CN112569327A - Semen lepidii traditional Chinese medicine compound preparation for treating patients with symptoms of new coronary pneumonia, phlegm retention and cough and common patients - Google Patents

Abstract

A semen Lepidii Chinese medicinal compound preparation for treating patients with new coronary pneumonia, phlegm retention and cough and pulse diseases and common patients is a mixture; the prescription composition comprises semen Lepidii, herba Ephedrae, fructus Jujubae, herba asari, Zingiberis rhizoma, pericarpium Arecae, and Poria. Purging lung, eliminating dampness, warming and resolving phlegm; is prepared from semen Lepidii and fructus Jujubae decoction for purging Lung, which is recorded in the book of Lai Kui Yao Fang Lun. Cough with profuse sputum, white or foamy; phlegm and saliva accumulation, dyspnea with cough and dyspnea with difficulty in lying down; edema, dribbling fluid, hydrothorax and abdominal dropsy, dysuria; ting Li Zi, Ma Huang and Zi Zao are the monarch drugs.

Description

Semen lepidii traditional Chinese medicine compound preparation for treating patients with symptoms of new coronary pneumonia, phlegm retention and cough and common patients

The technical field is as follows:

the invention relates to a semen lepidii Chinese medicinal compound preparation for treating patients with new coronary pneumonia, phlegm retention and cough and pulse diseases and common patients; is a decoction or a mixture, and is packaged into oral liquid. Is prepared from semen Lepidii and fructus Jujubae decoction for purging Lung, which is recorded in the book of Lai Kui Yao Fang Lun. The 'jin Kui Yao Fang Lun' is the miscellaneous diseases of the 'Shang Han miscellaneous diseases Lun' which is written by famous physicians in the east Han period of China. The semen lepidii traditional Chinese medicine compound preparation has the effects of treating, relieving and relieving new coronary pneumonia and phlegm retention cough syndrome and common phlegm retention cough syndrome.

The invention relates to a lung-warming prescription of semen lepidii, which comprises the following components in part by weight: 12 g of semen lepidii, 10 Chinese dates, 9 g of ephedra, 5 g of asarum, 9 g of dried ginger, 10 g of areca peel and 18 g of poria cocos; purge lung and remove dampness, warm and resolve phlegm-fluid retention. (10 Chinese dates 10 g in weight).

Typical symptoms of new coronary pneumonia: fever, dry cough and hypodynamia are the main clinical manifestations; a few patients are accompanied by the symptoms of nasal obstruction, watery nasal discharge, pharyngalgia, diarrhea and muscular soreness; lung sepsis develops and severe persons develop dyspnea. Early as common cold; the new coronary pneumonia is infectious, and the nucleic acid detection is positive; the common cold is not contagious. During the further development period of the disease course of the new coronary pneumonia patient, the treatment is carried out according to the syndrome differentiation of the traditional Chinese medicine: the syndrome type is the syndrome of wind-cold invading the lung; syndrome of cold-phlegm obstructing lung; syndrome of fluid retention in the chest and hypochondrium. [ FENG-HAN-ILLUNG ] cough with thin and clear expectoration, slight aversion to cold, fever, nasal obstruction, clear nasal discharge, itching throat, or body pain without sweating, thin and white tongue coating, and floating and tense pulse. [ CHINESE-TAN-BLOOD ] cough with excessive phlegm, sticky and thick phlegm, or clear, thin, white and large amount of phlegm, easy expectoration, chest distress, asthma, wheezy phlegm, cold limbs, pale tongue, white and greasy or white and slippery coating, and soft, slow or slippery pulse. [ YIN STOPPING CHEST AND CRUCIBLE ] fullness and pain in the chest and hypochondrium, severe cough and spitting pain, shortness of breath, vertigo, pain in chest and hypochondrium due to body turning or respiration, white and slippery tongue coating, and deep and wiry pulse.

Background art:

there is no Chinese patent medicine for Ting Li Zi, Ting Li Zi and Da Zao Xie Fei Tang. Ancient medical books record treatment of pulmonary abscess, pathogenic excess qi stagnation, dyspnea with insomnia; the branch and fluid stagnates in the lung. The excerpts are as follows:

page 85, version 1, 2008, 7 months, Shanghai science and technology Press, gold Kui Yao L.A.; lung abscess treated with syndrome of pathogenic excess and qi obstruction

Lung carbuncle, can not lie down, Tingli big jujube Xiefei Decoction is the main one. (11) Tingli Jujube Xiefei Decoction: Tingli (boiled to make yellow, pounding pills are as big as marbles) 12 jujubes. [Interpretation] This two discusses the syndromes and treatments of carbuncle carbuncle and severe asthma. Because of the evil heat in the lungs, burning body fluids into phlegm, stagnating in the lungs, the lungs are lost, so you cannot lie down while breathing; phlegm is stuck in the chest, the air machine is not good, so the chest is full and swelling; , The water is retrograde outside, so the face is swollen; Lung orifices are unfavorable, so nasal congestion, clear nose, no smell and sourness; lung failure, phlegm and qi reversal, cough reversal, wheezing and obstruction. Use Tingli Dazao Xiefei Decoction to remove phlegm and lower qi, and relieve the open and close of the lung. Fang Zhongtinglizi works hard and cold, can release lung qi, eliminate phlegm and drink, and turbid phlegm is driven out, lung qi can begin to fall, and the panting will be relieved. Only its medicine hurts the righteousness severely, so the jujube is added to ease the medicinal properties, warm and calm, so that the evil will be cured without hurting the righteousness. [Clinical application guidelines] This prescription not only treats patients with early stage of pulmonary carbuncle, pus has not yet formed, lungs are severely blocked, and the shape and qi are solid, but also can be used for cough and asthma caused by phlegm and qi closure. . However, if the patient has symptoms such as "nasal congestion, clear mucus, etc.", it is advisable to solve the problem first. You can take Xiaoqinglong Decoction and the like to relieve the evil of the skin and drink: or use the product compatible with the prescription to decompose the surface and the inside. evil.

Page 152, 1 st edition, 7 months, 2008, Shanghai science and technology Press, jin Kui Yao L ü e lecture; the syndrome of cough with phlegm-fluid retention is treated with the twelfth 3. the branch fluid retention obstructing the lung.

[ original ] If you can't stop drinking, Tingli Dazao Xiefei Decoction is the main one. Seeing lung carbuncle just now. (Twenty-seven). [Interpretation] This article discusses the syndromes and treatments of Zhiyin in the lungs. Drinking to gather the chest and diaphragm, the lungs are congested, so it is difficult to breathe. This is an emergency of qi and qi obstruction. You should use Tingli Dazao Xiefei Decoction to distill water to drink to relieve the lungs and lower the qi. [Clinical application guidelines] This formula can be used for all emergencies that are caused by drinking water to injure the lungs, or sputum turbidity in the lungs. The common pulse syndromes include coughing, shortness of breath, dyspnea, chest tightness, coughing, saliva, sputum, saliva, and moss. Greasy or slippery, slippery pulse string, etc. In clinical application, it is often flavored according to the symptoms. When the condition is severe, Tinglizi should be reused.

The traditional Chinese medicine is clinically applied to treating the diseases of phlegm-blood stasis obstructing the lung, phlegm-turbidity obstructing the lung and phlegm-dampness obstructing the lung. The excerpts are as follows:

the publication of internal medicine of traditional Chinese medicine, Shanghai science and technology, first edition, 6 months 1997, page 74; the second chapter of lung disease, the fourth lung distention; phlegm-blood stasis obstructing the lung. Symptoms are: cough with profuse sputum, white or foamy sputum, purulent sputum in throat, inability to lie flat with dyspnea, fullness in chest, oppression like a blocked sensation, pale and dark complexion, cyanosis of lips and nails, dark or dark purple tongue, increased thickness of blood stasis and tendons under tongue, greasy or turbid greasy coating, and wiry and slippery pulse. Therapeutic method: to remove phlegm and stasis, purge lung and relieve dyspnea. The prescription is as follows: ting Li Zi-Da Zao Xie Fei Tang (semen Lepidii and fructus Jujubae decoction for purging Lung fire) and Gui Zhi Fu Ling Wan (ramulus Cinnamomi and Poria pill). The publication of internal medicine of traditional Chinese medicine, Shanghai science and technology, first edition, 6 months 1997, page 71; the second chapter, lung disease, third panting; phlegm-turbidity obstructing the lung. Symptoms are: dyspnea with fullness in chest, suffocation, cough with sticky, greasy and white sputum. Therapeutic method: resolve phlegm and descend the adverse qi. The prescription is as follows: erchen decoction and Sanzi Yangqin decoction; fructus Gleditsiae Abnormalis and semen Lepidii can be added for patients with excessive phlegm and dyspnea. The publication of internal medicine of traditional Chinese medicine, Shanghai science and technology, first edition, 6 months 1997, page 94; the second chapter of lung disease, the seventh section of lung cancer; phlegm-dampness accumulates in the lung. Symptoms are: cough, expectoration, suffocating sensation, sticky and sticky sputum, white or yellowish white sputum, chest distress, chest pain, loose stool, mental fatigue and hypodynamia. Therapeutic method: move qi and eliminate phlegm, invigorate spleen and dry dampness. The prescription is as follows: erchen decoction and GUOTOUXIEBAIXIANXIA decoction; ting Li Zi and Da Zao Xie Fei Tang can be added to purge lung and drain water.

The textbook of Chinese materia medica introduces the medicine for treating abundant phlegm and saliva, edema and fluid retention. Extract as follows

Traditional Chinese medicine, Shanghai science and technology Press, first edition 6 month 1995, page 245; chao Twen Hua Zhi Chuan and Zhi Chuan. Ting Li Zi (semen Lepidii) (property, flavor, meridian tropism) is bitter, pungent and cold in nature. It enters lung and bladder meridians. [ EFFECT ] can purge lung, relieve dyspnea, induce diuresis, and alleviate edema. [ APPLICATION ] 1 is used for treating excessive phlegm and saliva, cough and asthma. 2. Can be used for treating edema, suspense, hydrothorax and abdominal dropsy, and dysuria. [ dosage for usage ] 5-10 g is decocted; 3-6 g of the powder is not taken after grinding.

Comprehensively summarizing; ting Li Zi, Ting Li Zi Zao Xie Fei Tang ancient treatment of pulmonary abscess and fluid retention in lung diseases. At present, the traditional Chinese medicine is used for treating lung distension, asthma and lung cancer of lung diseases. The traditional Chinese medicine is used for treating the syndrome of excessive phlegm and saliva, asthma and cough with difficulty in lying down; can be used for treating edema, pleural effusion, abdominal dropsy, and dysuria. And new coronary pneumonia, wind-cold invasion of lung, cold-phlegm obstruction of lung, and fluid retention in chest and hypochondrium. The recently published teaching materials are all identified as the syndrome of phlegm-fluid retention and cough. Page 138 of "the golden-scanty-key-grass lecture" shanghai science and technology press, 7 months, 2008; the twelfth syndrome of cough with phlegm-fluid retention; phlegm-fluid retention disease, which is related to and cough is caused by phlegm-fluid retention; phlegm-fluid retention is divided into phlegm-fluid retention, suspense fluid retention, overflow fluid retention and branch fluid retention. Phlegm-fluid retention is different in broad sense and narrow sense. The disease named phlegm-fluid retention refers to the disease caused by water retention in some part of the body, and belongs to generalized phlegm-fluid retention; only the pathological changes of the intestine and stomach caused by fluid retention are narrowly defined phlegm-fluid retention. The phlegm-fluid retention disease has the common symptoms of cough, asthma, shortness of breath, light headedness, fullness and distention in chest and hypochondrium, epigastric and abdomen, vomiting of foam, palpitation, body pain and difficult urination.

In summary; ting Li Zi, Ting Li Zi Da Zao Xie Fei Tang are good prescriptions for treating phlegm-fluid retention cough.

Disclosure of Invention

The invention relates to a semen lepidii Chinese medicinal compound preparation for treating patients with new coronary pneumonia, phlegm retention and cough and pulse diseases and common patients.

Typical symptoms of new coronary pneumonia: fever, dry cough and hypodynamia are the main clinical manifestations; a few patients are accompanied by the symptoms of nasal obstruction, watery nasal discharge, pharyngalgia, diarrhea and muscular soreness; lung sepsis develops and severe persons develop dyspnea. Early as common cold; the new coronary pneumonia is infectious, and the nucleic acid detection is positive; the common cold is not contagious. The disease course of the new coronary pneumonia patient is further developed, and the new coronary pneumonia patient is long-lived; treatment is carried out according to syndrome differentiation of traditional Chinese medicine: the syndrome type is the syndrome of wind-cold invading the lung; syndrome of cold-phlegm obstructing lung; syndrome of fluid retention in the chest and hypochondrium. Several symptoms are clinically present: cough with profuse sputum, white or foamy sputum, purulent sputum in the throat, and inability to lie flat with wheezing. Dyspnea with fullness in chest, suffocation, cough with sticky, greasy and white sputum. Cough, expectoration, suffocating sensation, sticky and sticky sputum with white or yellowish white sputum. Can be used for treating excessive phlegm and saliva, cough and asthma; can be used for treating edema, pleural effusion, abdominal dropsy, and dysuria.

The Chinese medicine compound preparation contains 12 g of semen lepidii, 10 Chinese dates (10 g), 9 g of ephedra, 5 g of asarum, 9 g of dried ginger, 10 g of areca peel and 18 g of tuckahoe. The traditional Chinese medicine composition of the application is a brand-new formula, and the prior art is not recorded to be similar to the formula. Semen lepidii, ephedra, and Chinese date are monarch drugs, asarum is ministerial drugs, areca peel and poria are adjuvant drugs, and dried ginger is messenger drug. The use method comprises the following steps: the decoction, mixture and single package are oral liquid; the instant decoction is taken without adding preservative, and the preservative and the flavoring agent are added in large-scale production; the antiseptic comprises sodium benzoate, ethyl p-hydroxybenzoate (or ethylparaben), and potassium sorbate; the correctant includes sucrose, stevioside, and saccharin sodium.

Ting Li Zi (semen Lepidii) in Ben Jing (the book of Jing). Traditional Chinese pharmacology, Shanghai science and technology Press, first edition 6 month 1995, page 245: "is the mature seed of Lepidium apetalum Willd, or Descurainia sophia (L.) Webb ex prantl, which is a crucifer herbaceous plant. The former is called "Bei Ting Li", mainly produced in Hebei, Liaoning, inner Mongolia and Jilin; the latter is called Nanting Li, and is mainly produced in Jiangsu, Shandong, Anhui, Zhejiang, etc. In summer, the plant is harvested when the fruit is ripe, dried in the sun, and the seeds are rubbed out to remove impurities, and the fruit is used unprocessed or fried. "" semen Lepidii contains cardiotonic substances, sinapine, fatty oil, protein, saccharide, etc.; semen Lepidii contains volatile oil (oil containing benzyl isothiocyanate, allyl isothiocyanate, etc.), fatty oil, cardiac glycoside (its one kind of severin A), etc. The two semen Lepidii alcohol extracts have cardiotonic effect, and can enhance myocardial contraction and slow heart rate. It can increase output and reduce venous pressure for weakened heart. Large dose can cause arrhythmia and other symptoms of cardiac glycoside poisoning. It also has the action of inducing diuresis. "

The Shanghai science and technology publishing society of traditional Chinese medicine pharmacology; first edition of month 1 of 2008, pages 37 to 39. Extracting: ma Huang is pungent, slightly bitter and warm in nature. It enters lung and bladder meridians. Has effects of inducing sweat, relieving exterior syndrome, dispersing lung qi, relieving asthma, inducing diuresis, and relieving swelling. Can be used for treating common cold due to wind-cold, chest distress, cough, and edema; bronchial asthma. The pharmacological action is as follows: sweating, relieving asthma, improving muscle strength, increasing blood pressure, resisting inflammation, resisting allergy, exciting central nervous system and blood vessel movement central system, and promoting urination. Note that: in the specification of the pharmacopoeia of the people's republic of China in 2005 edition, the ephedrine hydrochloride content of the ephedra is not less than 1% calculated according to dry products, the ephedrine content is limited to 20-90 mg calculated according to the recommended dosage of 2-9 g in the pharmacopoeia of the people's republic of China, and the ephedrine hydrochloride content is equivalent to the common dosage of clinical ephedrine hydrochloride. Ephedrine hydrochloride, pseudoephedrine hydrochloride, herba Ephedrae extract, and herba Ephedrae extract are all used as psychotropic drugs.

The invention creatively takes semen lepidii, ephedra and Chinese date as monarch drugs. The herba Ephedrae has effects of inducing sweat, relieving exterior syndrome, dispersing lung qi, relieving asthma, inducing diuresis, relieving swelling, and exciting central nervous system and vasomotor central nervous system. Semen Lepidii has cardiotonic effect, i.e. cardiac glycoside; the myocardial contractility can be enhanced, the heart rate is slowed down, the output can be increased for the weak heart, and the venous pressure is reduced; induce diuresis to alleviate edema. Clinical symptoms: cough with profuse sputum, white or foamy; can be used for treating excessive phlegm and saliva, cough and asthma; can be used for treating edema, pleural effusion, abdominal dropsy, and dysuria. The patient coughs and has more sputum to further develop and cause symptoms of pleurisy and pericardial effusion. The Chinese date has the effect of relieving the property of the medicine and relieving the toxic and side effects of the pepperweed seed. Whether during the course of disease development of patients with new coronary pneumonia or after long-term illness of common patients; cough with profuse sputum, white or foamy; abundant phlegm and saliva, dyspnea with cough and dyspnea with difficulty in lying down, edema, fluid retention, hydrothorax and abdominal dropsy, dysuria; the recipe can be applied to the syndrome of phlegm-fluid retention and cough.

The three aspects of the new traditional Chinese medicine for treating coronary pneumonia are introduced. 'three drugs' 01 golden flower cold-clearing granules; 02 Lianhua Qingwen capsule/granule; 03 Xuebijing injection. 'three-party' 01 lung clearing and toxin expelling soup; 02 formula for eliminating dampness and removing toxin; 03 formula for ventilating lung and relieving toxicity. Wherein the 02 formula for eliminating dampness and removing toxin has the effects of removing toxin, eliminating dampness, clearing heat and relieving asthma; the main ingredients comprise herba Ephedrae, herba Agastaches, Gypsum Fibrosum, semen Armeniacae amarum, rhizoma Pinelliae Preparata, cortex Magnolia officinalis, rhizoma Atractylodis, fructus Tsaoko, Poria, radix astragali, radix Paeoniae Rubra, semen Lepidii, radix et rhizoma Rhei, and Glycyrrhrizae radix. 03 lung ventilating and toxin removing prescription, has the effects of ventilating and resolving dampness, clearing heat and expelling pathogenic factors, and clearing lung and removing toxicity; the main ingredients comprise herba Ephedrae, semen Armeniacae amarum, Gypsum Fibrosum, Coicis semen, rhizoma Atractylodis, herba Agastaches, herba Artemisiae Annuae, rhizoma Polygoni Cuspidati, herba Verbenae, dry lalang grass rhizome, semen Lepidii, exocarpium Citri Grandis, and Glycyrrhrizae radix. The two prescriptions contain herba Ephedrae and semen Lepidii, and the clinical application proves that the two prescriptions are effective prescriptions! The two prescriptions are mainly used for clearing away heat and toxic materials.

The traditional Chinese medicine composition is a medicine with pungent and warm natures and has the effects of purging water and reducing swelling. This is different from "three drugs three parties".

The pepperweed seed lung-warming prescription discussed in the pharmacological aspect is superior to the existing clinical medicine for treating the new coronary pneumonia; the chloroquine and the Rudexiluwei are fried to obtain the medicine with fire heat. The chloroquine mechanism is inserted into a DNA double helix chain to break the nucleic acid chain. Reidesciclovir is a nucleotide analogue that interferes with metabolic function. Both drugs are similar to chemotherapeutic drugs and have no promise.

The traditional Chinese medicine compound preparation is a practical proved formula. Examples of information materials are as follows:

a certain piece, a woman; in 2008, 12 and 15, fullness and pain in the chest and hypochondrium, severe cough and spitting pain, shortness of breath or vertigo, pain in the chest and hypochondrium due to traction during respiration, white and slippery tongue coating, deep and wiry pulse. The disease pulse is diagnosed as phlegm-fluid retention cough; wind-cold affecting the lung. Seven doses of a pepperweed seed lung-warming prescription are taken in the morning, in the middle and at night three times each day; the disease condition is improved.

Some young, female, 50 years old; 28 days 3 and 28 months in 2020, cough with excessive phlegm, thin and white, large amount, easy expectoration, chest distress, asthma with purulent phlegm, cold limbs, pale tongue, white and greasy coating, and smooth pulse. The disease pulse is diagnosed as phlegm-fluid retention cough; the etiological factors of fluid retention in the rib of the chest. Fourteen formulas of semen lepidii for warming lung are taken three times in the morning, at noon and at night; the disease condition is improved.

Detailed Description

The raw materials prepared before the preparation are calculated according to the amount of 10000ml of liquid medicine:

pepperweed seed 12 g x 50; ephedra herb 9 g is multiplied by 50; chinese date 10 g multiplied by 50; asarum herb, asa; dried ginger 9 g × 50; 10 g of areca peel is multiplied by 50; poria cocos wolf 18 g x 50. (semen lepidii 600 g, ephedra 450 g, Chinese date 500 g, asarum 250 g, dried ginger 450 g, areca peel 500 g, poria cocos wolf 900 g).

The dosage of the pepperweed seed lung-warming prescription is 200ml of solution in each prescription; the traditional Chinese medicine of each prescription is 73 g and is dissolved in 200ml of liquid, namely 36 percent g/ml.

The Chinese medicinal decoction pieces are soaked in drinking water and decocted. The process comprises the following steps: 1. decocting twice, and mixing; 2. purifying, filtering the extractive solution to remove impurities, and collecting supernatant; 3. concentrating, filtering, concentrating the clear solution, and adding antiseptic and correctant to required amount; 4. subpackaging (filling) and sealing in a container; 5. and (3) sterilization, wherein: sometimes sterilized and then filled.

Claims (3)

1. A semen Lepidii Chinese medicinal compound preparation for treating patients with new coronary pneumonia, phlegm retention, cough and pulse and common patients is decoction, mixture, and oral liquid in single package; cough with profuse sputum, white or foamy; abundant phlegm and saliva, dyspnea with cough and dyspnea with difficulty in lying down, edema, fluid retention, hydrothorax and abdominal dropsy, dysuria; the prescription consists of monarch, minister, guide and adjuvant drugs, and is characterized in that the prescription is a traditional Chinese medicine composition, wherein the monarch drugs comprise semen lepidii, ephedra and Chinese date.

2. The Chinese medicinal composition as claimed in claim 1, wherein the formulation comprises the monarch, minister, guide and adjuvant drugs including semen Lepidii, herba Ephedrae, fructus Jujubae, herba asari, Zingiberis rhizoma, pericarpium Arecae and Poria.

3. The Chinese medicinal composition as claimed in claim 1, wherein the dosage of the monarch, minister, guide and adjuvant drugs in the prescription is 12 g of semen lepidii, 9 g of ephedra, 10 g of Chinese date, 5 g of asarum, 9 g of dried ginger, 10 g of areca peel and 18 g of tuckahoe; the process for producing the oral liquid comprises the steps of decocting water, soaking the traditional Chinese medicine decoction pieces; decocting, mixing decoctions, purifying, concentrating, adding antiseptic and correctant, bottling, sealing, and sterilizing.