CN110575529A - Cough and asthma treating ointment for treating chronic bronchitis and preparation method thereof - Google Patents
Cough and asthma treating ointment for treating chronic bronchitis and preparation method thereof Download PDFInfo
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- CN110575529A CN110575529A CN201910913860.7A CN201910913860A CN110575529A CN 110575529 A CN110575529 A CN 110575529A CN 201910913860 A CN201910913860 A CN 201910913860A CN 110575529 A CN110575529 A CN 110575529A
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- cough
- asthma
- decoction
- ointment
- chronic bronchitis
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Abstract
the invention discloses a cough and asthma relieving traditional Chinese medicine composition, which comprises astragalus mongholicus, adenophora tetraphylla, ephedra, bighead atractylodes rhizome, poria cocos, rhizoma pinellinae praeparata, semen lepidii, flos farfarae, asarum, polygala tenuifolia, rhizoma zingiberis, dried orange peel, schisandra chinensis, Chinese date and honey-fried licorice root. The invention also discloses an identification method of the effective components of the cough and asthma treating ointment and a content determination method of the effective components. The cough and asthma treating ointment for chronic bronchitis disclosed by the invention is prepared from pure traditional Chinese medicines, has small side effect and low cost, relieves the medical burden of patients and creates favorable conditions for smooth popularization; the identification method of the effective components of the chronic bronchitis cough and asthma ointment and the measurement method of the effective components are provided, so that the mixture with the drug effect meeting the pharmacopoeia specifications can be screened out, the treatment effect of the chronic bronchitis cough and asthma ointment is ensured, meanwhile, the screened ointment meets the detection standard of modern medicine, and the final link is opened for clinical popularization and application.
Description
Technical Field
the invention relates to compatibility of traditional Chinese medicines and a preparation method thereof, in particular to a cough and asthma treating chronic bronchitis ointment and a preparation method thereof.
Background
with the increase of industrial and atmospheric pollution, the pressure of life of people is increased, and the incidence and attack rate of asthma are also increased year by year, especially common in the elderly. Bronchial asthma is a common intractable disease, and no specific treatment method exists at present. The morbidity of countries in the world is 1-13%, and the morbidity of China is 1-4%. The western medicine for treating asthma mainly uses glucocorticoid and beta 2 receptor stimulant, has the advantages of strong local anti-inflammatory effect, small dosage and small systemic reactivity, and is generally recognized as the most basic treatment for controlling the long-term stability of asthma. However, the simple inhalation of glucocorticoid has a great side effect on the elderly, and the elderly patients are accompanied by diabetes, osteoporosis, digestive system diseases, etc., and the glucocorticoid can be applied to aggravate the disease condition or be limited in application. In recent years, with the intensive clinical research and the rise and intervention of new modern medical technology, the traditional Chinese medicine has better curative effect on asthma, and is particularly suitable for patients with bronchial asthma, especially old people with basic diseases.
Bronchial asthma is a chronic inflammatory disorder of the airways involving a variety of inflammatory cells and cell components. Bronchial asthma belongs to the category of 'asthma syndrome' and 'asthma syndrome' in traditional Chinese medicine. The "Nei Jing" suggests that asthma is mainly caused by pathological changes of the lung. For example, the lung diseases and dyspnea and cough (plain questions and the monogram's disease treatise on the disease), "the lung diseases and dyspnea with nose" (Ling Shu and Wu Yuan Wu Shi), and "the pathogenic factors are in the lung, so that the patient has a disease of … … asthma" (Ling Shu and Wu Shi), "the lung diseases and dyspnea and coughing with adverse qi" (plain questions and visceral qi Fa Shi). Wherein "wheezing", "wheezing" and "upbeat" refer to asthma. Therefore, Su Wen & Zhi Zhen Yao Da Lun summarize: all qi stagnation pertains to the lung. The basic pathological changes are phlegm-phlegm induced by touch, phlegm-qi accumulation, lung qi dispersion and descending, and wheezing and dyspnea. The attack stage is mainly caused by pathogenic excess and mainly includes cold asthma and heat asthma; the remission stage is mainly due to deficiency of healthy qi and closely related to the three zang-organs of lung, spleen and kidney.
Disclosure of Invention
The invention provides the chronic bronchitis cough and asthma treating paste in order to solve the problems in the western medicine treating process, the chronic bronchitis cough and asthma treating paste adopts the traditional Chinese medicines as treating means, combines treatment and maintenance, overcomes the disadvantages of western medicines, has better effects of relieving cough and asthma clinically, can greatly reduce attack times, has easily accepted mouthfeel and the like; meanwhile, the slow bronchitis cough and asthma treating paste is low in treatment cost and provides objective factors for popularization, the preparation method of the slow bronchitis cough and asthma treating paste and the identification and determination method of the effective components are provided, the slow bronchitis cough and asthma treating paste is guaranteed to contain the effective components for relieving cough and asthma, the content of the effective components meets the requirements, the requirements of pharmacopoeia specifications are met, further guarantee is provided for popularization and application of the slow bronchitis cough and asthma treating paste, and the final link of application of the slow bronchitis cough and asthma treating paste in clinic is opened.
the invention is realized by the following technical scheme:
A Chinese medicinal composition for relieving cough and asthma comprises radix astragali, radix Adenophorae, herba Ephedrae, Atractylodis rhizoma, Poria, rhizoma Pinelliae Preparata, semen Lepidii, flos Farfarae, herba asari, cortex et radix Polygalae, Zingiberis rhizoma, pericarpium Citri Tangerinae, fructus Schisandrae, fructus Jujubae, and radix Glycyrrhizae Preparata.
Further, 100-300 g of astragalus membranaceus, 200-300 g of adenophora tetraphylla, 85-150 g of ephedra, 150-250 g of bighead atractylodes rhizome, 150-250 g of poria cocos, 150-250 g of rhizoma pinellinae praeparata, 150-250 g of semen lepidii, 150-250 g of flos farfarfarae, 30-90 g of asarum, 85-150 g of polygala tenuifolia, 85-150 g of rhizoma zingiberis, 130-190 g of pericarpium citri reticulatae, 85-150 g of schisandra chinensis, 130-190 g of Chinese dates, 85-150 g of honey-fried licorice roots and 500-700 g of honey.
The ointment for treating cough and asthma of chronic bronchitis prepared from the Chinese medicinal composition is brown, viscous and semi-fluid.
furthermore, the chronic bronchitis cough and asthma treating ointment is also added with a benzoic acid solution and a ethylparaben solution, wherein the concentration of ethylparaben is 0.003g/mL, the concentration of potassium sorbate is 0.001g/mL, the concentration of menthol is 0.001g/mL and the concentration of sucrose is 150 g.
In addition, the invention also provides a preparation method of the cough and asthma treating chronic bronchitis paste, which comprises the following steps:
Step1, dipping: adding 10-20L of drinking normal-temperature water into the cough and asthma relieving traditional Chinese medicine composition, soaking overnight at the room temperature of 15-25 ℃, wherein the soaking is based on the principle that the medicinal material core is wet, and the total water absorption rate of the soaked medicinal material is 10-20% (W/W);
Step2, decocting: pouring the soaked cough and asthma relieving traditional Chinese medicine composition and the not completely absorbed soaking liquid into a jacketed kettle simultaneously, and decocting the soaked Chinese medicine composition and the soaking liquid at normal pressure by adopting circulating steam at 100 ℃ for three times, wherein the first decoction time is 2 hours, and the second and third decoction times are 1 hour respectively, the weight ratio of the cough and asthma relieving traditional Chinese medicine composition to the soaking liquid in the first decoction is 4-8 times (W/W) that of the drinking normal-temperature water, the later decoction liquid passes through a 200-mesh screen to obtain a first decoction liquid, and the filtrate is reserved;
Adding 4-6 times (W/W) of drinking water into filter residues for second decoction, wherein the decoction time is 1 hour, and then, passing the decoction through a 200-mesh screen to obtain a second decoction, and keeping the filtrate for later use;
Adding 4-6 times of drinking water into the filter residue again for carrying out third decoction for 1 hour, and sieving the decoction with a 200-mesh sieve to obtain a third decoction, wherein the filtrate is reserved; the filter residue is discarded.
Step3, concentration: mixing the first decoction with the second decoction and the third decoction, placing the mixture in a jacketed kettle, and under the condition of normal pressure circulating steam, enabling the decoction temperature to reach 100 ℃, continuously stirring, and concentrating to 800-1100 mL to obtain a concentrated solution for later use;
Step4, alcohol precipitation: standing the concentrated solution, naturally cooling to room temperature, then placing the concentrated solution into an alcohol precipitation tank, adding 95% ethanol, adjusting the ethanol content to 40% (mL/mL) at room temperature, continuously stirring for 40 minutes to ensure that the ethanol is fully and uniformly mixed, performing secondary alcohol precipitation, standing the concentrated solution at room temperature for 48 hours for the first time of alcohol precipitation, sucking supernatant alcohol precipitation solution for later use, adding ethanol into precipitation residues again, adjusting the ethanol content to 40% (mL/mL) in the same way as the first time of alcohol precipitation, standing the concentrated solution at room temperature for 12 hours for the second time of alcohol precipitation, filtering to obtain supernatant alcohol precipitation solution, and discarding residues;
step5, recovering ethanol: mixing the two ethanol precipitation solutions, and recovering ethanol under reduced pressure. Heating with steam to recover ethanol to obtain concentrated medicinal liquid, recovering ethanol, and standing;
continuously concentrating the concentrated liquid medicine after recovering the ethanol under normal pressure until the specific gravity is 1.15-1.30, immediately adding a prepared ethylparaben solution, and uniformly stirring for later use;
Step6, preparation of refined honey and refined sugar: boiling Mel in a jacketed kettle at 110-120 deg.C, refining to golden yellow and dripping Mel into filaments, filtering, and discarding impurities;
adding purified water and tartaric acid solution into sucrose, boiling at 110-120 ℃, stirring, dissolving, and sieving with a 100-mesh sieve to obtain sucrose syrup with a specific gravity of 1.40-1.60 for later use;
Mixing: continuously heating the liquid medicine after ethanol recovery, controlling the temperature to 100 ℃, adding refined honey and sucrose syrup, uniformly stirring, observing that no crystal is generated in the liquid medicine, and filtering by a 100-mesh screen for later use;
step7, sterilization and separation: putting concentrated solution of Chinese medicinal composition for relieving cough and asthma, Mel and refined sugar into cold and hot jar, adding ethylparaben as antiseptic, stirring, mixing, heating with steam, sterilizing at high temperature for 1 hr, naturally cooling to room temperature, slowly adding Mentholum liquid, and stirring;
Step8, preparation: adding appropriate amount of distilled water into the above medicinal liquid, stirring, adjusting volume to 1000mL, and packaging into a specified container to obtain brown viscous semifluid ointment for treating cough and asthma.
in the steps, the cough and asthma relieving pharmaceutical composition is filtered and precipitated with alcohol after being soaked and decocted, and the aim is to remove impurities to keep the active ingredients of the medicine; adding refined honey and cane sugar to prevent the growth of microorganisms and regulate the taste; and (5) correcting the taste of the menthol.
Meanwhile, in order to ensure the effect of the prepared chronic bronchitis cough and asthma paste, the effective components in the paste need to be identified, and the identification method of the astragaloside IV and the hesperidin in the chronic bronchitis cough and asthma paste adopts a thin-layer chromatography for identification.
Meanwhile, the invention provides a method for measuring the relative density of the cough and asthma treating ointment, which comprises the following steps:
Taking 10g of Manzhi cough and asthma paste, precisely weighing, adding 2 times of water, mixing uniformly to obtain a test solution, measuring according to a relative density measurement method, and calculating according to the following formula:
Wherein W1 is the weight of the test solution in the pycnometer; w2 is the weight of water in the pycnometer, wherein f is the weight of water added to the test article/(the weight of the test article + the weight of water added to the test article), and the relative density of the test article is not less than 1.20.
The content of ephedrine in the plaster is determined by high performance liquid chromatography, and ephedrine (C) is added to each 1g plaster10H5NO & HCl) and pseudoephedrine hydrochloride (C)10H5NO & HCl) is not less than 0.1mg, and each 1g of the cough and asthma relieving ointment is equivalent to 1.58g of the original medicinal materials.
The administration method of the cough and asthma treating plaster for chronic bronchitis comprises the following steps: the preparation is orally taken 22.5-30 g once and 3 times a day.
The invention has the beneficial effects that: 1. the cough and asthma treating ointment for chronic bronchitis disclosed by the invention is prepared from pure traditional Chinese medicines, has small side effect and low cost, relieves the medical burden of patients and creates favorable conditions for smooth popularization; 2. the invention discloses a chronic bronchitis cough and asthma paste, which is used for treating bronchial asthma, particularly the complicating basic diseases of the old, such as: patients with aggravated diseases or limited application such as diabetes, osteoporosis, digestive system diseases and the like provide a new treatment mode of relieving cough and asthma, and benefit the masses; 3. the invention discloses a preparation method of cough and asthma treating ointment for chronic bronchitis, which solves the key problems of production and preparation of the cough and asthma treating ointment and lays a foundation for clinical industrialized production of the cough and asthma treating ointment; 4. the invention adds low-concentration potassium sorbate and ethylparaben to achieve the aim of sterilization, so that the paste prepared by the invention is safer to take; 5. the invention provides an identification method of effective components of the chronic bronchitis cough and asthma ointment and a measurement method of the effective components, which can ensure that the ointment with the drug effect meeting the pharmacopoeia specification is screened out, ensure the treatment effect of the chronic bronchitis cough and asthma ointment, simultaneously the screened mixture meets the detection standard of modern medicine, meets the pharmacopoeia specification for medication, and provides a final link for clinical popularization and use; 6. the cough and asthma relieving composition provided by the invention contains additives such as sucrose, honey, menthol and the like, and the taste is more easily accepted by adults.
drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a flow chart of the preparation of the cough and asthma treating ointment;
FIG. 2 is a diagram of the clinical application of the cough and asthma treating ointment of the present invention.
Detailed Description
the present invention will be further specifically illustrated by the following examples for better understanding, but the present invention is not to be construed as being limited thereto, and certain insubstantial modifications and adaptations of the invention by those skilled in the art based on the foregoing disclosure are intended to be included within the scope of the invention.
a Chinese medicinal composition for relieving cough and asthma comprises radix astragali, radix Adenophorae, herba Ephedrae, Atractylodis rhizoma, Poria, rhizoma Pinelliae Preparata, semen Lepidii, flos Farfarae, herba asari, cortex et radix Polygalae, Zingiberis rhizoma, pericarpium Citri Tangerinae, fructus Schisandrae, fructus Jujubae, and radix Glycyrrhizae Preparata.
The astragalus root selected in the embodiment is the dried root of astragalus mongholicus or astragalus membranaceus of leguminous plants. Sweet taste and warm nature; entering lung and spleen meridians; invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, promoting fluid production, nourishing blood, removing stagnation, relieving arthralgia, removing toxic substance, expelling pus, and promoting granulation of wound of radix Ampelopsis. Can be used for treating deficiency of vital energy, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, spontaneous perspiration, qi deficiency, edema, internal heat, diabetes, blood deficiency, hemiplegia, numbness, carbuncle, cellulitis, and intractable ulcer.
Adenophora tetraphylla (root of Adenophora tetraphylla (Thunb.) Fisch. or Adenophora tetraphylla (Thunb.) Fisch. of Campanulaceae) is used as a medicine, and has slightly cold nature and sweet taste, and enters lung and stomach meridians. The herbal Zhenzhen: sha Shen has both nan and Bei types and has the action of clearing lung and stomach. Radix Glehniae is firm and cold in nature, and rich in lipid; the adenophora tetraphylla is thick and fat, and has light and clear smell; to nourish yin and clear lung-heat, nourish stomach and promote fluid production, resolve phlegm and tonify qi. Can be used for treating lung heat dry cough, yin deficiency cough, dry cough with sticky phlegm, stomach yin deficiency, anorexia, emesis, qi yin deficiency, dysphoria, and xerostomia.
herba Ephedrae is dry grass stem of Ephedra sinica Stapf, Ephedra sinica Stapf or Ephedra equiseti of Ephedraceae; pungent, slightly bitter and warm in nature; it enters lung and bladder meridians. Induce sweating and dispel cold, ventilate lung and relieve dyspnea, induce diuresis to alleviate edema. Can be used for treating common cold due to wind-cold, chest distress, cough, and edema due to wind-cold.
Atractylodis rhizoma is dried rhizome of Atractylodes macrocephala Koidz of Compositae. Sweet in taste, slightly bitter and warm in nature; spleen and stomach meridians entered; invigorating spleen, invigorating qi, eliminating dampness, promoting diuresis, arresting sweating, and preventing miscarriage; can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion.
Poria is dried sclerotium of Poria cocos (Schw.) wolf of Polyporaceae; it is mild in nature, light and sweet in taste; the heart, lung, spleen and kidney meridians are entered; promoting diuresis, eliminating dampness, invigorating spleen, and calming heart; can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, uneasiness, palpitation, and insomnia.
Rhizoma Pinelliae Preparata is dried rhizome of rhizoma Pinelliae of Araceae, and is processed product of rhizoma Pinelliae; pungent taste and warm nature; spleen, stomach and lung meridians entered; warming middle energizer to resolve phlegm, checking adverse rise of qi and arresting vomiting; can be used for treating phlegm and fluid retention emesis, and epigastric fullness.
Semen Lepidii (dry mature seed of Descurainia sophia (L.) DC. or Lepidium meyenii Walp. of Brassicaceae); pungent, slightly bitter and cold in flavor; entering lung and bladder meridians; purging lung, relieving asthma, promoting diuresis and relieving swelling; can be used for treating phlegm and saliva obstructing lung, cough and asthma with excessive phlegm, fullness and distention in chest and hypochondrium, insomnia, edema of chest and abdomen, and dysuria.
Flos Farfarae, which is dry flower bud of Farfarae of Compositae; pungent, slightly bitter and warm in nature; entering lung meridian; moistening lung, descending qi, relieving cough, and eliminating phlegm; can be used for treating chronic cough, cough with excessive phlegm, and cough with bloody sputum.
herba asari is dried root and rhizome of Aristolochiaceae plant such as herba asari Forbesii, herba asari Forbesii or herba asari Forbesii; pungent taste and warm nature; entering heart, lung and kidney meridians; relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging orifice, warming lung, and eliminating phlegm; can be used for treating common cold due to wind-cold, headache, toothache, nasal obstruction, nasal discharge, allergic rhinitis, nasosinusitis, rheumatic arthralgia, phlegm and fluid retention, and cough and asthma.
Cortex et radix Polygalae is dried root of Polygala tenuifolia Willd or Polygala sibirica pall of Polygalaceae; pungent, bitter and warm in nature; the heart, kidney and lung meridians are entered; tranquilization and intelligence development, heart and kidney communication, phlegm elimination and swelling reduction; can be used for treating insomnia, dreaminess, amnesia, pavor, absentmindedness, expectoration, skin and external diseases, swelling and pain of breast caused by imbalance between heart-yang and kidney-yin.
Zingiberis rhizoma, dried rhizome of Zingiber officinale Roscoe of Zingiberaceae; pungent taste and hot property; spleen, stomach, kidney, heart and lung meridians; warming the middle-jiao to dispel cold, restoring yang to activate collaterals, warming the lung to resolve fluid retention; can be used for treating abdominal psychroalgia, emesis, diarrhea, cold limbs, slight pulse, cough and asthma due to cold fluid retention.
Pericarpium Citri Tangerinae, which is dried mature pericarp of Rutaceae plant fructus Citri Tangerinae and its cultivar; bitter, pungent and warm in nature; entering lung and spleen meridians; regulating qi-flowing, invigorating spleen, eliminating dampness, and eliminating phlegm; can be used for treating abdominal distention, anorexia, vomiting, diarrhea, cough, and excessive phlegm; it is combined with cang Zhu and Hou Po to treat gastric and abdominal distention and pain, nausea and vomiting, diarrhea, etc. due to cold-dampness in middle energizer and qi stagnation in spleen and stomach.
Fructus Schisandrae chinensis, dried mature fruit of Schisandra chinensis of Magnoliaceae; sour, sweet and warm in nature; it enters lung, heart and kidney meridians; astringe, benefit qi, promote the production of body fluid, tonify kidney, calm heart; can be used for treating chronic cough, asthma, nocturnal emission, enuresis, frequent micturition, chronic diarrhea, spontaneous perspiration, night sweat, thirst due to body fluid consumption, internal heat, diabetes, palpitation, and insomnia.
Fructus Jujubae, dried mature fruit of Zizyphi fructus of Rhamnaceae family; sweet taste and warm nature; spleen, stomach and heart meridians entered; invigorating spleen, replenishing qi, nourishing blood, and tranquilizing; can be used for treating spleen deficiency, anorexia, asthenia, loose stool, and hysteria of women.
Radix Glycyrrhizae Preparata (dried root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. of Leguminosae); sweet in taste and mild in nature; entering heart, lung, spleen and stomach meridians; invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the above medicines; can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
The compatibility of the traditional Chinese medicines is designed according to the matching of monarch, minister, assistant and guide, and the Shennong's herbal Jing' is recorded in the cloud: one hundred and twenty Chinese medicines are used as monarch drugs to nourish life; one hundred and twenty Chinese medicines are ministerial and have main nourishing property; one hundred and twenty medicines are added as adjuvant medicines for treating diseases; the medicine should be combined with monarch, minister, assistant and guide. The compatibility of the traditional Chinese medicines in the cough and asthma relieving composition is as follows:
Monarch drug: astragalus root, pinellia tuber, ephedra;
ministerial drugs: asarum, semen lepidii, adenophora tetraphylla, flos farfarae, bighead atractylodes rhizome, poria cocos, polygala tenuifolia, dried orange peel and schisandra chinensis;
Adjuvant drugs: rhizoma Zingiberis and fructus Jujubae;
a messenger drug: mix the above herbs, dispel phlegm and relieve cough, relieve spasm and alleviate pain, and harmonize the effects of the above drugs.
The formula is based on Liujunzi decoction (bighead atractylodes rhizome, poria cocos, honey-fried licorice root, pinellia tuber and dried orange peel) + astragalus root, the qi tonifying function is enhanced on the basis of strengthening spleen and drying dampness, ephedra herb is supplemented to ventilate lung and relieve asthma, lepidium seed is supplemented to discharge lung and relieve asthma, asarum, schisandra chinensis and dried ginger are used for warming lung and dissolving fluid, adenophora tetraphylla, tussilago farfara and polygala root are used for eliminating phlegm and relieving cough, pinellia tuber, dried orange peel, poria cocos, dried ginger and Chinese date are used for enhancing the effect of warming middle-temperature and drying dampness. The formula focuses on improving lung function, and has the effects of tonifying qi and lung, relieving cough and reducing sputum and relieving asthma.
Example 1
corresponding to the monarch, minister, assistant and guide traditional Chinese medicine compatibility principle, the cough and asthma relieving traditional Chinese medicine composition in the embodiment comprises, by weight, 100g of astragalus membranaceus, 200g of adenophora tetraphylla, 85g of ephedra, 100g of bighead atractylodes rhizome, 100g of poria cocos, 100g of rhizoma pinellinae praeparata, 100g of semen lepidii, 100g of flos farfarae, 30g of asarum, 85g of polygala tenuifolia, 85g of dried ginger, 130g of pericarpium citri reticulatae, 85g of schisandra chinensis, 130g of Chinese dates, 85 g.
the cough and asthma relieving chronic bronchitis ointment is prepared from the traditional Chinese medicine composition for relieving cough and asthma, and as shown in figure 1, the preparation method of the mixture is as follows:
step1, dipping: adding 10-20L of drinking normal-temperature water into the cough and asthma relieving traditional Chinese medicine composition, soaking overnight at the room temperature of 15-25 ℃, wherein the soaking is based on the principle that the medicinal material core is wet, and the total water absorption rate of the soaked medicinal material is 10-20% (W/W);
Step2, decocting: pouring the soaked cough and asthma relieving traditional Chinese medicine composition and the not completely absorbed soaking liquid into a jacketed kettle simultaneously, and decocting the soaked Chinese medicine composition and the soaking liquid at normal pressure by adopting circulating steam at 100 ℃ for three times, wherein the first decoction time is 2 hours, and the second and third decoction times are 1 hour respectively, the weight ratio of the cough and asthma relieving traditional Chinese medicine composition to the soaking liquid in the first decoction is 4-8 times (W/W) that of the drinking normal-temperature water, the later decoction liquid passes through a 200-mesh screen to obtain a first decoction liquid, and the filtrate is reserved;
Adding 4-6 times (W/W) of drinking water into filter residues for second decoction, wherein the decoction time is 1 hour, and then, passing the decoction through a 200-mesh screen to obtain a second decoction, and keeping the filtrate for later use;
Adding 4-6 times of drinking water into the filter residue again for carrying out third decoction for 1 hour, and sieving the decoction with a 200-mesh sieve to obtain a third decoction, wherein the filtrate is reserved; the filter residue is discarded.
Step3, concentration: mixing the first decoction with the second decoction and the third decoction, placing the mixture in a jacketed kettle, and under the condition of normal pressure circulating steam, enabling the decoction temperature to reach 100 ℃, continuously stirring, and concentrating to 800-1100 mL to obtain a concentrated solution for later use;
step4, alcohol precipitation: standing the concentrated solution, naturally cooling to room temperature, then placing the concentrated solution into an alcohol precipitation tank, adding 95% ethanol, adjusting the ethanol content to 40% (mL/mL) at room temperature, continuously stirring for 40 minutes to ensure that the ethanol is fully and uniformly mixed, performing secondary alcohol precipitation, standing the concentrated solution at room temperature for 48 hours for the first time of alcohol precipitation, sucking supernatant alcohol precipitation solution for later use, adding ethanol into precipitation residues again, adjusting the ethanol content to 40% (mL/mL) in the same way as the first time of alcohol precipitation, standing the concentrated solution at room temperature for 12 hours for the second time of alcohol precipitation, filtering to obtain supernatant alcohol precipitation solution, and discarding residues;
Step5, recovering ethanol: mixing the two ethanol precipitation solutions, and recovering ethanol under reduced pressure. Heating with steam to recover ethanol to obtain concentrated medicinal liquid, recovering ethanol, and standing;
Continuously concentrating the concentrated liquid medicine after recovering the ethanol under normal pressure until the specific gravity is 1.15-1.30, immediately adding a prepared ethylparaben solution, and uniformly stirring for later use;
Step6, preparation of refined honey and refined sugar: boiling Mel in a jacketed kettle at 110-120 deg.C, refining to golden yellow and dripping Mel into filaments, filtering, and discarding impurities;
adding purified water and tartaric acid solution into sucrose, boiling at 110-120 ℃, stirring, dissolving, and sieving with a 100-mesh sieve to obtain sucrose syrup with a specific gravity of 1.40-1.60 for later use;
Mixing: continuously heating the liquid medicine after ethanol recovery, controlling the temperature to 100 ℃, adding refined honey and sucrose syrup, uniformly stirring, observing that no crystal is generated in the liquid medicine, and filtering by a 100-mesh screen for later use;
step7, sterilization and separation: putting concentrated solution of Chinese medicinal composition for relieving cough and asthma, Mel and refined sugar into cold and hot jar, adding ethylparaben as antiseptic, stirring, mixing, heating with steam, sterilizing at high temperature for 1 hr, naturally cooling to room temperature, slowly adding Mentholum liquid, and stirring;
Step8, preparation: adding appropriate amount of distilled water into the above medicinal liquid, stirring, adjusting volume to 1000mL, and packaging into a specified container to obtain brown viscous semifluid ointment for treating cough and asthma.
example 2
corresponding to the principle of compatibility of monarch, minister, assistant and guide traditional Chinese medicines, the cough and asthma relieving pharmaceutical composition in the embodiment comprises, by weight, 250g of astragalus membranaceus, 300g of adenophora tetraphylla, 150g of ephedra, 250g of bighead atractylodes rhizome, 250g of poria cocos, 250g of rhizoma pinellinae praeparata, 250g of semen lepidii, 250g of flos farfarae, 90g of asarum, 150g of polygala tenuifolia, 150g of rhizoma zingiberis, 190g of pericarpium citri reticulatae, 150g of schisandra chinensis, 190g of jujube, 150g of radix.
The preparation method of the cough and asthma treating ointment for chronic bronchitis is the same as that in example 1, except that 20L of normal temperature water is added when the ointment is soaked in Step1, and the ointment for chronic bronchitis and cough and asthma is prepared by the same steps.
example 3
corresponding to the principle of compatibility of monarch, minister, assistant and guide traditional Chinese medicines, the cough and asthma relieving composition of the embodiment comprises, by weight, 200g of astragalus membranaceus, 250g of adenophora tetraphylla, 100g of ephedra, 200g of bighead atractylodes rhizome, 200g of poria cocos, 200g of rhizoma pinellinae praeparata, 200g of semen lepidii, 200g of flos farfarae, 67g of asarum, 100g of polygala tenuifolia, 100g of dried ginger, 167g of dried orange peel, 100g of schisandra chinensis, 167g of Chinese dates, 100g of honey-fried licorice roots.
the preparation method of the cough and asthma treating chronic bronchitis is the same as that in example 1, except that 18L of normal temperature water is added when Step1 is soaked, and the cough and asthma treating chronic bronchitis is prepared by the same steps.
Example 4
The present embodiment identifies whether the chuanzhi cough and asthma ointment prepared in the above examples contains effective therapeutic ingredients, respectively:
(1) thin-layer chromatography determination of astragaloside
Taking 15g of the above samples, adding 40mL of methanol, heating and refluxing for 1 hour, filtering, evaporating the filtrate to dryness, adding 30mL of water into the residue to dissolve, shaking and extracting with diethyl ether for 3 times, 15mL each time, discarding the ethyl ether solution, volatilizing the diethyl ether from the water layer, shaking and extracting with water saturated n-butanol for 3 times, 20mL each time, combining the n-butanol solutions, washing with 1% sodium hydroxide solution saturated with n-butanol for 3 times, 20mL each time, washing with water saturated with n-butanol to neutrality, discarding the water solution, evaporating the n-butanol solution to dryness, adding 1mL of methanol into the residue to dissolve, and using the residue as a sample solution. Adding methanol into astragaloside IV control to obtain 1mg solution per 1ml, and making into control solution. Performing thin layer chromatography (general rule 0502) test, sucking the above two solutions each 5uL, respectively dropping on the same silica gel G thin layer plate, placing the layered lower layer solution below 10 deg.C with chloroform-ethyl acetate-methanol-water (15: 40: 22: 10) as developing agent, developing, taking out, air drying, spraying 10% sulphuric acid ethanol solution, heating until the spots are clearly developed, and inspecting under sunlight. Spots of the same color appear in the chromatogram of the test solution at positions corresponding to those in the chromatogram of the control solution. Through comparison and identification, the three groups of chronic bronchitis cough and asthma ointments obtained in the above examples contain active ingredient astragaloside IV.
(2) Thin-layer chromatography determination of hesperidin
Taking 10g of each sample of the above examples, adding 30mL of water to dissolve, shaking and extracting with diethyl ether for three times, 30mL each time, discarding the ethyl ether solution, shaking and extracting the water layer with ethyl acetate for 2 times, 20mL each time, combining the ethyl acetate extracts, and concentrating to 2mL to obtain a sample solution. Separately, collecting hesperidin control, and adding ethyl acetate to obtain 1mg solution per 1mL as control solution. Performing thin layer chromatography (general rule 0502) test, sucking 5uL of the above two solutions, respectively dropping on the same silica gel G thin layer plate, developing with chloroform-methanol-water (32: 17: 5) lower layer solution as developing agent, taking out, air drying, spraying with 1% aluminum trichloride ethanol solution, heating until the spots are clearly developed, and inspecting under ultraviolet lamp (365 nm). Spots of the same color appear in the chromatogram of the test solution at positions corresponding to those in the chromatogram of the control solution. Through detection, the three groups of chronic bronchitis cough and asthma ointments in the embodiment or the three groups of chronic bronchitis cough and asthma ointments contain an effective component, namely hesperidin.
example 5
in this example, the relative density of the cough and asthma treating ointment of chronic bronchitis is determined by the following method:
Taking 10g of Manzhi cough and asthma paste, precisely weighing, adding 2 times of water, mixing uniformly to obtain a test solution, and performing a photogrammetry method (general rule 0601) to calculate according to the following formula:
Wherein W1 is the weight of the test solution in the pycnometer; w2 is the weight of water in the bottle, wherein f is the weight of water added to the test article/(weight of test article + weight of water added to the test article)
The relative density of the test article should be determined to be not less than 1.20.
The density of the cough and asthma treating ointment for treating chronic bronchitis in the embodiment is respectively 1.3, 1.35 and 1.5, and the relative density requirements are met.
Example 6
In this example, the detection method for detecting insoluble substances in the cough and asthma treating ointment of chronic bronchitis prepared by the present invention is as follows:
Taking 5g of a sample, adding 200mL of hot water, stirring to dissolve, standing for 3 minutes, and observing to obtain no foreign matters such as coke breeze; the three groups of the slow-branch cough and asthma ointments prepared by the method all accord with insoluble substance detection tests.
Example 7
in this example, the content of astragaloside in the chronic bronchitis cough and asthma paste was determined as follows:
according to the requirements of pharmacopoeia of 2015 edition, the measurement is carried out according to four high performance liquid chromatography (general rule 0512).
(1) Chromatographic conditions and System suitability test
Polar-Phenyl chromatography column (5 μm, 120A, 250X 4.6 mm); mixing acetonitrile: 0.1% phosphoric acid solution (containing 0.1% triethylamine) (3:97) as a mobile phase; the detection wavelength was 210 nm. The number of theoretical plates is not less than 3000 calculated according to ephedrine hydrochloride and pseudoephedrine hydrochloride peaks.
(2) Preparation of control solutions
Taking appropriate amount of ephedrine hydrochloride and pseudoephedrine hydrochloride reference substances, precisely weighing, and adding methanol to obtain solutions containing 60 μ g and 30 μ g each per 1 mL.
(3) Preparation of test solution
Taking about 5g of the product, precisely weighing, placing the product in a conical flask with a plug, adding 50mL of 0.1% hydrochloric acid solution, weighing, ultrasonically treating (power 240W and frequency 45kHz) for 30 minutes, cooling, weighing again, supplementing the loss weight by using 0.1% hydrochloric acid solution, shaking up, filtering, precisely weighing 25mL of subsequent filtrate, dropwise adding ammonia water to adjust the pH value to 11-12, shaking up and extracting for 3 times by using diethyl ether, each time for 30mL, combining ethyl ether solution, adding 2mL of dilute hydrochloric acid, evaporating to dryness, dissolving residues by using a mobile phase, placing the residues in a 10mL measuring flask, adding the mobile phase to the scale, shaking up, filtering, and taking the subsequent filtrate to obtain the product.
(4) Assay method
precisely sucking 10uL of each of the reference solution and the sample solution, injecting into a liquid chromatograph, and measuring.
Each 1g of the product contains ephedrine hydrochloride (C) of herba Ephedrae10H5NO & HCl) and pseudoephedrine hydrochloride (C)10H5NO & HCl) of not less than 0.1mg in total. The herba Ephedrae in the above three groups of ointment for treating cough and asthma is ephedrine hydrochloride (C)10H5NO & HCl) and pseudoephedrine hydrochloride (C)10H5NO & HCl) were added in a total amount of 0.12mg, 0.22mg, 0.16mg, respectively.
the three groups of chronic bronchitis cough and asthma ointments prepared according to the embodiments have the effects of tonifying qi and lung, relieving cough and reducing sputum and relieving asthma. It can be used for treating lung and spleen deficiency, cough and asthma due to chronic diseases, short breath, asthenia, asthma due to exercise, cough, and short breath, such as chronic cough and asthma due to chronic bronchitis, emphysema, and cor pulmonale.
The ointment prepared by the invention is taken orally, 22.5-30 g each time, 3 times a day or following the advice of a doctor, and the product is stored and sealed and stored in a cool and dry place, and the quality guarantee period is 18 months.
example 7
Fig. 2 shows the clinical production batch of the cough and asthma treating chronic bronchitis, and the clinical application and data statistics of the cough and asthma treating chronic bronchitis of the invention are combined to obtain the clinical use effect, which is as follows:
all cases in this example were selected from 3 months 2014 to 3 months 2017 to the outpatient and hospitalized patients based on clinical presentation, symptom score, lung function (FVC, FEV1, MVV), eosinophil count (EOS) and immunoglobulin IgE levels. Meanwhile, according with the diagnosis standard and classification of western medicine bronchial asthma, the western medicine bronchial asthma belongs to mild-moderate acute attack stage and the traditional Chinese medicine belongs to cold asthma syndrome differentiation, 450 patients are selected for treatment, wherein 375 male patients and 75 female patients are treated, the average age is 40.3 (25-68), 450 patients with bronchial asthma are randomly divided into 3 groups, each group comprises 150 patients, each group is divided into 3 groups according to different symptom expressions, 50 patients in each group are taken by the slow-branch cough and asthma ointment in the embodiment 1, the first group is taken by oral administration, 20mL of each time and 3 times a day, the second group is taken by the slow-branch cough and asthma ointment in the embodiment 2, the administration method is the same as that of the first group, and the third group is taken by the slow-branch cough and asthma ointment in the embodiment 3, and the administration method is the same as that of the first group. After one month of treatment, statistics were performed on the treatment results of the three groups, and the statistical results are given in the following table:
TABLE 1 statistics of the effectiveness of the Chronic bronchitis cough and asthma ointments prepared in examples 1-3
| Chest stuffiness | cough with asthma | Asthma (asthma) | |
| Product of example 1 | |||
| number of users | 50 | 50 | 50 |
| Number of effective persons | 42 | 45 | 46 |
| Effective rate (%) | 84 | 90 | 92 |
| product of example 2 | |||
| Number of users | 50 | 50 | 50 |
| number of effective persons | 48 | 42 | 44 |
| effective rate (%) | 96 | 84 | 88 |
| Product of example 3 | |||
| Number of users | 50 | 50 | 50 |
| Number of effective persons | 47 | 45 | 46 |
| Effective rate (%) | 94 | 90 | 92 |
It can be seen from the table that the chronic bronchitis cough and asthma ointment prepared in example 1 is more suitable for patients with chest distress and other diseases, the chronic bronchitis cough and asthma ointment prepared in example 2 is suitable for patients with cough, and the chronic bronchitis cough and asthma ointment prepared in example 3 is more suitable for patients with complicated bronchial asthma, and has better conditioning effect.
Claims (10)
1. A Chinese medicinal composition for relieving cough and asthma is characterized by comprising astragalus, adenophora tetraphylla, ephedra, bighead atractylodes rhizome, poria cocos, rhizoma pinellinae praeparata, semen lepidii, flos farfarae, asarum, polygala tenuifolia, rhizoma zingiberis, dried orange peel, schisandra chinensis, Chinese dates, honey-fried licorice roots and honey.
2. the composition according to claim 1, wherein the composition comprises, by weight, 100-300 g of astragalus membranaceus, 200-300 g of adenophora tetraphylla, 85-150 g of ephedra, 150-250 g of bighead atractylodes rhizome, 150-250 g of poria cocos, 150-250 g of rhizoma pinellinae praeparata, 150-250 g of semen lepidii, 150-250 g of flos farfarae, 30-90 g of asarum, 85-150 g of polygala tenuifolia, 85-150 g of dried ginger, 130-190 g of dried orange peel, 85-150 g of schisandra chinensis, 130-190 g of Chinese dates, 85-150 g of honey-fried licorice root and 600-700 g of honey.
3. A chuanzhi chuanke ointment made of the composition as claimed in claim 1 or 2, which is brown and viscous semi-fluid.
4. The cough and asthma chronic bronchitis cream of claim 3, wherein ethylparaben solution, potassium sorbate solution, tartaric acid solution, menthol and sucrose are added to the cough and asthma chronic bronchitis cream.
5. The cough and asthma paste for chronic bronchitis as claimed in claim 4, wherein the concentration of ethylparaben added to the cough and asthma paste for chronic bronchitis is 0.0015-0.0045 g/mL, the concentration of potassium sorbate is 0.0005-0.002 g/mL, the concentration of tartaric acid is 0.0005-0.002 g/mL, the concentration of menthol is 0.0005-0.002 g/mL and the concentration of sucrose is 100-200 g.
6. The cough and asthma treating chronic bronchitis as claimed in claim 3, wherein the preparation method of the cough and asthma treating chronic bronchitis comprises:
Step1, dipping: adding 10-20L of drinking normal-temperature water into the cough and asthma relieving traditional Chinese medicine composition, soaking overnight at the room temperature of 15-25 ℃, wherein the soaking is based on the principle that the medicinal material core is wet, and the total water absorption rate of the soaked medicinal material is 10-20% (W/W);
step2, decocting: pouring the soaked cough and asthma relieving traditional Chinese medicine composition and the not completely absorbed soaking liquid into a jacketed kettle simultaneously, and decocting the soaked Chinese medicine composition and the soaking liquid at normal pressure by adopting circulating steam at 100 ℃ for three times, wherein the first decoction time is 2 hours, and the second and third decoction times are 1 hour respectively, the weight ratio of the cough and asthma relieving traditional Chinese medicine composition to the soaking liquid in the first decoction is 4-8 times (W/W) that of the drinking normal-temperature water, the later decoction liquid passes through a 200-mesh screen to obtain a first decoction liquid, and the filtrate is reserved;
adding 4-6 times (W/W) of drinking water into filter residues for second decoction, wherein the decoction time is 1 hour, and then, passing the decoction through a 200-mesh screen to obtain a second decoction, and keeping the filtrate for later use;
Adding 4-6 times of drinking water into the filter residue again for carrying out third decoction for 1 hour, passing the decoction through a 200-mesh screen to obtain a third decoction, and reserving the filtrate and discarding the filter residue;
Step3, concentration: mixing the first decoction with the second decoction and the third decoction, placing the mixture in a jacketed kettle, and under the condition of normal pressure circulating steam, enabling the decoction temperature to reach 100 ℃, continuously stirring, and concentrating to 800-1100 mL to obtain a concentrated solution for later use;
Step4, alcohol precipitation: standing the concentrated solution, naturally cooling to room temperature, then placing the concentrated solution into an alcohol precipitation tank, adding 95% ethanol, adjusting the ethanol content to 40% (mL/mL) at room temperature, continuously stirring for 40 minutes to ensure that the ethanol is fully and uniformly mixed, performing secondary alcohol precipitation, standing the concentrated solution at room temperature for 48 hours for the first time of alcohol precipitation, sucking supernatant alcohol precipitation solution for later use, adding ethanol into precipitation residues again, adjusting the ethanol content to 40% (mL/mL) in the same way as the first time of alcohol precipitation, standing the concentrated solution at room temperature for 12 hours for the second time of alcohol precipitation, filtering to obtain supernatant alcohol precipitation solution, and discarding residues;
step5, recovering ethanol: mixing the two ethanol precipitation solutions, recovering ethanol under reduced pressure, heating with steam to recover ethanol to obtain concentrated solution, and recovering ethanol;
Continuously concentrating the concentrated liquid medicine after recovering the ethanol under normal pressure until the specific gravity is 1.15-1.30, immediately adding a prepared ethylparaben solution, and uniformly stirring for later use;
Step6, preparation of refined honey and refined sugar: boiling Mel in a jacketed kettle at 110-120 deg.C, refining to golden yellow and dripping Mel into filaments, filtering, and discarding impurities;
Adding purified water and tartaric acid solution into sucrose, boiling at 110-120 ℃, stirring, dissolving, and sieving with a 100-mesh sieve to obtain sucrose syrup with a specific gravity of 1.40-1.60 for later use;
mixing: continuously heating the liquid medicine after ethanol recovery, controlling the temperature to 100 ℃, adding refined honey and sucrose syrup, uniformly stirring, observing that no crystal is generated in the liquid medicine, and filtering by a 100-mesh screen for later use;
step7, sterilization and separation: putting concentrated solution of Chinese medicinal composition for relieving cough and asthma, Mel and refined sugar into cold and hot jar, adding ethylparaben as antiseptic, stirring, mixing, heating with steam, sterilizing at high temperature for 1 hr, naturally cooling to room temperature, slowly adding Mentholum liquid, and stirring;
Step8, preparation: adding appropriate amount of distilled water into the above medicinal liquid, stirring, adjusting volume to 1000mL, and packaging into a specified container to obtain brown viscous semifluid ointment for treating cough and asthma.
7. The cough and asthma relieving chronic bronchitis cream of claim 6, wherein the cough and asthma relieving pharmaceutical composition is soaked and decocted, filtered and precipitated with alcohol in order to remove impurities to retain the active ingredients of the pharmaceutical composition; adding refined honey and cane sugar to prevent the growth of microorganisms and regulate the taste; and (5) correcting the taste of the menthol.
8. The cough and asthma paste of claim 3, wherein the identification method of astragaloside IV and hesperidin in the cough and asthma paste of Chronic bronchitis adopts thin layer chromatography.
9. The cough and asthma treating ointment of claim 3, wherein the relative density of the cough and asthma treating ointment is determined as follows:
Taking 10g of Manzhi cough and asthma paste, precisely weighing, adding 2 times of water, mixing uniformly to obtain a test solution, measuring according to a relative density measurement method, and calculating according to the following formula:
In the formula: w1 is the weight of the test solution in the pycnometer;
w2 is the weight of water in the pycnometer;
Wherein f is the weight of water added to the test article/(the weight of the test article + the weight of water added to the test article);
The relative density of the test article is not less than 1.20.
10. the cough and asthma chronic ointment of claim 3, wherein the content of ephedrine hydrochloride and pseudoephedrine hydrochloride in the cough and asthma chronic ointment is determined by high performance liquid chromatography, and ephedrine hydrochloride (C) is added to 1.0g of cough and asthma chronic ointment10H5NO & HCl) and pseudoephedrine hydrochloride (C)10H5NO & HCl) of not less than 0.1mg in total.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110314209A (en) * | 2019-08-09 | 2019-10-11 | 云南省第一人民医院 | A kind of stomach-nourishing mixture |
| CN112569327A (en) * | 2020-09-17 | 2021-03-30 | 武汉立志保健品有限责任公司 | Semen lepidii traditional Chinese medicine compound preparation for treating patients with symptoms of new coronary pneumonia, phlegm retention and cough and common patients |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110314209A (en) * | 2019-08-09 | 2019-10-11 | 云南省第一人民医院 | A kind of stomach-nourishing mixture |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110314209A (en) * | 2019-08-09 | 2019-10-11 | 云南省第一人民医院 | A kind of stomach-nourishing mixture |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110314209A (en) * | 2019-08-09 | 2019-10-11 | 云南省第一人民医院 | A kind of stomach-nourishing mixture |
| CN112569327A (en) * | 2020-09-17 | 2021-03-30 | 武汉立志保健品有限责任公司 | Semen lepidii traditional Chinese medicine compound preparation for treating patients with symptoms of new coronary pneumonia, phlegm retention and cough and common patients |
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Application publication date: 20191217 |