CN101274000B - Medicine use of herb aralia elata seem - Google Patents

Abstract

The invention relates to a traditional Chinese medicine preparation which is the application of herbal aralia elata with special effects on rheumatoid arthritis, cerebral thrombosis and the sequelae thereof and hypertension in the pharmaceutical industry. The application takes the herbal aralia elata as raw material for preparing capsules, tablets, granules, oral liquor, pills or wine and other conventional traditional Chinese medicine preparations. The preparation is characterized by simple process, short treatment course, no toxicity or side effects and high cure rate. An clinical administration observation of 68 cases of the patients with rheumatoid arthritis proves that the total effective rate is more than 97 percent; an administration observation of 48 cases of the patients with cerebral thrombosis proves that the total effective rate is more than 91.7 percent; and an administration observation of 38 cases of the patients with hypertension proves that the total effective rate is more than 98 percent.

Description

The medical usage of Caobenci tender shoots

Technical field

The present invention relates to a kind of Chinese medicine preparation, promptly to the medical usage of rheumatoid, cerebral thrombosis and sequela thereof, the specific Caobenci tender shoots of hypertension.

Background technology

In prior art, rheumatism is mainly in middle-aged and elderly people, mainly show as the pain of joint and surrounding tissue, cause arthralgia and distortion, change that pain was strong with overcast and rainy, cold day especially with the variation of weather, it fine then alleviation, outbreak repeatedly, prolonged, severe patient can influence orthobiosis and work.Treatment is based on antipyretic-antalgic class medicine, though can alleviating pain, can not solve the problem of outbreak repeatedly.

Cerebral embolism is a kind of common obstinate disease, and sickness rate is higher, and the people very easily gets this disease to person in middle and old age, and the lighter can cause hypomnesis, insomnia, weight person can cause numb hand and foot, dizziness, nervous, mouthful with crooked, god cause unclear, be unable to leave the bed, its mortality rate is high.

Hypertension is commonly encountered diseases, the cause of disease is that blood fat increases, the blood vessel wall constriction, or haemolysate reduces in the blood, thrombosis, cause blood flow to be obstructed, or surfeit is fertile, and food is had a liking for Sal, makes subcutaneous fat too much, the compressing blood vessel, it is superfluous and cause to occur blood flow in the pipe, is in a bad way that it is useless, hemiplegia to cause withering, or cerebrovascular accident occurs.Western medical treatment hypertension is often used sympathetic inhibitor, antipsychotic drugs, expansion blood vessel medicine, maincenter depressor at present, but can not effect a permanent cure.The traditional Chinese medical science thinks that hypertension belongs to dizzy card, and " interior warp " said: " all wind trembling and dizziness all belong to liver ... blood stored in the liver, and main air belongs to wood." follow this theoretical direction, the dizzy good effects that obtain of treatment deficiency syndrome more, but for because dizzy with dizzy arteries and veins that excess syndrome causes, the rare effect that obtains.(draw certainly: the hypertensive Chinese medicine composition of a kind of treatment, the patent No.: 02118000.8 patentee: Ding Hengtai; Zhang Haijun)

At present the medicine that uses in treatment rheumatoid, cerebral thrombosis and sequela or hypertension is more, in, Western medicine, medicated wine all have, curative effect is different, but have untoward reaction in various degree, toxic and side effects is bigger, cures the symptoms, not the disease, but the short-term relief of symptoms, simultaneously and can not tackle the problem at its root.In this type of medicine, used Chinese medicine is all based on compound recipe, and the prescription that has is kind more than 100 nearly, and its toxic and side effects is well imagined.Single is that medicinal active ingredient is used for the treatment of above-mentioned disease with the Caobenci tender shoots, does not find report and patent application is arranged.

" the Caobenci tender shoots is traditional wild herbs of Korea, and China is called long white Cortex Araliae Chinensis (AraliacontinentalisKitag), and medicine is called Aralia continentalis Kitag..The wild output of Caobenci tender shoots is extremely low, and Japan has carried out artificial culture to it, has also cultivated improved seeds.The area of Korea S's cultivation is in recent years uprushed, but China still is in the understanding stage.The Caobenci tender shoots and the Changbai Mountain king of medicine arrest the ginseng be the large-scale herbaceous plant that belongs to Araliaceae.The tender shoots that grow its spring fragrant color U.S. that distinguishes the flavor of, and has a health care, be rare high-grade precious wild herbs " (article: Changbai Mountain precious wild herbs Caobenci tender shoots, source: Yunnan agricultural information network〉agricultural science and technology〉techwatch〉content pages, distribute new dispatchs the time: 2002-8-28 11:28:24).Green rich special product association's accommodating seed seedling of Jilin Province's Meihekou City (Jilin Province's Meihekou City is evolved and pressed down the Ma Jia village) or Dashiqiao City, Liaoning Province scientific information research institute (telephone number: 0417-5612345) accommodating seed seedling.

The Caobenci tender shoots is mainly used in edible, can be rated as the king of mountain dish, uses in treatment rheumatoid, cerebral thrombosis and sequela or hypertension and does not appear in the newspapers.

Summary of the invention

The objective of the invention is to provide a kind of at above-mentioned deficiency is primary raw material with wild vegetable Caobenci tender shoots, makes the medical usage to specific Caobenci tender shoots of disease such as treatment rheumatoid, cerebral thrombosis, hypertension.

Technical solution of the present invention is: the purposes of Caobenci tender shoots in preparation treatment rheumatoid disease medicine.

The purposes of Caobenci tender shoots in preparation treatment cerebral thrombosis disease medicine.

The purposes of Caobenci tender shoots in preparation treatment high blood pressure disease medicine.

Can be mixed and made into other conventional formulations such as tablet, capsule, soft capsule, granule, pill, drop pill, oral liquid or medicated wine by pharmaceutical carrier, additive or adjuvant commonly used in above-mentioned medicinal raw material and the pharmacy.

Method for making: the medical material of gathering (root, stem, leaf) is rinsed well, cutting, airing is ground into fine powder and makes conventional Chinese medicine preparation.Or with the draft thorn tender bud through lixiviate, make extractum, drying and crushing is made conventional Chinese medicine preparation.

Medicated wine is made by following raw materials by weight percent: Caobenci tender shoots 5-20%, Chinese liquor 80-95%.The preferred brewing grains white spirit of Chinese liquor, 38-65 degree all can, the 50-55 degree is good.Chinese liquor can also use yellow wine, rice wine to replace.

Medicated wine method for making: the medical material of gathering (root, stem, leaf) is rinsed well cutting, airing.Cover immersion completely with Porcelain Jar in proportion, temperature is more than 10 ℃, and soak time was poured out the medicinal liquid precipitation 24 hours more than 150 hours, filtered bottling and got final product.

The traditional Chinese medical science thinks that rheumatism, rheumatoid disease are by exopathogen intrusion human bodies such as wind and cold are wet, and retardance meridians joint causes QI-blood circulation not smooth, joint, surrounding tissue pain, cruel bloated, numb occur, clinical symptoms such as joint stuffiness.The main cause of cerebral thrombosis morbidity is due to withered regretful, the lung qi hyperactivity of fire of painstaking effort, normally blood supply of the whole body, heart failure, dizziness, the hypertension, reduces phlegm, and the deflation of invigorating blood circulation, have one's ideas straightened out is the basic place for the treatment of this disease.The Caobenci tender shoots has " blood circulation promoting and blood stasis dispelling, analgesia antipruritic " effect.Modern pharmacological research shows that the Caobenci tender shoots is rich in vitamin, carotin, trace element, Cortex Araliae Chinensis Saponin etc., and the effect that strengthens body immunity is arranged, and can play regulating action to function of human body, has very high nutrition and medical value.But, can be used to treat rheumatism, rheumatoid arthritis and cerebral thrombosis and sequela thereof, hypertension in view of the above according to this mechanism of Caobenci tender shoots blood circulation promoting and blood stasis dispelling.Have the analgesia of dispeling the wind, relaxing muscles and tendons and activating QI and blood in the collateral, set upright with eliminating evil effect.

Function with cure mainly: blood circulation promoting and blood stasis dispelling, easypro network dispels the wind.Rheumatism, rheumatoid, cerebral thrombosis and diseases such as sequela, hypertension thereof there is specially good effect.

Usage and consumption: oral medicinal liquor, a 15-30 gram (yellow wine, rice wine infusion, dose is the 50-100 gram), every day 1-2 time, one month is a course of treatment.Oral capsule is grown up every day twice, each 3-5 grain (every 0.3g).Rheumatism, rheumatoid, gout 2-3 days are taken effect, seven days transference cures, cure 1-2 the course of treatment; Cerebral infarction sequela, hyperpietic were taken effect in 7 to 10 days, and 2-3 cures the course of treatment.

Advantage of the present invention is: 1, the Caobenci tender shoots has the effect of blood circulation promoting and blood stasis dispelling, adopts conventional easy method to make medicine, taking convenience, and restriction is few, has no side effect, and has excellent curative.2, take observation through the patient, this medicine reaches short treating period, instant effect, characteristics that cure rate is high equally.3, the Caobenci tender shoots has the drug effect of blood circulation promoting and blood stasis dispelling, adds soaking in Chinese liquor again, and both can further improve drug effect at interaction, makes the patient quicken absorption to medicine, and then reaches excellent curative.4, through clinical 68 rheumatoid patient are taken observation, total effective rate is more than 97%; 48 cerebral infarction sequela patients are taken observation, and total effective rate is more than 91.7%; 38 hyperpietics are taken observation, and total effective rate is more than 98%.

Below in conjunction with embodiment the present invention is described in further detail.

The specific embodiment

Embodiment 1: capsule

With the selected pulverizing of Caobenci tender shoots, porphyrize, encapsulated.

Embodiment 2: tablet

Selected Caobenci tender shoots is decocted with water twice, and each amount of water does not advance powder is advisable, and merges two decocting liquids, filters to get filtrate; Be condensed into proportion and be 1.35 extractum, add 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate; Dry under 45-50 ℃, make dry extract; It is ground into fine powder, adds adjuvant and be pressed into tablet.

Embodiment 3: granule

Make adhesive by the fine powder adding ethanol that embodiment 2 makes, add starch and make filler, be pressed into granule.

Embodiment 4: medicated wine is by Caobenci tender shoots 6%, and Chinese liquor 94% soaks and forms.

Embodiment 5: medicated wine is by Caobenci tender shoots 10%, and Chinese liquor 90% soaks and forms.

Embodiment 6: medicated wine is by Caobenci tender shoots 18%, and Chinese liquor 82% soaks and forms.

Embodiment 7: medicated wine is by Caobenci tender shoots 20%, and yellow wine 80% soaks and forms.

Embodiment 8: medicated wine is by Caobenci tender shoots 20%, and rice wine 80% soaks and forms.

Clinical experiment example 1

As follows through test that 68 rheumatoid patient (as following table) have been carried out taking medicine:

	Below 40 years old	41-50 year	51-60 year	More than 61 years old	Add up to
						The male	6	8	0	4	28
The women	10	10	14	6	40
						Add up to	16	18	24	10	68

The course of disease does not wait in the rheumatoid case, 10 of patients below 2 years, more than 2 years to 5 years 26, more than 5 years to 10 years 16, more than 10 years to 20 years 12, more than 20 years 2.

The rheumatoid arthritis diagnostic criteria:

1, primary symptom: continue more than one hour three above arthroncuss are arranged stiff every day in morning, and wrist, the palm, nearly articulations digitorum manus swell, and subcutaneous nodule is arranged, and the hands X-ray film changes (osteoporosis and joint space are narrow), the rheumatoid factor positive.

2, most with slow concealment mode onset.

3, before the symptom of the obvious joint of appearance, low grade fever several weeks, weak is arranged, symptoms such as general malaise.

4, send out the age well in 35-40 year, the women is higher than the male.

Having in the above primary symptom four above persons can examine and be rheumatoid arthritis.

Rheumatoid arthritis clinical development standard:

1, basic complete more: eliminate arthralgia, tenderness that the patient causes because of arthritis, morning stiff or abarticular symptom.

2, produce effects: promote the recovery of destroyed ossa articularia, and improve its function.

3, effective: the development of control disease reaches the clinical remission of long period.

4, invalid: as not have improvement with each side function before the medication.

Medication: oral medicinal liquor, adult every day 2 times, each 15-30 gram; Oral capsule, adult every day 2 times, each 3-5 grain.Early (or before sleeping) takes after ante cibum, the supper; One month is a course of treatment.Rheumatism, rheumatoid patient are taken and were taken effect in 2-3 days, and be almost recovered a course of treatment;

Find that through observing this medicine rheumatoid patient is taken the formation that the back influences rheumatoid factor and complex thereof, thus the control rheumatoid.

Rheumatoid medication curative effect

	Be almost recovered	Produce effects	Effectively	Invalid
					Number	37	22	7	3
Account for total number of persons %	54.4	32.3	10.3	2.9

This medicine is satisfactory through clinical test results, and this medicine instant effect, effect are lasting, and toxic and side effects is little, and total effective rate can reach more than 9 7%.

Model case

1, Haiqing Liu: the man, 35 years old, suffer from rheumatism more than 5 years, the medicated wine of whole body arthralgia, the thing infusion that takes this medicine, 2 days take effect, and a course of treatment, fully recovered (one month), and the pain complete obiteration was not recommitted in 2 years so far.

2, Sun Shujun: the woman, 68 years old, suffer from two more than ten years of rheumatoid arthritis, took the medicine irritation stomach of treatment rheumatism in the past, effect is also bad, takes effect in 4 days from eating the capsule that this medicine makes, take a month waist and just can straighten up, the disease that serve on two months these patients be almost recovered " this medicine is very good! Not only cure the disease but also do not stimulate stomach ".

This medicine is the rare Chinese crude drug in Changbai Mountain (a precious wild vegetable), and this medical material is rich in Cortex Araliae Chinensis Saponin, vitamin and various trace elements, has blood circulation promoting and blood stasis dispelling to dredge the effect of channels and activating collaterals, can strengthen immune function of human body simultaneously.

This medical material is invaded bubble with Chinese liquor, and both enhancement drug absorption that interact improve curative effect, thereby reaches good therapeutic effect.Evident in efficacy with this medicated wine and Drug therapy rheumatism, rheumatoid through clinical trial, obtained people from all walks of life's abundant affirmation.Think that this medicine can fundamentally treat rheumatism, rheumatoid, it is not thorough to above-mentioned disease treatment to remedy the fourth other medicines, the deficiency that side effect is big, and bad reflection has only dizzy phenomenon of moment.

Current rheumatism, rheumatoid are common stubborn diseases, sickness rate is higher, and seriously perplexing orthobiosis of people, rheumatism, rheumatoid treatment in the past is mostly based on antipyretic-antalgic class medicine, though energy alleviating pain, but outbreak repeatedly, and the invention of this medicine solved this type of difficult problem, rheumatism, rheumatoid patient be outbreak no longer repeatedly after this medicine is cured, have short treating period, cure rate advantages of higher, be subjected to high evaluation clinically, the invention of this medicine is a contribution greatly to the human rheumatoid treatment of diseases, is worthy of popularization very much.

Clinical experiment example 2

Be to 48 cerebral infarction sequela patients and 38 clinical application tests that the hyperpietic carries out below:

The cerebral thrombosis group

	41-50 year	51-60 year	More than 61 years old	Add up to
					The male	9	9	8	26
The women	7	9	6	22
					Add up to	16	18	14	48

Among cerebral thrombosis and the sequela patient thereof the course of disease 2 years with interior 14 people, 2 years to 5 years 21 people, the person is 13 more than 5 years.

Hypertension group

	41-50 year	51-60 year	More than 61 years old	Add up to
					The male	7	8	5	20
The women	4	8	6	18
					Add up to	11	16	11	38

Among the hyperpietic pathology 2 years with interior 11 people, 2-5 13 people, 14 people more than 5 years.

One, diagnostic criteria:

(1), cerebral thrombosis

1, primary symptom: hemiplegia; Deflective mouth and eye; Aphasia with stiff tongue; Hemianesthesia.

2, onset is anxious.

3, the multiple reason of falling ill, premorbid does not often have premonitory symptom.

4, send out the age well more than 40 years old.

Have primary symptom more than two, Acute onset is in conjunction with the diagnosis determined of aspects such as tongue, arteries and veins, inducement, tendency, age.

(2), hypertension

1, needing to measure three blood pressures at different time can determine.

2, antithesis has blood pressure to exceed person's normal range, and regularly repeated measure is to make a definite diagnosis.

3, seek the hypertensive cause of disease, check to have or not secondary hypertension.

Two, clinical development standard:

(1), cerebral thrombosis

1, be almost recovered: sanity, language performance is normal, and limb functional recover is normal.

2, produce effects: sanity, language performance is normal, and limb function is obviously progressive, near normal.

3, effective: sanity, language performance is normal, and limb function makes progress before the treatment.

4, invalid: as not have improvement with each side before the medication.

(2), hypertension

1, be almost recovered: blood pressure is basicly stable in the normal arterial pressure scope after the drug withdrawal.

2, produce effects: blood pressure was stabilized in normal range after the medication.

3, effective: as before the medication of medication bleeding from anus pressure ratio certain effect to be arranged.

4, invalid: blood pressure no change before and after the medication.

Medication: oral medicinal liquor, adult every day 2 times, each 15-30 gram; Oral capsule, adult every day 2 times, each 3-5 grain (every 0.3g).Early (or before sleeping) takes after ante cibum, the supper; One month is a course of treatment.The cerebral thrombus patient takes and took effect in 7-10 days, three the course of treatment symptom disappear substantially.

Find through observing, after cerebral thrombus patient and hyperpietic take,, influence platelet aggregation, reduce the blood denseness, thrombosis is dissolved as early as possible, bring high blood pressure down simultaneously by blood circulation.Clinical trial proves that this medicine also has trophic nerve, analgesia, antiinflammatory, antipruritic, treatment angular cheilitis, cramp, numbness, external effect such as invigorate blood circulation.

Cerebral thrombosis medication curative effect

	Be almost recovered	Produce effects	Effectively	Invalid
					Number	21	16	7	4
Account for total number of persons %	43.7	33.3	14.6	8.3

This medicine is satisfactory through clinical test results, and this medicine instant effect effect is lasting, and toxic and side effects is little, and treatment cerebral thrombosis and sequela total effective rate thereof can reach more than 91.7%.

Hypertension medication curative effect

	Be almost recovered	Produce effects	Effectively	Invalid
					Number	2	16	11	1
Account for total number of persons %	3.2	65.2	28.9	1.6

This medicine is fine to the high blood pressure disease effect through clinical trial, and total effective rate can reach more than 98%.

Model case:

Yang Fu: the man, 68 years old, suffered from cerebral thrombosis 3 years, after hospitalization is left hospital, stay numbness of hands and feet pain, do not listen to make, slurred speech, 4 bottle of 2000 gram of the medicated wine of the thing infusion that takes this medicine, sequela disappears substantially,, speech is normal, and legs and feet are walked normal, and housework is also competent.

Zhao Zhongmin: man 61 years old, suffered from cerebral thrombosis 6 years, stay the shakiness of walking, the defect that foot turns is taken the capsule that this medicine is made, and takes and takes effect in 8 days, serve on sick recovery from illness 2 courses of treatment, and the work in farmland has been picked up again.

Chen Zhong: the man, 57 years old, suffered from moderate hypertension 7 years, to keep to get off in several years by Western medicine in the past, blood glucose is also high to get up, and takes the medicated wine of this medicine infusion afterwards, every day 2 times, each 30 grams, blood pressure maintains 80-90/120-135 in normal range.

Liu Shuhui, the woman, 49 years old, suffered from hypertension nearly 8 years, in the past by the MENGNUO that has Western medicine, do not eat just highly, take medicine also often cough, from taking each 1.2g behind this medicine, day to obey 2 times, blood pressure maintained in basic normal range, no longer had Western medicine.

This medicine is the rare Chinese crude drug in Changbai Mountain " Aralia continentalis Kitag. ", and precious wild vegetable is rich in volatile oil, Cortex Araliae Chinensis Saponin, vitamin and various trace element; The effect that blood circulation promoting and blood stasis dispelling, meridians dredging are arranged can strengthen body immunity, with medicated wine and this Drug therapy of this medicine infusion

Above-mentioned disease has obtained people's abundant affirmation, thinks that this medicine can fundamentally treat above-mentioned disease.Having remedied other medicines to the big deficiency of above-mentioned treatment of diseases toxic and side effects, is the ideal medicine of above-mentioned disease, and medicated wine is taken in unique untoward reaction dizzy phenomenon of moment.

Current cerebral thrombosis, hypertension are common stubborn diseases, and sickness rate height, having a strong impact on people's orthobiosis, in the past cerebral infarction sequela patient and hyperpietic keep by Western medicine, Western medicine often toxic and side effects is big, the cerebral infarction sequela patient nearly 50% patient's sequela of thing (medicated wine, capsule) that takes this medicine has obtained basic healing, and all the other sequela of patient more than 40% patients can obtain improvement in various degree; The mild or moderate hyperpietic can both be controlled in normal range substantially, takes for a long time to have no side effect, and has solved the big deficiency of Western medicine blood pressure lowering side effect.

This medicine has been subjected to higher evaluation clinically, and this medicine is being worthy of popularization aspect treatment hypertension, the cerebral infarction sequela.

Claims (4)

1. the Caobenci tender shoots is preparing the purposes for the treatment of in the high blood pressure disease medicine.

2. according to the described purposes of claim 1, it is characterized in that this medicine is capsule, tablet, granule, oral liquid, pill or medicated wine.

3. according to the described purposes of claim 2, it is characterized in that making medicated wine: Caobenci tender shoots 5-20%, Chinese liquor 80-95% by following raw materials by weight percent.

4. according to the described purposes of claim 3, it is characterized in that Chinese liquor replaces with yellow wine or rice wine.