CN101543594B - Mulberry-chrysanthemum oral liquid - Google Patents
Mulberry-chrysanthemum oral liquid Download PDFInfo
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- CN101543594B CN101543594B CN 200910064917 CN200910064917A CN101543594B CN 101543594 B CN101543594 B CN 101543594B CN 200910064917 CN200910064917 CN 200910064917 CN 200910064917 A CN200910064917 A CN 200910064917A CN 101543594 B CN101543594 B CN 101543594B
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Abstract
The invention belongs to the field of the Chinese medicinal preparation. Each 1,000 ml of mulberry-chrysanthemum oral liquid is prepared by the following method that: 1) peppermint oil is extracted and dissolved in 3 to 5 ml of anhydrous alcohol for standby; 2) bitter almond is pressed to remove oil for standby; and peppermint residue obtained after the peppermint oil extraction is mixed with mulberry leaf, chrysanthemum, liquorice, common reed rhizome, fructus forsythiae and radix platycodi, the mixture is added with water for decoction twice, and obtained filtrates from the twice decoction are mixed, filtered and concentrated under a reduced pressure, so that the relative density of the medicinal liquid is between 1.05 and 1.12 at a temperature of below 20 DEG C; 3) the medicinal liquid obtained at the step 2 is subjected to alcohol precipitation refining, and the obtained filtrate is concentrated to be between 850 and 950 ml under reduced pressure; and 4) the obtained solution is added with auxiliary materials and alcoholic solution of peppermint oil, and then added with pure water to adjust the volume of the solution to 1,000 ml. Each 1,000 ml of the mulberry-chrysanthemum oral liquid can be used for 200 to 300 poultry for water drinking or mouth dripping, and the use of the mulberry-chrysanthemum oral liquid is quite convenient; and the clinical observation result shows that the mulberry-chrysanthemum oral liquid has quick effect and good curative effect compared with the prior powder.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to a kind of animal and use mulberry-chrysanthemum oral liquid.
Background technology
It is a kind of common animals medicine that Sang Ju Yin looses; Be used to treat various avian viral diseases and mycoplasma (duck infectious viral hepatitis, chicken typical case and diseases such as atypical newcastle disease, bird flu, fabricius bursa, chronic respiratory diseases, infectious bronchitis, laryngitis, epidemic disease characterized by swelling and redness of face of duck, gosling plague), and react by other respiratory tract morbid state that above-mentioned disease or vaccine stress cause.The diffusing former side of Sang Ju Yin is stated from Qing Dynasty's " Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases is rolled up a part of the body cavity above the diaphragm housing the heart and lungs piece of writing ", is drafted by Wu Jutong, contains Folium Mori, Flos Chrysanthemi, Semen Armeniacae Amarum, Fructus Forsythiae, Herba Menthae, Radix Platycodonis, Radix Glycyrrhizae, reed root eight flavor medical materials in the side altogether.We cure mainly pathogenic wind-warm from the beginning of cough card, its pathogenesis core is a lung invaded by wind-warm, the lung network receives heresy, loses in respectful and falls, so plan wind and heat dispersing, lung qi dispersing cough-relieving are method of treatment.Folium Mori, the sweet cold light weight of Flos Chrysanthemi in the side are longer than and are evacuated part of the body cavity above the diaphragm housing the heart and lungs wind heat; And Folium Mori are apt to away the lung network, again can clearing away and dispersing lung-heat and cough-relieving is coughed, and both are monarch drug altogether.Semen Armeniacae Amarum, Radix Platycodonis are declared sharp lung qi and cough-relieving, strengthen the power of Folium Mori cough-relieving; The hot cool dispelling wind and heat pathogens of Herba Menthae, the power of reinforcement monarch drug wind and heat dispersing, three medicines are ministerial drug altogether.The Fructus Forsythiae heat-clearing and toxic substances removing, Rhizoma Phragmitis clearing away heat and promoting production of body fluid and quenching the thirst is adjuvant drug altogether.The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is a messenger drug.All medicines share, the merit of long memorial wind heat clearing away altogether, lung qi dispersing cough-relieving.Modern medicine study proves, we have multiple efficacies such as antiinflammatory, antibiotic, analgesic, diaphoresis and enhance immunity, clinically is used to treat bacterial infection, viral infection, hypoimmunity associated diseases and obtained good effect.
At present, mainly concentrate in the human medication to the research of top, and veterinary medicine to remain with simple powder be main.Yet but there is following problem in powder: only be suitable for mixing and raise, can not mix drink; Medical material is processed full powder, and some effective ingredient still are present in the plant cell, need can be absorbed through digestion, the stripping of animal body, and the part animal alimentary canal is short, does not also have enough time to absorb effective ingredient and just medicine has been got rid of external.Therefore, the bioavailability that Sang Ju Yin looses is relatively low, uses inconvenience, and onset is slow.
Summary of the invention
Based on the problems referred to above, the inventor has carried out more deep research to the top, and purpose is in order to provide a kind of animal to use mulberry-chrysanthemum oral liquid, with overcome the powder bioavailability low, use inconvenience, onset to wait defective slowly.
For realizing this purpose, the present invention has adopted such technical scheme: mulberry-chrysanthemum oral liquid, and every 1000ml medicinal liquid is processed by following method: 1) get Herba Menthae 50-75g and extract Oleum menthae, the Oleum menthae of extraction is dissolved in the 3-5ml dehydrated alcohol subsequent use; 2) it is subsequent use after Semen Armeniacae Amarum 150-175g squeezing is deoiled; The Herba Menthae slag that extracted Oleum menthae and Folium Mori 180-225g, Flos Chrysanthemi 75-92g, Radix Glycyrrhizae 50-75g, Rhizoma Phragmitis 150-175g, Fructus Forsythiae 110-128g, Radix Platycodonis 150-175g are merged, add 6000-8000ml water, boil the back and add the Semen Armeniacae Amarum that squeezed, decoct 2-3h; Medicinal residues add 4000-6000ml water and decoct 1.5-2h once more; Collecting decoction filters, and it is 1.05-1.12 that concentrating under reduced pressure makes the relative density of medicinal liquid under 20 ℃; 3) to step 2) to carry out precipitate with ethanol refining for the medicinal liquid of gained, and filtrate decompression is concentrated into 850-950ml; 4) add adjuvant and Oleum menthae alcoholic solution, add pure water and regulate total amount to 1000ml.
Said step 2) decocts for the first time in and add 8000ml water, decoction 2h; Add 6000ml when decocting once more, decoct 2h.
Alcohol precipitation process in the said step 3) is: add ethanol, make pure content reach 75%, stir, 4 ℃ leave standstill 24h, filter decompression recycling ethanol; Add ethanol once more, make pure content reach 80%, stir, 4 ℃ leave standstill 24h, filter, and reclaim ethanol in the time of concentrating under reduced pressure filtrating.
Said Oleum menthae extracts with steam distillation.
Adjuvant in the said step 4) is the 3g sodium benzoate, uses as antiseptic.
Product to the step 4) gained carries out fill and autoclaving.
The present invention has set corresponding extraction scheme through the physicochemical property difference of pharmaceutically active ingredient in the serious analysis to different flavour of a drug, obtaining effective ingredient as much as possible, thereby makes the enrichment of finished product effective ingredient, efficacy stability.The finished product mulberry-chrysanthemum oral liquid is brown supernatant liquid, and relative density is not less than 1.01, and pH value is 4.5-6.0, and sweet, little hardship of distinguishing the flavor of has refrigerant sense.Oral liquid formulations had both made things convenient for medication, can improve the utilization rate of medicine again.Every 100mL mulberry-chrysanthemum oral liquid can supply 200-300 poultry drinking-water or drip to use, and is equivalent to per kilogram of body weight medication 0.2ml approximately, every day 1 time, logotype 3-5 days.
Mulberry-chrysanthemum oral liquid of the present invention is used for the chicken crowd, and clinical observation result is following:
One, clinical symptoms: chicken farm, Xinzheng City, Henan Province part chicken spirit is depressed, and feed intake and laying rate descend, and cough, snore, gets rid of head, shouts strangely chicken mortality rate about 2%.
Two, therapeutic regimen: the chicken that will fall ill is divided into two batches, and 250 every batch, a collection of with mulberry-chrysanthemum oral liquid drinking-water, add the 100ml medicinal liquid in per 100 kg of water, logotype 5 days; Another batch mixes the 1kg Sang Ju Yin and looses logotype 5 days with the diffusing spice of Sang Ju Yin in per 100 kilograms of feedstuffs.
Three, curative effect feedback: through paying a return visit on the spot, the chicken of taking " mulberry-chrysanthemum oral liquid " drinking-water after 2 days feed intake obviously rise, respiratory symptom alleviates, disappears, extremely the chicken phenomenon stops.The chicken of taking the diffusing spice of Sang Ju Yin just progressively recovers feed intake after 4 days, medication 5 days, and chicken the crowd get well.Feedback result shows that mulberry-chrysanthemum oral liquid is faster than the diffusing easier absorption of Sang Ju Yin, action effect.
The specific embodiment
Embodiment 1
Mulberry-chrysanthemum oral liquid, every 1000ml medicinal liquid is processed by following method:
1) gets Herba Menthae 50g, extract Oleum menthae, and be dissolved in the 3ml dehydrated alcohol Oleum menthae that extracts subsequent use with steam distillation;
2) it is subsequent use after Semen Armeniacae Amarum 150g squeezing is deoiled; The Herba Menthae slag that extracted Oleum menthae and Folium Mori 180g, Flos Chrysanthemi 75g, Radix Glycyrrhizae 50g, Rhizoma Phragmitis 150g, Fructus Forsythiae 110g, Radix Platycodonis 150g are merged, add 8000ml water, boil the back and add the Semen Armeniacae Amarum that squeezed, decoct 2h; Medicinal residues add 6000ml water and decoct 2h once more; Collecting decoction filters, and it is 1.07 that concentrating under reduced pressure makes the relative density of medicinal liquid under 20 ℃;
3) to step 2) to carry out precipitate with ethanol refining for the medicinal liquid of gained: add ethanol, make pure content reach 75%, stir, 4 ℃ leave standstill 24h, filter decompression recycling ethanol; Add ethanol once more, make pure content reach 80%, stir, 4 ℃ leave standstill 24h, filter, and concentrating under reduced pressure is filtrated to 900ml, reclaims ethanol simultaneously.
4) in medicinal liquid, add 3g sodium benzoate antiseptic after step 3) finishes and reach the Oleum menthae alcoholic solution, add pure water and regulate total amount, carry out fill and autoclaving then to 1000ml.
Embodiment 2
Mulberry-chrysanthemum oral liquid, every 1000ml medicinal liquid is processed by following method:
1) gets Herba Menthae 60g, extract Oleum menthae, and be dissolved in the 5ml dehydrated alcohol Oleum menthae that extracts subsequent use with steam distillation;
2) it is subsequent use after Semen Armeniacae Amarum 158g squeezing is deoiled; The Herba Menthae slag that extracted Oleum menthae and Folium Mori 190g, Flos Chrysanthemi 80g, Radix Glycyrrhizae 58g, Rhizoma Phragmitis 160g, Fructus Forsythiae 118g, Radix Platycodonis 158g are merged, add 6000ml water, boil the back and add the Semen Armeniacae Amarum that squeezed, decoct 2h; Medicinal residues add 5200ml water and decoct 2h once more; Collecting decoction filters, and it is 1.10 that concentrating under reduced pressure makes the relative density of medicinal liquid under 20 ℃;
3) to step 2) to carry out precipitate with ethanol refining for the medicinal liquid of gained: add ethanol, make pure content reach 75%, stir, 4 ℃ leave standstill 24h, filter decompression recycling ethanol; Add ethanol once more, make pure content reach 80%, stir, 4 ℃ leave standstill 24h, filter, and concentrating under reduced pressure filtrating is reclaimed ethanol simultaneously to 850ml.
4) in medicinal liquid, add 3g sodium benzoate antiseptic after step 3) finishes and reach the Oleum menthae alcoholic solution, add pure water and regulate total amount, carry out fill and autoclaving then to 1000ml.
Embodiment 3
Mulberry-chrysanthemum oral liquid, every 1000ml medicinal liquid is processed by following method:
1) gets Herba Menthae 70g, extract Oleum menthae, and be dissolved in the 4.7ml dehydrated alcohol Oleum menthae that extracts subsequent use with steam distillation;
2) it is subsequent use after Semen Armeniacae Amarum 165g squeezing is deoiled; The Herba Menthae slag that extracted Oleum menthae and Folium Mori 200g, Flos Chrysanthemi 86g, Radix Glycyrrhizae 67g, Rhizoma Phragmitis 170g, Fructus Forsythiae 125g, Radix Platycodonis 165g are merged, add 7000ml water, boil the back and add the Semen Armeniacae Amarum that squeezed, decoct 2.5h; Medicinal residues add 4500ml water and decoct 1.8h once more; Collecting decoction filters, and it is 1.05 that concentrating under reduced pressure makes the relative density of medicinal liquid under 20 ℃;
3) to step 2) to carry out precipitate with ethanol refining for the medicinal liquid of gained: add ethanol, make pure content reach 75%, stir, 4 ℃ leave standstill 24h, filter decompression recycling ethanol; Add ethanol once more, make pure content reach 80%, stir, 4 ℃ leave standstill 24h, filter, and concentrating under reduced pressure filtrating is reclaimed ethanol simultaneously to 920ml.
4) in medicinal liquid, add 3g sodium benzoate antiseptic after step 3) finishes and reach the Oleum menthae alcoholic solution, add pure water and regulate total amount, carry out fill and autoclaving then to 1000ml.
Embodiment 4
Mulberry-chrysanthemum oral liquid, every 1000ml medicinal liquid is processed by following method:
1) gets Herba Menthae 75g, extract Oleum menthae, and be dissolved in the 3.6ml dehydrated alcohol Oleum menthae that extracts subsequent use with steam distillation;
2) it is subsequent use after Semen Armeniacae Amarum 175g squeezing is deoiled; The Herba Menthae slag that extracted Oleum menthae and Folium Mori 225g, Flos Chrysanthemi 92g, Radix Glycyrrhizae 75g, Rhizoma Phragmitis 175g, Fructus Forsythiae 128g, Radix Platycodonis 175g are merged, add 7500ml water, boil the back and add the Semen Armeniacae Amarum that squeezed, decoct 3h; Medicinal residues add 4000ml water and decoct 1.5h once more; Collecting decoction filters, and it is 1.12 that concentrating under reduced pressure makes the relative density of medicinal liquid under 20 ℃;
3) to step 2) to carry out precipitate with ethanol refining for the medicinal liquid of gained: add ethanol, make pure content reach 75%, stir, 4 ℃ leave standstill 24h, filter decompression recycling ethanol; Add ethanol once more, make pure content reach 80%, stir, 4 ℃ leave standstill 24h, filter, and concentrating under reduced pressure filtrating is reclaimed ethanol simultaneously to 950ml.
4) in medicinal liquid, add 3g sodium benzoate antiseptic after step 3) finishes and reach the Oleum menthae alcoholic solution, add pure water and regulate total amount, carry out fill and autoclaving then to 1000ml.
Claims (6)
1. with the mulberry-chrysanthemum oral liquid of controlling respiratory disease of chicken, it is characterized in that every 1000ml medicinal liquid is processed by following method:
1) get Herba Menthae 50-75g and extract Oleum menthae, the Oleum menthae of extraction is dissolved in the 3-5ml dehydrated alcohol subsequent use;
2) it is subsequent use after Semen Armeniacae Amarum 150-175g squeezing is deoiled; The Herba Menthae slag that extracted Oleum menthae and Folium Mori 180-225g, Flos Chrysanthemi 75-92g, Radix Glycyrrhizae 50-75g, Rhizoma Phragmitis 150-175g, Fructus Forsythiae 110-128g, Radix Platycodonis 150-175g are merged, add 6000-8000ml water, boil the back and add the Semen Armeniacae Amarum that squeezed, decoct 2-3h; Medicinal residues add 4000-6000ml water and decoct 1.5-2h once more; Collecting decoction filters, and it is 1.05-1.12 that concentrating under reduced pressure makes the relative density of medicinal liquid under 20 ℃;
3) to step 2) to carry out precipitate with ethanol refining for the medicinal liquid of gained, and filtrate decompression is concentrated into 850-950ml;
4) add adjuvant and Oleum menthae alcoholic solution, add pure water and regulate total amount to 1000ml.
According to claim 1 with control respiratory disease of chicken mulberry-chrysanthemum oral liquid, it is characterized in that said step 2) in decoct for the first time and add 8000ml water, decoct 2h; Add 6000ml when decocting once more, decoct 2h.
According to claim 1 or claim 2 with control respiratory disease of chicken mulberry-chrysanthemum oral liquid, it is characterized in that alcohol precipitation process is in the said step 3): add ethanol, make pure content reach 75%, stir, 4 ℃ leave standstill 24h, filter decompression recycling ethanol;
Add ethanol once more, make pure content reach 80%, stir, 4 ℃ leave standstill 24h, filter, and reclaim ethanol in the time of concentrating under reduced pressure filtrating.
As the said usefulness of claim 3 control respiratory disease of chicken mulberry-chrysanthemum oral liquid, it is characterized in that said Oleum menthae extracts with steam distillation.
As the said usefulness of claim 4 control respiratory disease of chicken mulberry-chrysanthemum oral liquid, it is characterized in that the adjuvant in the said step 4) is the 3g sodium benzoate.
As the said usefulness of claim 5 control respiratory disease of chicken mulberry-chrysanthemum oral liquid, it is characterized in that, the product of step 4) gained is carried out fill and autoclaving.
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| CN 200910064917 CN101543594B (en) | 2009-05-15 | 2009-05-15 | Mulberry-chrysanthemum oral liquid |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101658577A (en) * | 2009-08-10 | 2010-03-03 | 黄山 | Granule for reducing sputum, stopping cough and relieving asthma |
| CN101972027A (en) * | 2010-09-21 | 2011-02-16 | 广州市香雪制药股份有限公司 | Natural plant beverage and preparation method thereof |
| CN102641439B (en) * | 2012-05-03 | 2014-01-01 | 青岛绿曼生物工程有限公司 | Compound propolis composition for curing chicken infectivity throat bronchitis and preparation method thereof |
| CN103652102A (en) * | 2012-09-03 | 2014-03-26 | 宁国红楼梦旅游产品开发有限公司 | Pathogenic fire-discharging rhizoma phragmitis tea and preparation method thereof |
| CN104225330A (en) * | 2014-09-29 | 2014-12-24 | 洛阳御平国生物科技有限公司 | Traditional Chinese medicine formula for influenza |
| CN107789593A (en) * | 2016-08-31 | 2018-03-13 | 瑞普（天津）生物药业有限公司 | A kind of traditional Chinese medicine oral liquid for being used to treat birds flu |
| CN106491966A (en) * | 2016-12-19 | 2017-03-15 | 刘杰 | Poria Ganoderma Rhizoma Polygonati Odorati oral liquid |
| CN106511782A (en) * | 2016-12-20 | 2017-03-22 | 刘杰 | Poria cocos and gastrodia elata lozenges |
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Non-Patent Citations (1)
| Title |
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| 国家药品监督管理局 编.中成药地方标准上升国家标准部分，内科 肺系（一）分册.《国家药品监督管理局 国家中成药标准汇编》.2002,339. * |
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