CN109528936A - It is a kind of for treating the composition of gout - Google Patents
It is a kind of for treating the composition of gout Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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Abstract
The present invention provides a kind of for treating the composition of gout, the composition is prepared by following raw material in parts by weight: 45-55 parts of honeysuckle, 25-35 parts of dandelion, 10-20 parts of ganoderma lucidum, 2-8 parts of Rhizoma Gastrodiae, 2-8 parts of American Ginseng, 2-8 parts of pallas pit viper, 10-20 parts of chrysanthemum, 10-20 parts of raspberry, 10-20 parts of mulberries；The composition for the treatment of gout provided by the invention, each raw material component have synergistic function, and raw material is natural animal-plant source, action temperature and, have no toxic side effect, can take for a long time；Therapeutic effect is significant, efficient high；Treating both manifestation and root cause of disease has and prevents and treats double action.
Description
Technical field
The present invention relates to compositions fields, and in particular to a kind of for treating the composition of gout.
Background technique
Gout is a kind of because of disorders of purine metabolism, hyperuricemia caused by the synthesis of uric acid increases or discharge is reduced, urine
Hydrochlorate deposition can lead to characteristic acute arthritis, tophaceous chornic arthritis, and main clinical manifestation is redness and swelling of joints, heat
Bitterly, joint motion is not flexible, and serious person can lead to joint deformity, joint is disabled, and often involve kidney, cause renal insufficiency or
Nephropathy, patients with acute exacerbation is in great pain, abnormal painful, causes serious adverse effect to the Health and Living of patient.
Gout is mainly in the middle-aged and the old, overweight people and brain worker, in recent years, as the improvement of people's living standards, gout illness
There is the trend risen year by year in rate, for clinical high-incidence disease at present.
Currently, the principle of western medical treatment gout is anti-inflammatory and antalgic and control uric acid level, belong to symptomatic treatment, lack to because
Treatment, recommended drug is mainly non-steroid anti-inflammatory drug, but drug is recommended to have liver renal toxicity etc. mostly in application process
Side effect, and easily repeatedly, therapeutic effect is not good enough for symptom after drug withdrawal.And Chinese medicine thinks, gout breaking-out is close with damp and hot, blood stasis, phlegm wet
Cut phase is closed, and is particular about diagnosis and treatment based on an overall analysis of the illness and the patient's condition, etiological treatment, with the combination of traditional Chinese medicine and modern medical theory, tcm therapy is embodied
Effectiveness and reliability, in gout treatment have wide potential applicability in clinical practice.
Summary of the invention
The purpose of the present invention is to provide a kind of for treating the composition of gout, to overcome the Western medicine of existing treatment gout
Toxic side effect is big and treats halfway problem, and the composition therapeutic effect is good, has no toxic side effect.
The present invention is achieved through the following technical solutions:
It is a kind of for treating the composition of gout, be prepared by following raw material in parts by weight: 45-55 parts of honeysuckle, Pu Gong
25-35 parts of English, 10-20 parts of ganoderma lucidum, 2-8 parts of Rhizoma Gastrodiae, 2-8 parts of American Ginseng, 2-8 parts of pallas pit viper, 10-20 parts of chrysanthemum, raspberry 10-20
Part, 10-20 parts of mulberries.
Preferably, a kind of for treating the composition of gout, it is prepared by following raw material in parts by weight: honeysuckle
48-52 parts, 28-32 parts of dandelion, 13-17 parts of ganoderma lucidum, 4-6 parts of Rhizoma Gastrodiae, 4-6 parts of American Ginseng, 4-6 parts of pallas pit viper, chrysanthemum 13-17
Part, 13-17 parts of raspberry, 13-17 parts of mulberries.
It is further preferable that it is a kind of for treating the composition of gout, it is prepared by following raw material in parts by weight: gold and silver
48-50 parts of flower, 28-30 parts of dandelion, 14-15 parts of ganoderma lucidum, 4-5 parts of Rhizoma Gastrodiae, 4-5 parts of American Ginseng, 4-5 parts of pallas pit viper, chrysanthemum 14-15
Part, 14-15 parts of raspberry, 14-15 parts of mulberries.
The present invention is used to treat the composition of gout, can extract active constituent and extract is made, addition is pharmaceutically made
Required proper auxiliary materials when standby different dosage forms, such as disintegrating agent, lubricant, emulsifier, adhesive, with conventional preparation method, system
At suitable dosage form, such as tablet, granule, capsule, powder, pill, oral solution and syrup.
Preferably, the dosage form is oral solution, granule, tablet or capsule.
Chlorogenic acid, microelement and vitamin rich in honeysuckle are from ancient times clearing heat and detoxicating good medicine, its property is sweet
Cold air fragrance, clear heat with drugs of sweet flavour and cold nature is without injuring one's stomach, and fragrance reaches thoroughly and eliminating evil；It can be used for the diseases such as dermexanthesis, macular eruption, heat toxin sore carbuncle, swelling and pain,
Significant effect；
Dandelion can clearing heat and detoxicating, carbuncle that disappears dissipating bind, can be used for removing heat from the liver, treatment the hot hot eyes of liver swelling and pain, carbuncle sore tumefacting virus, Yi Jiduo
Kind infection, purulent disease；
Ganoderma lucidum is also known as red sesame, containing Multiple components such as organic germanium, macromolecule polysaccharide body, three enzymes, glands, can be mended with benefiting qi and nourishing blood
Liver and qi, regulating menstruation and activating blood；The effect of having both removing toxic substances and qi-restoratives, not only salubrity consolidates, also to arthralgia caused by gout, joint
Inflammation has certain adjuvant treatment effect；
Rhizoma Gastrodiae is orchid family Gastrodia herbaceos perennial, has the effect of Inflammation Zhijing, suppressing liver-YANG, dispelling wind and removing obstruction in the meridians；It can use
In diseases such as child convulsion, epilepsy clonus, tetanus, headache and dizziness, hands and feet caused by paralysis, extremity numbness, rheumatic arthralgias.Rhizoma Gastrodiae contains phenol
The ingredients such as class, organic acid, polysaccharide, sterols and organic compounds containing nitrogen, Central nervous system, are exempted from cardiovascular system
Epidemic disease system etc. has effect；
American Ginseng, also known as American ginseng, belong to herbaceos perennial, have clearing heat and detoxicating, nourishing qi and blood, enriching yin and nourishing kidney and mouth
The effect of tooth promotes the production of body fluid is tired of that the symptoms such as tired, blood loss dry, chronic cough of deficiency lung have good curative effect for common abnormal heat；
Pallas pit viper is Viperidae animal Agkistrodon halys(pallas) remove the dry all of internal organ；It is sweet in flavor, it is warm-natured；It can dispel
Wind eases pain, removing toxic substances.For rheumatic arthralgia, leprosy, lymph node, tuberculosis, boil is physically weak, hidrosis etc.；
Chrysanthemum compositae plant chrysanthemum (Chrysanthemum morifoliumRamat. dry capitulum), chrysanthemum is sweet, bitter,
Slightly cold, return lung, Liver Channel have effects that calming the liver, improving eyesight, clearing away heat and toxic materials, can be used for treating that anemopyretic cold, eyes are dim-sighted, hot eyes is swollen
Bitterly, sore and toxic etc.；
Raspberry refers to the dry fruit of rosaceous plant rubus chingii Hu Rubus chingii Hu, sour, mild-natured, main peace five
It is dirty；With nourishing kidney yin, astringent sperm contracting urine, the effect of nourishing the liver to improve visual acuity；
Mulberries claim its " only quenching one's thirst, relieving the five internal organs joint, lead to vim and vigour, long term usage is not hungry, spirit sedation ", Ke Yizi in Compendium of Material Medica
Yin kidney tonifying, relievings asthma, is depressured, benefiting qi and nourishing blood, improving immunity.
The present invention combines according to the ratio through above-mentioned raw materials, has synergistic function, has the beneficial effect that:
1. component is natural animal-plant source provided by the present invention for the composition for treating gout, action temperature and, it is nontoxic
Side effect can take for a long time；
2. provided by the present invention, for treating the composition of gout, therapeutic effect is significant, efficient high；
3. the present invention is from Chinese medicine etiological treatment theory, clearing heat and detoxicating, wind dispelling eliminating evil, while nourishing liver and kidney, nourishing qi and blood,
Treating both manifestation and root cause of disease has and prevents and treats double action.
Specific embodiment
The present invention is further elaborated in conjunction with the embodiments, but embodiments of the present invention are not limited to the content.
Embodiment one
The preparation of composition material:
Raw material is weighed according to weight fraction: 48 parts of honeysuckle, 28 parts of dandelion, 14 parts of ganoderma lucidum, 4 parts of Rhizoma Gastrodiae, 4 parts of American Ginseng, Pallas pit viper
4 parts of snake, 14 parts of chrysanthemum, 15 parts of raspberry, 15 parts of mulberries；
Preparation method:
Extracting honeysuckle, dandelion, ganoderma lucidum, Rhizoma Gastrodiae, American Ginseng, pallas pit viper, chrysanthemum, raspberry, mulberries, by weight plus 15 times are measured
Water after cold water soak 30min, heating extraction 2 times, each 2h, collects combined extract, concentrated extracting solution to relative density is
1.20, obtain the extract of composition of the present invention for treating gout；
To extract obtained middle addition right amount of auxiliary materials, granulation, drying, whole grain, packing are to get present composition granule.
Embodiment two
The preparation of composition material:
Raw material is weighed according to weight fraction: 50 parts of honeysuckle, 30 parts of dandelion, 15 parts of ganoderma lucidum, 5 parts of Rhizoma Gastrodiae, 5 parts of American Ginseng, Pallas pit viper
5 parts of snake, 15 parts of chrysanthemum, 15 parts of raspberry, 15 parts of mulberries；
Preparation method:
Extracting honeysuckle, dandelion, ganoderma lucidum, Rhizoma Gastrodiae, American Ginseng, pallas pit viper, chrysanthemum, raspberry, mulberries, by weight plus 20 times are measured
Water after cold water soak 20min, heating extraction 2 times, each 2h, collects combined extract, concentrated extracting solution to relative density is
1.20, obtain the extract of composition of the present invention for treating gout；
To extract obtained middle addition right amount of auxiliary materials, granulation, tabletting, coating, packing are to get the traditional chinese medicine composition of the invention tablet.
Embodiment three
The preparation of composition material:
Raw material is weighed according to weight fraction: 52 parts of honeysuckle, 25 parts of dandelion, 10 parts of ganoderma lucidum, 6 parts of Rhizoma Gastrodiae, 8 parts of American Ginseng, Pallas pit viper
3 parts of snake, 20 parts of chrysanthemum, 10 parts of raspberry, 20 parts of mulberries；
Preparation method:
Extracting honeysuckle, dandelion, ganoderma lucidum, Rhizoma Gastrodiae, American Ginseng, pallas pit viper, chrysanthemum, raspberry, mulberries, by weight plus 10 times are measured
Water after cold water soak 25min, heating extraction 2 times, each 2h, collects combined extract, concentrated extracting solution to relative density is
1.20, obtain the extract of composition of the present invention for treating gout；
To extract obtained middle addition right amount of auxiliary materials, granulation, encapsulated, packing are to get present composition capsule.
Example IV
The preparation of composition material:
Raw material is weighed according to weight fraction: 45 parts of honeysuckle, 35 parts of dandelion, 20 parts of ganoderma lucidum, 8 parts of Rhizoma Gastrodiae, 2 parts of American Ginseng, Pallas pit viper
8 parts of snake, 10 parts of chrysanthemum, 20 parts of raspberry, 10 parts of mulberries；
Preparation method:
Extracting honeysuckle, dandelion, ganoderma lucidum, Rhizoma Gastrodiae, American Ginseng, pallas pit viper, chrysanthemum, raspberry, mulberries, by weight plus 15 times are measured
Water after cold water soak 40min, heating extraction 2 times, each 2h, is collected combined extract, is concentrated under reduced pressure, stand cooling, obtain this
The extract of composition of the invention for treating gout；
To extract obtained middle addition right amount of auxiliary materials, it is uniformly mixed, filtering, dispenses to get present composition oral solution.
The clinical test of composition of the present invention for treating gout and result are as follows:
1. case selection
Meet the traditional Chinese and western medicine diagnostic criteria of acute gouty arthritis；Age is between 18~65 years old；The course of disease is in 1-10
Between；Test case totally 50, wherein male 38, women 12, simple joint red and swollen heat pain person 32, two redness and swelling of joints
Hot pain person 18；It is randomly divided into treatment group, control group, every group of each 25 people.
2. treatment method
Treatment group: taking the present composition granule prepared according to embodiment one, and each 5g continuously takes 13 times a day
A month.
Control group: taking Allopurinol Tablets, and the 1st week: each 0.05g, 3 times a day；2nd week: each 0.1g, 3 times a day；
The 2-4 weeks: each 0.2g(half), 3 times a day；Continuously take 1 month.
3. criterion of therapeutical effect
Referring to Standards for Diagnosis and Curative Effect of Chinese Medical Symptom.Cure: redness and swelling of joints heat pain is basic to disappear, and joint motion is normal, blood uric acid
Value is in the normal range；Improve: arthroncus mitigates, and pain is alleviated earlier above, and blood uric acid inspection value is substantially reduced earlier above；It is invalid:
Symptom and blood uric acid check unchanged.
4. test result
After treatment 1 month, as a result statistics clinical efficacy, blood uric acid index and adverse reaction situation are shown in Table 1, table 2, table 3 respectively.
The clinical efficacy of 1 present composition of table
The pretherapy and post-treatment blood uric acid of table 2 compares
A situation arises for 3 adverse reaction of table
| Group | Case load | Feed is reduced | Pruitus | Nausea and vomiting | It is total |
| Treatment group | 25 | 0 | 0 | 0 | 0 |
| Control group | 25 | 2 | 3 | 0 | 5 |
Test result shows that patient's serum uric acid level can be significantly reduced provided by the present invention for the composition for treating gout, right
Gout has good therapeutic effect, and overall clinical efficacy rate has no adverse reaction up to 88%.
Claims (5)
1. a kind of for treating the composition of gout, which is characterized in that the composition for treating gout is by following weight
The raw material of number is prepared: 45-55 parts of honeysuckle, 25-35 parts of dandelion, and 10-20 parts of ganoderma lucidum, 2-8 parts of Rhizoma Gastrodiae, American Ginseng 2-
8 parts, 2-8 parts of pallas pit viper, 10-20 parts of chrysanthemum, 10-20 parts of raspberry, 10-20 parts of mulberries.
2. according to claim 1 a kind of for treating the composition of gout, which is characterized in that described for treating gout
Composition be prepared by following raw material in parts by weight: 48-52 parts of honeysuckle, 28-32 parts of dandelion, 13-17 parts of ganoderma lucidum,
4-6 parts of Rhizoma Gastrodiae, 4-6 parts of American Ginseng, 4-6 parts of pallas pit viper, 13-17 parts of chrysanthemum, 13-17 parts of raspberry, 13-17 parts of mulberries.
3. according to claim 1 a kind of for treating the composition of gout, which is characterized in that described for treating gout
Composition be prepared by following raw material in parts by weight: 48-50 parts of honeysuckle, 28-30 parts of dandelion, 14-15 parts of ganoderma lucidum,
4-5 parts of Rhizoma Gastrodiae, 4-5 parts of American Ginseng, 4-5 parts of pallas pit viper, 14-15 parts of chrysanthemum, 14-15 parts of raspberry, 14-15 parts of mulberries.
4. according to claim 1 a kind of for treating the composition of gout, which is characterized in that described for treating gout
Composition be prepared by following raw material in parts by weight: 50 parts of honeysuckle, 30 parts of dandelion, 15 parts of ganoderma lucidum, 5 parts of Rhizoma Gastrodiae,
5 parts of American Ginseng, 5 parts of pallas pit viper, 15 parts of chrysanthemum, 15 parts of raspberry, 15 parts of mulberries.
5. according to claim 1 a kind of for treating the composition of gout, which is characterized in that described for treating gout
Composition be prepared by following raw material in parts by weight: 48 parts of honeysuckle, 28 parts of dandelion, 14 parts of ganoderma lucidum, 4 parts of Rhizoma Gastrodiae,
4 parts of American Ginseng, 4 parts of pallas pit viper, 14 parts of chrysanthemum, 15 parts of raspberry, 15 parts of mulberries.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811632419.3A CN109528936A (en) | 2018-12-29 | 2018-12-29 | It is a kind of for treating the composition of gout |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811632419.3A CN109528936A (en) | 2018-12-29 | 2018-12-29 | It is a kind of for treating the composition of gout |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107260967A (en) * | 2017-05-15 | 2017-10-20 | 广州智润生物制药科技有限公司 | A kind of pharmaceutical composition for treating gout |
| CN107441354A (en) * | 2017-05-25 | 2017-12-08 | 天津怡昇园科技发展有限公司 | Application of the Chinese medicine composition in reducing blood lipid or anti-trioxypurine medicine and health products are prepared |
-
2018
- 2018-12-29 CN CN201811632419.3A patent/CN109528936A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107260967A (en) * | 2017-05-15 | 2017-10-20 | 广州智润生物制药科技有限公司 | A kind of pharmaceutical composition for treating gout |
| CN107441354A (en) * | 2017-05-25 | 2017-12-08 | 天津怡昇园科技发展有限公司 | Application of the Chinese medicine composition in reducing blood lipid or anti-trioxypurine medicine and health products are prepared |
Non-Patent Citations (1)
| Title |
|---|
| 卢嘉琦等: "中医内外合治急性痛风性关节炎60例疗效观察", 《云南中医中药杂志》 * |
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Application publication date: 20190329 |