CN112641863A - 一种用于治疗男性精子成活率低的中药丸剂 - Google Patents

一种用于治疗男性精子成活率低的中药丸剂 Download PDF

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CN112641863A
CN112641863A CN202110047527.XA CN202110047527A CN112641863A CN 112641863 A CN112641863 A CN 112641863A CN 202110047527 A CN202110047527 A CN 202110047527A CN 112641863 A CN112641863 A CN 112641863A
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parts
kidney
deficiency
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patients
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雷明
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Abstract

本申请涉及一种用于治疗男性精子成活率低的中药丸剂，包括如下原料药物：胎盘，阿胶，龟板胶，鹿角胶，丹参，肉苁蓉，益母草，鱼鳔，山药，山萸肉，何首乌，桑葚，杜仲，菟丝子，枸杞子，女贞子，肉桂，蛇床子，附子，巴戟天，蜂蜜。对于严重肾阳偏虚者加狗肾、仙茅、覆盆子；严重肾阴偏虚者加旱莲草、牡丹皮、熟地黄；对于严重气虚者加党参、黄芪；严重瘀血者加三棱、莪术。全方气、血、阴、阳兼顾，气血阴阳双补，温肾益气，养阴生精，补中寓清，滋而不腻，在滋补肾气阴阳同时辅以健脾益气，养血活血通络药物，则阴阳调和，气血充精生而使精子成活力增加。

Description

一种用于治疗男性精子成活率低的中药丸剂
技术领域
本发明涉及中药领域，具体涉及一种用于治疗男性精子成活率低的中药丸剂。
背景技术
精子的运动功能或运动能力的强弱直接关系到人类的生殖繁衍，只有正常作前向运动的精子才能确保精子抵达输卵管壶腹部与卵子结合形成受精卵。
现代西医检测标准中，健康男性精液中正常形态精子在30％左右。精子活力低下又称弱精症，是指精液参数中前向运动的精子小于50％或a级运动的精子小于25％的病症(国际分级法中III级精子少于25％)，弱精子症是精子质量低下最主要的类型，常与其它的精液异常症同时出现。精子密度越高、a级活动力精子率越高，顶体酶的活性就越高。因此，精子的密度、a级活性可作为判断男性生育能力的指标。
中医无弱精症病名, 但弱精症可见于“精寒”、“精冷”等证。因此，中医认为，男性精子的生成、与有无精子活力的强弱，关键就在于肾阳，所以，肾阳不足，精冷无力、或是因肾阴亏损，而引起精子活力低下；或是本身气虚血弱、及湿热内蕴精室，都可能引起男性精子活力低下。
西医治疗精子成活率低通常给予抗氧化治疗，如维生素C和维生素E，通过减少生精系统的氧化应激损伤，然后通过口服左卡尼汀，增加附睾运送精子过程的能量，从而增加精子的活力和活动力。中医主要是根据患者具体情况来治疗，如肾阳或者肾阴亏损，常见中成药如金匮肾气丸、左归丸等，往往不能针对具体辩证随症加减，不能适应更多患者，因此，提供一种在基本方剂基础上辩证加减的方剂很有必要。
发明内容
本发明的目的在于：提供一种治疗男性精子成活率低的中药丸剂及其制备方法，解决上述背景技术中提出的现有药物适应范围小、不能很好的辩证加减的问题。
本发明采用的技术方案如下：
一种治疗男性精子成活率低的中药丸剂滋肾双补丸基础方，包括如下重量份数原料药：胎盘20-40，阿胶20-40，龟板胶20-40，鹿角胶20-40，丹参20-40，肉苁蓉40-60，益母草20-40，鱼鳔40-60，山药20-40，山萸肉40-60，何首乌20-40，桑葚20-40，杜仲40-60，菟丝子40-60，枸杞子40-60，女贞子20-40，肉桂20-40，蛇床子20-40，附子20-40，巴戟天40-60，蜂蜜800-1200。对于严重肾阳偏虚者加狗肾20-40、仙茅20-40、覆盆子20-40；严重肾阴偏虚者加旱莲草、牡丹皮、熟地黄各20-40；严重气虚者加党参、黄芪各20-40；严重瘀血者加三棱、莪术各20-40。
中医理论认为：肾为先天之本，主生殖，藏生殖之精，藏元阴元阳，是发育生殖之源，其生存依赖于肾阴的滋养和肾阳的温煦，取决于肾中阴阳的盛衰。故治疗当以调补阴阳，益肾生精为要。肾阴阳是相互依存、相互制约的,阴损及阳，阳损及阴。无阳则阴无以生,无阴则阳无以化, 阳虚则精子失其温煦凝滞不动；阴虚则化精无源，精子形态缺陷，故可引起精子畸形率高。而现代男性嗜酒、嗜食肥甘者众, 且大多病程较长, 因此本病多兼脾虚、瘀血，因此，治疗时加入健脾益气，养血活血药物至关重要。
滋肾双补丸01号中重用菟丝子、巴戟天、鱼鳔、肉苁蓉、杜仲、蛇床子、枸杞子、制何首乌、鹿角胶、龟板胶、桑葚、女贞子、山萸肉，以达阴阳双补之功。其中，菟丝子、巴戟天滋肾生精；鱼鳔、肉苁蓉、杜仲、蛇床子温补肾阳，滋肾、补肾鼓动肾气，提高生精功能；枸杞子、何首乌补肝肾之阴，为生精血提供物质基础；鹿角胶、龟板胶填精固肾益髓；桑葚、女贞子、山萸肉滋补肾阴；附子、肉桂补火助阳，相互配合可增强滋阴效果，通过阳气运化以增强补阴功效；山药健脾益气，壮后天以养先天；胎盘、阿胶、益母草、丹参补气养血、活血调经。全方气、血、阴、阳兼顾，气血阴阳双补，温肾益气，养阴生精，补中寓清，滋而不腻，在滋补肾气阴阳同时辅以健脾益气，养血活血通络药物，则阴阳调和，气血充精生而使精子成活力增加。现代药理研究也证实, 补肾中药如菟丝子、淫羊藿等有雄性激素样作用, 能促进性腺功能及精液分泌。滋肾双补丸临床应用，确有改善精液质量，促进精子生成，增加精子数量，提高精子活力、活率的效果。
对于严重肾阳偏虚者加狗肾、仙茅、覆盆子（滋肾双补丸02号）；严重肾阴偏虚者加旱莲草、牡丹皮、熟地黄（滋肾双补丸03号）；对于严重气虚者加党参、黄芪；严重瘀血者加三棱、莪术。
原料药来源、功效、性味归经。
胎盘：又叫胞衣、衣胞、紫河车、胎衣、胎膜。胎盘（placenta）是后兽类和真兽类哺乳动物妊娠期间由胚胎的胚膜和母体子宫内膜联合长成的母子间交换物质的过渡性器官，为健康产妇娩出之胎盘。性味：甘咸、温。功能主治：补气，养血，益精。用于虚损、羸瘦、咳血气喘、劳热骨蒸、遗精等症。
阿胶：来源：马科动物驴Equus Asinus L.的皮经煎煮、浓缩制成的固体胶。性味：甘，平。归肺、肝、肾经。功能主治：补血滋阴，润燥，止血。用于血虚萎黄，眩晕心悸，肌痿无力，心烦不眠，虚风内动，肺燥咳嗽，劳嗽咯血，吐血尿血，便血崩漏，妊娠胎漏。
龟板胶：来源：龟科动物乌龟Chinemys reevesii （Gray）的背甲及腹甲。龟板胶为乌龟腹甲经煎熬、浓缩制成的固体胶。性味：偏平和，甘而咸。功能主治：滋阴潜阳、益肾健骨的作用，并兼补血止血。常用于肾阴不足引起的骨蒸潮热、盗汗。
鹿角霜：来源：鹿科动物梅花鹿或马鹿的角Cornu Cervi Degelatinatum熬制鹿角胶后剩余的骨渣，即本品为鹿角去胶质的角块（熬制鹿角胶剩下的骨渣）。性味：咸，温。归肝、肾经。功能主治：温肾助阳，收敛止血。用于脾肾阳痿，食少吐泻，白带，遗尿尿频，崩漏下血，痈疽痰核。
丹参：来源：唇形科植物丹参Salvia miltiorrhiza Bunge. 的干燥根及根茎。性味：苦，微寒。归心、肝经。功能主治：祛瘀止痛，活血通经，清心除烦。用于月经不调，经闭痛经，症瘕积聚，胸腹刺痛，热痹疼痛，疮疡肿痛，心烦不眠；肝脾肿大，心绞痛。
大云，即肉苁蓉。来源：列当科植物肉苁蓉Cistanche deserticola Y.C.Ma的干燥带鳞叶的肉质茎。性味：甘、咸，温。归肾、大肠经。功能主治：补肾阳，益精血，润肠通便。用于阳痿，不孕，腰膝酸软，筋骨无力，肠燥便秘。
益母草：来源：唇形科植物益母草Leonurus japonicus Houtt. 的新鲜或干燥地上部分。性味：苦、辛，微寒。归肝、心包经。功能主治：活血调经，利尿消肿。用于月经不调，痛经，经闭，恶露不尽，水肿尿少；急性肾炎水肿。
鱼鳔：来源：鲟形目鲟科施氏鲟Acipenser schrencki Brandt；中华鲟A.sinensis Gray，以鳔入药。性味：甘，平。归肾经。功能主治：补肾益精，滋养筋脉，止血，散瘀，消肿。治肾虚滑精，产后风痉，破伤风，吐血，血崩，创伤出血，痔疮。
山药：来源：薯蓣科植物薯蓣Dioscorea opposita Thunb. 的干燥根茎。性味：甘，平。归脾、肺、肾经。功能主治：补脾养胃，生津益肺，补肾涩精。用于脾虚食少，久泻不止，肺虚喘咳，肾虚遗精，带下，尿频，虚热消渴。麸炒山药补脾健胃。用于脾虚食少，泄泻便溏，白带过多。
山萸肉：来源：山茱萸科植物山茱萸Cornus officinalis Sieb. et Zucc. 的干燥成熟果肉。性味：酸、涩，微温。归肝、肾经。功能主治：补益肝肾，涩精固脱。用于眩晕耳鸣，腰膝酸痛，阳痿遗精，遗尿尿频，崩漏带下，大汗虚脱。内热消渴。
何首乌：来源：蓼科植物何首乌Polygonum multiflorum Thuna.的块根。性味：苦、甘、涩，温。归肝、心、肾经。功能主治：补肝肾，益精血，乌须发，强筋骨。用于血虚萎黄，眩晕耳鸣，须发早白，腰膝酸软，肢体麻木，崩漏带下，久疟体虚；高血脂。
桑葚：来源：桑科植物桑Morus alba L.的果穗。性味：寒、甘、酸。归肝、肾经。功能主治：滋阴养血；生津；润肠。主肝肾不足和血虚精亏的头晕目眩；腰酸耳鸣；须发早白；失眠多梦；津伤口渴；消渴；肠燥便秘。
杜仲：来源：杜仲科植物杜仲Eucommia ulmoides Oliv. 的干燥树皮。性味：甘，温。归肝、肾经。功能主治：补肝肾，强筋骨，安胎。用于肾虚腰痛，筋骨无力，妊娠漏血，胎动不安；高血压。
菟丝子：来源：旋花科植物菟丝子Cuscuta chinensis Lam. 的干燥成熟种子。性味：甘，温。归肝、肾、脾经。功能主治：滋补肝肾，固精缩尿，安胎，明目，止泻。用于阳痿遗精，尿有余沥，遗尿尿频，腰膝酸软，目昏耳鸣，肾虚胎漏，胎动不安，脾肾虚泻；外治白癜风。
枸杞：来源：茄科植物宁夏枸杞Lycium barbarum L. 的干燥成熟果实。性味：甘，平。归肝、肾经。功能主治：滋补肝肾，益精明目。用于虚劳精亏，腰膝酸痛，眩晕耳鸣，内热消渴，血虚萎黄，目昏不明。
女贞子：来源：木犀科植物女贞Ligustrum lucidum Ait. 的干燥成熟果实。性味：甘、苦，凉。归肝、肾经。功能主治：滋补肝肾，明目乌发。用于眩晕耳鸣，腰膝酸软，须发早白，目暗不明。
肉桂：来源：樟科植物肉桂Cinnamomum cassia Presl 的干燥树皮。性味：辛、甘，大热。归肾、脾、心、肝经。功能主治：补火助阳，引火归源，散寒止痛，活血通经。用于阳痿，宫冷，腰膝冷痛，肾虚作喘，阳虚眩晕，目赤咽痛，心腹冷痛，虚寒吐泻，寒疝，奔豚，经闭，痛经。
蛇床子：来源：伞形科植物蛇床Cnidium monnieri （L.）Cuss.的干燥成熟果实。性味：辛、苦，温；有小毒。归肾经。功能主治：温肾壮阳，燥湿，祛风，杀虫。用于阳痿，宫冷，寒湿带下，湿痹腰痛；外治外阴湿疹，妇人阴痒；滴虫性阴道炎。
附子：来源：毛茛科植物乌头Aconitum carmichaeli Debx.的子根的加工品。性味：辛、甘，大热；有毒。归心、肾、脾经。功能主治：回阳救逆，补火助阳，逐风寒湿邪。用于亡阳虚脱，肢冷脉微，阳萎，宫冷，心腹冷痛，虚寒吐泻，阴寒水肿，阳虚外感，寒湿痹痛。
巴戟天：来源：茜草科植物巴戟天Morinda officinalis How 的干燥根。性味：甘，辛，微温。
归肾、肝经。功能主治：补肾阳，强筋骨，祛风湿。用于阳痿遗精，宫冷不孕，月经不调，少腹冷痛，风湿痹痛，筋骨痿软。
蜂蜜：来源：蜜蜂科昆虫中华蜜蜂 Apis cerana Fabricius或意大利蜂APismellifera Linnaeus所酿的蜜。性味：甘，平。归肺、脾、大肠经。功能主治：补中，润燥，止痛，解毒。用于脘腹虚痛，肺燥干咳，肠燥便秘；外治疮疡不敛，水火烫伤。常作为丸剂的辅料。
狗肾：来源：犬科动物犬Canis familiaris L.（雄性）的干燥阴茎和睾丸。性味：咸，大热。功能主治：暖肾，壮阳，益精。用于肾虚阳痿，遗精，腰膝酸软。
仙茅：来源：石蒜科植物仙茅Curculigo orchioides Gaertn. 的干燥根茎。性味：辛，热；有毒。归肾、肝、脾经。功能主治：补肾阳，强筋骨，祛寒湿。用于阳痿精冷，筋骨痿软，腰膝冷痹，阳虚冷泻。
覆盆子：来源：本品为蔷薇科悬钩子属植物华东覆盆子Rubus chingii Hu的干燥果实。夏初果实由绿变绿黄时采收，除去梗、叶，置沸水中略烫或略蒸，取出，干燥。性味甘、酸，温。归经归肾、膀胱经。功能主治：益肾，固精，缩尿。用于肾虚遗尿，小便频数，阳痿早泄，遗精滑精。
旱莲草：来源：本品为菊科植物鳢肠Eclipta prostrata L.的干燥地上部分。花开时采割，晒干。性味甘、酸，寒。归经归肾、肝经。功能主治：滋补肝肾，凉血止血。用于牙齿松动，须发早白，眩晕耳鸣，腰膝酸软，阴虚血热、吐血、衄血、尿血，血痢，崩漏下血，外伤出血。
牡丹皮：来源：本品为毛茛科植物牡丹Paeonia suffruticosa Andr.的干燥根皮。秋季采挖根部，除去细根，剥取根皮，晒干。性味苦、辛，微寒。归经归心、肝、肾经。功能主治：清热凉血，活血化瘀。用于温毒发斑，吐血衄血，夜热早凉，无汗骨蒸，经闭痛经，痈肿疮毒，跌扑伤痛。
熟地黄：来源：本品为生地黄的炮制加工品。性状本品为不规则的块片、碎块，大小、厚薄不一。表面乌黑色，有光泽，黏性大。质柔软而带韧性，不易折断，断面乌黑色，有光泽。无臭，味甜。归经归肝、肾经。功能主治：滋阴补血，益精填髓。用于肝肾阴虚，腰膝酸软，骨蒸潮热，盗汗遗精，内热消渴，血虚萎黄，心悸怔忡，月经不调，崩漏下血，眩晕，耳鸣，须发早白。
党参：来源：本品为桔梗科植物党参 Codonopsis pilosula （Franch.） Nannf.、素花党参（西党参）Codonopsis pilosula Nannf. var. modesta （Nannf.） L. T. Shen或川党参Codonopsis tangshen Oliv.的干燥根。秋季采挖，洗净，晒干。性味甘，平。归经归脾、肺经。功能主治：补中益气，健脾益肺。用于脾肺虚弱，气短心悸，食少便溏，虚喘咳嗽，内热消渴。
黄芪：来源：豆科黄芪属植物膜荚黄芪Astragalus membranaceus （Fisch.）Bunge 及内蒙古黄芪A. mongholicus Bunge的根。性味：甘，微温。归脾、肺经。功能主治：补气升阳，益卫固表，托毒生肌，利水消肿。主治体虚自汗，久泻，脱肛，子宫脱垂，慢性肾炎，体虚浮肿，慢性溃疡，疮口久不愈合。
三棱：来源：本品为黑三棱科植物黑三棱Sparganium stoloniferum Buch.-Ham.的干燥块茎。冬季至次年春采挖，洗净，削去外皮，晒干。性味辛、苦，平。归经归肝、脾经。功能主治破血行气，消积止痛。用于症瘕痞块，瘀血经闭，食积胀痛。
莪术：来源：姜科植物蓬莪术Curcuma phaeocaulis Val.、广西莪术Curcumakwangsiensis S.G.Lee et C.F.Liang或温郁金Curcuma wenyujin Y.H.Chen et C.Ling的干燥根茎。性温，味辛、苦。归脾经、肝经。功能主治：行气破血、消积止痛。属于活血化瘀药下属的破血消癥药。
病例来源情况：
选取某医院近2年部分门诊及住院病例中的280例精子成活率低患者。中医整体观察辨证，精子活动力低下症多属肾虚, 对少数不属肾虚者未纳入本组。本组在治疗中将肾虚者分为3型, 临床中，肾虚者分为3种类型, 即肾阳虚型、肾阴虚型、肾阴阳两虚型。年龄最小者25岁，最大者45岁，平均年龄为26.7±3.4岁；病程最短者1.5年，最长者16年，平均病程5.0±2.8年；睾丸容积最小者为8ml, 最大者26ml, 平均为14.2±2.6ml。精液常规检查白细胞>15个Hp者62例，占21.43 %；性生活过频(每周4次以上)者40例，占14.29 %；婚前有手淫史者50例，占17.86%。本组280例中肾阴阳两虚型100例，占35.71%，采用滋肾双补丸01号方治疗；肾阴虚型计90 例，占32.14%，采用滋肾双补丸03号方治疗；肾阳虚型计90例，占32.14%，采用滋肾双补丸02号方。每日2次，早晚口服各10克，服药期间禁食辛辣食物以及其他药物。3个月为1疗程。治疗前及疗程结束后各检查1 次精液常规。
治疗方药：基本方（滋肾双补丸01号）按重量份：胎盘30，阿胶30，龟板胶30，鹿角胶30，丹参30，肉苁蓉50，益母草30，鱼鳔50，山药30，山萸肉50，何首乌30，桑葚30，杜仲50，菟丝子50，枸杞子50，女贞子30，肉桂30，蛇床子30，附子30，巴戟天50，蜂蜜1000。肾阳偏虚者加狗肾、仙茅、覆盆子各30；肾阴偏虚者加旱莲草、牡丹皮、熟地黄各30；严重气虚者加党参、黄芪各30；严重瘀血者加三棱、莪术各30。
具体实施方式
具体实施例1：
一种治疗男性精子成活率低的中药丸剂滋肾双补丸基础方，包括如下重量份数原料药：胎盘20-40，阿胶20-40，龟板胶20-40，鹿角胶20-40，丹参20-40，肉苁蓉40-60，益母草20-40，鱼鳔40-60，山药20-40，山萸肉40-60，何首乌20-40，桑葚20-40，杜仲40-60，菟丝子40-60，枸杞子40-60，女贞子20-40，肉桂20-40，蛇床子20-40，附子20-40，巴戟天40-60，蜂蜜800-1200。对于严重肾阳偏虚者加狗肾20-40、仙茅20-40、覆盆子20-40；严重肾阴偏虚者加旱莲草、牡丹皮、熟地黄各20-40；严重气虚者加党参、黄芪各20-40；严重瘀血者加三棱、莪术各20-40。
制备方法：取上述原料药，水洗，灭菌，干燥，粉碎，过筛，混合均匀；炼蜜，再加入水制成蜂蜜水，之后与药粉混合泛丸机制成水蜜丸，即得。
进一步的，取上述原料药，水洗，微波灭菌，干燥，粉碎，过110-120目筛，混合均匀；炼蜜到130-140℃，含水量为12-14%，再按蜂蜜：水1:4-1:5的重量比加入水，制成蜂蜜水，然后按药粉：蜜水1:1.3-1.5的重量比，混合均匀入泛丸机制成水蜜丸，水蜜丸300粒重40克。
具体实施例2：
一种治疗男性精子成活率低的中药丸剂滋肾双补丸基础方，包括如下重量份数原料药：胎盘30，阿胶30，龟板胶30，鹿角胶30，丹参30，肉苁蓉50，益母草30，鱼鳔50，山药30，山萸肉50，何首乌30，桑葚30，杜仲50，菟丝子50，枸杞子50，女贞子30，肉桂30，蛇床子30，附子30，巴戟天50，蜂蜜1000。对于严重肾阳偏虚者加狗肾30、仙茅30、覆盆子30；严重肾阴偏虚者加旱莲草、牡丹皮、熟地黄各30；严重气虚者加党参、黄芪各30；严重瘀血者加三棱、莪术各30。
制备方法：取上述原料药，水洗，灭菌，干燥，粉碎，过筛，混合均匀；炼蜜，再加入水制成蜂蜜水，之后与药粉混合泛丸机制成水蜜丸，即得。
进一步的，取上述原料药，水洗，微波灭菌，干燥，粉碎，过110-120目筛，混合均匀；炼蜜到130-140℃，含水量为12-14%，再按蜂蜜：水1:4-1:5的重量比加入水，制成蜂蜜水，然后按药粉：蜜水1:1.3-1.5的重量比，混合均匀入泛丸机制成水蜜丸，水蜜丸300粒重40克。
治疗结果1
本组280例服药最短者50天, 最长者260天, 平均服药时间为135.7±90.0天。本组病例各证型间的疗效未见明显差异。治疗前后精液常规变化见下表1。
表1 治疗前后精液常规指标比较(x±s)例(%)
精子密度(×10<sup>6</sup> ml) A级精子(%) B级精子(%) C级精子(%)
治疗前 13.5±0.6 18.3±0.9 11.8±1.3 25.7±7.8
治疗后 23.8±0.5<sup>#</sup> 40.2±1.0<sup>#</sup> 20.0±1.9<sup>#</sup> 57.1±3.0<sup>#</sup>
注:与治疗前比较, #P<0.05 。
由1表可知，治疗3个月后，患者精子密度、成活率、（A+B）级精子所占比例均显著升高，精子畸形率显著降低。由此可知，本发明药物可用于治疗男性不育症，疗效显著。
治疗结果2
还对治愈情况进行了统计，判断标准为无效、有效和显效。
无效：治疗后患者症状未改善；
有效：治疗后患者症状得到改善；
显效：治疗后患者症状完全消失；
有效率=（显效+有效）/总例数*100%。
统计结果见表2。
表2 治愈情况统计
n 显效 有效 无效 总有效率
280 226 30 14 95%
由表2可见，本发明药物可用于男性不育症，治疗效果显著，治愈率高、起效快、副作用小、疗程短。280 例均为精子活动力低下症患者, 经用滋肾双补丸后其妻怀孕或分娩。
典型病例：
1、李某，男，32岁，公司职员，2020年5月就诊。自述婚后3年未孕，夫妇同居，妻子检查身体正常。李某精液检查清冷，睾丸较小而质软。具体化验精液常规：精液量1.4 ml，灰白色，精子密度13.8×106ml, 活动率42%, A级16%, B级11%。精神萎靡，性欲减退，时有腰酸、乏力，舌苔白腻，脉细略数。证属肾阴亏虚。被诊断为男性不育症，精子活力低下。服用滋肾双补丸03号方共计1个月后，诸症明显减轻。继续服用该药2个月, 复查精液，检测结果：精液量2.6ml, 精子密度40×106ml, 精子活动力70%,A级28%, B级32%。继服上方半年, 其妻怀孕。
2、张某，男，38岁，被诊断为男性不育症，腰膝酸软，健忘盗汗，性欲减退，阴囊潮湿，舌质偏黯，苔腻，证属肾阳虚严重。服用本发明药物滋肾双补丸02号1个月后，腰膝酸软消失，性欲明显改善，继续服用至3个月，各症状恢复正常，随后每疗程随访1次，持续2年半，没有复发。
3、田某，男，28岁，自述半年来腰膝酸软，尤其是晨起加重。畏寒、肢冷、乏力、精神萎靡、性功能障碍。被诊断为男性不育症，精子活力低下。证属阴阳两虚。服用滋肾双补丸01号方，共计1个疗程后，诸症减轻。继续服用该药2个月, 复查，诸症明显减轻。继续服用本发明药物半年后，精神状态改善，腰膝酸软几乎消失，性欲明显改善，性生活正常。
与现有技术相比，本发明所述药物全方气、血、阴、阳兼顾，气血阴阳双补，温肾益气，养阴生精，补中寓清，滋而不腻，在滋补肾气阴阳同时辅以健脾益气，养血活血通络药物，则阴阳调和，气血充精生而使精子成活力增加。同时可显著改善肾虚腰痛，阳萎不举，精神萎靡，少气乏力等症，疗效显著，安全无副作用。
对于本领域技术人员而言，显然本发明不限于上述示范性实施例的细节，而且在不背离本发明的精神或基本特征的情况下，能够以其他的具体形式实现本 发明。因此，无论从哪一点来看，均应将实施例看作是示范性的，而且是非限 制性的，本发明的范围由所附权利要求而不是上述说明限定，因此旨在将落在 权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。

Claims (6)

1.一种用于治疗男性精子成活率低的中药丸剂，包括如下重量份数的原料药物：胎盘20-40，阿胶20-40，龟板胶20-40，鹿角胶20-40，丹参20-40，肉苁蓉40-60，益母草20-40，鱼鳔40-60，山药20-40，山萸肉40-60，何首乌20-40，桑葚20-40，杜仲40-60，菟丝子40-60，枸杞子40-60，女贞子20-40，肉桂20-40，蛇床子20-40，附子20-40，巴戟天40-60，蜂蜜800-1200。
2.一种用于治疗男性精子成活率低的中药丸剂，包括如下重量份数的原料药物：胎盘30，阿胶30，龟板胶30，鹿角胶30，丹参30，肉苁蓉50，益母草30，鱼鳔50，山药30，山萸肉50，何首乌30，桑葚30，杜仲50，菟丝子50，枸杞子50，女贞子30，肉桂30，蛇床子30，附子30，巴戟天50，蜂蜜1000。
3.如权利要求1或2所述的中药丸剂，对于严重肾阳偏虚者加狗肾20-40、仙茅20-40、覆盆子20-40；严重肾阴偏虚者加旱莲草、牡丹皮、熟地黄各20-40；严重气虚者加党参、黄芪各20-40；严重瘀血者加三棱、莪术各20-40。
4.权利要求3所述的中药丸剂，对于严重肾阳偏虚者加狗肾30、仙茅30、覆盆子30；严重肾阴偏虚者加旱莲草、牡丹皮、熟地黄各30；严重气虚者加党参、黄芪各30；严重瘀血者加三棱、莪术各30。
5.如权利要求1-4任一所述的中药丸剂的制备方法，取上述原料药，水洗，灭菌，干燥，粉碎，过筛，混合均匀；炼蜜，再加入水制成蜂蜜水，之后与药粉混合泛丸机制成水蜜丸，即得。
6.如权利要求5所述的中药丸剂的制备方法，取上述原料药，水洗，微波灭菌，干燥，粉碎，过110-120目筛，混合均匀；炼蜜到130-140℃，含水量为12-14%，再按蜂蜜：水1:4-1:5的重量比加入水，制成蜂蜜水，然后按药粉：蜜水1:1.3-1.5的重量比，混合均匀入泛丸机制成水蜜丸，水蜜丸300粒重40克。
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CN108478769A (zh) * 2018-05-28 2018-09-04 王代金 一种治疗男性不育症的药物及其制作方法

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