CN1814091A - External-use Chinese medicine preparation for treating angeitis and diabetes foot - Google Patents

Abstract

The invention discloses an external Chinese medicinal preparation for curing vasculitis and diabetic feet, and its active composition comprise the following traditional Chinese drugs in weight shares: rhubarb 3-8; Honeysuckle Flower 2-6; Toad Venom, yew, Huangling, Chinese Corktree Bark, Incised Notopterygium Rhizom, 1-3 each;and Pubescent Angelica Root, Pinellia Tuber, Rhizoma Arisaematis, Radix Notoginseng and Eucommia Bark, 1-5 each. It uses pure Chinese medicinal preparation to discriminatingly cure vasculitis and diabetic feet, and has characters of saving limbs from damage, high cure rate and fast showing effect.

Description

A kind of Chinese medicine for outer use for the treatment of vasculitis and diabetic foot

[technical field]

The present invention relates to a kind of Chinese medicine preparation for the treatment of vasculitis and diabetic foot.

[background technology]

Vasculitis is the difficult pertinacious disease that current medical circle is generally acknowledged, traditional therapy is taking medicine year after year, the way that the patient with severe symptoms then will have an injection, infuses and be in hospital and perform the operation, the course of treatment is long, cure rate is lower, recurrence easily, financial burden heavily wait to patient and family members and have brought misery and lost treatment confidence, so the people is turned pale at the mention of the tiger.

Along with onset diabetes rises year by year, diabetes foot pathological changes also day by day increases.Diabetic foot is one of more serious diabetic complication.The numeral that provides according to Beijing Hospital of Traditional Chinese Medicine, 15% diabetics can concurrent diabetic foots, wherein therefore amputation of 10%～14.5% patient, after the amputation in 30 days mortality rate be 10%.Statistics by 2002, in developing country, the sickness rate of Chinese diabetic foot is only second to India, ranks second.

Because the diabetictrunk angiopathy predilection site is a blood vessel below knee, promptly tibial artery and peroneal artery and branch thereof involve the bilateral lower limb usually, show as the lower limb blood supply insufficiency, skin malnutrition is the wax shape, and is dried and lossless, poor flexibility, alopecia, brothers are afraid of cold, send out cool, the lower limb muscles atrophy, become thin, the toenail thickening becomes fragile, and the vola takes place and callus or clavus, and it is unable to walk, most typical symptom is intermittent claudication, night's rest pain, and dorsal artery of foot is beaten and weakened or disappear.Often break or microtrauma, cause the foot wound surface to enlarge, fester, infect because of spontaneous vesicle, even the blackening necrosis.

Diabetic foot is the same with vasculitis to belong to difficult pertinacious disease, and also especially effective Therapeutic Method has not brought great misery to the patient at present.

[summary of the invention]

The problem that the present invention need solve just is to provide a kind of Chinese medicine for outer use for the treatment of vasculitis and diabetic foot, and it utilizes pure Chinese medicinal preparation, and treatment vasculitis and diabetic foot are characterized in saving from damage limbs, cure rate height, instant effect with identifying and correcting.

For addressing the above problem, the present invention adopts following technical scheme:

The present invention treats the Chinese medicine for outer use of vasculitis and diabetic foot, the Chinese medicine preparation that the active component of described Chinese medicine preparation is equipped with by following weight portion:

Radix Et Rhizoma Rhei: 3-8 part; Flos Lonicerae: 2-6 part; Venenum Bufonis, Ramulus et folium taxi cuspidatae, Radix Scutellariae, Cortex Phellodendri, each 1-3 part of Rhizoma Et Radix Notopterygii; Radix Angelicae Pubescentis, the Rhizoma Pinelliae, Rhizoma Arisaematis, Radix Notoginseng, each 1-5 part of the Cortex Eucommiae.

Preferably, the active component of Chinese medicine preparation of the present invention is prepared by the Chinese medicine that following weight portion is equipped with:

Radix Et Rhizoma Rhei: 5 parts; Flos Lonicerae: 4 parts; Respectively 2 parts of Venenum Bufonis, Ramulus et folium taxi cuspidatae, Radix Scutellariae, Cortex Phellodendri, Rhizoma Et Radix Notopterygiis; Respectively 3 parts of Radix Angelicae Pubescentis, the Rhizoma Pinelliae, Rhizoma Arisaematis, Radix Notoginseng, the Cortexs Eucommiae.

Further preferably, preparation of the present invention is an externally used paste.

Among the present invention, Radix Et Rhizoma Rhei claims Radix Et Rhizoma Rhei again.Radix Et Rhizoma Rhei is one of traditional Chinese medical science general medicine, is clinical the most frequently used medicine from ancient times to the present always, and its nature and flavor bitter cold is gone into taste, large intestine, liver, pericardium channel.Shennong's Herbal record: " main blood stasis, blood down close cold and heat, and broken lump in the abdomen, prolonged fluid-retention dyspepsia are cleansed the intestines and stomach, push away Chen Zhixin, tonneau water paddy, relieving dyspepsia in the accent, peace and the five internal organs ".In Compendium of Material Medica, point out: " main dysentery is red white, pain in the abdomen stomachache, dribbling urination, excess-heat dryness accumulated in the stomach and intestine, hectic fever delirium, all burn of jaundice ".

Among the present invention, Flos Lonicerae claims Flos Lonicerae again, belongs to the most frequently used medical material of tcm clinical practice, is the choice drug of heat-clearing and toxic substances removing, being used for the treatment of the swollen skin ulcer, affection due to external wind and heat, pestilence treated of pain from the beginning of, toxic-heat and blood stasis, determined curative effect.Before more than 2,000 years, Shennong's Herbal is just classified it as top grade, and the record of " clothes are made light of one's life by commiting suicide for a long time " is arranged; " Mingyi Bielu " records and narrates the effect that it has treatment " the summer-heat body is swollen "; The Li Shizhen (1518-1593 A.D.) Compendium of Material Medica says that it can control " all dampnesss, all toxic swellings, carbuncle scabies, heat radiation detoxifcation ",

Bufo siccus is the very high economic animal of a kind of medical value.Its whole body is precious, and the dry product of the ear rear gland of Bufo siccus, the white serosity of skin gland secretion is the Chinese crude drug of preciousness Venenum Bufonis, includes multiple biotic component, and effects such as detoxifcation, detumescence, pain relieving, heart tonifying diuresis, anticancer, anesthesia, radioprotective are arranged.

Ramulus et folium taxi cuspidatae, Ramulus et folium taxi cuspidatae has another name called Ramulus et folium taxi cuspidatae.Belong to the evergreen needle arbor of Semen Phaseoli section, the big peculiar HONGDOUGUO of knot red cherry.Ramulus et folium taxi cuspidatae is less in whole world NATURAL DISTRIBUTION, is classified as country-level focused protection plant by countries in the world.Ramulus et folium taxi cuspidatae has only 7 kinds in the whole world, China has accounted for 5 kinds.The medical value of Ramulus et folium taxi cuspidatae is mainly in its extract---secondary metabolism derivant: paclitaxel.It has the effect that diuresis is swollen clearly, the kidney warming stimulates the menstrual flow, and cures mainly the diabetes dysuria, menoxenia, symptoms such as postnatal blood stasis.

Radix Scutellariae has anti-allergic effects and stronger broad-spectrum antibiotic property.

Cortex Phellodendri heat clearing and damp drying, pathogenic fire purging are removed and are steamed, and skin ulcer is treated in detoxifcation.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Nourishing YIN to lower pathogenic fire.Be used for hyperactivity of fire caused by deficiency of YIN, the night sweat hectic fever due to YIN-deficiency.

Rhizoma Et Radix Notopterygii is one of conventional Chinese medicine material.General Chinese medicine preparation is all used it, cures mainly anemofrigid cold, pathogenic factor in the exterior cold and heat, and, extremities aching pain painful to headache, body, wind and cold arthromyodynia all have produce effects.

Radix Angelicae Pubescentis wind-expelling pain-stopping: cure mainly anemofrigid-damp arthralgia, lumbocrural pain; The volt wind headache is not touchingly healed.The damp eliminating of inducing sweat: be applicable to the wind and cold diseases caused by exogenous pathogenic factor, the damp of holding concurrently is than Sheng person, and disease is seen fever with aversion to cold, the headache heavy sensation of the body, and tongue fur is white thick etc.

The Rhizoma Pinelliae Rhizoma Pinelliae is conventional Chinese medicine, and is warm in nature, and acrid in the mouth is poisonous.Function with drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Be used for diseases such as abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache, vomiting regurgitation, breast gastral cavity painful abdominal mass are vexed, globus hystericus; Give birth to external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI more.Rhizoma Pinelliae Preparatum is used for drying dampness to eliminate phlegm more.

The Rhizoma Arisaematis expectorant that dispels the wind, spasmolytic epilepsy: be used among the anemophlegmatic accumulation that dizziness due to wind pathogen is dizzy, facial hemiparalysis, hemiplegia, tic infantile convulsion, often join the Rhizoma Pinelliae, Rhizoma Gastrodiae.

Radix Notoginseng not only haemostatic effect is remarkable, but also has the effect that promotes wound repair.

Cortex Eucommiae sweet in the mouth, warm in nature has invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect, for lumbago due to renal deficiency, the unable tool of muscles and bones curative effect preferably.

Drug matching is particular about: 1. mutual reinforcement between: i.e. the similar medicine fit applications of performance effect can strengthen that it is former effective in cure.2. the mutual-assistance: promptly in the medicine fit applications that certain general character is arranged aspect the performance effect, and based on a kind of medicine, another kind of medicine is auxilliary, can improve the curative effect of principal agent thing.3. mutual restraint between two drugs: i.e. a kind of toxic reaction of medicine or side effect can be alleviated by another kind of medicine or eliminate.Toxicity as Rhizoma Pinelliae and Arisaema Cum Bile can be alleviated by Rhizoma Zingiberis Recens and eliminate, thus Rhizoma Pinelliae and Arisaema Cum Bile fear Rhizoma Zingiberis Recens.4. the mutual-detoxication: promptly a kind of medicine can alleviate or eliminate the toxicity or the side effect of another kind of medicine.Can alleviate or eliminate the toxicity or the side effect of Rhizoma Pinelliae and Arisaema Cum Bile as Rhizoma Zingiberis Recens, thus the Rhizoma Zingiberis Recens poison of the Rhizoma Pinelliae and Arisaema Cum Bile of killing livestock.Hence one can see that, and mutual restraint between two drugs, the mutual-detoxication are actually two kinds of lifting manipulations of same compatibility relationship, are to treat mutually between medicine.5. the mutual inhibition: i.e. two kinds of drug combinations, a kind of medicine acts on mutually with another medicine and causes former powerful reduction, even the forfeiture drug effect.6. opposite: i.e. two kinds of drug combinations, can toxigenicity reaction or side effect.

The present invention selects medicine to follow mentioned above principle, selects the drug regimen of mutual reinforcement between, the mutual-assistance, and the compatibility science reaches the purpose of dredging cold expelling, blood circulation and channel invigorating, promoting flow of qi by warming channel, silt releasing and analgesia, heat clearing and inflammation relieving.

People's body itself has the immune system of getting rid of foreign body, defendance oneself, it promptly is the inherent resistance against diseases of body, the traditional Chinese medical science is referred to as " healthy energy " as long as healthy energy is vigorous in the body, and vertical have many paathogenic factors (pathogen), healthy energy also can resist (displacing or eliminate it) body just can to avoid sick.

The traditional Chinese medical science is emphasized " healthy energy " mastery reaction on pathogenesis very much." interior warp " said: " healthy energy deposit in, heresy can not be done ", " institute of heresy gathers, and its gas must be empty ".Think disease generation, develop and lapse to, depend on the growth and decline of good and evil struggle, thereby proposed the base therapy rule of " strengthening vital QI to eliminate pathogenic factors ".

The traditional Chinese medical science is divided into vasculitis and diabetes pedopathy in the noxious dampness and accumulates deficiency of both vital energy and Yin; Hyperactivity of toxic heat, the rotten injury of tendon and muscle of meat; Blood stasis due to qi deficiency, spleen kidney deficiency three types.The present invention controls respectively with Replenishing QI and nourishing YIN, the cleaning noxious dampness; Heat-clearing and toxic substances removing, invigorating blood circulation is rotten; The method that tonifying speen and tonifying kidney, granulation promoting are invigorated blood circulation is cured.

The present invention utilizes pure Chinese medicinal preparation, and treatment vasculitis and diabetic foot are characterized in saving from damage limbs, cure rate height, instant effect with identifying and correcting.Treat 1 phase, 2 phase thromboangiitis obliterans or diabetic foot effective percentage 100%, 96.2%, 3 phase of cure rate effective percentage 95%, cure rate 92.6%.Generally can cure with 4 months treatment of preparation of the present invention.

[specific embodiment]

Embodiment 1

Radix Et Rhizoma Rhei: 3 parts; Flos Lonicerae: 6 parts; Respectively 1 part of Venenum Bufonis, Ramulus et folium taxi cuspidatae, Radix Scutellariae, Cortex Phellodendri, Rhizoma Et Radix Notopterygii; Respectively 5 parts of Radix Angelicae Pubescentis, the Rhizoma Pinelliae, Rhizoma Arisaematis, Radix Notoginseng, the Cortexs Eucommiae, the externally applied ointment formulation preparation method is prepared into the plaster preparation routinely.

Embodiment 2

Radix Et Rhizoma Rhei: 5 parts; Flos Lonicerae: 4 parts; Respectively 2 parts of Venenum Bufonis, Ramulus et folium taxi cuspidatae, Radix Scutellariae, Cortex Phellodendri, Rhizoma Et Radix Notopterygiis; Respectively 3 parts of Radix Angelicae Pubescentis, the Rhizoma Pinelliae, Rhizoma Arisaematis, Radix Notoginseng, the Cortexs Eucommiae.The externally applied ointment formulation preparation method is prepared into the plaster preparation routinely.

Embodiment 3

Radix Et Rhizoma Rhei: 8 parts; Flos Lonicerae: 2 parts; Respectively 3 parts of Venenum Bufonis, Ramulus et folium taxi cuspidatae, Radix Scutellariae, Cortex Phellodendri, Rhizoma Et Radix Notopterygiis; Respectively 1 part of Radix Angelicae Pubescentis, the Rhizoma Pinelliae, Rhizoma Arisaematis, Radix Notoginseng, the Cortex Eucommiae.The externally applied ointment formulation preparation method is prepared into the plaster preparation routinely.

Case history 1

63 years old Tongzhou District, Beijing patient poplar uncle suffers from diabetes for many years now, because it is hale and hearty to take the advantage of own body always, for a long time, never accepts regular treatment.But once protecting in village's patrol of dusk one day, sole is unfortunate is stabbed by iron nail, and the poplar uncle who does not still draw attention the only clinic has nearby carried out simple wrapping.Serious infection and ulceration have just appearred in the foot of being pricked, and develop into the toe necrosis gradually but after a while.Owing to incured loss through delay best treatment time, after uncle Yang was sent to hospital, lobed foot amputation art was taked in hospital's suggestion, and poplar uncle household disagrees with operation plan, introduce the use this patent through friend, stick subsides in 3 days, every subsides 30g active component at affected area according to disease, after using 4 to paste, find that toes head slough has dense sexual secretion, night, the patient had pain, and the location of necrosis redness disappears substantially, after re-using 5 subsides, local toes head location of necrosis also has dense sexual secretion to ooze out, and pain relief also has fresh granulation to grow around the location of necrosis, after continuing the drug of topical application 5 subsides, location of necrosis has new tissue to grow, and dense sexual secretion reduces, and foot step tremulous pulse has little pulsatory feeling.Continue to paste medicine 5 and paste, the tissue necrosis position dwindles gradually, has new granulation to grow, and dorsal artery of foot enhancings of beating continues medication 3 and paste, and sb.'s illness took a favorable turn, and location of necrosis is dwindled, and does not have dense sexual secretion, and the continuation medication is until healing.Kept poplar uncle's foot.

Case history 2

Certain man, 34 years old, because of right side foot pain, with big toe for very, and the surplus prescription on individual diagnosis in 1 year of festering.

Hypomere once had trauma history in the shank of 10 years preceding right sides of patient.No obvious inducement is gradually felt right toes sole of the foot joint pain before 1 year, increases the weight of when walking, and has a rest and can alleviate.Pain increases the weight of gradually, is persistence, and prolongs and full foot, and ice-cold, and big toe festers gradually.Be " thromboangiitis obliterans " successively at several families hospital diagnosis.Multi-treatment is invalid, and the state of an illness constantly increases the weight of to come me to go to a doctor.The right sufficient persistence of readme has an intense pain, and, meets cold rnning and weighs for very with toes, and hypnalgia very has difficulty in going to sleep.

Look into: right foot is purple dark, swelling, and skin is thin, and toenail is thick and crisp.Big toe is livid purple, and the toe point slightly festers.Right foot is touched a tender spot obviously, and that touches is ice-cold, the disappearance of beating of dorsal artery of foot, posterior tibial artery.

Blue-purplish tongue, thready and hesitant pulse.

Tcm diagnosis: necrosis, cold blood stasis card.

Control suitable warming YANG to expel cold, blood circulation promoting and blood stasis dispelling.

Use Chinese medicine preparation of the present invention, pasted affected area in per 3 days one, after 1 month, suffer from sufficient pain and subtract slightly, purple dark swelling is disappeared substantially, and the reduction of area that festers is little.Continued medication 2 months, and suffered from foot and change temperature, pain disappears during rest, feels still during walking that pain, color and luster recovers normal, the face that festers healing.The about 4cm of the rope in about 3cm place is long, red slightly on the internal malleolus, touches a tender spot.The recovery from illness in January of reuse medicine.Follow up a case by regular visits to 1 year normally.

Case history 3

Certain man, 39 years old.Patient's extremity once endured cold history and smoking history for many years.Engendered left lower extremity pain before 5 years, several families hospital diagnosis is " thromboangiitis obliterans " in Lanzhou.Take a favorable turn during multi-treatment, but do not heal always, pain constantly increases the weight of over nearly 1 year, and ulcer appears in the 1st, 2 toe toes seams, does not meet for a long time.The readme left lower extremity is sent out cold, rest pain, meet and increase the weight of when cold or movable, with foot for very, sharp ache, more very have difficulty in going to sleep night.

Look into: left leg is slightly livid purple, amyotrophy, and left side foot is purple dark, and the toenail attenuation is coarse and crisp, the about 1.3 * 1.3cm of the 1st, 2 toe toes seam ulcer.Suffer from foot and touch a tender spot obviously, that touches is ice-cold, the disappearance of beating of dorsal artery of foot, posterior tibial artery.

The light red tongue purple has ecchymosis, thin fur, and hesitant pulse is unable.

Tcm diagnosis: necrosis, syndrome of blood stasis due to qi deficiency.

Control suitable tonifying QI to promote blood circulation, disperse blood stasis and dredge collateral.

Use preparation of the present invention, pasted affected area in per 3 days one, advise wine for giving off smoking, it is wet to go to a winter resort, anti-wound.Logotype future trouble in January foot pain subtracts slightly, ulcer such as preceding, and spirit is slightly better, continues logotype February again, and left lower extremity changes temperature, and shank pain disappears, and it is normal that color and luster recovers, muscle recovery.The sufficient pain in a left side disappears substantially, and can sleep peacefully night, meets and still feels that pain, color and luster recovers normally substantially when cold or movable, and ulcer is contracted to about 0.3 * 0.3cm, forms a scab on every side.Continue to use January, left sufficient pain disappears, and it is normal that color and luster recovers, the ulcer surface incrustation.New first grows, and color and luster is normal substantially.It is normal that complexion is recovered, spiritual amelioration.The former side of reuse consolidates curative effect.After January, ulcer healing, incrustation comes off.Follow up a case by regular visits to 1 year normally.

Case history 4

Certain man, 28 years old, swell and ache during patient's bilateral upper limb and feeling of numbness 2 years surplus, come upper limb to occur the thick hardness and pain bar rope of about chopsticks sometimes 1 year, it is tired heavy unable to occur two lower limbs then more, takes out bitterly behind the right whole end and the shank when walking, feel that gradually right hallux sends out cold, pain, increase the weight of when suffering from cold.Several families hospital diagnosis is " thromboangiitis obliterans " in Yinchuan, fails to respond to any medical treatment, and pain increases the weight of gradually, comes me to go to a doctor.Patient's misery of expressing one's feelings, ice-cold, the pain of the right foot of readme, hallux toe is for very, and have an intense pain night more bitterly, has difficulty in going to sleep.Companion's extremity are heavy unable, tired, are off one's feed.

Look into: it is ice-cold that right foot touches, palor, and hallux toe is slightly livid purple.Dorsal artery of foot, posterior tibial artery are faint.Pale tongue, there is indentation on the limit, greasy fur, soft pulse.

Tcm diagnosis: necrosis, cold-damp syndrome.

Control suitable Yang-warming and dampness-removing.

Fang Xuanben invention preparation is advised wine for giving off smoking, and it is wet to go to a winter resort, anti-wound.Pasted logotype January in per 3 days 1.Suffer from the more preceding temperature slightly of foot, pain relief.Spirit, food are received more preceding improvement.Former side's reuse January, to suffer from foot and change temperature, color and luster recovers normally substantially, and vola, hallux toe pain are still felt in pain disappearance during rest during walking.Fully recover after continuing to use January.Follow up a case by regular visits to 1 year normally.

Claims (3)

1, a kind of Chinese medicine for outer use for the treatment of vasculitis and diabetic foot is characterized in that: the Chinese medicine preparation that the active component of described Chinese medicine preparation is equipped with by following weight portion:

Radix Et Rhizoma Rhei: 3-8 part; Flos Lonicerae: 2-6 part; Venenum Bufonis, Ramulus et folium taxi cuspidatae, Radix Scutellariae, Cortex Phellodendri, each 1-3 part of Rhizoma Et Radix Notopterygii; Radix Angelicae Pubescentis, the Rhizoma Pinelliae, Rhizoma Arisaematis, Radix Notoginseng, each 1-5 part of the Cortex Eucommiae.

2, the Chinese medicine for outer use of treatment vasculitis as claimed in claim 1 and diabetic foot is characterized in that: the Chinese medicine preparation that the active component of described Chinese medicine preparation is equipped with by following weight portion:

Radix Et Rhizoma Rhei: 5 parts; Flos Lonicerae: 4 parts; Respectively 2 parts of Venenum Bufonis, Ramulus et folium taxi cuspidatae, Radix Scutellariae, Cortex Phellodendri, Rhizoma Et Radix Notopterygiis; Respectively 3 parts of Radix Angelicae Pubescentis, the Rhizoma Pinelliae, Rhizoma Arisaematis, Radix Notoginseng, the Cortexs Eucommiae.

3, the Chinese medicine for outer use of treatment vasculitis as claimed in claim 1 or 2 and diabetic foot is characterized in that: described preparation is an externally used paste.