an experimental 3 group (administration example 4 purified liquid), an experimental 4 group (administration example 5 purified liquid) and an experimental 5 group (administration example 6 purified liquid), wherein the dosage of the high-dose group is 20ml each time, 3 times each day, the medium-dose group is 10ml each time, 3 times each day, the low-dose group is 10ml each time, 1 time each day, the experimental 1 group, the experimental 2 group, the experimental 3 group, the experimental 4 group and the experimental 5 group have the same dosage and frequency as the medium-dose group, 10ml for each time, 3 times per day, the hypertension patients show effect of diastolic pressure reduction of 10-20mmHg, and show no effect of diastolic pressure reduction of 10 mmHg; patients with hyperlipidemia have effects of TG reduction more than or equal to 20%, effective in 10-20%, and ineffective in less than 10%. The results are shown in the following table, and it can be seen from the table that the herbal purification solution provided by the invention has obviously improved significant efficiency and efficiency compared with the existing product.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The herbal purification liquid is characterized by being prepared from the following components in parts by mass: 8-12 parts of salvia miltiorrhiza, 8-12 parts of ligusticum wallichii, 7-11 parts of radix puerariae, 4-6 parts of angelica sinensis, 7-9 parts of safflower, 3-5 parts of dragon blood, 3-5 parts of rheum officinale, 3-5 parts of notopterygium roots, 3-5 parts of bighead atractylodes rhizome, 3-5 parts of radix clematidis, 8-12 parts of liquorice, 3-5 parts of caulis spatholobi, 2-4 parts of ginger roots, 7-9 parts of astragalus membranaceus, 7-9 parts of lumbricus, 2-4 parts of rehmannia glutinosa, 2-4 parts of radix scrophulariae, 3-5 parts of radix sileris, 6-8 parts of borneol and 3-5 parts of polygonum multiflo.

2. The herbal purification solution as claimed in claim 1, wherein the herbal purification solution is prepared from the following components in parts by mass: 10 parts of salvia miltiorrhiza, 10 parts of ligusticum wallichii, 8 parts of radix puerariae, 5 parts of angelica sinensis, 8 parts of safflower, 4 parts of dragon's blood, 3 parts of rheum officinale, 3 parts of notopterygium root, 3 parts of bighead atractylodes rhizome, 3 parts of radix clematidis, 10 parts of liquorice, 3 parts of caulis spatholobi, 3 parts of ginger root, 8 parts of astragalus mongholicus, 8 parts of earthworm, 3 parts of rehmannia glutinosa, 3 parts of radix scrophulariae, 4 parts of radix sileris, 5 parts of borneol and 4 parts of polygonum multiflo.

3. The herbal purification solution as claimed in claim 1, wherein the herbal purification solution is prepared by the following steps:

and step four, mixing the salvia miltiorrhiza aqueous extract and the medicinal liquor solution, and concentrating under reduced pressure to 0.8-0.9g/ml to obtain the herbal purification solution.

4. The herbal purification solution as claimed in claim 3, wherein the Salvia miltiorrhiza Bunge is pulverized into particles with a particle size of 0.1-0.2mm, and the Ligusticum chuanxiong Hort, Pueraria lobata Ohwi, Angelica sinensis Kitagawa, Carthamus tinctorius, sanguis Draxonis, Rheum officinale, Notopterygium incisum, Atractylodes macrocephala, Clematis chinensis, Glycyrrhiza uralensis Fisch, caulis Spatholobi, rhizoma Zingiberis recens, Astragalus membranaceus, Pheretima, rehmanniae radix, Scrophularia ningpoensis, Saposhnikovi.

5. The herbal purification solution as claimed in claim 3, wherein in step two, the column volume of the Salvia miltiorrhiza Bunge raw material particles is 1/3 of the extraction column volume, the subcritical water temperature is 185-195 ℃, the pressure is 5.5-6.5MPa, and the extraction time is 60-90 min.

6. The herbal purification solution as claimed in claim 3, wherein the drying operation in the first step is as follows: placing the raw materials in a forced air drying oven, and drying at 45-65 deg.C for 8-10 h.