CN104547591A - Pharmaceutical composition for treating acute ankle sprain - Google Patents

Pharmaceutical composition for treating acute ankle sprain Download PDF

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Publication number
CN104547591A
CN104547591A CN201510039445.5A CN201510039445A CN104547591A CN 104547591 A CN104547591 A CN 104547591A CN 201510039445 A CN201510039445 A CN 201510039445A CN 104547591 A CN104547591 A CN 104547591A
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parts
herba
rhizoma
radix
pharmaceutical composition
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孟宪庆
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    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract

The invention relates to a pharmaceutical composition for treating acute ankle sprain. The pharmaceutical composition is prepared from the following active pharmaceutical ingredients in parts by weight: 50-150 parts of phyllagathis, 50-100 parts of carallia diplopetala hand.-mazz., 80-150 parts of hedychium coronarium koen, 20-50 parts of lignum aquilariae resinatum, 30-80 parts of fructus mume, 50-100 parts of cleisostoma scolopendrifolium, 20-70 parts of radix rehmanniae preparata, 60-90 parts of menyanthes trifoliata, 30-80 parts of herba artemisiae scopariae, 70-100 parts of folium rhododendri daurici, 30-60 parts of herba leonuri, 50-80 parts of fructus corni, 30-60 parts of mentha piperita l., 50-80 parts of flos caryophylli, 40-60 parts of aquilegia viridiflora pall., 50-80 parts of rhizoma dioscoreae, 40-80 parts of rhizoma polygoni cuspidati, 20-50 parts of folium artemisiae argyi, 50-100 parts of root of membranaceous beautyleaf and 50-90 parts of radix glycyrrhizae. The pharmaceutical composition for treating acute ankle sprain is reasonable in formula, achieves the efficacies of eliminating blood stasis and swelling, relaxing muscles and tendons and removing obstruction from meridians, promoting blood circulation to arrest pain, improving local circulation and activating and dredging the qi and blood stagnated around joints to remove swelling, the joint function can be effectively restored, and the pharmaceutical composition has the characteristics of definite curative effect, no toxic or side effect and low price, and is safe and convenient.

Description

A kind of pharmaceutical composition for the treatment of acute ankle sprain
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of pharmaceutical composition for the treatment of acute ankle sprain.
Background technology
Ankle joint is one of of paramount importance joint of human body.Ankle joint surrounding ligaments is sprained sickness rate and account for first place in each articular ligament of whole body is sprained.Cause laxity of ligament as dealt with improperly, cicatrization, ankle joint is unstable, so that repeatedly sprain, the probability that traumatic arthritis occurs in the future increases greatly, makes troubles and quality of life decline to life.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition for the treatment of acute ankle sprain.
In order to realize object of the present invention, the invention provides a kind of pharmaceutical composition for the treatment of acute ankle sprain, it is made up by weight of following bulk drugs: bright and beautiful Rhizoma et radix valerianae 50-150 part, sawtooth king 50-100 part, Rhizoma Hedychii Coronarii 80-150 part, Lignum Aquilariae Resinatum 20-50 part, Fructus Mume 30-80 part, Herba Cleisostomatis scolopendrifolii 50-100 part, Radix Rehmanniae Preparata 20-70 part, Herba menyanthis 60-90 part, Herba Artemisiae Scopariae 30-80 part, Folium Rhododendri Daurici 70-100 part, Herba Leonuri 30-60 part, Fructus Corni 50-80 part, Mentha piperita 30-60 part, Flos Caryophylli 50-80 part, Aquilegia viridiflora 40-60 part, Rhizoma Dioscoreae 50-80 part, Rhizoma Polygoni Cuspidati 40-80 part, Folium Artemisiae Argyi 20-50 part, Radix calophylli membranacei 50-100 part and Radix Glycyrrhizae 50-90 part.
Preferably, the pharmaceutical composition for the treatment of acute ankle sprain of the present invention is made up by weight of following bulk drugs: bright and beautiful Rhizoma et radix valerianae 100 parts, sawtooth king 70 parts, Rhizoma Hedychii Coronarii 90 parts, Lignum Aquilariae Resinatum 25 parts, Fructus Mume 50 parts, Herba Cleisostomatis scolopendrifolii 80 parts, Radix Rehmanniae Preparata 50 parts, Herba menyanthis 80 parts, Herba Artemisiae Scopariae 40 parts, Folium Rhododendri Daurici 80 parts, Herba Leonuri 50 parts, Fructus Corni 60 parts, Mentha piperita 50 parts, Flos Caryophylli 55 parts, Aquilegia viridiflora 45 parts, Rhizoma Dioscoreae 65 parts, Rhizoma Polygoni Cuspidati 50 parts, Folium Artemisiae Argyi 30 parts, Radix calophylli membranacei 60 parts and 60 parts, Radix Glycyrrhizae.
Preferably, described pharmaceutical composition can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or ointment.
The present invention also provides the purposes of compositions in the medicine of preparation treatment acute ankle sprain, described compositions is made up by weight of following bulk drugs: bright and beautiful Rhizoma et radix valerianae 50-150 part, sawtooth king 50-100 part, Rhizoma Hedychii Coronarii 80-150 part, Lignum Aquilariae Resinatum 20-50 part, Fructus Mume 30-80 part, Herba Cleisostomatis scolopendrifolii 50-100 part, Radix Rehmanniae Preparata 20-70 part, Herba menyanthis 60-90 part, Herba Artemisiae Scopariae 30-80 part, Folium Rhododendri Daurici 70-100 part, Herba Leonuri 30-60 part, Fructus Corni 50-80 part, Mentha piperita 30-60 part, Flos Caryophylli 50-80 part, Aquilegia viridiflora 40-60 part, Rhizoma Dioscoreae 50-80 part, Rhizoma Polygoni Cuspidati 40-80 part, Folium Artemisiae Argyi 20-50 part, Radix calophylli membranacei 50-100 part and Radix Glycyrrhizae 50-90 part.
Preferably, described compositions is made up by weight of following bulk drugs: bright and beautiful Rhizoma et radix valerianae 100 parts, sawtooth king 70 parts, Rhizoma Hedychii Coronarii 90 parts, Lignum Aquilariae Resinatum 25 parts, Fructus Mume 50 parts, Herba Cleisostomatis scolopendrifolii 80 parts, Radix Rehmanniae Preparata 50 parts, Herba menyanthis 80 parts, Herba Artemisiae Scopariae 40 parts, Folium Rhododendri Daurici 80 parts, Herba Leonuri 50 parts, Fructus Corni 60 parts, Mentha piperita 50 parts, Flos Caryophylli 55 parts, Aquilegia viridiflora 45 parts, Rhizoma Dioscoreae 65 parts, Rhizoma Polygoni Cuspidati 50 parts, Folium Artemisiae Argyi 30 parts, Radix calophylli membranacei 60 parts and 60 parts, Radix Glycyrrhizae.
Preferably, described medicine can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or ointment.
In the present invention, bright and beautiful Rhizoma et radix valerianae, sawtooth king are monarch drug; Rhizoma Hedychii Coronarii, Lignum Aquilariae Resinatum, Fructus Mume, Herba Cleisostomatis scolopendrifolii, Radix Rehmanniae Preparata are ministerial drug; Herba menyanthis, Herba Artemisiae Scopariae, Folium Rhododendri Daurici, Herba Leonuri, Fructus Corni, Mentha piperita, Flos Caryophylli, Aquilegia viridiflora, Rhizoma Dioscoreae, Rhizoma Polygoni Cuspidati, Folium Artemisiae Argyi, Radix calophylli membranacei are adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, plays the effect making medicine in the compositions of the present invention.All medicines are harmonious in the present invention, reasonable recipe, have determined curative effect, safe ready, have no side effect, cheap feature.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment ointment of the present invention
Take bright and beautiful Rhizoma et radix valerianae 100 grams, sawtooth king 70 grams, Rhizoma Hedychii Coronarii 90 grams, Lignum Aquilariae Resinatum 25 grams, Fructus Mume 50 grams, Herba Cleisostomatis scolopendrifolii 80 grams, Radix Rehmanniae Preparata 50 grams, Herba menyanthis 80 grams, Herba Artemisiae Scopariae 40 grams, Folium Rhododendri Daurici 80 grams, Herba Leonuri 50 grams, Fructus Corni 60 grams, Mentha piperita 50 grams, Flos Caryophylli 55 grams, Aquilegia viridiflora 45 grams, Rhizoma Dioscoreae 65 grams, Rhizoma Polygoni Cuspidati 50 grams, Folium Artemisiae Argyi 30 grams, Radix calophylli membranacei 60 grams and 60 grams, Radix Glycyrrhizae, add 6 liters, water, heating 3 hours under the condition of backflow, filter, filtrate is cooled to room temperature, adding dehydrated alcohol to alcohol content is 75 volume %, hold over night, filter, reclaim the ethanol in filtrate and make to be left without alcohol Ethylene recov evaporate to dryness, pulverize, add lanoline 250 grams, stir, obtain.
Experimental example
Select 100 routine patients, wherein man 72 example, female 28 example, the age be 22-46 year, mean age is 36 years old, all meet " Chinese medical disease Standardization of diagnosis and curative effect " (State Administration of Traditional Chinese Medicine. Chinese medical disease Standardization of diagnosis and curative effect [M]. Nanjing: publishing house of Nanjing University .1994:209.): have clear and definite trauma history, hinder posterior joint and namely occur pain, local swelling, subcutaneous tired speckle, local tenderness is obvious, has severe pain, and have limitation of activity during joint motion.X-ray is taken the photograph sheet inspection and is got rid of fracture.Clinical symptoms is: ankle joint swells and ache, skin blood stasis, joint motion are dumb or be restricted, and pain will be more violent during patient activity's legs and feet tibia, the all patients time of spraining is 0.5 hour ~ 2 days to treatment time, about 1.0 days average time, patient sprains type and is single sprain of ankle, and wherein 65 routine patients are left sprain of ankle, and 35 routine patients are right sprain of ankle, 62 routine patients are outer sprain of ankle, and 38 routine patients are sprain of the medial malleolus.
The ointment using embodiment to prepare is treated, and every day 2 times, at every turn for sore place, every square centimeter of uniform application 1 gram of ointment, treating 3 days is 1 course for the treatment of.
Efficacy determination
Recovery from illness: the injured local stasis of blood of the patient's ankle joint symptom that swells and ache is eliminated, and the function of plantar flexion and dorsiflexion all recovers normal, and no sequel occurs, daily exercise is flexible; Effective: the injured local stasis of blood of the patient's ankle joint symptom that swells and ache slowly is eliminated, and the effect of plantar flexion and dorsiflexion recovers gradually, and daily exercise is unrestricted; Take a turn for the better: the injured partial gall of ankle joint of patient takes a turn for the better to some extent and improves, but daily exercise is subject to certain obstruction; Invalid: be not any change through treatment acute ankle sprain, swelling and pain are without disappearance sign.
Therapeutic outcome
Through treatment, find in 100 routine patients, recovery from illness 72 example, effective 18 examples, take a turn for the better 10 examples, and total effective rate is 100%.Over the course for the treatment of, there is not Nausea and vomiting, dizzy clinical symptoms in patient.This illustrates that pharmaceutical composition of the present invention does not have obvious untoward reaction, and then proves that medicine does not have obvious toxic and side effects for human body.

Claims (6)

1. treat the pharmaceutical composition of acute ankle sprain for one kind, it is characterized in that, it is made up by weight of following bulk drugs: bright and beautiful Rhizoma et radix valerianae 50-150 part, sawtooth king 50-100 part, Rhizoma Hedychii Coronarii 80-150 part, Lignum Aquilariae Resinatum 20-50 part, Fructus Mume 30-80 part, Herba Cleisostomatis scolopendrifolii 50-100 part, Radix Rehmanniae Preparata 20-70 part, Herba menyanthis 60-90 part, Herba Artemisiae Scopariae 30-80 part, Folium Rhododendri Daurici 70-100 part, Herba Leonuri 30-60 part, Fructus Corni 50-80 part, Mentha piperita 30-60 part, Flos Caryophylli 50-80 part, Aquilegia viridiflora 40-60 part, Rhizoma Dioscoreae 50-80 part, Rhizoma Polygoni Cuspidati 40-80 part, Folium Artemisiae Argyi 20-50 part, Radix calophylli membranacei 50-100 part and Radix Glycyrrhizae 50-90 part.
2. the pharmaceutical composition for the treatment of acute ankle sprain according to claim 1, it is characterized in that, it is made up by weight of following bulk drugs: bright and beautiful Rhizoma et radix valerianae 100 parts, sawtooth king 70 parts, Rhizoma Hedychii Coronarii 90 parts, Lignum Aquilariae Resinatum 25 parts, Fructus Mume 50 parts, Herba Cleisostomatis scolopendrifolii 80 parts, Radix Rehmanniae Preparata 50 parts, Herba menyanthis 80 parts, Herba Artemisiae Scopariae 40 parts, Folium Rhododendri Daurici 80 parts, Herba Leonuri 50 parts, Fructus Corni 60 parts, Mentha piperita 50 parts, Flos Caryophylli 55 parts, Aquilegia viridiflora 45 parts, Rhizoma Dioscoreae 65 parts, Rhizoma Polygoni Cuspidati 50 parts, Folium Artemisiae Argyi 30 parts, Radix calophylli membranacei 60 parts and 60 parts, Radix Glycyrrhizae.
3. the pharmaceutical composition for the treatment of acute ankle sprain according to claim 2, is characterized in that, described pharmaceutical composition can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or ointment.
4. the purposes of compositions in the medicine of preparation treatment acute ankle sprain, it is characterized in that, described compositions is made up by weight of following bulk drugs: bright and beautiful Rhizoma et radix valerianae 50-150 part, sawtooth king 50-100 part, Rhizoma Hedychii Coronarii 80-150 part, Lignum Aquilariae Resinatum 20-50 part, Fructus Mume 30-80 part, Herba Cleisostomatis scolopendrifolii 50-100 part, Radix Rehmanniae Preparata 20-70 part, Herba menyanthis 60-90 part, Herba Artemisiae Scopariae 30-80 part, Folium Rhododendri Daurici 70-100 part, Herba Leonuri 30-60 part, Fructus Corni 50-80 part, Mentha piperita 30-60 part, Flos Caryophylli 50-80 part, Aquilegia viridiflora 40-60 part, Rhizoma Dioscoreae 50-80 part, Rhizoma Polygoni Cuspidati 40-80 part, Folium Artemisiae Argyi 20-50 part, Radix calophylli membranacei 50-100 part and Radix Glycyrrhizae 50-90 part.
5. purposes according to claim 4, it is characterized in that, described compositions is made up by weight of following bulk drugs: bright and beautiful Rhizoma et radix valerianae 100 parts, sawtooth king 70 parts, Rhizoma Hedychii Coronarii 90 parts, Lignum Aquilariae Resinatum 25 parts, Fructus Mume 50 parts, Herba Cleisostomatis scolopendrifolii 80 parts, Radix Rehmanniae Preparata 50 parts, Herba menyanthis 80 parts, Herba Artemisiae Scopariae 40 parts, Folium Rhododendri Daurici 80 parts, Herba Leonuri 50 parts, Fructus Corni 60 parts, Mentha piperita 50 parts, Flos Caryophylli 55 parts, Aquilegia viridiflora 45 parts, Rhizoma Dioscoreae 65 parts, Rhizoma Polygoni Cuspidati 50 parts, Folium Artemisiae Argyi 30 parts, Radix calophylli membranacei 60 parts and 60 parts, Radix Glycyrrhizae.
6. purposes according to claim 5, is characterized in that, described medicine can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or ointment.
CN201510039445.5A 2015-01-26 2015-01-26 Pharmaceutical composition for treating acute ankle sprain Pending CN104547591A (en)

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Publication number Priority date Publication date Assignee Title
CN106880783A (en) * 2017-03-20 2017-06-23 泰山医学院 A kind of Chinese medicine composition for treating acute ankle sprain
EP3342465A1 (en) * 2016-12-30 2018-07-04 Bayer Consumer Care AG Hedychium extract and compositions thereof and their use in the treatment of skin affected by harmful environmental influences

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3342465A1 (en) * 2016-12-30 2018-07-04 Bayer Consumer Care AG Hedychium extract and compositions thereof and their use in the treatment of skin affected by harmful environmental influences
WO2018121973A1 (en) * 2016-12-30 2018-07-05 Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic Composition comprising a plant extract of the specie hedychium coronarium, for use in a method for treatment of the human body by therapy
CN106880783A (en) * 2017-03-20 2017-06-23 泰山医学院 A kind of Chinese medicine composition for treating acute ankle sprain

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Application publication date: 20150429