CN1313128A - Chinese-medicinal capsule for treating diabetes and its preparing process - Google Patents
Chinese-medicinal capsule for treating diabetes and its preparing process Download PDFInfo
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- CN1313128A CN1313128A CN 01111063 CN01111063A CN1313128A CN 1313128 A CN1313128 A CN 1313128A CN 01111063 CN01111063 CN 01111063 CN 01111063 A CN01111063 A CN 01111063A CN 1313128 A CN1313128 A CN 1313128A
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Abstract
A Chinese medicine in the form of capsules for treating diabetes is prepared from 14 Chinese-medicinal materials including astragalus root, siberian solomonseal rhizome, corydalis tuber, dendrobium, etc. It has high curative effect.
Description
The present invention relates to a kind of Chinese patent medicine and production technology thereof for the treatment of diabetes.
The diabetes spp traditional Chinese medical science category of quenching one's thirst, it be a kind of be the incretion disease of main performance with the carbohydrate metabolism disturbance.Its sickness rate height, the course of disease is long, radical cure is difficult, and the fatality rate that disables is only second to tumor and cardiovascular disease, so be listed in one of the world's three serious diseases.The western medical treatment diabetes are used medicines such as sulphanylureas, biguanides and insulin mostly, though its hypoglycemic activity is obvious, only can reach the degree of regulating metabolism disorder, and side effect is big, take grievous injury liver, kidney for a long time, influence gastrointestinal function, its complication is difficult to control especially.TCM treatment of diabetes is with a long history, and ancient Chinese medicine doctor is thought: in the morbidity because the plain body deficiency of YIN or natural endowment deficiency, exopathogenic factor eating and drinking without temperance, surfeit delicious food pure wine, or direct stimulation, disorder of emotion, or labor is desired excessively, the cloudy essence of loss etc. is brought out and cause a disease.Damage of kidney-YIN is this, and lung dryness of the stomach heat is mark.Treatment is the medication of the side of something lost based on enriching yin and nourishing kidney, such as LIUWEI DIHUANG WAN, diabetes pill or the like.Though this type of prescription has certain therapeutical effect to diabetes, prove according to traditional Chinese medical science negative and positive academic viewpoint and clinical practice, sick deficiency of YIN affecting YANG for a long time, cause deficiency of both YIN and YANG or change positive person by the moon of common occurrence.Therefore, Chinese medicine preparation is in the past only paid attention to inborn nourishing, thinks little of posteriori taking good care of, and the different clinical manifestations that can not vary according to diabetics, gives treatment pointedly, and curative effect is not ideal enough as a result.
The present invention is intended to overcome the shortcoming of Chinese medicine preparation in the past, a kind of new Chinese medicine preparation and production method thereof are proposed, both considered the complementary relationship of congenital (kidney) and the day after tomorrow (spleen), be to fill a prescription for characteristics adjustment such as stomach Xingqi body fluid in conjunction with the diabetics thirst with desire to drink again, to reach the purpose that significantly improves the treatment of diabetes effect owing to insufficiency of the spleen.
Drug Capsule among the present invention, be made up of the Radix Astragali, Rhizoma Polygonati, Radix Scrophulariae, Herba Dendrobii, Poria, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Radix Platycodonis, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Radix Angelicae Sinensis, Radix Glycyrrhizae 14 flavor Chinese medicines, its proportioning is respectively Radix Astragali 10-14%, Rhizoma Polygonati 10-14%, Radix Scrophulariae 8-12%, Herba Dendrobii 4-8%, Poria 4-8%, Rhizoma Atractylodis Macrocephalae 8-12%, Rhizoma Atractylodis 4-8%, Rhizoma Dioscoreae 8-12%, Radix Panacis Quinquefolii 4-8, Radix Platycodonis 2-6%, Pericarpium Citri Reticulatae 2-6%, Endothelium Corneum Gigeriae Galli 3-7%, Radix Angelicae Sinensis 2-5%, Radix Glycyrrhizae 2-5% by weight percentage.
The preparing process step of above-mentioned Chinese medicinal capsule is:
(1) choosing the Radix Astragali, Rhizoma Polygonati, Radix Scrophulariae, Herba Dendrobii, Poria, Radix Angelicae Sinensis Six-element Chinese medicine by weight ratio soaks;
(2) decoct three times;
(3) collecting decoction, filtration;
(4) simmer down to thick paste;
(5) choosing the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Radix Platycodonis, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae eight flavor Chinese medicines by weight ratio pulverizes, sieves;
(6) with fine powder mix homogeneously such as the concentrated thick pastes such as the above-mentioned Radix Astragali and the Rhizoma Atractylodis Macrocephalaes;
(7) cold drying;
(8) pulverize, sieve;
(9) branch is encapsulated.
The present invention is owing to be monarch with the Radix Astragali in the side, and assistant is with Radix Panacis Quinquefolii, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae four flavors, and tonification gas spleen invigorating lung merit is concentrated one's efforts grand, drinks to add Chinese Angelica blood replonishing simply, qi and blood tonifying.Cloudy and the essence of reinforcing the kidney of Rhizoma Dioscoreae strengthening the spleen, Rhizoma Atractylodis dampness and sword spleen essence, Radix Scrophulariae, Rhizoma Polygonati, Herba Dendrobii QI invigorating nourishing the stomach YIN nourishing, to make the dry strong property of pale art, Pericarpium Citri Reticulatae is regulated the flow of vital energy and harmonizing the functional activities of vital QI, Radix Platycodonis lung qi dispersing promoting the circulation of QI, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Especially simply, say according to " in the inner feelings ginseng west record " with Endothelium Corneum Gigeriae Galli: " person that use the Endothelium Corneum Gigeriae Galli, so contain saccharic in the disease, use to help taste strong, during dissipating fluid-retention is eaten saccharic be body fluid also ".All medicines share, and spleen reinforcing soil helps Hua Yuan, and the multiple Tianjin of gas also is total to the spleen invigorating of income gas, qi and blood tonifying, the effect of nourishing the stomach to promote the production of body fluid.Therefore, Chinese medicinal capsule is applicable to non-insulin-dependent diabetes mellitus, rapid digestion of food and polyorexia, stomach are received day subtract, deficiency of QI with disinclination to talk, asthenia fatigue, rare when doing when spontaneous perspiration, numb limbs and tense tendons, stool are crouched in happiness, health puffiness due to deficiency is unable or day by day become thin etc., and disease has significant curative effect.
For showing the present invention, through 108 routine clinical observations and select same period western medicine primary disease 100 examples to contrast, existing results of comparison is analyzed as follows the treatment of diabetes effect:
One, diagnostic criteria
1, fasting glucose>7.8mmol/L and or two hours after the meal blood glucose>11.1mmol/L,
2, glucose in urine (~ ++ ++).
Two, clinical data
All did blood, glucose in urine chemical examination before and after treatment by Chinese herbs group 108 examples and the western medicine group 100 example treatments, the rapid blood sugar instrument that the blood glucose chemical examination all adopts group of U.S. Johnson ﹠ Johnson to produce, the copper sulfate reducing process is adopted in the glucose in urine test.Patient's cardinal symptom is: rapid digestion of food and polyorexia, stomach receive day subtract, deficiency of QI with disinclination to talk, asthenia fatigue, rare when doing when spontaneous perspiration, numb limbs and tense tendons, stool are crouched in happiness, health puffiness due to deficiency is unable or day by day become thin etc.Two groups all have comparability at aspects such as sex composition, age difference, course of disease length, see attached list one:
Three: Therapeutic Method
Western medicine group 100 examples all adopt Western medicine such as glyburide, metformin, acarbose to treat continuously, and one month is a course of treatment, finish that recurrence of disease at the same time next year is had a blood test, glucose in urine per course of treatment.The treatment by Chinese herbs group is used Chinese medicinal capsule of the present invention, in conjunction with patient's chemical examination index, looks the different clinical manifestation of patient, diagnosis and prescription: each consumption 4-8 grain, and day clothes 2-3 time, ante cibum, half an hour, light salt brine took.One month is a course of treatment.Wherein, the treatment by Chinese herbs winding is subjected to the first course of therapy person, 108 examples to account for 100%, accept second the course of treatment person's 106 examples account for 98.2%, accept the 3rd the course of treatment person's 104 examples account for 96.3%, the western medicine winding be subjected to first the course of treatment person's 100 examples account for 100%, accept second the course of treatment person's 93 examples account for 93%, accept the 3rd the course of treatment person's 87 examples account for 87%.
Four: efficacy assessment standard
Produce effects: the clinical symptoms complete obiteration, blood, glucose in urine index are normal substantially.
Effectively: clinical symptoms makes moderate progress, and blood, glucose in urine index slightly descend before the treatment.
Invalid: clinical symptoms and blood, glucose in urine index no change before and after treatment.
Five, therapeutic outcome
Treatment by Chinese herbs group 108 examples, produce effects 77 examples account for 71.3%, effective 29 examples account for 26.9%, invalid 1 example, total effective rate are 98.2%.Western medicine group 100 examples, produce effects 23 examples account for 23%, effective 31 examples account for 31%, invalid 46 examples, total effective rate are 54%.
Table two: two groups of curative effect situations
Total routine number | The produce effects number | Obvious effective rate | Significant figure | Effective percentage | Invalid number | Total effective rate | |
The treatment group | ??108 | ???77 | ??71.3% | ???29 | ??26.9% | ???2 | ????98.2% |
Matched group | ??100 | ???23 | ???23% | ??331 | ???31% | ???46 | ????54% |
Six, therapeutic outcome analysis
Two groups of therapeutic outcomes are carried out statistical analysis handle, contrast blood, glucose in urine natural rate of interest, subjective symptoms normalization rate see Table three, table four:
Table three: the blood of treatment group and matched group, urine are learned and are checked relatively
Group | Number positive | Complex constant | |
Blood glucose | The treatment group | ????108 | ????92% |
Matched group | ????100 | ????24% | |
Glucose in urine | The treatment group | ????92 | ????90.5% |
Matched group | ????89 | ????17.6% |
Table four: treatment group and matched group clinical symptoms are improved situation
Number positive | Complex constant | |||
The treatment group | Matched group | The treatment group | Matched group | |
Polydipsia | 93 | ?88 | ?92% | 43% |
Polyphagia | 82 | ?78 | ?91.6% | 50% |
Become thin | 95 | ?81 | ?96.2% | 38% |
Fatigue and weakness | 80 | ?90 | ?95% | 27% |
Happiness spontaneous perspiration for sleeping in | 86 | ?83 | ?84.3% | 11% |
Numb limbs and tense tendons | 79 | ?74 | ?81% | 6% |
Learn by statistics to handle and show that this medicine obviously is better than western medicine group to the control of blood, glucose in urine and the improvement effect of clinical symptoms in the process of treatment diabetes, so Chinese medicine preparation for the treatment of diabetes advanced person, science really of the present invention.
The present invention will further be illustrated by following examples.
A kind of Chinese medicinal capsule for the treatment of diabetes, its composition and content are: Radix Astragali 30g (12.5%), Rhizoma Polygonati 30g (12.5%), Radix Scrophulariae 24g (10%), Herba Dendrobii 15g (6%), Poria 15g (6%), Rhizoma Atractylodis Macrocephalae 24g (10%), Rhizoma Atractylodis 15g (6%), Rhizoma Dioscoreae 30g (12.5%), Radix Panacis Quinquefolii 15g (6%), Radix Platycodonis 9g (4%), Pericarpium Citri Reticulatae 9g (4%), Endothelium Corneum Gigeriae Galli 12g (5%), Radix Angelicae Sinensis 7g (3%), Radix Glycyrrhizae 6g (2.5%).Its preparation steps is:
(1) Radix Astragali that will choose, Rhizoma Polygonati, Radix Scrophulariae, Herba Dendrobii, Poria, Radix Angelicae Sinensis Six-element Chinese medicine add the water of ten times of doses, soak 24 hours;
(2) decoct three times, decocting liquid was extracted in slow fire boiling for the first time in 3 hours; Add for the second time seven times of decoctings again and boil 2 hours extraction decocting liquids; Add the quintuple decocting for the third time again and boil 1 hour extraction decocting liquid;
(3) collecting decoction, filtration;
(4) simmer down to thick paste (relative density is 1.23-1.26 (a 60-65 degree));
(5) Rhizoma Atractylodis Macrocephalae that will choose, Rhizoma Atractylodis, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Radix Platycodonis, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae eight flavor Chinese medicines are pulverized, are sieved;
(6) with fine powder mix homogeneously such as the concentrated thick pastes such as the above-mentioned Radix Astragali and the Rhizoma Atractylodis Macrocephalaes;
(7) cold drying;
(8) pulverize, sieve;
(9) divide encapsulated (every 0.3 gram, about 500);
(10) the x ray irradiation x sterilization is concentrated in the sealing back.
Claims (4)
1, a kind of Chinese medicinal capsule for the treatment of diabetes is characterized in that it is made by following materials of weight proportions: Radix Astragali 10-14%, Rhizoma Polygonati 10-14%, Radix Scrophulariae 8-12%, Herba Dendrobii 4-8%, Poria 4-8%, Rhizoma Atractylodis Macrocephalae 8-12%, Rhizoma Atractylodis 4-8%, Rhizoma Dioscoreae 8-12%, Radix Panacis Quinquefolii 4-8%, Radix Platycodonis 2-6%, Pericarpium Citri Reticulatae 2-6%, Endothelium Corneum Gigeriae Galli 3-7%, Radix Angelicae Sinensis 2-5%, Radix Glycyrrhizae 2-5%.
2,, it is characterized in that the weight proportion of described each raw material is: the Radix Astragali 12.5%, Rhizoma Polygonati 12.5%, Radix Scrophulariae 10%, Herba Dendrobii 6%, Poria 6%, the Rhizoma Atractylodis Macrocephalae 10%, Rhizoma Atractylodis 6%, Rhizoma Dioscoreae 12.5%, Radix Panacis Quinquefolii 6%, Radix Platycodonis 4%, Pericarpium Citri Reticulatae 4%, Endothelium Corneum Gigeriae Galli 5%, Radix Angelicae Sinensis 3%, Radix Glycyrrhizae 2.5% according to the described Chinese medicinal capsule of claim 1.
3, the compound method of the Chinese medicinal capsule of the described treatment diabetes of claim 1 is characterized in that it may further comprise the steps:
(1) choosing the Radix Astragali, Rhizoma Polygonati, Radix Scrophulariae, Herba Dendrobii, Poria, Radix Angelicae Sinensis Six-element Chinese medicine by weight ratio soaks;
(2) decoct three times;
(3) collecting decoction, filtration;
(4) simmer down to thick paste;
(5) choosing the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Radix Platycodonis, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae eight flavor Chinese medicines by weight ratio pulverizes, sieves;
(6) with fine powder mix homogeneously such as the concentrated thick pastes such as the above-mentioned Radix Astragali and the Rhizoma Atractylodis Macrocephalaes;
(7) cold drying;
(8) pulverize, sieve;
(9) branch is encapsulated.
4, according to the compound method of the described Chinese medicinal capsule of claim 3, it is characterized in that described step (1) soaks, be the water logging bubble 24 hours that adds ten times of doses; Step (2) decocts three times, is first slow fire boiling 3 hours, adds seven times of water gagings again behind the extraction decocting liquid and decocts for the second time 2 hours, adds quintuple water again behind the extraction decocting liquid and decocts for the third time 1 hour.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101199780B (en) * | 2007-12-13 | 2011-06-22 | 孙瑞龙 | Chinese medicine preparation for treating guard main non-hard anaphylactic rhinitis |
CN104940638A (en) * | 2015-05-26 | 2015-09-30 | 霍山县淮源农业科技发展有限公司 | Traditional Chinese medicine combined decoction for treating diabetes and preparation method of traditional Chinese medicine combined decoction |
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2001
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101199780B (en) * | 2007-12-13 | 2011-06-22 | 孙瑞龙 | Chinese medicine preparation for treating guard main non-hard anaphylactic rhinitis |
CN104940638A (en) * | 2015-05-26 | 2015-09-30 | 霍山县淮源农业科技发展有限公司 | Traditional Chinese medicine combined decoction for treating diabetes and preparation method of traditional Chinese medicine combined decoction |
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