CN112703183B - 用于治疗rna病毒感染的芳基-n-芳基衍生物 - Google Patents

用于治疗rna病毒感染的芳基-n-芳基衍生物 Download PDF

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CN112703183B
CN112703183B CN201980045933.3A CN201980045933A CN112703183B CN 112703183 B CN112703183 B CN 112703183B CN 201980045933 A CN201980045933 A CN 201980045933A CN 112703183 B CN112703183 B CN 112703183B
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group
ring
rna
formula
compound
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CN112703183A (zh
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D·谢雷
J·塔泽
F·马于托-贝茨尔
R·那杰曼
J·桑托斯
C·阿波利特
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Institut Curie
Wittycell
Universite de Montpellier
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Wittycell
Universite de Montpellier
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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
HUE066072T2 (hu) * 2019-07-19 2024-07-28 Abivax Aril-N-aril-származékok RNS vírus fertõzés kezelésére
AU2020321955A1 (en) 2019-07-30 2022-03-17 Eikonizo Therapapeutics, Inc. HDAC6 inhibitors and uses thereof
EP4125845A4 (en) * 2020-04-02 2024-05-15 Southern Research Institute NEW 2-PYRIMIDONE ANALOGUES AS EFFECTIVE ANTIVIRAL AGENTS AGAINST ALPHAVIRES
CN118324717A (zh) * 2020-11-24 2024-07-12 中国人民解放军海军军医大学 一类取代苯甲酰哌嗪类化合物及在制备抗基孔肯雅病毒药物中的应用
JP2024506858A (ja) 2021-02-02 2024-02-15 リミナル・バイオサイエンシーズ・リミテッド Ｇｐｒ８４アンタゴニストおよびその使用
WO2022195522A1 (en) * 2021-03-17 2022-09-22 Ildong Pharmaceutical Co., Ltd. Inhibitors of ano6 and their uses thereof
IL316201A (en) 2022-04-08 2024-12-01 Eikonizo Therapeutics Inc Oxadiazole HDAC6 inhibitors and their uses

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101965341A (zh) * 2008-01-10 2011-02-02 国家科研中心 用于治疗由剪接异常引起的疾病的抑制剪接机理的化学分子
WO2012131656A2 (en) * 2011-04-01 2012-10-04 Société Splicos Compounds for use as therapeutic agents affecting p53 expression and/or activity

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070244120A1 (en) 2000-08-18 2007-10-18 Jacques Dumas Inhibition of raf kinase using substituted heterocyclic ureas
US7429599B2 (en) * 2000-12-06 2008-09-30 Signal Pharmaceuticals, Llc Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
FR2830862A1 (fr) 2001-10-16 2003-04-18 Lipha Derives nitroso de la diphenylamine a fonction ether ou thioether, compositions pharmaceutiques les contenant et leur utilisation pour la preparation de medicaments
FR2836917B1 (fr) 2002-03-11 2006-02-24 Lipha Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant en tant que medicaments utilisables dans le traitement des pathologies caracterisees par une situation de stress oxydatif
DE602004020073D1 (de) * 2003-08-21 2009-04-30 Osi Pharm Inc 3-substituierte imidazopyridinderivate als c-kit-inhibitoren
FR2859474B1 (fr) 2003-09-04 2006-01-13 Centre Nat Rech Scient Utilisation de composes derives d'indole pour la preparation d'un medicament utile pour le traitement de maladies genetiques resultant de l'alteration des processus d'epissage
EP1697343B1 (en) 2003-12-18 2009-07-01 Tibotec Pharmaceuticals Ltd. Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication
FR2866647B1 (fr) 2004-02-20 2006-10-27 Servier Lab Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2006037117A1 (en) * 2004-09-27 2006-04-06 Amgen Inc. Substituted heterocyclic compounds and methods of use
ES2574670T3 (es) 2005-03-17 2016-06-21 Janssen Sciences Ireland Uc 1,3-Dihidro-bencimidazol-2-ilidenoaminas como inhibidores de replicación del virus sincicial respiratorio
US9409856B2 (en) 2005-11-28 2016-08-09 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
CN101443334A (zh) * 2005-12-21 2009-05-27 艾博特公司 抗病毒化合物
ATE475660T1 (de) 2005-12-21 2010-08-15 Abbott Lab Antivirale verbindungen
US7915411B2 (en) 2005-12-21 2011-03-29 Abbott Laboratories Anti-viral compounds
FR2901273B1 (fr) * 2006-05-19 2010-12-24 Anaconda Pharma Inhibiteurs du virus du papillome humain et les compositions pharmaceutiques les contenant
JP4486667B2 (ja) * 2007-10-01 2010-06-23 株式会社沖データ 媒体搬送装置及び画像形成装置
US8117648B2 (en) * 2008-02-08 2012-02-14 Intersections, Inc. Secure information storage and delivery system and method
US20140187641A1 (en) * 2012-08-23 2014-07-03 Gtx Estrogen receptor ligands and methods of use thereof
SI2440547T1 (sl) * 2009-06-12 2023-05-31 Abivax Nove kemične molekule, ki zavirajo mehanizem spajanja za zdravljenje bolezni, ki so posledica napak pri spajanju
JP2011026251A (ja) 2009-07-27 2011-02-10 Kowa Co ２−アリールアミノキノリン化合物及びこれを有効成分として含有するエリスロポエチン産生促進剤
US8846713B2 (en) 2010-06-24 2014-09-30 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds as phosphodiesterases (PDEs) inhibitors
EP2465502A1 (en) 2010-12-15 2012-06-20 Société Splicos Compounds useful for treating AIDS
FR2972719B1 (fr) * 2011-03-15 2013-04-12 Gaztransp Et Technigaz Bloc isolant pour la fabrication d'une paroi de cuve etanche
EP2712862A1 (en) * 2012-09-28 2014-04-02 Splicos New anti-invasive compounds
WO2014164667A1 (en) 2013-03-11 2014-10-09 Georgetown University Dengue and west nile virus protease inhibitors
CA2916623C (en) * 2013-07-05 2021-09-14 Abivax Bicyclic compounds useful for treating diseases caused by retroviruses
WO2015028989A1 (en) * 2013-09-02 2015-03-05 Actelion Pharmaceuticals Ltd Novel heterocyclic compounds as antimalarial agents
RU2628800C2 (ru) 2014-03-12 2017-08-22 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Амидные соединения, способы получения, применение в качестве средств для лечения и профилактики заболеваний, вызываемых рнк-содержащими вирусами
KR102265277B1 (ko) * 2014-04-11 2021-06-16 판옵테스 파르마 게스.엠.베.하. 바이러스 억제 화합물로서의 항-염증제
US20160143884A1 (en) * 2014-11-26 2016-05-26 Esanex, Inc. Use of tetrahydroindazolylbenzamide and tetrahydroindolylbenzamide derivatives for the treatment of human immunodeficiency virus (hiv) and acquired immune deficiency syndrome (aids)
EP3059591A1 (en) 2015-02-23 2016-08-24 Abivax Methods for screening compounds for treating or preventing a viral infection or a virus-related condition
EP3058940A1 (en) 2015-02-23 2016-08-24 Abivax Quinoline derivatives for use in the treatment or prevention of viral infection
PT3429998T (pt) 2016-03-18 2021-11-04 Prosynergia S A R L Processo para preparação de derivados de quinolin-2-il-fenilamina e seus sais

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101965341A (zh) * 2008-01-10 2011-02-02 国家科研中心 用于治疗由剪接异常引起的疾病的抑制剪接机理的化学分子
WO2012131656A2 (en) * 2011-04-01 2012-10-04 Société Splicos Compounds for use as therapeutic agents affecting p53 expression and/or activity

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