CN112616863A - Disinfectant preparation process - Google Patents
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- CN112616863A CN112616863A CN202011509522.6A CN202011509522A CN112616863A CN 112616863 A CN112616863 A CN 112616863A CN 202011509522 A CN202011509522 A CN 202011509522A CN 112616863 A CN112616863 A CN 112616863A
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- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
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Abstract
The invention discloses a disinfectant preparation process, which selects the following raw materials: radix sophorae flavescentis, baicalin, berberine, honeysuckle, aloe, triclosan, a modified auxiliary agent, a buffer solution and a compound iodine solution. The disinfectant is prepared by compounding radix sophorae flavescentis and berberine, radix sophorae flavescentis and baicalin, radix sophorae flavescentis and honeysuckle, baicalin and berberine, honeysuckle and berberine, and the synergistic effect is shown, in addition, aloe extracts are added into the raw materials, aloin A, wound hormone, polypeptide mannan and the like in aloe juice have the functions of resisting virus infection and diminishing inflammation and sterilizing, in addition, the modification auxiliary agent is added into the prepared plant disinfectant, the clarity of the disinfectant can be effectively improved while the disinfection effect of the disinfectant is not influenced, the quality of the disinfectant is further improved, the disinfection effect of the disinfectant can be greatly improved after the compounding of the compound iodine solution is utilized, and the bacteriostasis duration is greatly improved.
Description
Technical Field
The invention relates to the technical field of disinfectant, in particular to a process for preparing a disinfectant.
Background
The sterilization mechanism is to release nascent atomic oxygen and oxidize active groups in thalli; the sterilization is characterized by fast and strong action and can kill all microorganisms including bacterial spores and viruses. Mainly uses surface disinfection, such as chlorine dioxide, hydrogen peroxide, ozone, sodium hypochlorite and the like, and the disinfectants are sterilizing agents.
The Chinese patent publication No. CN104719356A provides a disinfectant and a preparation method thereof, which comprises the following raw materials by weight: 25-35g of folium artemisiae argyi, 20-30g of clove, 25-35g of fructus amomi, 15-25g of radix sophorae flavescentis, 20-30g of fructus schisandrae, 20-30g of fructus forsythiae and 8-12g of liquorice; in the scheme, a plurality of traditional Chinese medicine raw materials are mixed twice and boiled with water, and the two filtered extracting solutions are mixed to obtain a disinfectant;
most of traditional disinfectant is chemical disinfectant, which has large skin irritation to users, and the disinfection effect of the disinfectant is not ideal, and the bacteriostasis time is short; the traditional Chinese medicine disinfectant in the comparison scheme has weak disinfection capability and small sterilization range, does not play a role in fungi and viruses with strong vitality and strong infectivity, and provides a disinfectant preparation process for solving the problems.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a process for preparing a disinfectant, which comprises the steps of selecting the raw materials of the disinfectant as sophora flavescens, baicalin, berberine, honeysuckle, aloe, triclosan, a modification auxiliary agent, a buffer solution and a compound iodine solution, taking escherichia coli and staphylococcus aureus as tested bacteria, compounding the sophora flavescens and the berberine, the sophora flavescens and the baicalin, the sophora flavescens and the honeysuckle, the baicalin and the berberine, and the compounded compounds of the scutellaria baicalensis and the berberine to show synergistic action on the bacteria, and in addition, by adding an aloe extract into the raw materials, the aloe has the effects of diminishing inflammation, resisting bacteria, enhancing skin elasticity, protecting skin mucous membranes, preventing acnes, preventing freckles and wrinkles, cleaning skin, resisting seborrhea skin, preventing suppurative dermatosis, moisturizing the skin, preventing aging, arresting sweating and removing sweat, solves the problems that the traditional, the disinfection effect of the disinfectant is not ideal, and the bacteriostasis time is short; the traditional Chinese medicine disinfectant in the comparison scheme has weak disinfection capability and small sterilization range and does not work for some fungi and viruses with strong vitality and strong infectivity.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: a manufacturing process of a disinfectant specifically comprises the following steps:
step one, selecting raw materials of a disinfectant: radix sophorae flavescentis, baicalin, berberine, honeysuckle, aloe, triclosan, a modified auxiliary agent, a buffer solution and a compound iodine solution;
step two, respectively mashing radix sophorae flavescentis and aloe to obtain juice, filtering to obtain radix sophorae flavescentis extract and aloe extract, drying and grinding honeysuckle to obtain honeysuckle extract for later use;
adding the baicalin, the berberine and the honeysuckle extract into a vortex mixer, mixing for 5min at the rotating speed of 3000r/min, uniformly mixing the three raw materials, adding the modification auxiliary agent into the mixed raw materials, continuously mixing for 3min at the same rotating speed, taking out the mixed raw materials, putting the mixed raw materials into a round-neck flask provided with a mechanical stirring device, putting the round-neck flask into a water bath constant-temperature oscillator, and stirring and dissolving for 30min in a constant-temperature water bath at the temperature of 70 ℃ to obtain a component A;
step four, adding triclosan dropwise into the ethanol solution, and uniformly stirring to obtain a component B;
step five, dripping the sophora flavescens extract and the aloe extract into a buffer solution, and stirring and dissolving the mixed solution in a water bath constant-temperature oscillator in a constant-temperature water bath at the temperature of 50 ℃ for 60min to obtain a component C;
step six, dropwise adding the component B into the component A, stirring for 30min by using a mechanical stirring device at the rotation speed of 1800r/min, dropwise adding the component C into a mixed solution of the component A and the component B, and continuously stirring for 30min by using the mechanical stirring device at the same rotation speed to obtain an intermediate;
and step seven, compounding the intermediate and the compound iodine solution, and stirring and dissolving for 60min in a water bath constant temperature oscillator in a constant temperature water bath at the temperature of 50 ℃ to obtain the disinfectant.
Preferably, in the first step, the disinfectant comprises the following raw materials in parts by weight: 10-20 parts of radix sophorae flavescentis, 4-5 parts of baicalin, 1-2 parts of berberine, 1-2 parts of honeysuckle, 6-10 parts of aloe, 1-3 parts of triclosan, 2-5 parts of a modification auxiliary agent, 1-3 parts of a buffer solution and 10-18 parts of a compound iodine solution.
Preferably, in the third step, the modification auxiliary agent with the concentration of 3% is adopted, and in the fourth step, the consumption volume ratio of the triclosan to the ethanol solution is 3: 10.
preferably, the buffer is prepared by the following method:
preparing 0.2mol/L methyl solution from sodium dihydrogen phosphate dodecahydrate by using double distilled water;
taking disodium hydrogen phosphate, and preparing the disodium hydrogen phosphate into 0.2mol/L solution B by using double distilled water;
the buffer solution is obtained by compounding the solution A and the solution B according to the volume ratio of 7: 5.
Preferably, the modification assistant is prepared by the following method:
step A1, introducing dried chloroplatinic acid and distilled isopropanol into a conical flask provided with a mechanical stirring device, and stirring the chloroplatinic acid and the isopropanol for 20-30min by using the mechanical stirring device to obtain a catalyst;
step A2, adding allyl polyether and hydrogen-containing silicone oil into a 250mL three-neck flask provided with a nitrogen inlet, a magnetic stirrer and a thermometer, introducing nitrogen into the three-neck flask to discharge air and water in the three-neck flask, setting the temperature of the three-neck flask to be 75 ℃, dropwise adding a catalyst, carrying out stirring reaction for 4-6h by using the magnetic stirrer, and after the internal reaction of the three-neck flask is finished, carrying out reduced pressure distillation to remove low-boiling-point substances to obtain a product A;
and step A3, adding Tween-80 into the product A for compounding, introducing nitrogen into the three-neck flask to exhaust air and moisture in the three-neck flask, setting the temperature of the three-neck flask to be 60 ℃, and stirring and reacting for 2-3h by using a magnetic stirrer to obtain the modification auxiliary agent.
Preferably, in the step A1, the use mass ratio of the chloroplatinic acid to the isopropanol is 1:50, and in the step A2, the consumption volume ratio of the allyl polyether to the hydrogen-containing silicone oil is 15: 7, in step A3, Tween-80 was added in an amount of 26% of the total mass of product A.
Preferably, the compound iodine solution is prepared by the following method:
step S1, adding povidone into a three-neck flask provided with a dropping funnel and a magnetic stirrer, simultaneously adding distilled water into the three-neck flask, setting the temperature of the three-neck flask to be 85-100 ℃, and stirring the interior of the three-neck flask by using the magnetic stirrer to completely dissolve the povidone;
s2, dissolving iodine in a potassium iodide solution to prepare a mixed solution A, then dropwise adding the mixed solution A into the three-neck flask through a dropping funnel, and stirring and reacting the interior of the three-neck flask for 4-6h by using a magnetic stirrer under a sealed condition, wherein the rotating speed of the magnetic stirrer is 1600-;
and step S3, after stirring reaction, when the temperature of the three-neck flask is reduced to 50-60 ℃, adding nonylphenol polyoxyethylene ether and chlorhexidine gluconate into the three-neck flask, continuously stirring and reacting for 1-2 hours by using a magnetic stirrer under the condition of keeping the three-neck flask sealed, finally, when the temperature of the three-neck flask is reduced to 20-40 ℃, adding ethanol into the three-neck flask, adding water into the three-neck flask to prepare a mixed solution B, continuously stirring the mixed solution B uniformly by using the magnetic stirrer, and adjusting the pH value of the mixed solution to 2-4 to obtain the composite iodine solution.
Preferably, the mass ratio of povidone to distilled water in step S1 is 3:10, the mass ratio of iodine to potassium iodide solution in step S2 is 1.5:8, the mass ratio of nonylphenol polyoxyethylene ether to gluconic acid chloride in step S3 is 1:5, and the mass ratio of ethanol to water is 7: 10.
(III) advantageous effects
The invention provides a disinfectant preparation process. Compared with the prior art, the method has the following beneficial effects:
the production process of the disinfectant comprises selecting the raw materials of the disinfectant as sophora flavescens, baicalin, berberine, honeysuckle, aloe, triclosan, a modification auxiliary agent, a buffer solution and a compound iodine solution, taking escherichia coli and staphylococcus aureus as tested bacteria, and showing synergistic effect on the tested bacteria after compounding the sophora flavescens and the berberine, the sophora flavescens and the baicalin, the sophora flavescens and the honeysuckle, the baicalin and the berberine, and in addition, by adding aloe extracts into the raw materials, the aloe has the effects of diminishing inflammation and resisting bacteria, enhancing skin elasticity, protecting skin mucous membrane, preventing acne, preventing freckles and wrinkles, cleaning skin and resisting seborrhea, preventing suppurative dermatosis, moistening skin, preventing aging, astringing sweat and removing sweat, the aloe juice squeezed out contains aloe tincture which is a substance with strong antibacterial property and can kill germs such as fungi, mould, bacteria, viruses and the like, the bacteria for inhibiting and killing the development and reproduction of pathogens include: white larynx fungus, tetanus fungus, pneumonia fungus, lactic acid bacteria, dysentery fungus, coliform bacteria, black dead bacteria, cholera fungus and pathogenic bacteria causing otitis media, cystitis, suppuration, measles, rabies, poliomyelitis, epidemic encephalitis, etc.; the slow kininase of the aloe can be combined with vascular tension to resist inflammation, particularly, polysaccharides of the aloe can enhance the resistance of a human body to diseases and cure diseases such as dermatitis, aloin A, wound hormone, polypeptide mannan and the like in the aloe juice have the functions of resisting virus infection and promoting wound healing and recovery, and have the functions of diminishing inflammation, sterilizing, clearing heat, diminishing swelling, softening skin and keeping cell activity;
by compounding the plant disinfectant and the compound iodine solution, the problems that the plant iodine solution is weak in disinfection capability, small in sterilization range and incapable of functioning on fungi and viruses with strong vitality and strong infectivity can be solved, the disinfection effect on the iodine solution can be greatly improved after the compound iodine solution is utilized, and the bacteriostasis duration is greatly improved.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A manufacturing process of a disinfectant specifically comprises the following steps:
step one, selecting raw materials of a disinfectant: radix sophorae flavescentis, baicalin, berberine, honeysuckle, aloe, triclosan, a modified auxiliary agent, a buffer solution and a compound iodine solution;
step two, respectively mashing radix sophorae flavescentis and aloe to obtain juice, filtering to obtain radix sophorae flavescentis extract and aloe extract, drying and grinding honeysuckle to obtain honeysuckle extract for later use;
adding the baicalin, the berberine and the honeysuckle extract into a vortex mixer, mixing for 5min at the rotating speed of 3000r/min, uniformly mixing the three raw materials, adding the modification auxiliary agent into the mixed raw materials, continuously mixing for 3min at the same rotating speed, taking out the mixed raw materials, putting the mixed raw materials into a round-neck flask provided with a mechanical stirring device, putting the round-neck flask into a water bath constant-temperature oscillator, and stirring and dissolving for 30min in a constant-temperature water bath at the temperature of 70 ℃ to obtain a component A;
step four, adding triclosan dropwise into the ethanol solution, and uniformly stirring to obtain a component B;
step five, dripping the sophora flavescens extract and the aloe extract into a buffer solution, and stirring and dissolving the mixed solution in a water bath constant-temperature oscillator in a constant-temperature water bath at the temperature of 50 ℃ for 60min to obtain a component C;
step six, dropwise adding the component B into the component A, stirring for 30min by using a mechanical stirring device at the rotation speed of 1800r/min, dropwise adding the component C into a mixed solution of the component A and the component B, and continuously stirring for 30min by using the mechanical stirring device at the same rotation speed to obtain an intermediate;
and step seven, compounding the intermediate and the compound iodine solution, and stirring and dissolving for 60min in a water bath constant temperature oscillator in a constant temperature water bath at the temperature of 50 ℃ to obtain the disinfectant.
In the first step, the disinfectant comprises the following raw materials in parts by weight: 10 parts of radix sophorae flavescentis, 4 parts of baicalin, 1 part of berberine, 1 part of honeysuckle, 6 parts of aloe, 1 part of triclosan, 2 parts of a modification auxiliary agent, 1 part of buffer solution and 10 parts of compound iodine solution.
In the third step, a 3% modified auxiliary agent is adopted, and in the fourth step, the consumption volume ratio of the triclosan to the ethanol solution is 3: 10.
the buffer was prepared as follows:
preparing 0.2mol/L methyl solution from sodium dihydrogen phosphate dodecahydrate by using double distilled water;
taking disodium hydrogen phosphate, and preparing the disodium hydrogen phosphate into 0.2mol/L solution B by using double distilled water;
the buffer solution is obtained by compounding the solution A and the solution B according to the volume ratio of 7: 5.
The modified assistant is prepared by the following method:
step A1, introducing dried chloroplatinic acid and distilled isopropanol into a conical flask with a mechanical stirring device, and stirring the chloroplatinic acid and the isopropanol for 20min by using the mechanical stirring device to obtain a catalyst;
step A2, adding allyl polyether and hydrogen-containing silicone oil into a 250mL three-neck flask provided with a nitrogen inlet, a magnetic stirrer and a thermometer, introducing nitrogen into the three-neck flask to discharge air and water in the three-neck flask, setting the temperature of the three-neck flask to be 75 ℃, dropwise adding a catalyst, carrying out stirring reaction for 4 hours by using the magnetic stirrer, and after the internal reaction of the three-neck flask is finished, carrying out reduced pressure distillation to remove low-boiling-point substances to obtain a product A;
and step A3, adding Tween-80 into the product A for compounding, introducing nitrogen into the three-neck flask to exhaust air and moisture in the three-neck flask, setting the temperature of the three-neck flask to be 60 ℃, and stirring and reacting for 2 hours by using a magnetic stirrer to obtain the modification auxiliary agent.
In the step A1, the using mass ratio of the chloroplatinic acid to the isopropanol is 1:50, and in the step A2, the consumption volume ratio of the allyl polyether to the hydrogen-containing silicone oil is 15: 7, in step A3, Tween-80 was added in an amount of 26% of the total mass of product A.
The compound iodine solution is prepared by the following method:
step S1, adding povidone into a three-neck flask provided with a dropping funnel and a magnetic stirrer, simultaneously adding distilled water into the three-neck flask, setting the temperature of the three-neck flask to be 85 ℃, and stirring the interior of the three-neck flask by using the magnetic stirrer to completely dissolve the povidone;
step S2, dissolving iodine in a potassium iodide solution to prepare a mixed solution A, then dropwise adding the mixed solution A into a three-neck flask through a dropping funnel, and stirring and reacting the interior of the three-neck flask for 4 hours by using a magnetic stirrer under a sealed condition, wherein the rotating speed of the magnetic stirrer is 1600 r/min;
and step S3, after stirring reaction, when the temperature of the three-neck flask is reduced to 50 ℃, adding nonylphenol polyoxyethylene ether and chlorhexidine gluconate into the three-neck flask, continuously stirring and reacting for 1h by using a magnetic stirrer under the condition that the three-neck flask is sealed, finally, when the temperature of the three-neck flask is reduced to 20 ℃, adding ethanol into the three-neck flask, adding water into the three-neck flask to prepare a mixed solution B, continuously and uniformly stirring the mixed solution B by using the magnetic stirrer, and adjusting the pH value of the mixed solution to be 2 to obtain the compound iodine solution.
In step S1, the mass ratio of povidone to distilled water was 3:10, in step S2, the mass ratio of iodine to potassium iodide solution was 1.5:8, in step S3, the mass ratio of nonylphenol polyoxyethylene ether to gluconic acid chloride was 1:5, and the mass ratio of ethanol to water was 7: 10.
Example 2
A manufacturing process of a disinfectant specifically comprises the following steps:
step one, selecting raw materials of a disinfectant: radix sophorae flavescentis, baicalin, berberine, honeysuckle, aloe, triclosan, a modified auxiliary agent, a buffer solution and a compound iodine solution;
step two, respectively mashing radix sophorae flavescentis and aloe to obtain juice, filtering to obtain radix sophorae flavescentis extract and aloe extract, drying and grinding honeysuckle to obtain honeysuckle extract for later use;
adding the baicalin, the berberine and the honeysuckle extract into a vortex mixer, mixing for 5min at the rotating speed of 3000r/min, uniformly mixing the three raw materials, adding the modification auxiliary agent into the mixed raw materials, continuously mixing for 3min at the same rotating speed, taking out the mixed raw materials, putting the mixed raw materials into a round-neck flask provided with a mechanical stirring device, putting the round-neck flask into a water bath constant-temperature oscillator, and stirring and dissolving for 30min in a constant-temperature water bath at the temperature of 70 ℃ to obtain a component A;
step four, adding triclosan dropwise into the ethanol solution, and uniformly stirring to obtain a component B;
step five, dripping the sophora flavescens extract and the aloe extract into a buffer solution, and stirring and dissolving the mixed solution in a water bath constant-temperature oscillator in a constant-temperature water bath at the temperature of 50 ℃ for 60min to obtain a component C;
step six, dropwise adding the component B into the component A, stirring for 30min by using a mechanical stirring device at the rotation speed of 1800r/min, dropwise adding the component C into a mixed solution of the component A and the component B, and continuously stirring for 30min by using the mechanical stirring device at the same rotation speed to obtain an intermediate;
and step seven, compounding the intermediate and the compound iodine solution, and stirring and dissolving for 60min in a water bath constant temperature oscillator in a constant temperature water bath at the temperature of 50 ℃ to obtain the disinfectant.
In the first step, the disinfectant comprises the following raw materials in parts by weight: 20 parts of sophora flavescens, 5 parts of baicalin, 2 parts of berberine, 2 parts of honeysuckle, 10 parts of aloe, 3 parts of triclosan, 5 parts of a modification auxiliary agent, 3 parts of a buffer solution and 18 parts of a compound iodine solution.
In the third step, a 3% modified auxiliary agent is adopted, and in the fourth step, the consumption volume ratio of the triclosan to the ethanol solution is 3: 10.
the buffer was prepared as follows:
preparing 0.2mol/L methyl solution from sodium dihydrogen phosphate dodecahydrate by using double distilled water;
taking disodium hydrogen phosphate, and preparing the disodium hydrogen phosphate into 0.2mol/L solution B by using double distilled water;
the buffer solution is obtained by compounding the solution A and the solution B according to the volume ratio of 7: 5.
The modified assistant is prepared by the following method:
step A1, introducing dried chloroplatinic acid and distilled isopropanol into a conical flask with a mechanical stirring device, and stirring the chloroplatinic acid and the isopropanol for 30min by using the mechanical stirring device to obtain a catalyst;
step A2, adding allyl polyether and hydrogen-containing silicone oil into a 250mL three-neck flask provided with a nitrogen inlet, a magnetic stirrer and a thermometer, introducing nitrogen into the three-neck flask to discharge air and water in the three-neck flask, setting the temperature of the three-neck flask to be 75 ℃, dropwise adding a catalyst, carrying out stirring reaction for 6 hours by using the magnetic stirrer, and after the internal reaction of the three-neck flask is finished, carrying out reduced pressure distillation to remove low-boiling-point substances to obtain a product A;
and step A3, adding Tween-80 into the product A for compounding, introducing nitrogen into the three-neck flask to exhaust air and moisture in the three-neck flask, setting the temperature of the three-neck flask to be 60 ℃, and stirring and reacting for 3 hours by using a magnetic stirrer to obtain the modification auxiliary agent.
In the step A1, the using mass ratio of the chloroplatinic acid to the isopropanol is 1:50, and in the step A2, the consumption volume ratio of the allyl polyether to the hydrogen-containing silicone oil is 15: 7, in step A3, Tween-80 was added in an amount of 26% of the total mass of product A.
The compound iodine solution is prepared by the following method:
step S1, adding povidone into a three-neck flask provided with a dropping funnel and a magnetic stirrer, simultaneously adding distilled water into the three-neck flask, setting the temperature of the three-neck flask to be 100 ℃, and stirring the interior of the three-neck flask by using the magnetic stirrer to completely dissolve the povidone;
step S2, dissolving iodine in a potassium iodide solution to prepare a mixed solution A, then dropwise adding the mixed solution A into a three-neck flask through a dropping funnel, and stirring and reacting the interior of the three-neck flask for 6 hours by using a magnetic stirrer under a sealed condition, wherein the rotating speed of the magnetic stirrer is 2000 r/min;
and step S3, after stirring reaction, when the temperature of the three-neck flask is reduced to 60 ℃, adding nonylphenol polyoxyethylene ether and chlorhexidine gluconate into the three-neck flask, continuously stirring and reacting for 2 hours by using a magnetic stirrer under the condition of keeping the three-neck flask sealed, finally, when the temperature of the three-neck flask is reduced to 40 ℃, adding ethanol into the three-neck flask, simultaneously adding water into the three-neck flask to prepare a mixed solution B, continuously and uniformly stirring the mixed solution B by using the magnetic stirrer, and adjusting the pH value of the mixed solution to be 4 to obtain the compound iodine solution.
In step S1, the mass ratio of povidone to distilled water was 3:10, in step S2, the mass ratio of iodine to potassium iodide solution was 1.5:8, in step S3, the mass ratio of nonylphenol polyoxyethylene ether to gluconic acid chloride was 1:5, and the mass ratio of ethanol to water was 7: 10.
Example 3
A manufacturing process of a disinfectant specifically comprises the following steps:
step one, selecting raw materials of a disinfectant: radix sophorae flavescentis, baicalin, berberine, honeysuckle, aloe, triclosan, a modified auxiliary agent, a buffer solution and a compound iodine solution;
step two, respectively mashing radix sophorae flavescentis and aloe to obtain juice, filtering to obtain radix sophorae flavescentis extract and aloe extract, drying and grinding honeysuckle to obtain honeysuckle extract for later use;
adding the baicalin, the berberine and the honeysuckle extract into a vortex mixer, mixing for 5min at the rotating speed of 3000r/min, uniformly mixing the three raw materials, adding the modification auxiliary agent into the mixed raw materials, continuously mixing for 3min at the same rotating speed, taking out the mixed raw materials, putting the mixed raw materials into a round-neck flask provided with a mechanical stirring device, putting the round-neck flask into a water bath constant-temperature oscillator, and stirring and dissolving for 30min in a constant-temperature water bath at the temperature of 70 ℃ to obtain a component A;
step four, adding triclosan dropwise into the ethanol solution, and uniformly stirring to obtain a component B;
step five, dripping the sophora flavescens extract and the aloe extract into a buffer solution, and stirring and dissolving the mixed solution in a water bath constant-temperature oscillator in a constant-temperature water bath at the temperature of 50 ℃ for 60min to obtain a component C;
step six, dropwise adding the component B into the component A, stirring for 30min by using a mechanical stirring device at the rotation speed of 1800r/min, dropwise adding the component C into a mixed solution of the component A and the component B, and continuously stirring for 30min by using the mechanical stirring device at the same rotation speed to obtain an intermediate;
and step seven, compounding the intermediate and the compound iodine solution, and stirring and dissolving for 60min in a water bath constant temperature oscillator in a constant temperature water bath at the temperature of 50 ℃ to obtain the disinfectant.
In the first step, the disinfectant comprises the following raw materials in parts by weight: 10 parts of sophora flavescens, 5 parts of baicalin, 1 part of berberine, 1 part of honeysuckle, 10 parts of aloe, 3 parts of triclosan, 2 parts of a modification auxiliary agent, 3 parts of a buffer solution and 14 parts of a compound iodine solution.
In the third step, a 3% modified auxiliary agent is adopted, and in the fourth step, the consumption volume ratio of the triclosan to the ethanol solution is 3: 10.
the buffer was prepared as follows:
preparing 0.2mol/L methyl solution from sodium dihydrogen phosphate dodecahydrate by using double distilled water;
taking disodium hydrogen phosphate, and preparing the disodium hydrogen phosphate into 0.2mol/L solution B by using double distilled water;
the buffer solution is obtained by compounding the solution A and the solution B according to the volume ratio of 7: 5.
The modified assistant is prepared by the following method:
step A1, introducing dried chloroplatinic acid and distilled isopropanol into a conical flask with a mechanical stirring device, and stirring the chloroplatinic acid and the isopropanol for 25min by using the mechanical stirring device to obtain a catalyst;
step A2, adding allyl polyether and hydrogen-containing silicone oil into a 250mL three-neck flask provided with a nitrogen inlet, a magnetic stirrer and a thermometer, introducing nitrogen into the three-neck flask to discharge air and water in the three-neck flask, setting the temperature of the three-neck flask to be 75 ℃, dropwise adding a catalyst, carrying out stirring reaction for 5 hours by using the magnetic stirrer, and after the internal reaction of the three-neck flask is finished, carrying out reduced pressure distillation to remove low-boiling-point substances to obtain a product A;
and step A3, adding Tween-80 into the product A for compounding, introducing nitrogen into the three-neck flask to exhaust air and moisture in the three-neck flask, setting the temperature of the three-neck flask to be 60 ℃, and stirring and reacting for 2 hours by using a magnetic stirrer to obtain the modification auxiliary agent.
In the step A1, the using mass ratio of the chloroplatinic acid to the isopropanol is 1:50, and in the step A2, the consumption volume ratio of the allyl polyether to the hydrogen-containing silicone oil is 15: 7, in step A3, Tween-80 was added in an amount of 26% of the total mass of product A.
The compound iodine solution is prepared by the following method:
step S1, adding povidone into a three-neck flask provided with a dropping funnel and a magnetic stirrer, simultaneously adding distilled water into the three-neck flask, setting the temperature of the three-neck flask to be 90 ℃, and stirring the interior of the three-neck flask by using the magnetic stirrer to completely dissolve the povidone;
step S2, dissolving iodine in a potassium iodide solution to prepare a mixed solution A, then dropwise adding the mixed solution A into a three-neck flask through a dropping funnel, and stirring and reacting the interior of the three-neck flask for 5 hours by using a magnetic stirrer under a sealed condition, wherein the rotating speed of the magnetic stirrer is 1800 r/min;
and step S3, after stirring reaction, when the temperature of the three-neck flask is reduced to 60 ℃, adding nonylphenol polyoxyethylene ether and chlorhexidine gluconate into the three-neck flask, continuously stirring and reacting for 2 hours by using a magnetic stirrer under the condition of keeping the three-neck flask sealed, finally, when the temperature of the three-neck flask is reduced to 30 ℃, adding ethanol into the three-neck flask, simultaneously adding water into the three-neck flask to prepare a mixed solution B, continuously and uniformly stirring the mixed solution B by using the magnetic stirrer, and adjusting the pH value of the mixed solution to be 3 to obtain the compound iodine solution.
In step S1, the mass ratio of povidone to distilled water was 3:10, in step S2, the mass ratio of iodine to potassium iodide solution was 1.5:8, in step S3, the mass ratio of nonylphenol polyoxyethylene ether to gluconic acid chloride was 1:5, and the mass ratio of ethanol to water was 7: 10.
And those not described in detail in this specification are well within the skill of those in the art.
Comparative example 1
The comparative example differs from example 1 in that no modification aid is used in the disinfectant preparation process;
comparative example 2
The difference between the comparative example and the example 1 is that the compound iodine solution is not compounded in the process of preparing the disinfectant;
comparative example 3
The comparative example is a disinfectant on the market;
respectively carrying out sterilization performance detection on the sterilizing fluids of the examples 1-3 and the comparative examples 1-3, taking 6 test tubes, wherein each test tube is filled with staphylococcus aureus, pneumococcus, diphtheria bacillus, vibrio cholerae, tetanus bacillus, pertussis bacillus, hemolytic streptococcus, influenza virus and herpes simplex virus, respectively dripping the sterilizing fluids of the examples 1-3 and the comparative examples 1-3 into the test tubes in equal amount, and measuring the sterilization performance results of the sterilizing fluids as shown in the table 1;
TABLE 1
| Sterilizing performance/%) | Clarity of the product | |
| Example 1 | 86.5 | Clarification |
| Example 2 | 82.8 | Clarification |
| Example 3 | 83.1 | Clarification |
| Comparative example 1 | 80.3 | Has turbidity |
| Comparative example 2 | 71.5 | Clarification |
| Comparative example 3 | 68.3 | Has turbidity |
As can be seen from Table 1, the disinfecting solutions prepared in examples 1 to 3 are superior to those prepared in comparative examples 1 to 3 in both sterilizing performance and clarity.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. A process for preparing a disinfectant, which is characterized by comprising the following steps: the method specifically comprises the following steps:
step one, selecting raw materials of a disinfectant: radix sophorae flavescentis, baicalin, berberine, honeysuckle, aloe, triclosan, a modified auxiliary agent, a buffer solution and a compound iodine solution;
step two, respectively mashing radix sophorae flavescentis and aloe to obtain juice, filtering to obtain radix sophorae flavescentis extract and aloe extract, drying and grinding honeysuckle to obtain honeysuckle extract for later use;
adding the baicalin, the berberine and the honeysuckle extract into a vortex mixer, mixing for 5min at the rotating speed of 3000r/min, uniformly mixing the three raw materials, adding the modification auxiliary agent into the mixed raw materials, continuously mixing for 3min at the same rotating speed, taking out the mixed raw materials, putting the mixed raw materials into a round-neck flask provided with a mechanical stirring device, putting the round-neck flask into a water bath constant-temperature oscillator, and stirring and dissolving for 30min in a constant-temperature water bath at the temperature of 70 ℃ to obtain a component A;
step four, adding triclosan dropwise into the ethanol solution, and uniformly stirring to obtain a component B;
step five, dripping the sophora flavescens extract and the aloe extract into a buffer solution, and stirring and dissolving the mixed solution in a water bath constant-temperature oscillator in a constant-temperature water bath at the temperature of 50 ℃ for 60min to obtain a component C;
step six, dropwise adding the component B into the component A, stirring for 30min by using a mechanical stirring device at the rotation speed of 1800r/min, dropwise adding the component C into a mixed solution of the component A and the component B, and continuously stirring for 30min by using the mechanical stirring device at the same rotation speed to obtain an intermediate;
and step seven, compounding the intermediate and the compound iodine solution, and stirring and dissolving for 60min in a water bath constant temperature oscillator in a constant temperature water bath at the temperature of 50 ℃ to obtain the disinfectant.
2. The process for preparing a disinfecting solution as claimed in claim 1, wherein: in the first step, the disinfectant comprises the following raw materials in parts by weight: 10-20 parts of radix sophorae flavescentis, 4-5 parts of baicalin, 1-2 parts of berberine, 1-2 parts of honeysuckle, 6-10 parts of aloe, 1-3 parts of triclosan, 2-5 parts of a modification auxiliary agent, 1-3 parts of a buffer solution and 10-18 parts of a compound iodine solution.
3. The process for preparing a disinfecting solution as claimed in claim 1, wherein: in the third step, a 3% modified auxiliary agent is adopted, and in the fourth step, the consumption volume ratio of the triclosan to the ethanol solution is 3: 10.
4. the process for preparing a disinfecting solution as claimed in claim 1, wherein: the buffer is prepared by the following method:
preparing 0.2mol/L methyl solution from sodium dihydrogen phosphate dodecahydrate by using double distilled water;
taking disodium hydrogen phosphate, and preparing the disodium hydrogen phosphate into 0.2mol/L solution B by using double distilled water;
the buffer solution is obtained by compounding the solution A and the solution B according to the volume ratio of 7: 5.
5. The process for preparing a disinfecting solution as claimed in claim 1, wherein: the modification auxiliary agent is prepared by the following method:
step A1, introducing dried chloroplatinic acid and distilled isopropanol into a conical flask provided with a mechanical stirring device, and stirring the chloroplatinic acid and the isopropanol for 20-30min by using the mechanical stirring device to obtain a catalyst;
step A2, adding allyl polyether and hydrogen-containing silicone oil into a 250mL three-neck flask provided with a nitrogen inlet, a magnetic stirrer and a thermometer, introducing nitrogen into the three-neck flask to discharge air and water in the three-neck flask, setting the temperature of the three-neck flask to be 75 ℃, dropwise adding a catalyst, carrying out stirring reaction for 4-6h by using the magnetic stirrer, and after the internal reaction of the three-neck flask is finished, carrying out reduced pressure distillation to remove low-boiling-point substances to obtain a product A;
and step A3, adding Tween-80 into the product A for compounding, introducing nitrogen into the three-neck flask to exhaust air and moisture in the three-neck flask, setting the temperature of the three-neck flask to be 60 ℃, and stirring and reacting for 2-3h by using a magnetic stirrer to obtain the modification auxiliary agent.
6. The process for preparing a disinfecting solution as claimed in claim 5, wherein: in the step A1, the using mass ratio of the chloroplatinic acid to the isopropanol is 1:50, and in the step A2, the consumption volume ratio of the allyl polyether to the hydrogen-containing silicone oil is 15: 7, in step A3, Tween-80 was added in an amount of 26% of the total mass of product A.
7. The process for preparing a disinfecting solution as claimed in claim 1, wherein: the composite iodine solution is prepared by the following method:
step S1, adding povidone into a three-neck flask provided with a dropping funnel and a magnetic stirrer, simultaneously adding distilled water into the three-neck flask, setting the temperature of the three-neck flask to be 85-100 ℃, and stirring the interior of the three-neck flask by using the magnetic stirrer to completely dissolve the povidone;
s2, dissolving iodine in a potassium iodide solution to prepare a mixed solution A, then dropwise adding the mixed solution A into the three-neck flask through a dropping funnel, and stirring and reacting the interior of the three-neck flask for 4-6h by using a magnetic stirrer under a sealed condition, wherein the rotating speed of the magnetic stirrer is 1600-;
and step S3, after stirring reaction, when the temperature of the three-neck flask is reduced to 50-60 ℃, adding nonylphenol polyoxyethylene ether and chlorhexidine gluconate into the three-neck flask, continuously stirring and reacting for 1-2 hours by using a magnetic stirrer under the condition of keeping the three-neck flask sealed, finally, when the temperature of the three-neck flask is reduced to 20-40 ℃, adding ethanol into the three-neck flask, adding water into the three-neck flask to prepare a mixed solution B, continuously stirring the mixed solution B uniformly by using the magnetic stirrer, and adjusting the pH value of the mixed solution to 2-4 to obtain the composite iodine solution.
8. The process of claim 7, wherein: in step S1, the mass ratio of povidone to distilled water was 3:10, in step S2, the mass ratio of iodine to potassium iodide solution was 1.5:8, in step S3, the mass ratio of nonylphenol polyoxyethylene ether to gluconic acid chloride was 1:5, and the mass ratio of ethanol to water was 7: 10.
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