CN1205226A

CN1205226A - Sanxiaodan capsule for treating diabetes and its prepn. method

Info

Publication number: CN1205226A
Application number: CN 98107248
Authority: CN
Inventors: 康永政
Original assignee: Individual
Current assignee: Individual
Priority date: 1998-04-01
Filing date: 1998-04-01
Publication date: 1999-01-20

Abstract

A Chinese patent medicine in the form of capsule for treating diabetes is prepared from 14 Chinese-medicinal materials such as astragalus root, siberian solomonseal rhizome, scrophularia root, dendrobium, tuckahoe, etc.

Description

The Sanxiaodan capsule and the compound method thereof of treatment diabetes

The present invention relates to a kind of Chinese patent medicine and production technology thereof for the treatment of diabetes.

The diabetes spp traditional Chinese medical science category of quenching one's thirst, it be a kind of be the incretion disease of main performance with the carbohydrate metabolism disturbance.Its sickness rate height, the course of disease is long, radical cure is difficult, and the fatality rate that disables is only second to tumor and cardiovascular disease, so be listed in one of the world's three serious diseases.The western medical treatment diabetes are used medicines such as sulphanylureas, biguanides and insulin mostly, though its hypoglycemic activity is obvious, only can reach the degree of regulating metabolism disorder, and side effect is big, take grievous injury liver, kidney for a long time, influence gastrointestinal function, its complication is difficult to control especially.TCM treatment of diabetes is with a long history, and ancient Chinese medicine doctor is thought: in the morbidity because the plain body deficiency of YIN or natural endowment deficiency, exopathogenic factor eating and drinking without temperance, surfeit delicious food pure wine, or direct stimulation, disorder of emotion, or labor is desired excessively, the cloudy essence of loss etc. is brought out and cause a disease.Damage of kidney-YIN is this, and lung dryness of the stomach heat is mark.Treatment is the medication of the side of something lost based on enriching yin and nourishing kidney, such as LIUWEI DIHUANG WAN, diabetes pill or the like.Though this type of prescription has certain therapeutical effect to diabetes, prove according to traditional Chinese medical science negative and positive academic viewpoint and clinical practice, sick deficiency of YIN affecting YANG for a long time, cause deficiency of both YIN and YANG or change positive person by the moon of common occurrence.Therefore, Chinese medicine preparation is in the past only paid attention to inborn nourishing, thinks little of posteriori taking good care of, and the different clinical manifestations that can not vary according to diabetics, gives treatment pointedly, and curative effect is not ideal enough as a result.

The present invention is intended to overcome the shortcoming of Chinese medicine preparation in the past, a kind of new Chinese medicine preparation and production method thereof are proposed, both considered the complementary relationship of congenital (kidney) and the day after tomorrow (spleen), be to fill a prescription for characteristics adjustment such as stomach Xingqi body fluid in conjunction with the diabetics thirst with desire to drink again, to reach the purpose that significantly improves the treatment of diabetes effect owing to insufficiency of the spleen.

The present invention's Sanxiaodan capsule, be made up of the Radix Astragali, Rhizoma Polygonati, Radix Scrophulariae, Herba Dendrobii, Poria, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Radix Platycodonis, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Radix Angelicae Sinensis, Radix Glycyrrhizae 14 flavor Chinese medicines, its proportioning is respectively Radix Astragali 10-14%, Rhizoma Polygonati 10-14%, Radix Scrophulariae 8-12%, Herba Dendrobii 4-8%, Poria 4-8%, Rhizoma Atractylodis Macrocephalae 8-12%, Rhizoma Atractylodis 4-8%, Rhizoma Dioscoreae 8-12%, Radix Panacis Quinquefolii 4-8, Radix Platycodonis 2-6%, Pericarpium Citri Reticulatae 2-6%, Endothelium Corneum Gigeriae Galli 3-7%, Radix Angelicae Sinensis 2-5%, Radix Glycyrrhizae 2-5% by weight percentage.

The capsular preparation process of Sanxiaodan is:

(1) choosing the Radix Astragali, Rhizoma Polygonati, Radix Scrophulariae, Herba Dendrobii, Poria, Radix Angelicae Sinensis Six-element Chinese medicine by weight ratio soaks;

(2) decoct three times;

(3) collecting decoction, filtration;

(4) simmer down to thick paste;

(5) choosing the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Radix Platycodonis, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae eight flavor Chinese medicines by weight ratio pulverizes, sieves;

(6) with fine powder mix homogeneously such as the concentrated thick pastes such as the above-mentioned Radix Astragali and the Rhizoma Atractylodis Macrocephalaes;

(7) cold drying;

(8) pulverize, sieve;

(9) branch is encapsulated.

The present invention is owing to be monarch with the Radix Astragali in the side, and assistant is with Radix Panacis Quinquefolii, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae four flavors, and tonification gas spleen invigorating lung merit is concentrated one's efforts grand, drinks to add Chinese Angelica blood replonishing simply, qi and blood tonifying.Cloudy and the essence of reinforcing the kidney of Rhizoma Dioscoreae strengthening the spleen, Rhizoma Atractylodis dampness and sword spleen essence, Radix Scrophulariae, Rhizoma Polygonati, Herba Dendrobii QI invigorating nourishing the stomach YIN nourishing, to make the dry strong property of pale art, Pericarpium Citri Reticulatae is regulated the flow of vital energy and harmonizing the functional activities of vital QI, Radix Platycodonis lung qi dispersing promoting the circulation of QI, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Especially simply, say according to " (in the inner feelings ginseng west record " with Endothelium Corneum Gigeriae Galli: " person that use the Endothelium Corneum Gigeriae Galli, so contain saccharic in the disease, use to help taste strong, during dissipating fluid-retention is eaten saccharic be body fluid also ".All medicines share, and spleen reinforcing soil helps Hua Yuan, and the multiple Tianjin of gas also is total to the spleen invigorating of income gas, qi and blood tonifying, the effect of nourishing the stomach to promote the production of body fluid.Therefore, the Sanxiaodan capsule is applicable to non-insulin-dependent diabetes mellitus, rapid digestion of food and polyorexia, stomach are received day subtract, deficiency of QI with disinclination to talk, asthenia fatigue, rare when doing when spontaneous perspiration, numb limbs and tense tendons, stool are crouched in happiness, health puffiness due to deficiency is unable or day by day become thin etc., and disease has significant curative effect.

The present invention will further be illustrated by following examples.

A kind of Sanxiaodan capsule for the treatment of diabetes, its composition and content are: Radix Astragali 30g (12.5%), Rhizoma Polygonati 30g (12.5%), Radix Scrophulariae 24g (10%), Herba Dendrobii 15g (6%), Poria 15g (6%), Rhizoma Atractylodis Macrocephalae 24g (10%), Rhizoma Atractylodis 15g (6%), Rhizoma Dioscoreae 30g (12.5%), Radix Panacis Quinquefolii 15g (6%), Radix Platycodonis 9g (4%), Pericarpium Citri Reticulatae 9g (4%), Endothelium Corneum Gigeriae Galli 12g (5%), Radix Angelicae Sinensis 7g (3%), Radix Glycyrrhizae 6g (2.5%).Its preparation process is:

(1) Radix Astragali that will choose, Rhizoma Polygonati, Radix Scrophulariae, Herba Dendrobii, Poria, Radix Angelicae Sinensis Six-element Chinese medicine add the water of ten times of doses, soak 24 hours;

(2) decoct three times, decocting liquid was extracted in slow fire boiling for the first time in 3 hours; Add for the second time seven times of decoctings again and boil 2 hours extraction decocting liquids; Add the quintuple decocting for the third time again and boil 1 hour extraction decocting liquid;

(3) collecting decoction, filtration;

(4) simmer down to thick paste (relative density is 1.23-1.26 (a 60-65 degree));

(5) Rhizoma Atractylodis Macrocephalae that will choose, Rhizoma Atractylodis, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Radix Platycodonis, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae eight flavor Chinese medicines are pulverized, are sieved;

(7) cold drying;

(8) pulverize, sieve;

(9) divide encapsulated (every 0.3 gram, about 500);

(10) the x ray irradiation x sterilization is concentrated in the sealing back.

Instructions of taking: each consumption 4-8 grain, day clothes 2-3 time, one month is a course of treatment.Ante cibum, half an hour, light salt brine took.Clinical practice: in the 108 routine diabeticss, take this medicine after six courses of treatment total effective rate reach 98.4%.

Claims

1, the Sanxiaodan capsule of treatment diabetes, the composition that it is characterized in that it by: the Radix Astragali, Rhizoma Polygonati, Radix Scrophulariae, Herba Dendrobii, Poria, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Rhizoma Dioscoreae, Radix Panacis Quinquefolii, Radix Platycodonis, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Radix Angelicae Sinensis, Radix Glycyrrhizae 14 Chinese medicines are formed.

2,, it is characterized in that described composition by its weight proportion is: Radix Astragali 10-14%, Rhizoma Polygonati 10-14%, Radix Scrophulariae 8-12%, Herba Dendrobii 4-8%, Poria 4-8%, Rhizoma Atractylodis Macrocephalae 8-12%, Rhizoma Atractylodis 4-8%, Rhizoma Dioscoreae 8-12%, Radix Panacis Quinquefolii 4-8%, Radix Platycodonis 2-6%, Pericarpium Citri Reticulatae 2-6%, Endothelium Corneum Gigeriae Galli 3-7%, Radix Angelicae Sinensis 2-5%, Radix Glycyrrhizae 2-5% according to the described Sanxiaodan capsule of claim 1.

3,, it is characterized in that described composition optimum weight proportioning is: the Radix Astragali 12.5%, Rhizoma Polygonati 12.5%, Radix Scrophulariae 10%, Herba Dendrobii 6%, Poria 6%, the Rhizoma Atractylodis Macrocephalae 10%, Rhizoma Atractylodis 6%, Rhizoma Dioscoreae 12.5%, Radix Panacis Quinquefolii 6%, Radix Platycodonis 4%, Pericarpium Citri Reticulatae 4%, Endothelium Corneum Gigeriae Galli 5%, Radix Angelicae Sinensis 3%, Radix Glycyrrhizae 2.5% according to the described Sanxiaodan capsule of claim 2.

4, a kind of capsular compound method of Sanxiaodan for the treatment of diabetes is characterized in that technological process comprises:

(2) decoct three times;

(3) collecting decoction, filtration;

(4) simmer down to thick paste;

(7) cold drying;

(8) pulverize, sieve;

(9) branch is encapsulated.

5, according to the capsular compound method of the described Sanxiaodan of claim 4, it is characterized in that described technological process (1) soaks, be the water logging bubble 24 hours that adds ten times of doses; Technological process (2) decocts three times, is first slow fire boiling 3 hours, adds seven times of water gagings again behind the extraction decocting liquid and decocts for the second time 2 hours, adds quintuple water again behind the extraction decocting liquid and decocts for the third time 1 hour.