CN1062751C - Compound Chinese and western medicinal compsn. for treating 'down elimination' diabetes - Google Patents
Compound Chinese and western medicinal compsn. for treating 'down elimination' diabetes Download PDFInfo
- Publication number
- CN1062751C CN1062751C CN97107209A CN97107209A CN1062751C CN 1062751 C CN1062751 C CN 1062751C CN 97107209 A CN97107209 A CN 97107209A CN 97107209 A CN97107209 A CN 97107209A CN 1062751 C CN1062751 C CN 1062751C
- Authority
- CN
- China
- Prior art keywords
- parts
- diabetes
- chinese
- medicine
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a medicine composition for treating down elimination type diabetes, which comprises the following raw materials by weight percentage: 0.25% to 0.35% of glibenclamide, 6% to 11% of tortoise plastron powder, 2.5% to 3.5% of centipede powder, 6% to 11% of ventriculi galli mucosa power, 11% to 16% of ground cinnamon powder and 58.15% to 74.45% of traditional Chinese medicine immersion ointment containing wolfberry bark, fructus lycii, red sage root, motherwort, morinda root, dogwood fruit and corn stigma. The medicine composition overcomes the defects of reliable short-term treatment effect but unfavorable long-term treatment effect, high toxic and side effect, constant sudden failure, etc. of chemical synthesis medicines singly used in clinic at present and provides a novel Chinese and western combined series medicine namely a compound diabetes capsule III for determining and treating the symptoms of three types of diabetes in clinic and treating both manifestation and root reasons of diseases.
Description
The present invention relates to a kind of medicine series for the treatment of diabetes.
Diabetes are a kind of common endocrine-metabolic diseases, its sickness rate has the trend that increases year by year, be listed in the third-largest disease after cardiovascular disease and tumor in developed country, deadly and the disability rate of diabetes and complication thereof has become world medicine man stubborn problem, annual countries in the world are expended huge fund this disease are studied, but produce little effect.The domestic and international chemical synthetic drug that adopts is treated at present, its short term effect is satisfied, late result is not fully up to expectations, and the defective that toxic and side effects is big etc., as: phenformin is for a long time with easily producing the lactate acidemia, serious adverse reactions such as ketonemia, countries such as the present U.S. have banned use of biguanides; Sulfonylureas (tolbutamide, glibenclamide) often curative effect is better in just with several weeks, using had 10～15% patients to lose curative effect suddenly after 6～12 months, reason is not bright, the old excellent easy generation of person, can take place serious ketoacidosis cause death insulin for a long time with produce antibody, biological activity reduces dosage and increases, and then can cause machine-processed compensation response-can cause hyperinsulinemia and blood glucose fluctuation.To go up a disadvantage in order overcoming, actively to seek solution route both at home and abroad at present from traditional Chinese medical science prescription face.
The traditional Chinese medical herbal treatment diabetes have history remote, and the traditional Chinese medical science claims that diabetes are " diabetes ", and are divided into " on disappear ", " in disappear ", " diabetes due to kidney-deficiency " three types according to the primary and secondary difference of symptom performance." on disappear " based on polydipsia, polyuria, and polyphagia takes second place; Based on polyphagia, the polydipsia polyuria takes second place " in disappear "; Based on polyuria, the polydipsia polyphagia takes second place " diabetes due to kidney-deficiency ".Traditional treatment by Chinese herbs, and the doctor need be according to the dialectical evolution of different patients, very inconvenient, and patient is also very time-consuming bothersome when taking, and prescription drugs can not satisfy need of industrial production, Gu also be difficult to satisfy a large amount of patients' demand.At present domestic clinical also have adopt Chinese medicine to treat, but these Chinese patent medicines general all general be applied to diabetes (diabetes), so poor effect.(include the Radix Astragali, Radix Ginseng, pollen as the Radix Ginseng metformin that uses clinically, the Radix Rehmanniae, Radix Ophiopogonis, the Rhizoma Anemarrhenae, Gypsum Fibrosum, Poria, Rhizoma Dioscoreae, Radix Glycyrrhizae, Cortex Lycii, Stigma Maydis) it generally is used for treating diabetes, its effective percentage only is 63.3% and (sees the Kuang Anzong chief editor, Hunan science tech publishing house publishes " diabetes are in China " P:279), and according to the tcm syndrome differentiation and typing treatment, curative effect is then also low.Clinical present employed diabetes pill (includes Radix Astragali 5%, the Radix Rehmanniae 15%, pollen 24%, every ball also contains glyburide 0.25mg) also be the Chinese medicine and western medicine compound preparation, because of it was developed in the sixties, according to its prescription as can be known, be applicable to that mainly diabetes initial stage or diabetes " upper elimination type " just can get a desired effect.In the diabetes generaI investigation as for present stage, because of living standard improves, the health medical treatment system improves, the average life span generally prolongs, clinical this type of patient at least 80% has entered middle and advanced stage, and all with cardiovascular complications in various degree, thereby has limited the subject range of diabetes pill.
The objective of the invention is to overcome above-mentioned shortcoming, on the prescription dosage form design, based on motherland's medical science to the diabetes three types of diabetes theory of dividing and ruling, check weighing is to the characteristics of " diabetes due to kidney-deficiency type " blood stasis due to renal deficiency, provide a kind of and be adapted to " diabetes due to kidney-deficiency type " diabetics especially, and the curative effect height, toxic and side effects little by chemical synthetic drug with the plant medium-height grass to be compound recipe Chinese and western medicinal composition-compound diabetes-treating capsule III of forming of material combination number.
Technical scheme of the present invention is finished like this: the compound recipe Chinese and western medicinal composition of treatment " diabetes due to kidney-deficiency type " diabetes includes following raw materials in percentage by weight:
Glibenclamide 0.25%～0.35%, Tortoise Shell 6%～11%, Scolopendra powder 2.5%～3.5% Endothelium Corneum Gigeriae Galli powder 6%～11%, Cortex Cinnamomi powder 11%～16%, Chinese medical concrete 58.15%～74.45%, this Chinese medical concrete is made by the following weight proportion raw material: 25～35 parts of Cortex Lycii, 10～20 parts of Fructus Lyciis, 10～20 parts of Radix Salviae Miltiorrhizaes, 3～8 parts of Herba Leonuris, 5～15 parts of Radix Morindae Officinaliss, 10～20 parts of Fructus Corni, 5～15 parts of Stigma Maydis.
The present invention has the following advantages: the prescription composition is seted forth one's views in the doctor trained in Western medicine differential diagnosis of diseases, differential diagnosis in tcm, the Chinese and western medical combination, by modern high tech method, fine condesation and suitable select, effectively carrying out dosage form improves, thereby become a kind of small amount and special effect, exempt to fry in shallow oil easy clothes, carry taking convenience, can take for a long time for this type of patient, become a kind of novel form of specially controlling " diabetes due to kidney-deficiency type " diabetes.
Its Chinese and western medicinal composition be also advantageous in that the synergism that compatibility produced between the each component, Western medicine takes stopgap measures fast, and Chinese medicine effects a permanent cure, and has adapted to the needs of " diabetes due to kidney-deficiency type " diabetics homeostasis, its " polyuria " symptom obviously alleviates, and blood glucose, blood fat also obviously reduce.
On theory of Chinese medical science, based on pathogenetic understanding and the Therapeutic Principle of ancestral's medical science to diabetes, confirm to have sure blood sugar lowering, blood fat reducing, blood pressure lowering, vessel softening, delay comprehensive function such as body aging through modern pharmacology, lay particular emphasis on again have blood circulation promoting and blood stasis dispelling, the vegetable Chinese herbal medicine of training spleen reinforcing renal function is dialectical and effect a permanent cure; Assistant activates sick islet tissue with the microchemistry compound glibenclamide speed that sure blood sugar reducing function is arranged, and recovers to divide secret endogenous islets of langerhans to take stopgap measures; The combination of Chinese and Western medicine, Chinese medicine and western medicine is had complementary advantages, and adds effective dosage form improvement, thereby overcome traditional western medicines in treatment diabetes, the dosage of drug is big, decoction inconvenience, though chemosynthesis medicine treatment diabetes have specially good effect, toxic and side effects is big, the disadvantage of normal catastrophic failure after use a period of time.Novel form of the present invention can be controlled blood, level of sugar effectively when stressing to solve diabetes polydipsia symptom, reach the comprehensive General Symptoms that improves, and can stop or the generation of delaying complications of diabetes, reaches in the recent period and takes stopgap measures fast, the intended purposes of effecting a permanent cure long term.
The embodiment of the invention is as follows: the compound recipe Chinese and western medicinal composition of treatment " diabetes due to kidney-deficiency type " diabetes comprises following raw materials in percentage by weight: glibenclamide 0.25%～0.35%, Tortoise Shell 6%～11%, Scolopendra powder 2.5%～3.5% Endothelium Corneum Gigeriae Galli powder 6%～11%, Cortex Cinnamomi powder 11%～16%, Chinese medical concrete 58.15%～74.45%, this Chinese medical concrete is made by the following weight proportion raw material: 25～35 parts of Cortex Lycii, 10～20 parts of Fructus Lyciis, 10～20 parts of Radix Salviae Miltiorrhizaes, 3～8 parts of Herba Leonuris, 5～15 parts of Radix Morindae Officinaliss, 10～20 parts of Fructus Corni, 5～15 parts of Stigma Maydis.
The optimum weight ratio range of preparation Chinese medical concrete is: 28～32 parts of Cortex Lycii, 13～17 parts of Fructus Lyciis, 13～17 parts of Radix Salviae Miltiorrhizaes, 4～6 parts of Herba Leonuris, 8～12 parts of Radix Morindae Officinaliss, 13～17 parts of Fructus Corni, 8～12 parts of Stigma Maydis.
Its preparation method is: at first prepare Chinese medical concrete, take by weighing each component chopping of Chinese herbal medicine by the proportioning in the prescription of the present invention, add water to submerge, soak and decocted 1～2 hour after 2～3 hours, filter, leave and take filtrate after, add water, repeated to decoct 1～2 hour, filter twice filtrate of merging, filtrate concentrates with cryogenic vacuum, to the thick paste shape, oven dry, being ground into fine powder, to cross 80～100 mesh sieves stand-by.
Include 0.25～0.35 gram glibenclamide by per 100 grams medicine of the present invention, 6～11 gram Tortoise Shells, 6～11 gram Endothelium Corneum Gigeriae Galli powder, 2.5～3.5 gram Scolopendra powder, 11～16 gram Cortex Cinnamomi powders, the proportioning of 58.15～74.45 gram Chinese medical concretes takes by weighing each component, and it is stirred.
Aforementioned pharmaceutical compositions is incapsulated, by the every capsules 0.3 gram medicine III capsule of packing into, make every capsules include glibenclamide 1～1.5mg, Tortoise Shell 22.5～27.5mg, Scolopendra powder 7～11mg, Endothelium Corneum Gigeriae Galli powder 22.5～27.5mg, Cortex Cinnamomi powder 35～45mg, Chinese medical concrete 187.5～220mg, i.e. preparation cost invention medicine (compound diabetes-treating capsule III number).
Now the present invention is operated embodiment in table 1 table 2.
Its table 1 is the proportional quantity of preparation Chinese medical concrete in the table 2.
Table 1
Table 2
Medicine of the present invention is suitable for diabetes blood stasis due to renal deficiency (diabetes due to kidney-deficiency type) disease to be seen based on the polyuria symptom, have concurrently polyphagia, polydipsia, urine amount many frequently, muddy as fat, soreness of the waist and knees, aversion to cold and cold limbs, tinnitus is hard of hearing, binocular is dim-sighted, numb limbs and tense tendons, purplish tongue or ecchymosis, deep pulse are arranged or carefully puckery symptom such as unable.Be mainly used to non-insulin-dependent diabetes mellitus.
Medicine of the present invention can be prepared into various peroral dosage forms such as capsule, tablet, oral liquid or electuary.
The usage and dosage of medicine of the present invention is: oral: each 1～2, and every day three times, taking medicine before meal.General logotype is after three months, look the state of an illness and the dose that cuts down according to the circumstance to maintenance dose (be every day 2～3 times).Still note diet, exercise and mood regulation during keeping treatment.
The therapeutic effect of medicine of the present invention has obtained checking by system's clinical experiment of 100 routine patients.
Its experimental technique is:
1. subjects, type people (meeting the diagnostic criteria of the WHO type) patient who selects to go to a doctor is based on the polyuria symptom, have polydipsia, polyphagia concurrently, other symptom have the urine amount frequently many, muddy as fat, soreness of the waist and knees, aversion to cold and cold limbs, tinnitus is hard of hearing, binocular is dim-sighted, numb limbs and tense tendons, purplish tongue or ecchymosis, deep pulse are arranged or carefully puckery symptom such as unable.
2. randomized controlled design: with " diabetes due to kidney-deficiency type " diabetic of above-mentioned selection by sex, age, occupation, diabetic duration, diabetes family history, to have or not equilibriums such as concurrent hypertension or coronary heart disease, blood glucose, blood fat be two groups, be defined as test group (48 example) and matched group (52 example) with simple random sampling then, test group is taken each 2 of medicine of the present invention, every day three times, matched group is taken diabetes pill, each 10 balls, every day three times.
Experimental result sees Table 3, table 4:
Table 3: blood glucose (mg/dl) situation of change in two groups of therapeutic processes
| Before the treatment | After treating February | |
| The test group matched group | n x±s 48 210±59 52 190±40 | n x±s 45 172±42** 50 189±45 |
* represents P＜0.01
Table 4: the situation of change of triglyceride (mg/dl) in two groups of research process
| Before the treatment | After treating February | |
| The test group matched group | n x±s 48 184±82 52 188±158 | n x±s 45 161±65* 50 186±178 |
* represent p＜0.05
Above experimental result shows, medicine of the present invention all is better than diabetes pill to blood sugar lowering, the lipid-lowering effect of " diabetes due to kidney-deficiency type " diabetics, embody medicine of the present invention and complied with the dialectical Therapeutic Principle who controls that executes, produced the not available good efficacy of the similar compound Chinese patent medicine of existing treatment diabetes.It is 86% that medicine of the present invention is used for the treatment of its effective percentage of " diabetes due to kidney-deficiency type " diabetics, (being total to " clinical disease diagnosis is according to curing the improvement standard " of the revision in 1987 of the PLA General Logistics Department in the criterion of therapeutical effect reference), the effect of agents alleviate diabetics polyuria symptom of the present invention is significantly better than the remission effect of diabetes pill.Medicine of the present invention was through clinic trial 1 year, and accidental poison is paid effect, as be index with common it " hypoglycemia " reaction of glibenclamide, through 100 examples to blind two photographs through X
2Handle its P＜0.01, show that its difference has remarkable meaning, illustrate that curative effect of medication of the present invention is better than the pure chemistry synthetic drug.Showed that simultaneously distinct Chinese characteristics, the combination of Chinese and Western medicine have the extensive studies prospect.
Claims (2)
1. compound recipe Chinese and western medicinal composition for the treatment of diabetes due to kidney-deficiency type diabetes, it is made up of the component of following weight percent: glibenclamide 0.25%～0.35%, Tortoise Shell 6%～11%, Scolopendra powder 2.5%～3.5% Endothelium Corneum Gigeriae Galli powder 6%～11%, Cortex Cinnamomi powder 11%～16%, Chinese medical concrete 58.15%～74.45%, this Chinese medical concrete is made by the following weight proportion raw material: 25～35 parts of Cortex Lycii, 10～20 parts of Fructus Lyciis, 10～20 parts of Radix Salviae Miltiorrhizaes, 3～8 parts of Herba Leonuris, 5～15 parts of Radix Morindae Officinaliss, 10～20 parts of Fructus Corni, 5～15 parts of Stigma Maydis.
2. according to the Chinese and western medicinal composition of the described treatment diabetes due to kidney-deficiency of claim (1) type diabetes, it is characterized in that said Chinese medical concrete made by the following weight proportion raw material: 28～32 parts of Cortex Lycii, 13～17 parts of Fructus Lyciis, 13～17 parts of Radix Salviae Miltiorrhizaes, 4～6 parts of Herba Leonuris, 8～12 parts of Radix Morindae Officinaliss, 13～17 parts of Fructus Corni, 8～12 parts of Stigma Maydis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97107209A CN1062751C (en) | 1997-11-20 | 1997-11-20 | Compound Chinese and western medicinal compsn. for treating 'down elimination' diabetes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97107209A CN1062751C (en) | 1997-11-20 | 1997-11-20 | Compound Chinese and western medicinal compsn. for treating 'down elimination' diabetes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1196942A CN1196942A (en) | 1998-10-28 |
| CN1062751C true CN1062751C (en) | 2001-03-07 |
Family
ID=5169384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97107209A Expired - Fee Related CN1062751C (en) | 1997-11-20 | 1997-11-20 | Compound Chinese and western medicinal compsn. for treating 'down elimination' diabetes |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1062751C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274285B (en) * | 2011-07-20 | 2014-07-02 | 天津市聚星康华医药科技有限公司 | Pharmaceutical composition for treating type 2 diabetes and complications thereof |
| CN102342506B (en) * | 2011-09-02 | 2013-01-09 | 李传梅 | Food therapy composition capable of preventing and treating diabetes and making method thereof |
| CN104623372A (en) * | 2015-02-05 | 2015-05-20 | 李念虎 | Medicament for treating gestational diabetes |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131020A (en) * | 1995-03-11 | 1996-09-18 | 朱立群 | Medicine for reducing blood sugar and its preparation method and use |
-
1997
- 1997-11-20 CN CN97107209A patent/CN1062751C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131020A (en) * | 1995-03-11 | 1996-09-18 | 朱立群 | Medicine for reducing blood sugar and its preparation method and use |
Non-Patent Citations (1)
| Title |
|---|
| 河北中医1992,14(5) 1992.5.31 殷志远等，"克糖灵"系列方治疗II型糖尿病325例临床观察 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1196942A (en) | 1998-10-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1475229A (en) | Antifatigue compound Chinese medicine prescription and its preparation method | |
| CN1053826C (en) | Tonic hypoglycemic capsule and preparing process thereof | |
| CN113521134A (en) | Traditional Chinese medicine composition for treating type II diabetes and application thereof | |
| CN1159050C (en) | Compound traditional Chinese medicine preparation for treating type 2 diabetes | |
| CN1062751C (en) | Compound Chinese and western medicinal compsn. for treating 'down elimination' diabetes | |
| CN102366497B (en) | Medicinal compound preparation for treating diabetes and preparation method of medicinal compound preparation | |
| CN1748760A (en) | Medicine for treating female menstrual disorder (stagnancy of qi and blood stasis) | |
| CN1063644C (en) | Compound Chinese and western medicinal compsn. for treating 'upper elimination' diabetes | |
| CN1066332C (en) | Hypoglycemic compound capsule | |
| CN1063645C (en) | Compound Chinese and western medicinal compsn. for treating 'medium elimination' diabetes | |
| CN109771578A (en) | The composition for preventing and treating diabetes and complication | |
| CN1054524C (en) | Medicine composition for treating diabetes mellitus | |
| CN1054525C (en) | Medicinal composition for treating diabetes involving lower jiao | |
| CN100339119C (en) | Traditional Chinese medicine prepns. for treating diabete | |
| CN1058403C (en) | A pharmaceutical composition for the treatment of diabetes | |
| CN104547105A (en) | Agent for reducing blood glucose | |
| CN100534486C (en) | Chinese medicinal preparation for treating proteinuria caused by diabetic nephropathy and preparation method thereof | |
| CN1557378A (en) | Medicine for treating diabetes | |
| CN115779046B (en) | Traditional Chinese medicine composition, traditional Chinese medicine preparation and application for preventing and treating diabetes | |
| CN1183933C (en) | Medicine for treating incomplete kidney function and its prepn | |
| CN1101213C (en) | Diabetes treating medicine | |
| CN1813855A (en) | Medicine for treating cardio-cerebrovascular disease | |
| CN1602921A (en) | Medicine for treating diabetes and its preparing process | |
| CN102727671B (en) | Traditional Chinese medicine composition for treating diabetic neuropathy and preparation method and application thereof | |
| CN100388938C (en) | Capsule for treating diabetic coronary heart disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |