CN102579926A - Formula of cough-relieving medicament and preparation method thereof - Google Patents
Formula of cough-relieving medicament and preparation method thereof Download PDFInfo
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- CN102579926A CN102579926A CN2012100839366A CN201210083936A CN102579926A CN 102579926 A CN102579926 A CN 102579926A CN 2012100839366 A CN2012100839366 A CN 2012100839366A CN 201210083936 A CN201210083936 A CN 201210083936A CN 102579926 A CN102579926 A CN 102579926A
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Abstract
The invention discloses a formula of a cough-relieving medicament and a preparation method thereof. The medicament is composition solution prepared by procedures such as decoction, filtering, boiling and mixing of folium eriobotryae, pericarpium papaveris, radix stemonae, cynanchum glaucescens, the root bark of white mulberry, platycodon grandiflorum, menthol crystal, cane sugar, citric acid, essence, sodium benzoate, dextromethorphan hydrobromide, promethazine hydrochloride, 75% of alcoholic solution, distilled water and the like. The cough-relieving medicament can be suitable for curing cough caused by various respiratory incentives. After patients orally take the cough-relieving medicament, no body function allergic reaction occurs. The cough-relieving medicament has no toxic or side effect and can be rapidly absorbed and utilized by bodies. The cure purpose of relieving cough and asthma can be achieved by tonifying kidneys, strengthening spleens and moistening lungs. The cough-relieving medicament is low in cost, and the preparation process is simple, convenient and easy to implement.
Description
Technical field
The present invention relates to a kind of cough suppressing medicine, relate to the prescription and the method for preparing of this cough suppressing medicine specifically.
Background technology
Cough is a kind of protectiveness respiratory reflex action of human body.Can effectively remove the secretions in the respiratory tract or get into the foreign body of air flue through coughre flex.But cough also has a disadvantageous one side, and violent cough can cause respiratory tract hemorrhage, as for a long time, frequently, acutely the cough work that influences, rest, even causes laryngalgia, hoarseness with breathe myalgia, then belong to pathological phenomenon.Upper respiratory tract infection, bronchitis, pneumonia, acute laryngitis etc. all can cause cough; The pharmaceutical preparation that has the cough-relieving curative effect in the market is many; But for Western medicine, the one, price comparison is expensive, continues several courses of treatment; Increase no small financial burden to the patient, the 2nd, long medication brings certain side effect to physical function especially respiratory system easily; For the pure Chinese medicinal preparation on the market especially oral formulations; Drug effect is slow; Instability helps balance breathing but can not eradicate the inducement that cough produces, and needs of patients has a kind of good effect; Make the obvious and effect stability of cough suppressing effect, and the relatively cheap medicine of price solves the problems referred to above.
Summary of the invention
The object of the invention promptly is to above-mentioned deficiency, on the basis of secret prescription handed down in the family from generation to generation, in conjunction with modern Chinese and western medicine technology; A kind of cough suppressing medicine is provided, relates to the prescription and the method for preparing of this cough suppressing medicine specifically, the preparation that the present invention processes; Go for the cough that various respiratory tract inducements cause; With its oral no physical function anaphylaxis in back, have no side effect, medicine can be absorbed by health rapidly; Reach the therapeutic purposes of relieving cough and asthma through the kidney invigorating, spleen invigorating, lung moistening, and with low cost, reparation technology is simple and easy to do.
Technical scheme of the present invention is described below: preparation of the present invention is the composition solution that is prepared into by materials such as Folium Eriobotryae, Pericarpium Papaveris, the Radix Stemonae, Rhizoma Cynanchi Stauntonii, Cortex Mori, Radix Platycodonis, Mentholum, sucrose, citric acid, essence, sodium benzoate, dextromethorphan hydrobromide, promethazine hydrochloride and 75% alcoholic solution, distilled water.
Wherein the quality proportioning of each component is:
Folium Eriobotryae 65-75 mass parts Pericarpium Papaveris 45-55 mass parts Radix Stemonae 10-18 mass parts
Rhizoma Cynanchi Stauntonii 6-10 mass parts Cortex Mori 5-8 mass parts Radix Platycodonis 5-8 mass parts
Mentholum 0.1-0.2 mass parts sucrose 500-800 mass parts essence 1-2 mass parts
Citric acid 0.2-0.6 mass parts
In addition, sodium benzoate 2-4 mass parts dextromethorphan hydrobromide 0.5-0.8 mass parts
Promethazine hydrochloride 0.5-1.0 mass parts
75% alcoholic solution 2-6 mass parts distilled water 1000-1500 mass parts.
In order to obtain better effect, the present invention preferably raw material mass mixture ratio is:
Folium Eriobotryae 65-69 mass parts Pericarpium Papaveris 50-55 mass parts Radix Stemonae 15-18 mass parts
Rhizoma Cynanchi Stauntonii 6-9 mass parts Cortex Mori 6-8 mass parts Radix Platycodonis 6-8 mass parts
Mentholum 0.15-0.2 mass parts sucrose 600-800 mass parts essence 1 mass parts
Citric acid 0.5-0.6 mass parts
In addition, sodium benzoate 2-3 mass parts dextromethorphan hydrobromide 0.7-0.8 mass parts
Promethazine hydrochloride 0.9-1.0 mass parts
75% alcoholic solution 4-6 mass parts distilled water 1200-1500 mass parts.
Certainly, in order to obtain further good effect, the present invention also preferably raw material mass mixture ratio be:
The Folium Eriobotryae 69 mass parts Pericarpium Papaveriss 50 mass parts Radixs Stemonae 15 mass parts
Rhizoma Cynanchi Stauntonii 9 mass parts Cortex Mori 6 mass parts Radix Platycodoniss 6 mass parts
Mentholum 0.15 mass parts sucrose 600 mass parts essence 1 mass parts
Citric acid 0.5 mass parts
In addition, sodium benzoate 2.5 mass parts dextromethorphan hydrobromides 0.7 mass parts
Promethazine hydrochloride 0.9 mass parts
75% alcoholic solution, 4 mass parts distilled water, 1200 mass parts.
Method for preparing according to the cough suppressing medicine of above-mentioned several mass ranges comprises the steps:
1), Folium Eriobotryae, Pericarpium Papaveris, the Radix Stemonae, Rhizoma Cynanchi Stauntonii, Cortex Mori, Radix Platycodonis adding distil water are decocted secondary, the distilled water consumption is 3/4ths of whole distilled water, decocts 2 hours at every turn, merges twice decocting liquid then, filters the back and concentrates subsequent use;
2), above-mentioned solution is added sodium benzoate, fully stir and make it dissolving, and then make it abundant mixing with sucrose, continue then to be heated to and boil, kept 20 minutes, it is subsequent use to leave standstill 30 minutes after-filtration;
3), with 75% dissolve with ethanol solution essence, itself and Mentholum, citric acid are joined in the above-mentioned solution, abundant stirring and evenly mixing left standstill 30 minutes then, filtered subsequent use then;
4), above-mentioned composition solution is added dextromethorphan hydrobromide, promethazine hydrochloride, add remaining 1/4th distilled water then, both stirred mixing, packing, sterilization then.
The preparation of producing is a solution, is applicable to orally, and it is every two hours once oral to be grown up, each 10-15 milliliter, the cough that can be used for catching cold, a variety of causes such as influenza and similar upper respiratory tract infection causes, dry cough, abundant expectoration cough, sensitivity cough etc.
Theoretical foundation of the present invention is, analyzes in conjunction with China's Traditional Chinese medical theory and the modern Chinese medicine property of medicine, in above-mentioned prescription:
Folium Eriobotryae, Folium Eriobotryae are the leaf of rosaceous plant Folium Eriobotryae Eriobotryajaponica (Thunb.) Lindl., have another name called Ba Ye, Lu Juye (" Chinese crude drug handbook).Former plant Folium Eriobotryae has another name called: Lu's Fructus Citri tangerinae (Guangdong), hardship is slightly cold.The effect of clearing away lung-heat to relieve cough, regulating the stomach and sending down the abnormal ascending QI are arranged, quenching the thirst.Classics "Do not record": "Lord Death agriculture, more than, the next gas." contained amygdalin is decomposited micro-hydrocyanic acid at lower digestive tract by microbial enzyme, and the latter has sedation to respiratory center, so the antitussive effect of relievining asthma is arranged.
Pericarpium Papaveris is claimed Plantula Papaveris, foxtail millet shell, small-mouthed jar foxtail millet shell, rice capsule shell again, and these article are the drying and ripening shell of Papaveraceae poppy Semen Papaveris Papaver somniferum L..The mature fruit that will extract behind the juice autumn is taken, and breaks, and removes seed and branch stalk, drying.Sour, puckery, flat; Poisonous.Return lung, large intestine, kidney channel.Can astringe the lung, astringing intestine to stop diarrhea, pain relieving.Be used for chronic cough, chronic diarrhea, proctoptosis etc.
The Radix Stemonae is the dried root of Stemonaceae plant Radix Stemonae Stemona sessilifolia (Miq.) Miq., Radix stemonae japonicae Stemona japonica (Bl.) Miq. or radix stemonae tuberosae Stemona tuberosa Lour..Property is sweet, bitter, tepor.Return lung meridian.Function cures mainly nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Can be used for new chronic cough and cough, pulmonary tuberculosis cough, pertussis etc.
Rhizoma Cynanchi Stauntonii, RhizomaCynanchiStauntonii, medicinal herbs.Have another name called Radix Homonoiae Ripariae, goose Rhizoma Cynanchi Stauntonii, careless Rhizoma Cynanchi Stauntonii, Baima tiger, Shi Lan, the medicine of coughing.Hot, bitter, tepor.Return lung meridian.Can lowering the adverse-rising QI to resolve phlegm, cough-relieving is applied in this prescription, can treat cough with copious phlegm, asthma.This article slightly warm in nature and not dry strong is longer than and is eliminated the phlegm, and falls lung qi with flat cough with asthma, and no matter belongs to the cold heat that belongs to, the diseases caused by exogenous pathogenic factor internal injury, the chronic cough of newly coughing all available it.
Cortex Mori, the root bark of moraceae plants Mulberry Morus alba L..Main product is in China Anhui, Henan, Zhejiang, Jiangsu, Hunan and other places.Effect in this prescription is eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.Be applicable to the lung-heat cough with asthma, the edema of the face, diseases such as dysuria.
Radix Platycodonis (Platycodon grandiforus) is campanulaceae Platycodon grandiflouorum plant, perennial herb; Avette or the ovum shape lanceolar of leaf; Flower skipper or dark violet white can be done ornamental flower, and the Koreans are edible as wild herbs; On the traditional Chinese medical science, can be used as medicine, can eliminating phlegm and stopping cough in this prescription, lung qi dispersing, evacuation of pus.
Mentholum, in this prescription as a kind of chemical agent, be by in the leaf of Herba Menthae and the stem extract, white crystal is the main component in Herba Menthae and the lavender quintessence oil.In the world, China and Brazil are main natural Herba Menthae manufacturing country, and the annual production of Oleum menthae all reaches 2000-3000t.As excitants, act on skin or mucosa pharmaceutically, refrigerant itching-relieving action is arranged; Take orally and can be used as carminative, be used for headache and nose; Pharynx; Laryngitis etc.
Citric acid has another name called citric acid, is a kind of important organic acid, and clear crystal often contains a part water of crystallization, and odorless has very strong tart flavour, and is soluble in water.Than being prone to dissolving in the hot water, this character is commonly used to identify and separation of citric acid its calcium salt in cold water.The suitable temperature of control can obtain anhydrous citric acid during crystallization.In industry, grocery trade, the industry of making up waits has extremely many purposes.
Sodium benzoate is benzoic sodium salt.Sodium benzoate is the food preservative that is in daily use, and has to prevent the rotten effect of turning sour, extending the shelf life, and all is widely used in countries in the world.
Dextromethorphan hydrobromide, English name: Dextromethorphan Hydrobromide composition is a dextromethorphan hydrobromide, and this prescription is an antitussive class nonprescription drugs medicine, and these article are central antitussive, mainly suppress the coughing centre of medulla oblongata and play a role.Be used for flu, acute/chronic bronchitis, pharyngolaryngitis, bronchial asthma, few productive cough that pulmonary tuberculosis and other upper respiratory tract infection cause is coughed.
Promethazine hydrochloride, English name: promethazine hydrochloridee, can reduce its permeability to the telangiectasis due to the antihistamine, alleviate bronchial smooth muscle panting due to shrinking, strong and lasting than the diphhydramine hydrochloride effect.Because of being prone to get into cerebral tissue, so tangible sedation is arranged; Can strengthen the central inhibitory action of hypnotic, analgesic and anesthetics; Be used for skin and mucous membrane hypersusceptibility, allergic rhinitis, asthma, food anaphylaxis etc.
Simultaneously, alcoholic solution can strengthen opsonic action as surfactant, and combines and further strengthen metabolism with calcium, magnesium ion in the water, accelerates to suppress the cough inducement.
Clinical experiment 1:
1), observing time: under the situation that technical scheme of the present invention had not disclosed, select the one month in year March in February, 2011 to 2011.
2), the object of observation: Futian District the People's Hospital Pneumology Department is selected 40 routine cases in the Shenzhen City, Guangdong Province: male 20 examples, women 20 examples; Age: 16-25 years old 18 example, 25-35 years old 22 example; Occupation: student's 10 examples, workman's 10 examples, peasant's 5 examples, teacher's 10 examples, other 5 examples.The course of disease: lasting from coughing, be stabilized to consultation time, 5 examples in half a year, 20 examples in month, 15 examples in the two weeks.
3), method for using: everyone is every two hours once oral by above-mentioned case with preparation of the present invention, and each 15 milliliters, 7 days was 1 course of treatment, and 3 courses of treatment are as observation of curative effect.
4), observing effect:
Effect standard is divided into: significantly, in the unit interval cough number of times reduce 50% or more than; Effectively, the cough number of times reduces below 50% more than 30% in the unit interval; Effect is general, and the cough number of times reduces less than 30% in the unit interval; Invalid, the cough symptom is not improved basically and is alleviated.
As a result in 40 examples, remarkable 20 examples, effective 13 examples, general 5 examples of effect, invalid 2 examples, total effective rate is 95%.
Clinical experiment 2:
1), observing time: under the situation that technical scheme of the present invention had not disclosed, select the one month in year October in JIUYUE, 2011 to 2011.
2), the object of observation: Pneumology Department is selected 50 routine cases in First People's Hospital, Shenzhen City, Guangdong Province: male 30 examples, women 20 examples; Age: 16-25 years old 18 example, 25-45 years old 32 example; Occupation: student's 10 examples, workman's 20 examples, peasant's 5 examples, teacher's 10 examples, other 5 examples.The course of disease: lasting from coughing, be stabilized to consultation time, 5 examples in month, 20 examples in the two weeks, 25 examples in the week.
3), method for using: everyone is every two hours once oral by above-mentioned case with preparation of the present invention, and each 15 milliliters, 7 days was 1 course of treatment, and 3 courses of treatment are as observation of curative effect.
4), observing effect:
Effect standard is divided into: significantly, in the unit interval cough number of times reduce 50% or more than; Effectively, the cough number of times reduces below 50% more than 30% in the unit interval; Effect is general, and the cough number of times reduces less than 30% in the unit interval; Invalid, the cough symptom is not improved basically and is alleviated.
As a result in 50 examples, remarkable 28 examples, effective 12 examples, general 7 examples of effect, invalid 3 examples, total effective rate is 94%.
According to Traditional Chinese medical theory, the mechanism of cough illness is " the positive deficiency of vital energy (deficiency of both QI and YIN), excess of pathogen (expectorant, fire, wet), the evil mistake due to the Sheng "." the spleen being the source of producing phlegm, the lung being the utensil for storing phlegm, the many strange illnesses of phlegm retention.Be detained the bottom of heart, stop up and hinder in lung, mistake department falls in a surname ".Consequently: " yin and yang imbalance ", visceral dysfunction influences each other, so endlessly touching, outbreak repeatedly is difficult to radical cure.
According to the traditional Chinese medical science: " treating different diseases with the same therapeutic principle " reach the principle spleen and the theory of mutual generation of five phases restriction or checking relation in five elements of " prolonged illness is then empty ", recognize that the cause of disease of cough illness is: " defend the impaired exopathogen that can not the consolidating superficial resistance meaning receives of gas and attack and cough by the lung being damaged by lasted cough, the deficiency of the lung.The deficiency of the lung and spleen, insufficiency of the spleen difficultyization water is wet and give birth to expectorant, insufficiency of the spleen strong fortune, the imbalance of isolating clear and discharging turbid, on hold precise and tiny ineffective and cough, the kidney deficiency of time supplementing nutrition, failure of the kidney in receiving QI and breathing heavily.Finally decrease and cause spleen kidney two void " by the lung qi deficiency of YIN.
Therefore, effect a radical cure cough, cough illness must be directed against more than multiple factor, instruct recipe is prescribed after the establishment of the principle of treatment down in the principle of integral viewpoint determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, in medication,, clearly mend flat the benefit and hold up it just in line with supplementing QI and nourishing YIN, heat-clearing and toxic substances removing removes it and wets, moistening the lung and resolving phlegm relieving cough and asthma its heresy of dispelling.Regulate function and recover equilibrium between yin and yang in the body, improve patient's immunocompetence, thereby reach the purpose of radical cure cough illness; According to the preparation that above-mentioned analysis the present invention processes, in conjunction with above clinical data and theoretical foundation of the present invention, visible its beneficial effect is; The present invention goes for the cough that various respiratory tract inducements cause; With its oral no physical function anaphylaxis in back, have no side effect, medicine can be absorbed by health rapidly; Reach the therapeutic purposes of relieving cough and asthma through the kidney invigorating, spleen invigorating, lung moistening, and with low cost, reparation technology is simple and easy to do.
The specific embodiment
Below in conjunction with embodiment the present invention is explained detailedly:
Embodiment 1:
The preferred raw materials quality of the present invention is (gram):
Folium Eriobotryae 65-75 Pericarpium Papaveris 45-55 Radix Stemonae 10-18
Rhizoma Cynanchi Stauntonii 6-10 Cortex Mori 5-8 Radix Platycodonis 5-8
Mentholum 0.1-0.2 sucrose 500-800 essence 1-2
Citric acid 0.2-0.6
In addition, sodium benzoate 2-4 dextromethorphan hydrobromide 0.5-0.8
Promethazine hydrochloride 0.5-1.0
75% alcoholic solution 2-6 distilled water 1000-1500.
The method for preparing of above-mentioned cough arresting comprises the steps:
1), Folium Eriobotryae, Pericarpium Papaveris, the Radix Stemonae, Rhizoma Cynanchi Stauntonii, Cortex Mori, Radix Platycodonis adding distil water are decocted secondary, the distilled water consumption is 3/4ths of whole distilled water, decocts 2 hours at every turn, merges twice decocting liquid then, filters the back and concentrates subsequent use;
2), above-mentioned solution is added sodium benzoate, fully stir and make it dissolving, and then make it abundant mixing with sucrose, continue then to be heated to and boil, kept 20 minutes, it is subsequent use to leave standstill 30 minutes after-filtration;
3), with 75% dissolve with ethanol solution essence, itself and Mentholum, citric acid are joined in the above-mentioned solution, abundant stirring and evenly mixing left standstill 30 minutes then, filtered subsequent use then;
4), above-mentioned composition solution is added dextromethorphan hydrobromide, promethazine hydrochloride, add remaining 1/4th distilled water then, both stirred mixing, packing, sterilization then.
Embodiment 2:
The present invention also preferably raw materials quality be (gram):
Folium Eriobotryae 65-69 Pericarpium Papaveris 50-55 Radix Stemonae 15-18
Rhizoma Cynanchi Stauntonii 6-9 Cortex Mori 6-8 Radix Platycodonis 6-8
Mentholum 0.15-0.2 sucrose 600-800 essence 1
Citric acid 0.5-0.6
In addition, sodium benzoate 2-3 dextromethorphan hydrobromide 0.7-0.8
Promethazine hydrochloride 0.9-1.0
75% alcoholic solution 4-6 distilled water 1200-1500.
Method for preparing such as embodiment 1.
Embodiment 3:
Wherein the quality of each component is (gram):
Folium Eriobotryae 65 Pericarpium Papaveriss 50 Radixs Stemonae 15
Rhizoma Cynanchi Stauntonii 6 Cortex Mori 8 Radix Platycodoniss 6
Mentholum 0.15 sucrose 800 essence 1
Citric acid 0.5
In addition, sodium benzoate 2 dextromethorphan hydrobromides 0.7
Promethazine hydrochloride 0.9
75% alcoholic solution, 4 distilled water 1200.
Method for preparing such as embodiment 1.
Embodiment 4:
Wherein the quality of each component is (gram):
Folium Eriobotryae 69 Pericarpium Papaveriss 55 Radixs Stemonae 18
Rhizoma Cynanchi Stauntonii 9 Cortex Mori 8 Radix Platycodoniss 7
Mentholum 0.2 sucrose 700 essence 1
Citric acid 0.5
In addition, sodium benzoate 2 dextromethorphan hydrobromides 0.8
Promethazine hydrochloride 1.0
75% alcoholic solution, 5 distilled water 1300.
Method for preparing such as embodiment 1.
The foregoing description only is several kinds of the numerous embodiments of the present invention, and as each prescription being strengthened in the ratio in the technical scheme or reducing dose, this cough arresting curative effect that makes is also unaffected, also will drop within the rights protection scope of the present invention.
Claims (4)
1. cough suppressing medicine; It is characterized in that; Medicine of the present invention is the composition solution that is prepared into by materials such as Folium Eriobotryae, Pericarpium Papaveris, the Radix Stemonae, Rhizoma Cynanchi Stauntonii, Cortex Mori, Radix Platycodonis, Mentholum, sucrose, citric acid, essence, sodium benzoate, dextromethorphan hydrobromide, promethazine hydrochloride and 75% alcoholic solution, distilled water, and wherein the quality proportioning of each component is:
Folium Eriobotryae 65-75 mass parts Pericarpium Papaveris 45-55 mass parts Radix Stemonae 10-18 mass parts
Rhizoma Cynanchi Stauntonii 6-10 mass parts Cortex Mori 5-8 mass parts Radix Platycodonis 5-8 mass parts
Mentholum 0.1-0.2 mass parts sucrose 500-800 mass parts essence 1-2 mass parts
Citric acid 0.2-0.6 mass parts
In addition, sodium benzoate 2-4 mass parts dextromethorphan hydrobromide 0.5-0.8 mass parts
Promethazine hydrochloride 0.5-1.0 mass parts
75% alcoholic solution 2-6 mass parts distilled water 1000-1500 mass parts.
2. a kind of cough suppressing medicine according to claim 1, its characteristic are that also the quality proportioning of each component is:
Folium Eriobotryae 65-69 mass parts Pericarpium Papaveris 50-55 mass parts Radix Stemonae 15-18 mass parts
Rhizoma Cynanchi Stauntonii 6-9 mass parts Cortex Mori 6-8 mass parts Radix Platycodonis 6-8 mass parts
Mentholum 0.15-0.2 mass parts sucrose 600-800 mass parts essence 1 mass parts
Citric acid 0.5-0.6 mass parts
In addition, sodium benzoate 2-3 mass parts dextromethorphan hydrobromide 0.7-0.8 mass parts
Promethazine hydrochloride 0.9-1.0 mass parts
75% alcoholic solution 4-6 mass parts distilled water 1200-1500 mass parts.
3. a kind of cough suppressing medicine according to claim 1 and 2, its characteristic also is: the quality proportioning of each component is:
The Folium Eriobotryae 69 mass parts Pericarpium Papaveriss 50 mass parts Radixs Stemonae 15 mass parts
Rhizoma Cynanchi Stauntonii 9 mass parts Cortex Mori 6 mass parts Radix Platycodoniss 6 mass parts
Mentholum 0.15 mass parts sucrose 600 mass parts essence 1 mass parts
Citric acid 0.5 mass parts
In addition, sodium benzoate 2.5 mass parts dextromethorphan hydrobromides 0.7 mass parts
Promethazine hydrochloride 0.9 mass parts
75% alcoholic solution, 4 mass parts distilled water, 1200 mass parts.
4. the method for preparing of a cough suppressing medicine is characterized in that, it comprises the steps:
1), Folium Eriobotryae, Pericarpium Papaveris, the Radix Stemonae, Rhizoma Cynanchi Stauntonii, Cortex Mori, Radix Platycodonis adding distil water are decocted secondary, the distilled water consumption is 3/4ths of whole distilled water, decocts 2 hours at every turn, merges twice decocting liquid then, filters the back and concentrates subsequent use;
2), above-mentioned solution is added sodium benzoate, fully stir and make it dissolving, and then make it abundant mixing with sucrose, continue then to be heated to and boil, kept 20 minutes, it is subsequent use to leave standstill 30 minutes after-filtration;
3), with 75% dissolve with ethanol solution essence, itself and Mentholum, citric acid are joined in the above-mentioned solution, abundant stirring and evenly mixing left standstill 30 minutes then, filtered subsequent use then;
4), above-mentioned composition solution is added dextromethorphan hydrobromide, promethazine hydrochloride, add remaining 1/4th distilled water then, both stirred mixing, packing, sterilization then.
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| CN106511523A (en) * | 2016-12-07 | 2017-03-22 | 郑州仁宏医药科技有限公司 | Cough relieving Chinese and western medicine composition and preparation method thereof |
| CN106728090A (en) * | 2016-12-07 | 2017-05-31 | 郑州仁宏医药科技有限公司 | A kind of cough suppressing medicine and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103169908A (en) * | 2013-04-06 | 2013-06-26 | 湖北东信药业有限公司 | Cough and asthma relieving syrup and preparation method thereof |
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| CN103432489B (en) * | 2013-08-08 | 2015-02-25 | 海安常大技术转移中心有限公司 | Pharmaceutical composition containing dextromethorphan hydrobromide |
| CN104857347A (en) * | 2015-06-01 | 2015-08-26 | 袁志贤 | Cough relief medicine and preparation method thereof |
| CN104922510A (en) * | 2015-06-01 | 2015-09-23 | 袁志贤 | Phlegm-expelling and asthma-relieving medicine and preparation method thereof |
| CN106511523A (en) * | 2016-12-07 | 2017-03-22 | 郑州仁宏医药科技有限公司 | Cough relieving Chinese and western medicine composition and preparation method thereof |
| CN106728090A (en) * | 2016-12-07 | 2017-05-31 | 郑州仁宏医药科技有限公司 | A kind of cough suppressing medicine and preparation method thereof |
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Application publication date: 20120718 |