CN112689536A - 血浆分离装置 - Google Patents

血浆分离装置 Download PDF

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Publication number
CN112689536A
CN112689536A CN201980059759.8A CN201980059759A CN112689536A CN 112689536 A CN112689536 A CN 112689536A CN 201980059759 A CN201980059759 A CN 201980059759A CN 112689536 A CN112689536 A CN 112689536A
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CN
China
Prior art keywords
reservoir
fraction
sample
plasma
whole blood
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Pending
Application number
CN201980059759.8A
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English (en)
Chinese (zh)
Inventor
I·范德克莱恩
D·马里努茨
K·M·阿比萨姆拉
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Truvian Sciences Inc
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Truvian Sciences Inc
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Publication date
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Publication of CN112689536A publication Critical patent/CN112689536A/zh
Pending legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5002—Partitioning blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Centrifugal Separators (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • External Artificial Organs (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN201980059759.8A 2018-08-23 2019-07-30 血浆分离装置 Pending CN112689536A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862722050P 2018-08-23 2018-08-23
US62/722,050 2018-08-23
US16/515,974 US11638918B2 (en) 2018-08-23 2019-07-18 Blood plasma separation device
US16/515,974 2019-07-18
PCT/US2019/044018 WO2020040945A1 (en) 2018-08-23 2019-07-30 Blood plasma separation device

Publications (1)

Publication Number Publication Date
CN112689536A true CN112689536A (zh) 2021-04-20

Family

ID=69587179

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980059759.8A Pending CN112689536A (zh) 2018-08-23 2019-07-30 血浆分离装置

Country Status (10)

Country Link
US (3) US11638918B2 (https=)
EP (1) EP3840878A1 (https=)
JP (1) JP2021536583A (https=)
CN (1) CN112689536A (https=)
AU (1) AU2019325155A1 (https=)
BR (1) BR112021003289A2 (https=)
CA (1) CA3110351A1 (https=)
MX (2) MX2021002115A (https=)
WO (1) WO2020040945A1 (https=)
ZA (1) ZA202101462B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114270178A (zh) 2019-02-26 2022-04-01 特鲁维安科学公司 测定装置及其使用方法
CN114302761A (zh) 2019-05-09 2022-04-08 特鲁维安科学公司 逆转血小板聚集的方法和组合物
CA3217713A1 (en) 2022-11-15 2024-05-15 Truvian Sciences, Inc. Systems and methods for drying reagents in multiwell plates
USD1116151S1 (en) 2023-05-03 2026-03-03 Truvian Sciences, Inc. Monolayer
US12287321B2 (en) 2023-09-08 2025-04-29 Truvian Sciences, Inc. Optical multianalyte detection

Citations (9)

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Publication number Priority date Publication date Assignee Title
CN1603820A (zh) * 2003-09-29 2005-04-06 株式会社立佳 一种分离生物样品的仪器及其分离方法
CN1613542A (zh) * 2003-03-21 2005-05-11 Steag显微部件股份有限公司 从含有微粒的液体中分离出液态成分的微结构分离装置和微液方法
CN1856366A (zh) * 2003-08-05 2006-11-01 贝克顿·迪金森公司 收集生物流体样品及处理选定成分的装置和方法
US20080028821A1 (en) * 2004-08-09 2008-02-07 Yasuhiro Horiike Blood Analysis Apparatus and Blood Analysis Method
CN101909760A (zh) * 2007-11-01 2010-12-08 加利福尼亚大学董事会 收集管装置、系统和方法
CN103974777A (zh) * 2011-11-01 2014-08-06 朴铉贞 可迅速离心分离的离心分离用容器
CN105998067A (zh) * 2010-03-11 2016-10-12 安托万·图瑞兹 伤口修复剂组合物的制备工艺、管子及装置
CN106582908A (zh) * 2016-11-30 2017-04-26 深圳市达科为生物工程有限公司 一种富血小板血浆快速分离装置及方法
CN108008122A (zh) * 2016-10-31 2018-05-08 希森美康株式会社 测定用盒体以及送液方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040182795A1 (en) 2003-03-21 2004-09-23 Randel Dorian Apparatus and method for concentration of plasma from whole blood
US7220593B2 (en) 2002-10-03 2007-05-22 Battelle Memorial Institute Buffy coat separator float system and method
KR20140136277A (ko) * 2013-05-20 2014-11-28 삼성전자주식회사 미세유동장치

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1613542A (zh) * 2003-03-21 2005-05-11 Steag显微部件股份有限公司 从含有微粒的液体中分离出液态成分的微结构分离装置和微液方法
CN1856366A (zh) * 2003-08-05 2006-11-01 贝克顿·迪金森公司 收集生物流体样品及处理选定成分的装置和方法
CN1603820A (zh) * 2003-09-29 2005-04-06 株式会社立佳 一种分离生物样品的仪器及其分离方法
US20080028821A1 (en) * 2004-08-09 2008-02-07 Yasuhiro Horiike Blood Analysis Apparatus and Blood Analysis Method
CN101909760A (zh) * 2007-11-01 2010-12-08 加利福尼亚大学董事会 收集管装置、系统和方法
CN105998067A (zh) * 2010-03-11 2016-10-12 安托万·图瑞兹 伤口修复剂组合物的制备工艺、管子及装置
CN103974777A (zh) * 2011-11-01 2014-08-06 朴铉贞 可迅速离心分离的离心分离用容器
CN108008122A (zh) * 2016-10-31 2018-05-08 希森美康株式会社 测定用盒体以及送液方法
CN106582908A (zh) * 2016-11-30 2017-04-26 深圳市达科为生物工程有限公司 一种富血小板血浆快速分离装置及方法

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TINGJIE LI等: "《Out-of-plane microvalves for whole blood separation on lab-on-a-CD》", 《JOURNAL OF MICROMECHANICS AND MICROENGINEERING》 *

Also Published As

Publication number Publication date
EP3840878A1 (en) 2021-06-30
US20240197976A1 (en) 2024-06-20
AU2019325155A1 (en) 2021-04-15
JP2021536583A (ja) 2021-12-27
BR112021003289A2 (pt) 2021-05-18
US20200064329A1 (en) 2020-02-27
US11944735B2 (en) 2024-04-02
MX2021002115A (es) 2021-06-23
MX2024014368A (es) 2024-12-06
US11638918B2 (en) 2023-05-02
WO2020040945A1 (en) 2020-02-27
US20230241608A1 (en) 2023-08-03
ZA202101462B (en) 2024-03-27
CA3110351A1 (en) 2020-02-27

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