CN110123962A - A kind of loquat composition and preparation method thereof - Google Patents
A kind of loquat composition and preparation method thereof Download PDFInfo
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Abstract
The present invention is rationally assembled using loguat leaf, reed root, lily, Loquat-Shaped Cake cream, campanulaceae, mulberry leaf, dried orange peel, radix glycyrrhizae preparata；Oligosaccharide is added, obtains a kind of loquat composition.Loquat composition provided by the invention has beneficial effect for improving sub-health state, has apparent effect in terms of the anti-inflammatory, cough-relieving and eliminating the phlegm and in terms of defaecation according to zoopery.
Description
Technical field
The present invention relates to pharmaceutical technology fields, and in particular to a kind of loquat composition and preparation method.
Background technique
It " is recorded in " Mingyi Bielu ", loguat leaf, alias rake leaf, Lu Juye, Ba Ye, medicinal material formal name used at school Folium
Eriobotryae；For the dried leaf of dicotyledon rosaceae loquat.Loguat leaf whole year can harvest.Its cold nature, bitter,
Return lung, stomach meridian have the effect of clearing lung and relieving cough, stopping nausea and vomiting by lowering the adverse flow of QI, and it is anxious to be usually used in treating cough with lung heat, circulation of vital energy in the wrong direction asthma, and stomach energy is vomitted inverse, dysphoria with smothery sensation
The illnesss such as thirsty.Modern pharmacy research shows that loguat leaf have effects that it is following: (1) antibechic, eliminating the phlegm, antiasthmatic effect: contained by this product
The hydrogen cyanide that amygdalin hydrolyzes generation in vivo has antitussive action, and water decoction or ethyl acetate extract have eliminating the phlegm and work of relievining asthma
With the contained volatile oil of leaf has slight phlegm-dispelling functions；(2) antibacterial action: experiment shows that this product water decoction or ethyl acetate mention
Object is taken to have antibacterial action to white or staphylococcus aureus, Diplococcus pneumopniae, shigella flexneri；(3) anti-inflammatory effect: have
Report points out that loguat leaf ethyl alcohol cold soaking extract has anti-inflammatory effect to foot swelling local application caused by rat carrageenan.
Reed root is the subterranean stem of grass family herbaceos perennial reed.Its nature and flavor is sweet, cold, attaches to the lung and stomach meridians.With clear
The effect of heat is promoted the production of body fluid, and is relieved restlessness and prevented vomiting.It is usually used in consumption of body fluid caused by febrile disease, dysphoria and thirsty, stomach energy is vomitted inverse, the card such as cough with lung heat." Xin Xiuben
Grass " record its energy " treatment is vomitted against not lower food, pathogenic heat in the stomach, and typhoid patients are more good ".Modern pharmacology research discovery reed root includes (1)
Skeletal muscle inhibiting effect: the oxygen of contractile response caused by the electro photoluminescence of frog neuromuscular sample and diaphragm in rats can be inhibited to absorb
And anaerobic glycolysis, and the reaction of actin-adenosine triphosphate system can be inhibited, there are also weaker central inhibitory action,
Show as having sedation to rat and mouse, and can be with caffeine phase antagonism；(2) it intestinal tube relexation: can significantly inhibit
Isolated rabbit intestinal contraction.
Lily is the meat bulb of Liliaceae herbaceos perennial lily.Its nature and flavor is sweet, slightly cold, return lung, the heart channel of Hang-Shaoyin.Tool
There is the effect of moistening lung to arrest cough, clearing away the heart fire and tranquillizing.It is usually used in cough with lung heat, dysphoria palpitates with fear, the card such as insomnia and dreamful sleep.Supplementary Amplifications of the Compendium of Materia Medica
Record its energy " clear convulsive seizure due to phlegm-fire, qi-restoratives damage ".Modern pharmacology research discovery lily includes (1) Antitussive and Expectorant Effect: to SO2Cause
Mouse cough, have apparent antitussive effect；(2) increase lung function and hypoxia-bearing capability: can significantly extend Lung Qi deficiency animal
Model swimming time.
Campanulaceae is the root of Campanulaceae herbaceos perennial campanulaceae.Its is bitter in taste, pungent, flat, distributed in lung channel.With opening promoting the dispersing function of the lung
The effect of gas, eliminating the phlegm apocenosis.It is usually used in coughing with a lot of sputum, chest diaphragm ruffian is bored, pulmonary abscess pectoralgia, cough vomiting of pus and blood, and phlegm Huang is stench to wait card." name
Doctor records " record it can " relieving the five internal organs stomach, fills blood, and except fever and chills, wandering arthritis, middle benefit gas disappears paddy ".Modern pharmacology research finds tangerine
Stalk includes (1) eliminating the phlegm and antitussive effect: anesthetized dog takes orally this product decoction 1g/kg, can the significant secretion for increasing respiratory mucus
Amount, intensity can be compared with ammonium chloride；(2) anti-inflammatory effect: thick platycodoside has anti-inflammatory effect, gavages the cause of 1/10~1/5 half
The dosage extremely measured is swollen to rat hindlimb Irish moss colloidality foot to have antiphlogistic effects with acetic acid swelling；(3) thick platycodoside has town
Quiet, analgesia and refrigeration function.
Mulberry leaf are the leaf of Moraceae defoliation small arbor plant mulberry tree.Its is bitter in taste, sweet, cold, return lung, Liver Channel.It is clear with dispelling wind
Heat, the effect of clearing liver and improving vision.It is usually used in affection of exogenous wind-heat, fever and cough, puckery pain of hot eyes caused by abscess of throat or Liver Channel real heat etc.
Card.Compendium of Material Medica, which records it, " to control labor heat cough, improving eyesight long hair ".It is antibacterial that modern pharmacology research discovery mulberry leaf include (1)
Anti-inflammatory effect: white mulberry vein-juice has good growth to press down most of gram-positive bacterias and Gram-negative bacteria and partial yeast bacterium
Production is used, and the rutin sophorin in mulberry leaf can significantly inhibit Rat Models of Traumatic edema, and conjunctivitis, auricle can be prevented scorching, pulmonary edema
Development；(2) spasmolysis, anti-ulcer effect: the Quercetin in mulberry leaf can reduce intestines, bronchial smooth muscle tension, and rutin sophorin can reduce
The stomach motor function of rat, and intestinal smooth muscle spasm caused by barium chloride can be released；(3) improve gut function, relax bowel and defecation and
Antiobesity action: minerals and carbohydrate contained by mulberry leaf act on after entering large intestine with intestinal flora, generate butyric acid, propionic acid, lactic acid, acetic acid
Equal organic acids make enteral environment become acid, and intestinal contents acidity increases, and can inhibit the proliferation of harmful bacteria, play adjusting
Enteron aisle, the effect for improving constipation, catharsis defaecation and weight-reducing.
Dried orange peel, for Rutaceae evergreen dungarunga plant tangerine and its pericarp for the ripening fruits for belonging to various plants.Its nature and flavor
Acrid, bitter, warm, return lung, the spleen channel.With in qi-regulating tune, eliminating dampness and eliminating phlegm effect.Be usually used in abdominal fullness and distention caused by the taste stagnation of the circulation of vital energy,
The card such as gas, nausea and vomiting；And phlegm dampness obstruction pattern, impairment of dispersing and descending function of the lung, the card such as coughing with a lot of sputum circulation of vital energy in the wrong direction.Compendium of Material Medica records " orange peel, hardship
Can let out can it is dry, it is pungent can dissipate, temperature can and.It controls all kinds of diseases and ailments, always takes the function of its qi-regulating eliminating dampness ".Modern pharmacology research finds dried orange peel
Include (1) antibacterial action: citrus chachiensis hortorum in vitro can inhibit staphylococcus, catarrh how the growth of Salmonella, hemolytic haemophilic bacterium,
Dried orange peel and the mixture of small banyan in vitro also have bacteriostasis:；(2) eliminating phlegm and relieving asthma acts on: the volatile oil contained in dried orange peel can pierce
Swash bronchus, glandular secretion is caused to increase, to reach phlegm-dispelling functions, effective ingredient is limonene；(3) anti-allergic effects:
Nobiletin can significantly fight the isolated ileum segments in guinea pigs of egg white sensitization and bronchial anaphylaxis is shunk；(4) anti-ulcer effect:
Experimental Gastric Ulcer in Rats is treated with methyl hesperidine, 100 or 500mg/kg is subcutaneously injected in preceding and experiment in testing, continuous 6
It, has the obvious effect for inhibiting ulcer to occur, and there are also anti-gastric acid secretions to act on.
Radix glycyrrhizae preparata is the root and rhizome of leguminous perennial herb Radix Glycyrrhizae.Its nature and flavor is sweet, flat, return heart, lung, spleen, stomach
Through.With invigorating the spleen and benefiting qi, the effect of moistening lung to arrest cough.It is usually used in weakness of the spleen and the stomach, the deficiency of qi in middle-jiao, shortness of breath and fatigue, anorexia and loose stool, cough
The card such as asthma." Bencao Tujing " records " Radix Glycyrrhizae can solve hundred poison, for wanting for many medicines ".Modern pharmacology research finds radix glycyrrhizae preparata tool
Have: (1) similar adrenocortical hormones fuction: having inhibiting effect to gastroxia caused by histamine, and have it is antiacid and
Alleviate the effect of gastrointestinal smooth muscle spasmus；(2) contained licoflavone, enoxolone have apparent kobadrin to make in radix glycyrrhizae preparata
With；(3) anti-inflammatory, anti-allergic effects: extract of licorice root and glycyrrhizic acid have protective effect to throat and tracheae mucosal inflammation.
Theory of traditional Chinese medical science thinks that phlegm coming from spleen, lung is the device for storing up phlegm.The dysfunction of the spleen in transport, wet being difficult, retention of water-damp gather
Into phlegm.Phlegm dampness in lungs, then impairment of dispersing and descending function of the lung, cough with dyspnea；Phlegm wet stops stomach, then stomach Qi rising, nausea and vomiting；Phlegm wet is hindered in chest
Diaphragm, then functional activity of QI being not smooth, stomach duct and abdomen ruffian is bored, dysfunction of the spleen in transportation and transformation.This product is monarch with loguat leaf, can clearing lung and eliminating phlegm, relieving cough and asthma and clear
Stomach energy, preventing or arresting vomiting are inverse.Cooperating reed root, lily, campanulaceae, mulberry leaf is minister, and the monarch and his subjects match, and plays clearing lung-heat moistening lung, relieving cough and reducing sputum function altogether.This
Product, which are helped, had been able to cooperate the eliminating dampness and eliminating phlegm power of the monarch and his subjects' enhancing, but also energy invigorating the spleen qi-regulating not only with dried orange peel with the source of producing phlegm of shutting out, and embodiment is controlled phlegm and first managed
Gas, gas is along the meaning that then phlegm disappears.It is to make medicine, invigorating spleen, coordinating the drug actions of a prescription with radix glycyrrhizae preparata.This product prescription compatibility is rigorous, and scattered receipts are suitable,
Mend and rush down and combine, giving consideration to both the incidental and fundamental.
Open (bulletin) number discloses a kind of loquat for a kind of patent " loquat leaf momordica grosvenori beverage " of CN104705460B
Leaf beverage made of Momordica grosvenorii Swingle, the beverage are mixed with Siraitia grosvenorii by loguat leaf as raw material, are added pure water to boil, are filtered, by filtrate
Concentration is liquid extract, then plus pure water dilution, edible menthol ethanol solution is added and mixes composition.
The patent " a kind of loquat cough relieving tea and preparation method thereof " of open (bulletin) number for CN102177990B, invention public affairs
A kind of loquat cough relieving tea and preparation method thereof is opened.Loguat leaf, perillaseed and dried orange peel are extracted with ethyl alcohol respectively, extract adds pure
It mixes after water dilution with solar dried green tea, is made after fermenting by known Pu'er tea pile fermentation technique.
Summary of the invention
The prior art utilizes loguat leaf, and mostly by loguat leaf soak extraction, simple process, ingredient is simple, and effect is general.
To solve the above technical deficiency, the present invention provides a kind of loquat combination of compositions object and preparation method thereof and
Using.Loguat leaf and one or more pharmaceutically acceptable additive composition function compositions, function composition are used in production
Application in anti-inflammatory, cough-relieving and eliminating the phlegm and prevention or in terms for the treatment of constipation and adjusting the intestinal flora of human body in health drink.
The present invention is added to oligosaccharide according to theory of traditional Chinese medical science many experiments, reasonable formula, helps to adjust enteron aisle
Tiny ecosystem.
The present invention is achieved by the following technical solutions:
The present invention provides a kind of loquat composition, the material proportion for preparing the loquat composition is as follows: loguat leaf 50-100
Part, 40-60 parts of reed root, 30-50 parts of lily, cream 20-40 parts of Loquat-Shaped Cake, 10-30 parts of campanulaceae, 10-30 parts of mulberry leaf, dried orange peel 10-30
Part, 4-6 parts of radix glycyrrhizae preparata；After above-mentioned integration of drinking and medicinal herbs herbal compound is added water to cook, is concentrated, Sucralose is added, is made.
Preferably, loquat composition can add one or more pharmaceutically acceptable oligosaccharides substances.
The preferred oligosaccharides substance is oligoisomaltose, oligofructose and xylo-oligosaccharide.
The material proportion that loquat composition prepares the addition of 1000 milliliters of liquid is as follows:
Loguat leaf 100g, reed root 50g, lily 40g, Loquat-Shaped Cake cream 30g, campanulaceae 20g, mulberry leaf 20g, dried orange peel 20g, radix glycyrrhizae preparata 5g；
Sucralose 30mg, IMO-50 type isomaltooligosaccharide syrup 40g, FOS55.75% oligofructose starches the oligomeric wood of 30g, XOS-70 type
Syrup 15g.
Steps are as follows for loquat preparation method of composition:
Take loguat leaf, reed root, lily, campanulaceae, mulberry leaf, dried orange peel, radix glycyrrhizae preparata seven flavor medicine material, add water to cook it is secondary, for the first time 1.0~
2.0 hours, second 1.0~2.0 hours, collecting decoction filtered, and filtrate decompression is concentrated into required volume, and Loquat-Shaped Cake cream is added,
Obtain traditional Chinese medicine extraction concentrate；Add the Sucralose and two kinds or two kinds that weight/volume percent is 0.002~0.005%
Above oligosaccharide is heated to dispensing at 70 ~ 80 DEG C, sterilizes 30~60 minutes at 110~121 DEG C, obtains loquat composition.
Preferably, oligosaccharide described in above-mentioned steps is that IMO-50 type isomaltooligosaccharide syrup, FOS55.75% are oligomeric
Fructose syrup and XOS-70 type xylo-oligosaccharide slurry, additional amount are that iso-maltose syrup 30-50g, oligofructose slurry is added in 1000mL liquid
20-40g, XOS-70 type xylo-oligosaccharide starch 10-20g.
The loquat composition that this patent provides can be applied in terms of improving sub-health status, in anti-inflammatory, cough-relieving and eliminating the phlegm
The application of aspect has important application in terms of relax bowel and defecation adjusts human enteric bacteria health drink.
The beneficial effects of the present invention are: a kind of (1) loquat composition provided by the invention, provides a kind of new for loguat leaf
Application approach；(2) according to theory of traditional Chinese medical science many experiments, reasonable formula arranges in pairs or groups the Chinese medicine of a variety of integration of drinking and medicinal herbs；(3)
It is added to oligosaccharide, is conducive to improve Tiny ecosystem circulation in human body, adjusts blood sugar for human body, blood lipid；(4) present invention is for improving
Sub-health state has beneficial effect, is had significantly in terms of anti-inflammatory, cough-relieving and eliminating the phlegm with defaecation face according to zoopery
Effect.
Specific embodiment
The preparation of 1 loquat composition of embodiment
Each traditional Chinese medicine ingredients: loguat leaf 100g, reed root 50g, lily 40g, Loquat-Shaped Cake cream 30g, campanulaceae are weighed according to following proportion
20g, mulberry leaf 20g, dried orange peel 20g, radix glycyrrhizae preparata 5g, in addition to Loquat-Shaped Cake cream, above seven taste adds water to soak in water, and amount of water is 12 times of materials
Doses is impregnated 60 minutes.100 DEG C are extracted 60 minutes, and filtering or centrifugation, it is spare to obtain supernatant, and filter residue adds water 10 times of amounts, and 100
It DEG C extracts 60 minutes, filtering or centrifugation obtain supernatant, merge supernatant, about 1000ml is concentrated into, by Loquat-Shaped Cake cream 30g, trichlorine
Sucrose 30mg, isomaltooligosaccharide syrup (IMO-50 type) 40g, oligofructose slurry (FOS55.75%) 30g are added in above-mentioned liquid, mix
It is even.It is heated to dispensing at 70 ~ 80 DEG C, sterilizes 30~60 minutes at 110~121 DEG C, obtain loquat composition.
The preparation of 2 loquat composition of embodiment
Each food and medicine consangunity material composition: loguat leaf 50g, reed root 40g, lily 30g, Loquat-Shaped Cake cream is weighed according to following proportion
20g, campanulaceae 10-g, mulberry leaf 10g, dried orange peel 10g, radix glycyrrhizae preparata 4g, in addition to Loquat-Shaped Cake cream, above seven taste adds water to soak in water,
Amount of water is 12 times of quantity of material, is impregnated 60 minutes.100 DEG C are extracted 60 minutes, and filtering or centrifugation obtain that supernatant is spare, and filter residue is again
Add 10 times of water amounts, 100 DEG C are extracted 60 minutes, and filtering or centrifugation obtain supernatant, merge supernatant, be concentrated into about 1000ml, be added
Loquat-Shaped Cake cream 20g, Sucralose 40mg, isomaltooligosaccharide syrup (IMO-50 type) 40g, oligofructose slurry (FOS55.75%)
30g is added in above-mentioned liquid, mixes.It is heated to dispensing at 70 ~ 80 DEG C, sterilizes 30~60 minutes at 110~121 DEG C, obtain loquat
Composition.
The preparation of more than 3 plants of loquat compositions of embodiment
Each food and medicine consangunity material composition: loguat leaf 100g, reed root 60g, lily 50g, Loquat-Shaped Cake cream is weighed according to following proportion
40g, campanulaceae 30g, mulberry leaf 30g, dried orange peel 30g, radix glycyrrhizae preparata 6g, in addition to Loquat-Shaped Cake cream, above seven taste adds water to soak in water, amount of water
For 12 times of quantity of material, impregnate 60 minutes.100 DEG C are extracted 60 minutes, and filtering or centrifugation obtain that supernatant is spare, and filter residue adds water 10
It measures again, 100 DEG C are extracted 60 minutes, filtering or centrifugation, obtain supernatant, and merging supernatant is concentrated into about 1000ml, Loquat-Shaped Cake is added
Cream 40g, Sucralose 20mg, isomaltooligosaccharide syrup (IMO-50 type) 40g, xylo-oligosaccharide are starched in (XOS-70 type) 15g addition
It states in liquid, mixes.It is heated to dispensing at 70 ~ 80 DEG C, sterilizes 30~60 minutes at 110~121 DEG C, obtain loquat composition.
Embodiment 4 investigates the anti-inflammatory of loquat composition, cough-relieving and phlegm-dispelling functions
Experiment purpose:
The anti-inflammatory of loquat composition, cough-relieving and the effect of eliminating the phlegm are investigated by animal model.
Experimental material:
Dimethylbenzene is purchased from Sinopharm Chemical Reagent Co., Ltd.；
Ammonium hydroxide is purchased from Sinopharm Chemical Reagent Co., Ltd.；
Sodium bicarbonate is purchased from Sinopharm Chemical Reagent Co., Ltd.；
It is phenol red to be purchased from Solabio
Laboratory apparatus:
Microplate reader, TECAN
Electronic scale, Sartoriou(CPA225D)
Test medicine:
Loquat composition
Experimental animal:
Cleaning grade male mouse of kunming, weight (18-22) g amount to 60, are provided by Shandong University's Experimental Animal Center.
Experimental program:
1. the anti-inflammatory cough-relieving of loquat composition is studied
Experiment divides loquat composition group and negative control group, and loquat composition group gives loquat composition original by 50ml/kg stomach-filling
Liquid, negative control group give isometric purified water, and continuous 7 days, 12 h were deprived of food but not water before last dose, last dose
After 30min, mouse right ear is uniformly smeared with 20ul dimethylbenzene, cervical dislocation puts to death mouse after 30min, ears is removed, with diameter 8mm
Punch lays auricle in ears same area and weighs, and it is swelling that every mouse auris dextra sheet weight subtracts left auricle again.By two
The swelling result of group carries out one-way analysis of variance, and P < 0.05 thinks that there are statistical differences.
Experimental result:
Shown in experimental result table 1, compared with negative control group, loquat composition group mouse ear swelling degree is significantly less than negative control
Group shows that loquat composition has certain anti-inflammatory effect.
The anti-inflammatory effect of 1 loquat composition of table
Note: compared with negative control group, P < 0.05 *.
The antitussive action of loquat composition is studied
Experiment divides loquat composition group and negative control group, and loquat composition group gives loquat composition original by 50ml/kg stomach-filling
Liquid, wherein negative control group gives isometric purified water, and continuous 7 days, 12 h were deprived of food but not water before last dose, last dose
After 30min, mouse is buckled into 500ml beaker, then the cotton balls for injecting 0.2ml concentrated ammonia liquor is put into beaker rapidly, is remembered immediately
The cough number in the cough latent period and 2 minutes of mouse is recorded, the experimental result of control group and administration group is subjected to single factor test side
Difference analysis, P < 0.05 thinks that there are statistical differences.
Experimental result:
Shown in experimental result table 2, compared with negative control group, loquat composition can extend the incubation period of mouse cough and reduction
Cough number in 3min shows that loquat composition has certain antitussive action.
The antitussive action of 2 loquat composition of table
Note: compared with negative control group, P < 0.05 *；**P<0.01.
The phlegm-dispelling functions of loquat composition are studied
Experiment divides loquat composition group and negative control group, and loquat composition group gives loquat composition original by 50ml/kg stomach-filling
Liquid, wherein negative control group gives isometric purified water, and continuous 7 days, 12 h were deprived of food but not water before last dose, last dose
After 30min, 5% phenol red solution is injected intraperitoneally by weight in every mouse, and after injecting phenol red 30min, cervical dislocation puts to death animal, removing
Tracheae surrounding tissue cuts one section of tracheae from thyroid cartilage to tracheae bifurcation, is put into and fills 5% sodium bicarbonate solution of 1mL,
3000r/min is centrifuged 5min, takes supernatant, surveys OD value at wavelength 546nm with spectrophotometer, bent according to phenol red standard
Line computation goes out phenol red excretion.The experimental result of control group and administration group is subjected to one-way analysis of variance, P < 0.05 is thought to deposit
In statistical difference.
Experimental result:
Shown in experimental result table 3, compared with negative control group, loquat composition can increase the phenol red excretion of mouse, show Pi
Rake composition has certain phlegm-dispelling functions.
The phlegm-dispelling functions of 3 loquat composition of table
Note: compared with negative control group, P < 0.05 *.
The bowel relaxing functions of the investigation loquat composition of embodiment 5
Experiment purpose:
The function of relaxing bowel of loquat composition is investigated by animal model.
Experimental material:
India ink, purchased from leaves moisting biology
Loperamide hydrochloride capsules originate from Xian-Janssen Pharmaceutical Ltd.
Laboratory apparatus:
Meter ruler, capable production
Electronic scale, Sartoriou(CPA225D)
Test medicine:
Loquat composition stoste,
Experimental animal:
Cleaning grade male mouse of kunming, weight (18-22) g, each test are divided four groups by weight at random, and every group 10, two are tried
Total 80 are tested, is provided by Shandong University's Experimental Animal Center.
Experimental program:
1. mouse Intestinal pushing is tested
Experiment divides loquat composition high dose group, low dose group, model group and negative control group.Loquat composition high dose group is pressed
By same volume administration, negative control group and model after loquat composition stoste is given in 50ml/kg stomach-filling, low dose group dilutes twice
Group gives the purified water of same volume, and continuous 14 days.12 h of fasting after the last administration, in addition to negative control group gives purified water,
After remaining mouse gives Loperamide hydrochloride capsules 30min by 5mg/kg dosage stomach-filling, each group gives ink by 20ml/kg dosage stomach-filling
Juice.After giving 25 min of prepared Chinese ink, cervical dislocation put to death mouse, open abdominal cavity separate mesenterium, clip upper end from pylorus, under
It holds to the intestinal tube of ileocecus, is placed on pallet, small intestine is gently pulled into straight line and is measured.Length of intestine is " small intestine overall length
Degree " is " prepared Chinese ink propulsion length " from pylorus to prepared Chinese ink forward position.Ink progradation (P), ink progradation is calculated according to the following formula
(P)=prepared Chinese ink promotes length/total small intestinal length × 100 %, test result result is carried out one-way analysis of variance, P < 0.05 is recognized
For there are statistical differences.
Experimental result:
Shown in experimental result table 4, loquat composition high dose group mouse propulsion rate is higher than model group, shows that loquat composition has
Certain Intestinal pushing effect.
4 mouse Intestinal pushing test result of table
Note: 1. low dose groups are 2 times of dilutions of high dose group；
2. compared with negative control group, P < 0.05 *；Compared with model group, P < 0.01 △ △.
The test of mouse defecation
Experiment divides loquat composition high dose group, low dose group, model group and negative control group.Loquat composition high dose group is pressed
By same volume administration, negative control group and model after loquat composition stoste is given in 50ml/kg stomach-filling, low dose group dilutes twice
Group gives the purified water of same volume, and continuous 14 days.12 h of fasting after the last administration, in addition to negative control group gives purified water,
After remaining mouse gives Loperamide hydrochloride capsules 30min by 10mg/kg dosage stomach-filling, each group is given by 20ml/kg dosage stomach-filling
Prepared Chinese ink starts simultaneously at timing, since filling prepared Chinese ink, records every animal first grain row's melena time, defecation grain number and weighs in 8h.
Experimental result carries out one-way analysis of variance, and P < 0.05 thinks that there are statistical differences.
Experimental result:
Shown in experimental result table 5, compared with model group, defecation time extends loquat composition high and low dose group mouse for the first time, row
Just number of cases and weight increase, and show that loquat composition has certain defecating feces excretion.
5 mouse defecation test result of table
Note: 1. low dose groups are 2 times of dilutions of high dose group；
2. compared with negative control group, P < 0.01 * P < 0.05, * *；Compared with model group, P < 0.01 △ P < 0.05, △ △.
The above is only the preferred embodiment of this patent, it is noted that for the ordinary skill people of the art
For member, under the premise of not departing from the art of this patent principle, several improvement and replacement can also be made, these are improved and replacement
Also it should be regarded as the protection scope of this patent.
Claims (7)
1. a kind of loquat composition, which is characterized in that the material proportion for preparing the loquat composition is as follows: loguat leaf 50-100
Part, 40-60 parts of reed root, 30-50 parts of lily, cream 20-40 parts of Loquat-Shaped Cake, 10-30 parts of campanulaceae, 10-30 parts of mulberry leaf, dried orange peel 10-30
Part, 4-6 parts of radix glycyrrhizae preparata；After above-mentioned integration of drinking and medicinal herbs herbal compound is added water to cook, is concentrated, oligosaccharide and Sucralose system are added
?.
2. a kind of loquat composition according to claim 1, it is characterised in that: the loquat composition can add it is a kind of or
A variety of pharmaceutically acceptable oligosaccharide substances.
3. a kind of loquat composition according to claim 5, it is characterised in that: the oligosaccharide substance is oligomeric
Isomaltose and oligofructose, xylo-oligosaccharide.
4. a kind of loquat composition according to claim 1-3, which is characterized in that the loquat composition preparation
The material proportion of 1000 milliliters of liquid addition is as follows:
Loguat leaf 100g, reed root 50g, lily 40g, Loquat-Shaped Cake cream 30g, campanulaceae 20g, mulberry leaf 20g, dried orange peel 20g, radix glycyrrhizae preparata 5g；
Sucralose 30mg, MO-50 type isomaltooligosaccharide syrup 40g, FOS55.75% oligofructose starches 30g, XOS-70 type xylo-oligosaccharide
Starch 15g.
5. a kind of loquat preparation method of composition according to claim 1, which is characterized in that the loquat composition preparation
Method and step is as follows:
Take loguat leaf, reed root, lily, campanulaceae, mulberry leaf, dried orange peel, radix glycyrrhizae preparata seven flavor medicine to eat same source material, add water to cook it is secondary, the
One time 1.0~2.0 hours, second 1.0~2.0 hours, collecting decoction filtered, and filtrate decompression is concentrated into required volume, was added
Loquat-Shaped Cake cream obtains traditional Chinese medicine extraction concentrate；Add the Sucralose and two that weight/volume percent is 0.002~0.005%
Kind or two or more oligosaccharides, are heated to dispensing at 70 ~ 80 DEG C, sterilize 30~60 minutes, obtain at 110~121 DEG C
Loquat composition.
6. a kind of loquat preparation method of composition according to claim 8, which is characterized in that described in claim 5
Oligosaccharide is IMO-50 type isomaltooligosaccharide syrup, FOS55.75% oligofructose slurry, XOS-70 type xylo-oligosaccharide slurry, is added
Amount is that iso-maltose syrup 30-50g is added in 1000mL liquid, and oligofructose starches 20-40g, and xylo-oligosaccharide starches 10-20g.
7. a kind of application of loquat composition according to claim 8, which is characterized in that the combination improves sub- in preparation
The application of health food or drug in terms of health status is adjusted in terms of preparing anti-inflammatory, cough-relieving and eliminating the phlegm or in relax bowel and defecation
Application in terms of human enteric bacteria health drink.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114869972A (en) * | 2022-05-06 | 2022-08-09 | 黄山柒尚生物科技有限公司 | Preparation method of loquat composition based on probiotic fermentation |
| CN115487109A (en) * | 2022-09-21 | 2022-12-20 | 上海利康精准医疗技术有限公司 | Bead-blasting chewing gum pill with function of inhibiting helicobacter pylori and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114869972A (en) * | 2022-05-06 | 2022-08-09 | 黄山柒尚生物科技有限公司 | Preparation method of loquat composition based on probiotic fermentation |
| CN115487109A (en) * | 2022-09-21 | 2022-12-20 | 上海利康精准医疗技术有限公司 | Bead-blasting chewing gum pill with function of inhibiting helicobacter pylori and preparation method thereof |
| CN115487109B (en) * | 2022-09-21 | 2024-02-27 | 上海利康精准医疗技术有限公司 | Bead-explosion fragrant pill with helicobacter pylori inhibiting function and preparation method thereof |
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Application publication date: 20190816 |