CN112585168A - 抗bcma抗体、其抗原结合片段及其医药用途 - Google Patents

抗bcma抗体、其抗原结合片段及其医药用途 Download PDF

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CN112585168A
CN112585168A CN202080004455.4A CN202080004455A CN112585168A CN 112585168 A CN112585168 A CN 112585168A CN 202080004455 A CN202080004455 A CN 202080004455A CN 112585168 A CN112585168 A CN 112585168A
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seq
antibody
binding fragment
bcma
bcma antibody
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CN112585168B (zh
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花海清
包如迪
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Jiangsu Hansoh Pharmaceutical Group Co Ltd
Shanghai Hansoh Biomedical Co Ltd
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Jiangsu Hansoh Pharmaceutical Group Co Ltd
Shanghai Hansoh Biomedical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/6877—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the antibody being an immunoglobulin containing regions, domains or residues from different species
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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Abstract

提供了抗BCMA抗体、其抗原结合片段及其医药用途。进一步地，提供了包含所述抗BCMA抗体CDR区的嵌合抗体、人源化抗体，以及包含抗BCMA抗体或其抗原结合片段的药物组合物，以及其作为抗癌药物和治疗自身免疫疾病的用途。尤其地，提供了一种人源化的抗BCMA抗体，及其在制备用于治疗BCMA介导的疾病或病症的药物中的用途和用于疾病检测和诊断中的用途。

Description

PCT国内申请，说明书已公开。

Claims (23)

  1. PCT国内申请，权利要求书已公开。
CN202080004455.4A 2019-07-30 2020-07-29 抗bcma抗体、其抗原结合片段及其医药用途 Active CN112585168B (zh)

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CN2019106955979 2019-07-30
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PCT/CN2020/105408 WO2021018168A1 (zh) 2019-07-30 2020-07-29 抗bcma抗体、其抗原结合片段及其医药用途

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US (1) US20220251228A1 (zh)
EP (1) EP4006055A4 (zh)
JP (1) JP2022542088A (zh)
KR (1) KR20220068984A (zh)
CN (1) CN112585168B (zh)
AU (1) AU2020322588A1 (zh)
BR (1) BR112022001546A2 (zh)
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