CN118078920A

CN118078920A - Preparation for promoting blood circulation, removing blood stasis, dissolving thrombus and reducing three highs and preparation method thereof

Info

Publication number: CN118078920A
Application number: CN202410280269.3A
Authority: CN
Inventors: 刘保东; 刘宝兴; 别红红
Original assignee: Henan Yushengtang Pharmaceutical Co ltd
Current assignee: Henan Yushengtang Pharmaceutical Co ltd
Priority date: 2024-03-12
Filing date: 2024-03-12
Publication date: 2024-05-28

Abstract

The invention discloses a preparation for promoting blood circulation, removing blood stasis, dissolving thrombus and reducing three highs, which is prepared from the following raw materials of medicines such as gastrodia tuber, ligusticum wallichii, root of red rooted saliva, earthworm protein peptide, kudzuvine root, eucommia ulmoides leaf, haw, chinese yam, red rice, selfheal, cassia seed, wolfberry fruit, natto powder, cyclocarya paliurus, grape seed powder, astragalus root extract, herba siegesbeckiae and fistular onion stalk. The invention relates to the technical field of medical health care. The traditional Chinese medicine composition is prepared from raw materials with homology of medicine and food, has the effects of reducing blood fat, reducing blood pressure and dredging blood through mutual matching and synergistic effect of the components, and can treat and prevent hypertension and blood vessel blockage.

Description

Preparation for promoting blood circulation, removing blood stasis, dissolving thrombus and reducing three highs and preparation method thereof

Technical Field

The invention relates to the technical field of medical health care, in particular to a preparation for activating blood, removing stasis, dissolving thrombus and reducing three highs and a preparation method thereof.

Background

The three highs are the general names of hyperlipidemia, hypertension and hyperglycemia, and are the most common cardiovascular diseases. The modern society has fast rhythm, vigorous competition, great pressure for life, study and work, frequent stay up, insufficient sleep, and incapacity of fully relaxing even at rest, and many people neglect the attention to self health, and easily cause cardiovascular and cerebrovascular diseases. On the other hand, with the improvement of living standard, the diet structure of people is mainly high-salt, high-fat, high-sugar and high-calorie diet, and the diet is irregular, people do not eat meal when busy, hu Chihai plug in the gathering process, and cholesterol and fat are accumulated in the body to become a fuse for inducing three-high. Another cause of the three-high diseases such as hypertension is related to the fact that the quantity of exercise of people is too small, work is busy, pressure is high, people sit for a long time during working, exercise is lacking after working, physical activity is little, and people suffering from hypertension, hyperglycemia and hyperlipidemia are more and more caused by poor life habits.

The normal human blood vessel intima is smooth and smooth, and is like arterial wall elasticity, peripheral resistance of blood vessel, blood viscosity are the important factors for forming hypertension, but blood fat increase can be gradually deposited under blood vessel intima to form yellow atheromatous plaque, if not treated, gradual collapse, bleeding, blood vessel narrowing and blood fluidity weakening can lead to blood fat increase and blood pressure increase, and the three factors are directly related to hyperlipidemia. The long-term accumulation of blood fat can cause arteriosclerosis, so that the elasticity of the blood vessel wall is weakened, the blood pressure is increased, the interaction of the hyperlipidemia and the hypertension is not only bad, and the hyperlipidemia can reduce the sensitivity of antihypertensive drugs due to the simultaneous occurrence of the hyperlipidemia and the hypertension, so that the treatment of the hypertension and the hyperlipidemia is coordinated to be carried out in a unilateral treatment.

At present, no special method is provided for three highs, western medicine is generally adopted, but western medicine is taken to only temporarily control three highs index, can not radically cure the three highs, and needs to be taken for life, so that the side effect on human bodies is large; some western medicines have obvious treatment effect, but are expensive, and a large burden is formed on patients due to long-term administration.

The traditional Chinese medicine for treating hypertension has the advantages of being capable of adjusting the functional balance among all systems of an organism effectively, reducing three-high, being mild in effect, good in effect and less in side effect from the aspect of overall adjustment and treatment. Therefore, the external preparation which has the advantages of reducing blood pressure and blood lipid, reducing blood sugar, clearing heat and detoxicating, wide applicable crowd, small side effect, suitability for long-term use, safety and reliability has good economic and social significance.

Disclosure of Invention

The invention provides a preparation for promoting blood circulation, removing blood stasis, dissolving thrombus and reducing hypertension, hyperglycemia and hyperlipidemia, which is prepared from the following raw materials, by weight, 30-60 parts of gastrodia elata, 30-60 parts of ligusticum wallichii, 60-100 parts of red sage root, 60-100 parts of earthworm protein peptide, 85-140 parts of radix puerariae, 50-76 parts of eucommia ulmoides leaves, 60-100 parts of hawthorn, 30-60 parts of Chinese yam, 15-40 parts of red yeast rice, 25-50 parts of selfheal, 25-50 parts of semen cassiae, 25-50 parts of medlar, 25-50 parts of natto powder, 25-50 parts of cyclocarya paliurus, 25-50 parts of grape seed powder, 25-50 parts of astragalus mongholicus extract, 50-100 parts of herba siegesbeckiae and 30-60 parts of fistular onion white.

Preferably, the traditional Chinese medicine composition is prepared from the following raw materials, by weight, 45 parts of gastrodia elata, 45 parts of ligusticum wallichii, 80 parts of red sage root, 80 parts of earthworm protein peptide, 112.5 parts of radix puerariae, 63 parts of eucommia ulmoides leaves, 80 parts of hawthorn, 45 parts of Chinese yam, 27.5 parts of red yeast rice, 37.5 parts of selfheal, 37.5 parts of semen cassiae, 37.5 parts of medlar, 37.5 parts of natto powder, 37.5 parts of cyclocarya paliurus, 37.5 parts of grape seed powder, 37.5 parts of astragalus extract, 75 parts of herba siegesbeckiae and 45 parts of fistular onion stalk.

A preparation method of a preparation for promoting blood circulation, removing blood stasis, dissolving thrombus and reducing three highs comprises the following steps,

Step one: preparing a medicine, namely weighing the raw materials according to the weight components;

Step two: grouping, namely the medicines are prepared according to the following main medicines: gastrodia tuber, ligusticum wallichii, root of red rooted saliva, selfheal, and cassia seed; adjuvant drug: radix Puerariae, folium Eucommiae, fructus crataegi, fructus Lycii, ramulus et folium Litseae, and grape seed powder; dispensing: earthworm protein peptide, yam and natto powder; adjuvant drug: herba Siegesbeckiae and Bulbus Allii Fistulosi; radix astragali extract and red rice;

Step three: extracting the main medicine and the auxiliary medicine by using a water extraction method, mixing and concentrating to obtain a mixed extract;

step four: extracting the medicine by alcohol extraction, concentrating and drying to obtain extract powder;

step five: extracting adjuvant with water, and concentrating to obtain fluid extract;

step six: mixing the mixed extract in the third step, the extract powder in the fourth step and the clear paste in the fifth step, adding the astragalus extract, uniformly mixing again, and concentrating to obtain paste;

step seven: grinding red rice, mixing with the paste prepared in the step six, and sterilizing by irradiation at 60 ℃ to obtain the preparation.

Red yeast rice: red rice with mycelium parasitized on polished round-grained rice has sweet taste and slightly warm nature; spleen, large intestine and liver meridian; strengthening spleen, promoting digestion, promoting blood circulation and removing blood stasis;

preferably, the red rice flour is ground by a grinder, the rotating speed of the grinder is set to 600-800 revolutions per minute, and the ground red rice flour is sieved to 80-100 meshes.

Preferably, the preparation method of the mixed extracting solution in the third step comprises the following steps,

Step one: preparing rhizoma Gastrodiae, rhizoma Ligustici Chuanxiong, saviae Miltiorrhizae radix, prunellae Spica, and semen Cassiae respectively;

The mechanism of each component in the invention is as follows:

gastrodia elata Blume: has effects of calming endogenous wind, relieving spasm, suppressing liver yang, dispelling pathogenic wind, and dredging collaterals; can be used for treating internal stirring of liver wind, convulsion, epilepsy, convulsion, dizziness, headache, numbness of limbs, hand and foot paralysis, rheumatalgia, etc.

Ligusticum wallichii: it is commonly used for promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, relieving pain, and eliminating pungent, warm, fragrant and dry nature of rhizoma Ligustici Chuanxiong, and can promote dispersion and ascend to peak; blood flows into the body and down to the sea; the effects of activating blood and removing stasis are wide, and the traditional Chinese medicine composition is suitable for various diseases of blood stasis retardation; has good effect of dispelling wind and relieving pain, and can be used for treating headache due to wind-damp arthralgia.

Root of red-rooted salvia: has effects of promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood, and resolving carbuncle; can be used for treating chest pain, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease.

Spica Prunellae: has effects of removing liver fire for improving eyesight, clearing heat, resolving hard mass, and lowering blood pressure;

semen Cassiae has effects of clearing liver fire, dispelling pathogenic wind and dampness, invigorating kidney and improving eyesight;

Step two: mixing, adding 8-10 times of water, decocting at 80-90deg.C for 1-3 hr, and filtering;

Step three: adding 4-6 times of water into the filter residue in the second step, boiling at 70-80 ℃ for 40-50min, and filtering;

Combining the filtrate filtered in the second step and the filtrate filtered in the third step to obtain filtrate 1;

step four: taking radix Puerariae, folium Eucommiae, fructus crataegi, fructus Lycii, ramulus et folium Litseae and grape seed powder;

The mechanism of each component in the invention is as follows:

radix Puerariae: has effects in invigorating yang, promoting salivation, promoting blood circulation, dredging collaterals, and strengthening spleen by promoting fluid production;

Eucommia ulmoides: eucommia ulmoides contains various effective components, wherein more than 40 compounds such as iridoids, lignans, phenylpropanoids and the like are included, and the pharmacological effects are wide; has effects in lowering blood pressure, resisting aging, resisting tumor, resisting bacteria and virus, and enhancing immunity;

Hawthorn fruit, fructus crataegi, sour and sweet in nature, slightly warm in nature, has the effects of entering spleen, stomach and liver meridians, and is mainly used for resolving food stagnation, dispelling blood stasis and expelling tapeworm. For treating meat stagnation, abdominal mass, phlegm retention, distention and fullness, acid regurgitation, diarrhea, intestinal wind, lumbago, infantile back pain after hernia, lochia, and infantile dyspepsia. Promoting digestion, invigorating stomach, promoting qi circulation, and dispelling blood stasis. Can be used for treating food stagnation, flatulence, diarrhea, abdominal pain, blood stasis amenorrhea, puerperal blood stasis, pain of heart and abdomen, hernia pain, and hyperlipidemia;

Wolfberry fruit: has sweet and flat taste; enter meridians, liver and kidney meridians; the main functions are nourishing liver and kidney, replenishing vital essence and improving eyesight;

Cyclocarya paliurus: bitter in flavor, pungent in flavor, flat in property, good in property, enter lung meridian and liver meridian. The green Qian Liupi, the leaves and the roots have the effects of killing parasites, relieving itching, diminishing inflammation, relieving pain and dispelling wind, and the health care tea prepared from the tender leaves of the lysimachia christinae Liu Chuchun has the functions of reducing blood pressure, blood sugar and blood fat, and simultaneously has unique effects of enhancing the immunity of human bodies, resisting oxidation and resisting aging;

Grape seed powder: can obviously improve the vascular resistance and reduce the permeability of capillary vessels; with age, the elastic fibers in the artery gradually oxidize and harden; this sclerosis is a major cause of hypertension in the elderly; procyanidins increase vascular elasticity and reduce blood pressure; after the procyanidine capsules are taken by a patient for a period of time, the blood pressure can be obviously reduced; animal experiments and clinical studies also show that procyanidins can reduce (cholesterol) levels, reducing the volume of cholesterol deposits deposited on the vessel wall; procyanidin soft capsule can also reduce blood pressure by inhibiting activity of angiotensin reversing alcohol;

Step five: mixing, adding 6-7 times of water, decocting at 80-90deg.C for 1-3 hr, and filtering;

Step six: adding 4-5 times of water into the filter residue in the fifth step, boiling at 70-80 ℃ for 40-50min, and filtering;

Combining the filtrate filtered in the step five and the filtrate filtered in the step six to obtain filtrate 2;

Step seven: mixing filtrate 1 and filtrate 2, and concentrating at 70-80deg.C to 1g crude drug/1 ml; filtering to obtain filtrate, and steam sterilizing the filtrate at 121deg.C and 0.11MPa for 30min to obtain mixed extractive solution.

Preferably, the radix Puerariae is processed by segmentation, the thickness of the segmented radix Puerariae is 1-3cm, and the folium Eucommiae, fructus crataegi, fructus Lycii and herba Lysimachiae Christinae are pulverized, and sieved for 100-150 meshes.

Preferably, the preparation method of the extract powder in the fourth step comprises the following steps,

Step one: preparing earthworm protein peptide, chinese yam and natto powder respectively;

Earthworm protein peptide: salty and cold in taste, entering liver, spleen and lung meridians, dredging collaterals, and lowering blood pressure;

Chinese yam: contains mucin, has blood sugar reducing effect, can effectively prevent blood lipid from precipitating on blood vessel wall, and can prevent heart blood diseases;

Natto powder: as a vegetable food, it is most rich in crude protein and fat. The natto is a high-protein nourishing food, and the enzyme contained in the natto can remove part of cholesterol in the body and decompose acidification type lipid in the body after being eaten, so that abnormal blood pressure is recovered to be normal;

step two: adding the prepared Chinese medicinal materials into an extraction tank, and adding ethanol solution into the extraction tank;

step three: extracting the prepared Chinese medicinal materials with alcohol in an extraction tank for a predetermined time;

Step four: filtering the mixture in the extraction tank, and removing residues to obtain an alcohol extract;

Step five: concentrating the ethanol extract under reduced pressure to obtain corresponding thick extract, and recovering ethanol; the concentration conditions used were: the temperature is 55-65 ℃ and the vacuum degree is 0.08MPa; concentrating the alcohol extract to a relative density of 1.20-1.25;

step six: and (3) carrying out vacuum drying on the thick extract, crushing and sieving the dried extract to obtain extract powder.

Preferably, the preparation method of the fluid extract in the fifth step comprises the following steps,

Step one: weighing herba Siegesbeckiae and Bulbus Allii Fistulosi;

Herba Siegesbeckiae is dry aerial part of Siegesbeckiae herba, or Siegesbeckiae herba; cold, pungent and bitter; has effects in dispelling pathogenic wind and dampness, benefiting articulation, and removing toxic substances, and can be used for treating rheumatalgia, tendons and bones weakness, soreness of waist and knees, quadriplegia, hemiplegia, and rubella;

The Bulbus Allii Fistulosi is bulb of Allium fistulosum of Allium of Liliaceae; pungent and warm; induce sweating to relieve exterior syndrome, activate yang, induce diuresis; can be used for treating common cold, headache, and nasal obstruction; for external use, the preparation is used for treating difficult urination, carbuncles and furuncles;

step two: reflux-extracting with 40-70% ethanol for 1-4 hr for 2-3 times each time with ethanol amount 4-10 times of the total amount of the medicinal materials, mixing the extractive solutions, and filtering;

Step three: concentrating the filtrate to obtain fluid extract with relative density of 1.05-1.20 at 70-80deg.C to obtain active ingredient.

Preferably, the preparation method of the astragalus extract takes traditional Chinese medicinal material astragalus as a raw material, and comprises a medicinal material extraction step, an elution and desugaring step, a decoloring step and a purification step;

wherein the step of eluting and desugaring is to put the supernatant obtained by filtering the water extract obtained in the step of extracting the medicinal materials into a macroporous adsorption resin column under pressure, and elute and remove saccharide impurities with purified water with the volume of 10-15 times of the column volume;

The decoloring step is that firstly, an alkaline aqueous solution with the mass percentage concentration of 0.2-0.5% of the column volume is used for eluting, then an alcohol solution with the mass percentage concentration of 30-60% of the column volume of 5-10 times is used for eluting, and then an alcohol solution with the mass percentage concentration of 70-80% of the column volume of 5-10 times is used for eluting;

combining the three eluents in the decoloring step, concentrating to a small volume, and centrifuging to obtain a precipitate, namely a crude astragalus extract;

The purification step is to heat and dissolve the crude astragalus extract with proper amount of ethanol, filter, cool the filtrate at 2-8 ℃ for 24-48 hours, and centrifuge to obtain the astragalus extract with the purity of more than 98%.

Radix astragali: has effects in invigorating qi, supporting yang, consolidating superficial resistance, relieving sweating, inducing diuresis, relieving edema, promoting salivation, nourishing blood, removing stagnation, relieving arthralgia, removing toxic materials, expelling pus, healing sore, and promoting granulation.

Preferably, the preparation is granule, tablet, pill, paste, capsule, powder, decoction, oral liquid or teabag.

Compared with the prior art, the invention has the beneficial effects that:

the traditional Chinese medicine composition is prepared from raw materials with homology of medicine and food, has the effects of reducing blood fat, reducing blood pressure and dredging blood through mutual matching and synergistic effect of the components, and can treat and prevent hypertension and blood vessel blockage.

The invention adopts Chinese herbal medicines as raw materials, has low cost, quick curative effect, lasting effect and no toxic or side effect, and has the effects of activating blood circulation, anticoagulation, thrombolysis, promoting the circulation of stagnancy, resolving masses, eliminating phlegm, reducing blood pressure, detoxifying and the like.

The invention fundamentally regulates the functions of the viscera such as spleen, liver, kidney and the like, and can maintain and regulate the functions of the viscera while smoothly regulating three highs. The traditional Chinese medicine composition has the advantages that the traditional effect is ensured, the body resistance is stabilized, the long-term effect is more stable, and patients with hypertension, hyperglycemia and hyperlipidemia are not affected by pain.

The active ingredients extracted from hawthorns, herba siegesbeckiae, fistular onion stalks and the like can strengthen immunity, purify blood impurities and reduce blood fat content, and the absorption availability of the extracted active ingredients is better and is more acceptable.

Detailed Description

The present invention will be described in further detail with reference to the following embodiments. The embodiments of the invention have been presented for purposes of illustration and description, and are not intended to be exhaustive or limited to the invention in the form disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, and to enable others of ordinary skill in the art to understand the invention for various embodiments with various modifications as are suited to the particular use contemplated.

The embodiment 1 of the preparation for promoting blood circulation, removing blood stasis, dissolving thrombus and reducing three highs is prepared from the following raw materials in parts by weight.

The embodiment 2 of the preparation for promoting blood circulation, removing blood stasis, dissolving thrombus and reducing three highs is prepared from the following raw materials in parts by weight.

The embodiment 3 of the preparation for promoting blood circulation, removing blood stasis, dissolving thrombus and reducing three highs is prepared from the following raw materials in parts by weight.

Example 4 based on examples 1,2 and 3, a preparation method of a preparation for promoting blood circulation, removing blood stasis, dissolving thrombus and reducing three highs comprises the following steps,

Grinding red rice with a grinder at 600-800 rpm, and sieving with 80-100 mesh sieve.

Example 5, the preparation method of the mixed extract in step three, based on example 4, comprises the following steps,

The radix Puerariae is processed by segmentation, the thickness of the segmented radix Puerariae is 1-3cm, and folium Eucommiae, fructus crataegi, fructus Lycii, and ramulus et folium Litseae are pulverized, and sieved for 100-150 meshes.

Example 6, the preparation method of the extract powder in the fourth step on the basis of example 4, comprises the following steps,

Step five: concentrating the ethanol extract under reduced pressure to obtain corresponding soft extract, and recovering ethanol; the concentration conditions used were: the temperature is 55-65 ℃ and the vacuum degree is 0.08MPa; concentrating the ethanol extract to a relative density of 1.20-1.25;

Step six: vacuum drying the soft extract, pulverizing the dried extract, and sieving to obtain extract powder.

Example 7, the method for preparing the fluid extract in the fifth step, based on example 4, comprises the following steps,

Step one: weighing herba Siegesbeckiae and Bulbus Allii Fistulosi;

Embodiment 8, based on embodiment 4, the preparation method of astragalus extract takes astragalus as a raw material, and comprises a medicinal material extraction step, an elution desugaring step, a decoloring step and a purification step;

Wherein the step of eluting and removing sugar is to put the supernatant obtained by filtering the water extract obtained in the step of extracting the medicinal materials into a macroporous adsorption resin column under pressure, and elute and remove sugar impurities with purified water with the volume of 10-15 times of the column volume;

Combining the three eluents in the decoloring step, concentrating to a small volume, and centrifuging to obtain a precipitate, namely the crude astragalus extract;

The preparation is granule, tablet, pill, unguent, capsule, powder, decoction, oral liquid or teabag.

Case 1: zhang Mou, male, 52 years old, had hypertension, which often persisted at 28-24/14.7-13.3 kilopascals (210-180/110-100 millimeters of mercury). Often dizziness, headache, dysphoria, irritability, insomnia, dreaminess, soreness of waist and knees, numbness of limbs, flushed complexion, dysphoria with feverish sensation in chest, red tongue and thin and yellow coating, and the traditional Chinese medicine is not effective when taken once. The preparation of the invention is administered for more than 2 months because the symptoms are yin deficiency of liver and kidney, the symptoms are healed immediately, the patients are followed for more than 2 years after stopping taking, and the patients do not have blood pressure rise and focus is removed.

Case 2: chen X, male, 55 years old. Self-complaints: patients with "three highs" for 20 years. Hyperglycemia (fasting blood glucose 15.4 mmoI/L), hyperlipidemia (triglyceride 4.1mmoI/L, total cholesterol 12.7 mmoI/L), hypertension (high pressure 181mmHg/kpa, low pressure 142 mmHg/kpa), multiple therapy is ineffective, and after 2 courses of treatment with the formulation of the invention, blood pressure, blood glucose and blood lipid indicators fall below diagnostic criteria: fasting blood glucose 10.8mmoI/L; blood lipid (triglyceride 2.6mmoI/L, total cholesterol 10.4 mmoI/L); blood pressure (high pressure 145mmHg/kpa, low pressure 93 mmHg/kpa). One year later, no recurrence was observed.

It will be apparent that the described embodiments are only some, but not all, embodiments of the invention. All other embodiments, which can be made by those skilled in the art and which are included in the embodiments of the present invention without the inventive step, are intended to be within the scope of the present invention. Structures, devices and methods of operation not specifically described and illustrated herein, unless otherwise indicated and limited, are implemented according to conventional means in the art.

Claims

1. A preparation for promoting blood circulation, removing blood stasis, dissolving thrombus and reducing three highs is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials, by weight, 30-60 parts of gastrodia elata, 30-60 parts of ligusticum wallichii, 60-100 parts of red sage root, 60-100 parts of earthworm protein peptide, 85-140 parts of radix puerariae, 50-76 parts of eucommia ulmoides leaves, 60-100 parts of hawthorn, 30-60 parts of Chinese yam, 15-40 parts of red rice, 25-50 parts of selfheal, 25-50 parts of semen cassiae, 25-50 parts of medlar, 25-50 parts of natto powder, 25-50 parts of cyclocarya paliurus, 25-50 parts of grape seed powder, 25-50 parts of astragalus extract, 50-100 parts of herba siegesbeckiae and 30-60 parts of fistular onion stalk.

2. The preparation for promoting blood circulation, removing blood stasis, dissolving thrombus and reducing hypertension, hyperglycemia and hyperlipidemia according to claim 1, wherein the preparation is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials of 45 parts by weight of gastrodia elata, 45 parts by weight of ligusticum wallichii, 80 parts by weight of red sage root, 80 parts by weight of earthworm protein peptide, 112.5 parts by weight of radix puerariae, 63 parts by weight of eucommia ulmoides leaves, 80 parts by weight of hawthorn, 45 parts by weight of Chinese yam, 27.5 parts by weight of red yeast rice, 37.5 parts by weight of selfheal, 37.5 parts by weight of semen cassiae, 37.5 parts by weight of medlar, 37.5 parts by weight of natto powder, 37.5 parts by weight of cyclocarya paliurus, 37.5 parts by weight of grape seed powder, 37.5 parts by weight of astragalus extract, 75 parts by weight of herba siegesbeckiae and 45 parts by weight of fistular onion stalk.

3. A preparation method of a preparation for activating blood, removing stasis, dissolving thrombus and reducing three highs is characterized by comprising the following steps: comprises the steps of,

4. The method for preparing the preparation for activating blood circulation, removing stasis, dissolving thrombus and reducing hypertension, hyperglycemia and hyperlipidemia according to claim 3, which is characterized in that: the red rice flour is ground by a grinder, the rotating speed of the grinder is set to 600-800 rpm, and the ground red rice flour is sieved to 80-100 meshes.

5. The method for preparing the preparation for activating blood circulation, removing stasis, dissolving thrombus and reducing hypertension, hyperglycemia and hyperlipidemia according to claim 3, which is characterized in that: the preparation method of the mixed extracting solution in the third step comprises the following steps,

6. The method for preparing the preparation for promoting blood circulation, removing blood stasis, dissolving thrombus and reducing hypertension, hyperglycemia and hyperlipidemia according to claim 5, which is characterized in that: the radix Puerariae is processed by segmentation, the thickness of the segmented radix Puerariae is 1-3cm, and the folium Eucommiae, fructus crataegi, fructus Lycii and herba Lysimachiae Christinae are pulverized, and sieved for 100-150 meshes.

7. The method for preparing the preparation for activating blood circulation, removing stasis, dissolving thrombus and reducing hypertension, hyperglycemia and hyperlipidemia according to claim 3, which is characterized in that: the preparation method of the extract powder in the fourth step comprises the following steps,

8. The method for preparing the preparation for activating blood circulation, removing stasis, dissolving thrombus and reducing hypertension, hyperglycemia and hyperlipidemia according to claim 3, which is characterized in that: the preparation method of the fluid extract in the fifth step comprises the following steps,

Step one: weighing herba Siegesbeckiae and Bulbus Allii Fistulosi;

9. The method for preparing the preparation for activating blood circulation, removing stasis, dissolving thrombus and reducing hypertension, hyperglycemia and hyperlipidemia according to claim 3, which is characterized in that: the preparation method of the astragalus extract takes Chinese medicinal material astragalus as a raw material, and comprises a medicinal material extraction step, an elution desugaring step, a decoloring step and a purification step;

10. The method for preparing the preparation for activating blood circulation, removing stasis, dissolving thrombus and reducing hypertension, hyperglycemia and hyperlipidemia according to claim 3, which is characterized in that: the preparation is granule, tablet, pill, paste, capsule, powder, decoction, oral liquid or teabag.