CN105707625A - Composition obtained by fermenting folium eriobotryae with probiotics and preparing method and application of composition - Google Patents
Composition obtained by fermenting folium eriobotryae with probiotics and preparing method and application of composition Download PDFInfo
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- 239000006041 probiotic Substances 0.000 title claims abstract description 57
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 57
- 239000000203 mixture Substances 0.000 title claims abstract description 51
- 238000000034 method Methods 0.000 title claims abstract description 9
- 238000000855 fermentation Methods 0.000 claims abstract description 28
- 230000004151 fermentation Effects 0.000 claims abstract description 28
- 239000000843 powder Substances 0.000 claims abstract description 26
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 claims abstract description 22
- 230000001105 regulatory effect Effects 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920001100 Polydextrose Polymers 0.000 claims abstract description 11
- 229910017053 inorganic salt Inorganic materials 0.000 claims abstract description 11
- 230000000968 intestinal effect Effects 0.000 claims abstract description 11
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- 229940035035 polydextrose Drugs 0.000 claims abstract description 11
- 235000013856 polydextrose Nutrition 0.000 claims abstract description 11
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 10
- 239000001888 Peptone Substances 0.000 claims abstract description 10
- 108010080698 Peptones Proteins 0.000 claims abstract description 10
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 10
- 229940041514 candida albicans extract Drugs 0.000 claims abstract description 10
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- 239000012138 yeast extract Substances 0.000 claims abstract description 10
- 206010011224 Cough Diseases 0.000 claims abstract description 9
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- 208000004880 Polyuria Diseases 0.000 claims abstract description 6
- 230000035619 diuresis Effects 0.000 claims abstract description 6
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- 230000008569 process Effects 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims description 23
- 238000002360 preparation method Methods 0.000 claims description 17
- 241000894006 Bacteria Species 0.000 claims description 12
- 241000186016 Bifidobacterium bifidum Species 0.000 claims description 12
- 241000186660 Lactobacillus Species 0.000 claims description 12
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 12
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- 239000007836 KH2PO4 Substances 0.000 claims description 6
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical group [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 6
- 229910000396 dipotassium phosphate Inorganic materials 0.000 claims description 6
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 6
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 6
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 6
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 6
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 6
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- 239000011686 zinc sulphate Substances 0.000 claims description 6
- 241000186018 Bifidobacterium adolescentis Species 0.000 claims description 5
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- 240000006024 Lactobacillus plantarum Species 0.000 claims description 5
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- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 5
- 235000019408 sucralose Nutrition 0.000 claims description 5
- 239000005720 sucrose Substances 0.000 claims description 5
- 241000186000 Bifidobacterium Species 0.000 claims description 4
- 240000001046 Lactobacillus acidophilus Species 0.000 claims description 4
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims description 4
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 4
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- 102220485321 ATP-dependent DNA/RNA helicase DHX36_G55L_mutation Human genes 0.000 claims 3
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
- A23L2/382—Other non-alcoholic beverages fermented
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A—HUMAN NECESSITIES
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- A23V2400/137—Delbrueckii
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/169—Plantarum
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2400/00—Lactic or propionic acid bacteria
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- A23V2400/513—Adolescentes
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a composition obtained by fermenting folium eriobotryae with probiotics and a preparing method of the composition. The composition is prepared through the steps that folium eriobotryae is dried and smashed into powder, the folium eriobotryae powder is soaked with water, added with glucose, peptone, yeast extract, yeast powder and a sweetening agent, added with inorganic salt, sterilized and then subjected to fermentation treatment with probiotics, polydextrose and oligosaccharide fructose syrup are added, and the composition obtained by fermenting folium eriobotryae with probiotics is obtained. The composition has the effects of removing heat from the lung to relieve coughs, harmonizing the stomach and inducing diuresis, quenching thirst, regulating intestinal flora balance, improving the gastrointestinal function and the like. Compared with a traditional dehairing technology, the technology process is optimized, labor intensity and production cost are reduced, the extraction ratio of effective ingredients of raw materials is greatly increased, the composition can be easily absorbed by the intestinal tract, the utilization rate is increased, and the burden of the intestinal tract of the human body is relieved.
Description
Technical field
The present invention relates to a kind of probiotics fermention Folium Eriobotryae composition and method of making the same, belong to functional health product field.
Background technology
The leaf that Folium Eriobotryae (EriobotryajaponicaThunb.) is rosaceous plant Folium Eriobotryae.There are clearing away lung-heat to relieve cough, stomach function regulating diuresis, the effect quenched the thirst.All there is cultivation in most of China area, is distributed in the ground such as Central-South and Shaanxi, Gansu, Jiangsu, Anhui, Zhejiang, Jiangxi, Fujian, Taiwan, Sichuan, Guizhou, Yunnan, and the whole year all can gather.Folium Eriobotryae was the Chinese medicine that China is embodied in pharmacopeia for a long time, because its drug effect is safe especially to human body, has no side effect, and was approved for new resource food (Guo Wei planning commission [2014] 20) in 2014.
At present, exploitation for Folium Eriobotryae product, focus primarily upon simple for different material proportioning, make the health promoting beverage with different efficacies, such as clearing heat and moistening lung beverage its preparation method (patent No.: CN201310592032), a kind of loquat health-care beverage and preparation method thereof (patent No.: CN201310605007) etc., these methods are simply extensive, though having certain effect, but the effective ingredient that really can be absorbed by human body is very little, waste is serious, therefore Folium Eriobotryae should be developed deeply, product effective ingredient is made to be fully utilized, scientific and technological content is higher, to meet consumer demand.
Living away from home in human body intestinal canal substantial amounts of microbial population, wherein health is played vital effect by probiotic bacteria.Probiotic bacteria can catabolism upper digestive tract system can not catabolic composition of food, produce short-chain fatty acid, for gastrointestinal mucosa cells with nutrient material.Some composition simultaneously for oral drugs especially natural drug can carry out catabolism, the precursor substance of medicine is transformed into active pharmaceutical ingredient and plays a role.
Summary of the invention
The present invention utilizes modern biotechnology, by Folium Eriobotryae through probiotics fermention, and in-vitro simulated human body intestinal canal environment, in advance to the various effective ingredient in Folium Eriobotryae, decompose so that it is directly absorbed after entering human body, alleviate human body burden, add prebiotics simultaneously, regulate human body intestinal canal environment.
It is an object of the present invention to provide the compositions of a kind of probiotics fermention Folium Eriobotryae, described compositions is Folium Eriobotryae drying, it is ground into powder, through water logging, add glucose, peptone, yeast extract, yeast powder and sweeting agent, add inorganic salt, process through probiotics fermention after sterilizing, add polydextrose, oligofructose slurry, obtain the compositions of probiotics fermention Folium Eriobotryae.
Described probiotic bacteria is bacillus bifidus and lactobacillus.
The compositions of this probiotics fermention Folium Eriobotryae has and has clearing away lung-heat to relieve cough, stomach function regulating diuresis, quenches the thirst, regulating intestinal canal colony balance, improves the effects such as gastrointestinal function.
The preparation method that it is a further object to provide the compositions of a kind of probiotics fermention Folium Eriobotryae, comprises the following steps:
(1) pulverize: dry Folium Eriobotryae is pulverized, more than 100 orders, (generally adopting common crushing technology to prepare Folium Eriobotryae powder, after crushed, the specific surface area of raw material increases fineness, thus being more beneficial for the dissolution of material effective component, considerably increase the extraction ratio of material effective component).
(2) prepare extract: take Folium Eriobotryae powder, add distilled water immersion 30 minutes, in soak, add glucose, peptone, yeast extract, yeast powder, add inorganic salt, add sweeting agent, regulate pH value 6.5-7.0,115 DEG C of sterilizings 50 minutes, obtain aseptic Folium Eriobotryae fermented product.
(3) fermentation: when aseptic Folium Eriobotryae fermented product temperature is down to 39 DEG C, inoculating pre-incubated percent by volume is respectively one or both and the above bacillus bifidus bacterium solution of 0.5%, after cellar culture about 3 ~ 8 hours, again inoculating pre-incubated percent by volume is respectively one or both and the above lactobacillus bacterium solution of 0.5%, continues fermentation 20 ~ 22 hours.When pH value is down to below 4.2, reduce fermentation temperature to 28 DEG C, continue fermentation to pH value and be down to 4.0, terminate fermentation, namely obtain probiotics fermention Folium Eriobotryae liquid.
(4) allotment, inactivation: probiotics fermention Folium Eriobotryae liquid in (3) is crossed tube centrifuge and filters, be centrifuged, obtain centrifugal liquid；Centrifugal liquid is added polydextrose, oligofructose slurry (G55L), stirs evenly dissolving；After about 115 DEG C sterilizings 15 minutes, obtain the compositions of probiotics fermention Folium Eriobotryae.
In above-mentioned preparation method, in step (2), taken Folium Eriobotryae powder weight g/ volume ml percentage ratio in distilled water immersion liquid is 6-10%.
In above-mentioned preparation method, add glucose that weight g/ volume ml percentage ratio is 0.5 ~ 1.5% in the step (2), yeast extract that peptone that weight g/ volume ml percentage ratio is 0.1 ~ 1%, weight g/ volume ml percentage ratio are 0.05 ~ 0.2%, weight g/ volume ml percentage ratio are the yeast powder of 0.01 ~ 0.1%, and described inorganic salt is K2HPO4·3H2O0.1g/100ml、KH2PO40.1g/100ml、FeSO4·7H2O5.0mg/100ml、ZnSO4·7H2O4.4mg/100ml、MgSO4·7H2O50mg/100ml。
In above-mentioned preparation method, in order to improve the mouthfeel of beverage, before regulating pH value in the step (2), add a certain amount of sweeting agent, described sweeting agent is weight g/ volume ml percentage ratio be 3% sucrose, weight g/ volume ml percentage ratio be the sucralose of 0.008%.
Step (4) adds polydextrose that weight g/ volume ml percentage ratio is 1 ~ 5%, weight g/ volume ml percentage ratio be 0.1 ~ 0.7% oligofructose slurry (G55L).
In above-mentioned preparation method, bacillus bifidus described in step (3) is selected from bifidobacterium bifidum, bifidobacterium breve, bifidobacterium adolescentis or bifidobacteria infantis；Described lactobacillus is selected from bacillus acidophilus, Deshi Lactobacillus, lactobacillus casei, lactobacillus rhamnosus or Lactobacillus plantarum.
It is also another object of the present invention to provide the compositions of probiotics fermention Folium Eriobotryae of the present invention and improve the application in respiratory system disease, the food regulating gastrointestinal function or health food in preparation.
The compositions of probiotics fermention Folium Eriobotryae of the present invention, has clearing away lung-heat to relieve cough, stomach function regulating diuresis in preparation, quenches the thirst, regulating intestinal canal colony balance, improves the application in the health product of gastrointestinal function or beverage.Such as, can be fermented Folium Eriobotryae or its supernatant by many probiotics of the present invention, according to known conventional method, add one or more and have identical, similar or different biological is active, and to the existing auxiliary of primary activity component list or synergism, but mutually not other naturally occurring or synthetic function compositions of antagonism or its mixture again each other, is configured to mixture, the Emulsion etc. that are suitable to be administered orally.
Also many probiotics of the present invention can be fermented Folium Eriobotryae compositions by suitable drying means, prepare pressed powder, add one or more and have identical, similar or different biological is active, and to the existing auxiliary of primary activity component list or synergism, but other naturally occurring or synthetic function composition or mixture of mutual not antagonism again each other, the dosage form such as the capsule being configured to be suitable to be administered orally, tablet, granule.
The invention have the advantages that
1, Folium Eriobotryae is carried out pulverization process by the present invention, and product is to human respiratory tract's nonirritant, compared with traditional unhairing technique, simple, efficient, reduces labor intensity and production cost.
2, Folium Eriobotryae effective ingredient is carried out high pressure, high temperature extraction by the present invention, considerably increases the extraction ratio of material effective component.
3, Folium Eriobotryae powder is added directly in probiotics fermention culture medium by the present invention, and through high pressure, its effective ingredient of high temperature extraction, carrying raw material slag ferments, and improves the utilization rate of Folium Eriobotryae, optimizes technological process.
4, the present invention simulates human body intestinal canal environment, utilizes many probiotics to ferment, and makes the effective ingredient of Folium Eriobotryae become feasible to, by the active substance of intestinal absorption, improve utilization rate, decreases human body intestinal canal burden.
5, utilizing Folium Eriobotryae to provide the nutrition of abundance for growth of probiotics, probiotic bacteria also makes the effectiveness of Folium Eriobotryae be improved.
6, adding the water soluble dietary fiber polydextrose not being absorbed by the body and oligofructose in this compositions, sweet mouthfeel is agreeable to the taste, in stable condition, can significantly improve human body intestinal canal environment.
7, this compositions is not added with any preservative, through high temperature sterilize, sterile filling, long shelf-life, drinks convenience, safety.
Detailed description of the invention
Below by way of the description of detailed description of the invention, the invention will be further described, but this is not limitation of the present invention, those skilled in the art's basic thought according to the present invention, various modifications may be made or improves, but without departing from the basic thought of the present invention, all within the scope of the present invention.
Embodiment 1:Taking Folium Eriobotryae powder weight g/ volume ml percentage ratio in distilled water immersion liquid is 6-10%.
A kind of preparation of the compositions of probiotics fermention Folium Eriobotryae, concrete grammar is as follows:
Taking dry Folium Eriobotryae, pulverized 100 mesh sieves, g/ volume ml takes Folium Eriobotryae powder than 6% and adds distilled water immersion 30 minutes by weight；
In soak add glucose 0.7%(weight g/ volume ml), peptone 0.4%(weight g/ volume ml), yeast extract 0.13%(weight g/ volume ml), yeast powder 0.07%(weight g/ volume ml), inorganic salt (K2HPO4·3H2O0.1g/100ml、KH2PO40.1g/100ml、FeSO4·7H2O5.0mg/100ml、ZnSO4·7H2O4.4mg/100ml、MgSO4·7H2O50mg/100ml), sucrose 3.0%(weight g/ volume ml) and sucralose 0.008%(weight g/ volume ml).Regulate pH6.5-7.0, about 115 DEG C sterilizings 50 minutes, obtain aseptic Folium Eriobotryae fermented product；
When extract temperature is down to about 39 DEG C, accessing the good bifidobacterium bifidum of preculture (normal human separates, and identifies) and bifidobacterium breve (AS1.2213) bacterium solution through Institute of Microorganism, Academia Sinica, inoculum concentration is 0.5%(volume/volume).Accessing pre-incubated Lactobacillus plantarum (AS1.19) bacterium solution again after fermenting 6 hours, inoculum concentration is 0.5%(volume/volume).37 DEG C are continued fermentation 22 hours, and pH value is down to less than 4.2, reduce fermentation temperature to 28 DEG C, continue fermentation and are down to 4.0 to pH, terminate fermentation, namely obtain probiotics fermention Folium Eriobotryae liquid.
Probiotics fermention Folium Eriobotryae liquid is crossed tube centrifuge be centrifuged, obtain centrifugal liquid.In centrifugal liquid add polydextrose 2%(weight g/ volume ml), oligofructose slurry (G55L) 0.7%(weight g/ volume ml), stir evenly dissolving, obtain semi-finished product.Semi-finished product are carried out autoclaving, after about 115 DEG C sterilizings 15 minutes, fill under aseptic condition, obtain probiotics fermention Folium Eriobotryae beverage finished product (specification is 100ml/ bottle).
Embodiment 2:
A kind of preparation of the compositions of probiotics fermention Folium Eriobotryae, concrete grammar is as follows:
Taking dry Folium Eriobotryae, pulverized 100 mesh sieves, g/ volume ml takes Folium Eriobotryae powder than 8% and adds distilled water immersion 30 minutes by weight；
In soak add glucose 0.6%(weight g/ volume ml), peptone 0.3%(weight g/ volume ml), yeast extract 0.1%(weight g/ volume ml), yeast powder 0.05%(weight g/ volume ml), inorganic salt (K2HPO4·3H2O0.1g/100ml、KH2PO40.1g/100ml、FeSO4·7H2O5.0mg/100ml、ZnSO4·7H2O4.4mg/100ml、MgSO4·7H2O50mg/100ml), sucrose 3.0%(weight g/ volume ml) and sucralose 0.008%(weight g/ volume ml).Regulate pH6.5-7.0, about 115 DEG C sterilizings 50 minutes, obtain aseptic Folium Eriobotryae fermented product；
When extract temperature is down to about 39 DEG C, accessing the good bifidobacteria infantis (AS1.853) of preculture, bifidobacterium adolescentis (AS1.2190) and bifidobacterium breve (AS1.2213) bacterium solution, inoculum concentration is 0.5%(volume/volume).Accessing pre-incubated Deshi Lactobacillus (AS1.1480) and lactobacillus rhamnosus (AS1.22) bacterium solution after fermenting 7 hours again, inoculum concentration is 0.5%(volume/volume).37 DEG C are continued fermentation 21 hours, and pH value is down to less than 4.2, reduce fermentation temperature to 28 DEG C, continue fermentation and are down to 4.0 to pH, terminate fermentation, namely obtain probiotics fermention Folium Eriobotryae liquid；
Probiotics fermention Folium Eriobotryae liquid is crossed tube centrifuge be centrifuged, obtain centrifugal liquid.In centrifugal liquid add polydextrose 1.5%(weight g/ volume ml), oligofructose slurry (G55L) 0.6%(weight g/ volume ml), stir evenly dissolving, obtain semi-finished product.Semi-finished product are carried out autoclaving, after about 115 DEG C sterilizings 15 minutes, fill under aseptic condition, obtain probiotics fermention Folium Eriobotryae beverage finished product (specification is 100ml/ bottle).
Embodiment 3:
A kind of preparation of the compositions of probiotics fermention Folium Eriobotryae, concrete grammar is as follows:
Taking dry Folium Eriobotryae, pulverized 100 mesh sieves, g/ volume ml takes Folium Eriobotryae powder than 10% and adds distilled water immersion 30 minutes by weight；
In soak add glucose 0.5%(weight g/ volume ml), peptone 0.2%(weight g/ volume ml), yeast extract 0.08%(weight g/ volume ml), yeast powder 0.03%(weight g/ volume ml), inorganic salt (K2HPO4·3H2O0.1g/100ml、KH2PO40.1g/100ml、FeSO4·7H2O5.0mg/100ml、ZnSO4·7H2O4.4mg/100ml、MgSO4·7H2O50mg/100ml), sucrose 3.0%(weight g/ volume ml) and sucralose 0.008%(weight g/ volume ml).Regulate pH6.5-7.0, about 115 DEG C sterilizings 50 minutes, obtain aseptic Folium Eriobotryae fermented product；
When extract temperature is down to about 39 DEG C, accessing the good bifidobacterium bifidum of preculture (normal human separates, and identifies) and bifidobacterium adolescentis (AS1.2190) bacterium solution through Institute of Microorganism, Academia Sinica, inoculum concentration is 0.5%(volume/volume).Accessing pre-incubated bacillus acidophilus (AS1.1854), Deshi Lactobacillus (AS1.1480) and Lactobacillus plantarum (AS1.19) bacterium solution after fermenting 8 hours again, inoculum concentration is 0.5%(volume/volume).37 DEG C are continued fermentation 21 hours, and pH value is down to less than 4.2, reduce fermentation temperature to 28 DEG C, continue fermentation and are down to 4.0 to pH, terminate fermentation, namely obtain probiotics fermention Folium Eriobotryae liquid；
Probiotics fermention Folium Eriobotryae liquid is crossed tube centrifuge be centrifuged, obtain centrifugal liquid.In centrifugal liquid add polydextrose 1%(weight g/ volume ml), oligofructose slurry (G55L) 0.5%(weight g/ volume ml), stir evenly dissolving, obtain semi-finished product.Semi-finished product are carried out autoclaving, after about 115 DEG C sterilizings 15 minutes, fill under aseptic condition, obtain probiotics fermention Folium Eriobotryae beverage finished product (specification is 100ml/ bottle).
Experimental example: fermentation composition prepared by the embodiment of the present invention drinks effect experimental:
This experimental example is intended to take the change of symptom before and after this fermentation composition by observation different crowd examination, to determine that this fermentation composition has clearing away lung-heat to relieve cough, stomach function regulating diuresis, quenches the thirst, and regulating intestinal canal colony balance improves effect of gastrointestinal function.
1, scheme:
(1) examination takes sample: fermentation composition prepared by embodiment；Matched group is the unfermentable Folium Eriobotryae extracting solution of comparable sodium.
(2) examination take mode: 100ml/ day/people, one day twice, each 50ml, the cycle of taking is 30 days/people, 50 people/group；Matched group is ibid.
(3) examination takes object: cough or dry cough；There are expectorant or thin sputum；Gastrointestinal function is not good.
(4) result statistics: after drinking, substantially sensation is coughed or dry cough, has expectorant or thin sputum, gastrointestinal function is not good waits transference cure, is designated as effective；That drinks that rear above-mentioned symptom alleviates to some extent is designated as effectively；Being designated as that after drinking, nothing is improved is invalid.
2 results:
Examination takes result in Table 1.
The examination of table 1 probiotics fermention Folium Eriobotryae compositions takes effect
Examination clothes are it is shown that the examination person of clothes is had good effect by the compositions of probiotics fermention Folium Eriobotryae of the present invention, and total effective rate is all more than 90%, and relatively matched group has a clear superiority in.Therefore, illustrating that Folium Eriobotryae is after probiotics fermention, improves a lot in effect, the deep exploitation of Folium Eriobotryae is had progressive meaning by the present invention.
Claims (10)
1. the compositions of a probiotics fermention Folium Eriobotryae, it is characterized in that, described compositions is Folium Eriobotryae drying, it is ground into Folium Eriobotryae powder, through water logging, adds glucose, peptone, yeast extract, yeast powder and sweeting agent, add inorganic salt, process through probiotics fermention after sterilizing, add polydextrose, oligofructose slurry G55L, obtain the compositions of probiotics fermention Folium Eriobotryae；
Described probiotic bacteria is bacillus bifidus and lactobacillus.
2. the compositions of probiotics fermention Folium Eriobotryae according to claim 1, it is characterised in that described Folium Eriobotryae powder weight g/ volume ml percentage ratio in distilled water immersion liquid is 6-10%.
3. the compositions of probiotics fermention Folium Eriobotryae according to claim 1, it is characterized in that, the addition of described glucose be weight g/ volume ml percentage ratio 0.5 ~ 1.5%, described peptone addition be weight g/ volume ml percentage ratio 0.1 ~ 1%, described yeast extract addition be weight g/ volume ml percentage ratio 0.05 ~ 0.2%, described yeast powder addition be weight g/ volume ml percentage ratio 0.01 ~ 0.1%.
4. the compositions of probiotics fermention Folium Eriobotryae according to claim 1, it is characterised in that described inorganic salt is K2HPO4·3H2O0.1g/100ml、KH2PO40.1g/100ml、FeSO4·7H2O5.0mg/100ml、ZnSO4·7H2O4.4mg/100ml、MgSO4·7H2O50mg/100ml。
5. the compositions of probiotics fermention Folium Eriobotryae according to claim 1, it is characterised in that described sweeting agent is weight g/ volume ml percentage ratio be 3% sucrose, weight g/ volume ml percentage ratio be the sucralose of 0.008%.
6. the compositions of probiotics fermention Folium Eriobotryae according to claim 1, it is characterised in that the addition of described polydextrose be weight g/ volume ml percentage ratio 1 ~ 5%, described oligofructose slurry G55L addition be weight g/ volume ml percentage ratio 0.1 ~ 0.7%.
7. the compositions of the probiotics fermention Folium Eriobotryae according to any one of claim 1-6, it is characterised in that described bacillus bifidus is selected from bifidobacterium bifidum, bifidobacterium breve, bifidobacterium adolescentis or bifidobacteria infantis；Described lactobacillus is selected from bacillus acidophilus, Deshi Lactobacillus, lactobacillus casei, lactobacillus rhamnosus or Lactobacillus plantarum.
8. the preparation method of the compositions of the probiotics fermention Folium Eriobotryae described in any one of claim 1-7, it is characterised in that preparation method step is as follows:
(1) pulverize: being pulverized by dry Folium Eriobotryae is Folium Eriobotryae powder, and fineness is more than 100 orders；
(2) prepare extract: take Folium Eriobotryae powder, add distilled water immersion 30 minutes, in soak, add glucose, peptone, yeast extract, yeast powder, add inorganic salt, add sweeting agent, regulate pH value 6.5-7.0,115 DEG C of sterilizings 50 minutes, obtain aseptic Folium Eriobotryae fermented product；
(3) fermentation: when aseptic Folium Eriobotryae fermented product temperature is down to 39 DEG C, inoculating pre-incubated percent by volume is respectively one or both and the above bacillus bifidus bacterium solution of 0.5%, after cellar culture 3 ~ 8 hours, again inoculating pre-incubated percent by volume is respectively one or both and the above lactobacillus bacterium solution of 0.5%, continues fermentation 20 ~ 22 hours；When pH value is down to below 4.2, reduce fermentation temperature to 28 DEG C, continue fermentation to pH value and be down to 4.0, terminate fermentation, namely obtain probiotics fermention Folium Eriobotryae liquid；
(4) allotment, inactivation: raw bacterium fermentation Folium Eriobotryae liquid step (3) obtained is crossed tube centrifuge and filtered, is centrifuged, and obtains centrifugal liquid；Centrifugal liquid is added polydextrose, oligofructose slurry G55L, stirs evenly dissolving；After 115 DEG C of sterilizings 15 minutes, obtain the compositions of described probiotics fermention Folium Eriobotryae；
Bacillus bifidus described in step (3) is selected from bifidobacterium bifidum, bifidobacterium breve, bifidobacterium adolescentis or bifidobacteria infantis；Described lactobacillus is selected from bacillus acidophilus, Deshi Lactobacillus, lactobacillus casei, lactobacillus rhamnosus or Lactobacillus plantarum.
9. the preparation method of the compositions of probiotics fermention Folium Eriobotryae according to claim 8, it is characterised in that described inorganic salt is K2HPO4·3H2O0.1g/100ml、KH2PO40.1g/100ml、FeSO4·7H2O5.0mg/100ml、ZnSO4·7H2O4.4mg/100ml、MgSO4·7H2O50mg/100ml。
10. the compositions of probiotics fermention Folium Eriobotryae improves the application in respiratory system disease, the food regulating gastrointestinal function or health food in preparation；Or: the compositions of probiotics fermention Folium Eriobotryae has clearing away lung-heat to relieve cough, stomach function regulating diuresis in preparation, quenches the thirst, regulating intestinal canal colony balance, improves the application in the health product of gastrointestinal function or beverage.
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| CN110038093A (en) * | 2019-05-23 | 2019-07-23 | 山东大学 | Micro ecological technology fermentation loquat composition and preparation method thereof |
| CN110123962A (en) * | 2019-05-23 | 2019-08-16 | 山东大学 | A kind of loquat composition and preparation method thereof |
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