CN110038093A - Micro ecological technology fermentation loquat composition and preparation method thereof - Google Patents
Micro ecological technology fermentation loquat composition and preparation method thereof Download PDFInfo
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- CN110038093A CN110038093A CN201910433182.4A CN201910433182A CN110038093A CN 110038093 A CN110038093 A CN 110038093A CN 201910433182 A CN201910433182 A CN 201910433182A CN 110038093 A CN110038093 A CN 110038093A
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Abstract
The present invention utilizes loguat leaf, reed root, lily, Loquat-Shaped Cake cream, campanulaceae, mulberry leaf, dried orange peel, radix glycyrrhizae preparata；Fermentation batches and oligosaccharide are added, is fermented using more probiotics in particular to Bifidobacterium, lactobacillus, a kind of micro ecological technology fermentation liquid loquat composition is obtained.Micro ecological technology fermentation loquat composition of the invention has beneficial effect for improving sub-health state, has apparent effect in terms of anti-inflammatory, cough-relieving, eliminating the phlegm and defaecation according to zoopery.
Description
Technical field
The present invention relates to pharmaceutical technology fields, and in particular to a kind of micro ecological technology fermentation loquat composition and its preparation side
Method.
Background technique
It is recorded in " Mingyi Bielu ", loguat leaf, alias rake leaf, Lu Juye, Ba Ye, medicinal material formal name used at school Folium
Eriobotryae；For the dried leaf of dicotyledon rosaceae loquat.Loguat leaf whole year can harvest.Its cold nature, bitter,
Return lung, stomach meridian have the effect of clearing lung and relieving cough, stopping nausea and vomiting by lowering the adverse flow of QI, and it is anxious to be usually used in treating cough with lung heat, circulation of vital energy in the wrong direction asthma, and stomach energy is vomitted inverse, dysphoria with smothery sensation
The illnesss such as thirsty.Modern pharmacy research shows that loguat leaf have effects that it is following: (1) antibechic, eliminating the phlegm, antiasthmatic effect: contained by this product
The hydrogen cyanide that amygdalin hydrolyzes generation in vivo has antitussive action, and water decoction or ethyl acetate extract have eliminating the phlegm and work of relievining asthma
With the contained volatile oil of leaf has slight phlegm-dispelling functions；(2) antibacterial action: experiment shows that this product water decoction or ethyl acetate mention
Object is taken to have antibacterial action to white or staphylococcus aureus, Diplococcus pneumopniae, shigella flexneri；(3) anti-inflammatory effect: have
Report points out that loguat leaf ethyl alcohol cold soaking extract has anti-inflammatory effect to foot swelling local application caused by rat carrageenan.
Reed root is the subterranean stem of grass family herbaceos perennial reed.Its nature and flavor is sweet, cold, attaches to the lung and stomach meridians.With clear
The effect of heat is promoted the production of body fluid, and is relieved restlessness and prevented vomiting.It is usually used in consumption of body fluid caused by febrile disease, dysphoria and thirsty, stomach energy is vomitted inverse, the card such as cough with lung heat." Xin Xiuben
Grass " record its energy " treatment is vomitted against not lower food, pathogenic heat in the stomach, and typhoid patients are more good ".Modern pharmacology research discovery reed root includes (1)
Skeletal muscle inhibiting effect: the oxygen of contractile response caused by the electro photoluminescence of frog neuromuscular sample and diaphragm in rats can be inhibited to absorb
And anaerobic glycolysis, and the reaction of actin-adenosine triphosphate system can be inhibited, there are also weaker central inhibitory action,
Show as having sedation to rat and mouse, and can be with caffeine phase antagonism；(2) it intestinal tube relexation: can significantly inhibit
Isolated rabbit intestinal contraction.
Lily is the meat bulb of Liliaceae herbaceos perennial lily.Its nature and flavor is sweet, slightly cold, return lung, the heart channel of Hang-Shaoyin.Tool
There is the effect of moistening lung to arrest cough, clearing away the heart fire and tranquillizing.It is usually used in cough with lung heat, dysphoria palpitates with fear, the card such as insomnia and dreamful sleep.Supplementary Amplifications of the Compendium of Materia Medica
Record its energy " clear convulsive seizure due to phlegm-fire, qi-restoratives damage ".Modern pharmacology research discovery lily includes (1) Antitussive and Expectorant Effect: to SO2Cause
Mouse cough, have apparent antitussive effect；(2) increase lung function and hypoxia-bearing capability: can significantly extend Lung Qi deficiency animal
Model swimming time.
Campanulaceae is the root of Campanulaceae herbaceos perennial campanulaceae.Its is bitter in taste, pungent, flat, distributed in lung channel.With opening promoting the dispersing function of the lung
The effect of gas, eliminating the phlegm apocenosis.It is usually used in coughing with a lot of sputum, chest diaphragm ruffian is bored, pulmonary abscess pectoralgia, cough vomiting of pus and blood, and phlegm Huang is stench to wait card." name
Doctor records " record it can " relieving the five internal organs stomach, fills blood, and except fever and chills, wandering arthritis, middle benefit gas disappears paddy ".Modern pharmacology research finds tangerine
Stalk includes (1) eliminating the phlegm and antitussive effect: anesthetized dog takes orally this product decoction 1g/kg, can the significant secretion for increasing respiratory mucus
Amount, intensity can be compared with ammonium chloride；(2) anti-inflammatory effect: thick platycodoside has anti-inflammatory effect, gavages the cause of 1/10~1/5 half
The dosage extremely measured is swollen to rat hindlimb Irish moss colloidality foot to have antiphlogistic effects with acetic acid swelling；(3) thick platycodoside has town
Quiet, analgesia and refrigeration function.
Mulberry leaf are the leaf of Moraceae defoliation small arbor plant mulberry tree.Its is bitter in taste, sweet, cold, return lung, Liver Channel.It is clear with dispelling wind
Heat, the effect of clearing liver and improving vision.It is usually used in affection of exogenous wind-heat, fever and cough, puckery pain of hot eyes caused by abscess of throat or Liver Channel real heat etc.
Card.Compendium of Material Medica, which records it, " to control labor heat cough, improving eyesight long hair ".It is antibacterial that modern pharmacology research discovery mulberry leaf include (1)
Anti-inflammatory effect: white mulberry vein-juice has good growth to press down most of gram-positive bacterias and Gram-negative bacteria and partial yeast bacterium
Production is used, and the rutin sophorin in mulberry leaf can significantly inhibit Rat Models of Traumatic edema, and conjunctivitis, auricle can be prevented scorching, pulmonary edema
Development；(2) spasmolysis, anti-ulcer effect: the Quercetin in mulberry leaf can reduce intestines, bronchial smooth muscle tension, and rutin sophorin can reduce
The stomach motor function of rat, and intestinal smooth muscle spasm caused by barium chloride can be released；(3) improve gut function, relax bowel and defecation and
Antiobesity action: minerals and carbohydrate contained by mulberry leaf act on after entering large intestine with intestinal flora, generate butyric acid, propionic acid, lactic acid, acetic acid
Equal organic acids make enteral environment become acid, and intestinal contents acidity increases, and can inhibit the proliferation of harmful bacteria, play adjusting
Enteron aisle, the effect for improving constipation, catharsis defaecation and weight-reducing.
Dried orange peel, for Rutaceae evergreen dungarunga plant tangerine and its pericarp for the ripening fruits for belonging to various plants.Its nature and flavor
Acrid, bitter, warm, return lung, the spleen channel.With in qi-regulating tune, eliminating dampness and eliminating phlegm effect.Be usually used in abdominal fullness and distention caused by the taste stagnation of the circulation of vital energy,
The card such as gas, nausea and vomiting；And phlegm dampness obstruction pattern, impairment of dispersing and descending function of the lung, the card such as coughing with a lot of sputum circulation of vital energy in the wrong direction.Compendium of Material Medica records " orange peel, hardship
Can let out can it is dry, it is pungent can dissipate, temperature can and.It controls all kinds of diseases and ailments, always takes the function of its qi-regulating eliminating dampness ".Modern pharmacology research finds dried orange peel
Include (1) antibacterial action: citrus chachiensis hortorum in vitro can inhibit staphylococcus, catarrh how the growth of Salmonella, hemolytic haemophilic bacterium,
Dried orange peel and the mixture of small banyan in vitro also have bacteriostasis:；(2) eliminating phlegm and relieving asthma acts on: the volatile oil contained in dried orange peel can pierce
Swash bronchus, glandular secretion is caused to increase, to reach phlegm-dispelling functions, effective ingredient is limonene；(3) anti-allergic effects:
Nobiletin can significantly fight the isolated ileum segments in guinea pigs of egg white sensitization and bronchial anaphylaxis is shunk；(4) anti-ulcer effect:
Experimental Gastric Ulcer in Rats is treated with methyl hesperidine, 100 or 500mg/kg is subcutaneously injected in preceding and experiment in testing, continuous 6
It, has the obvious effect for inhibiting ulcer to occur, and there are also anti-gastric acid secretions to act on.
Radix glycyrrhizae preparata is the root and rhizome of leguminous perennial herb Radix Glycyrrhizae.Its nature and flavor is sweet, flat, return heart, lung, spleen, stomach
Through.With invigorating the spleen and benefiting qi, the effect of moistening lung to arrest cough.It is usually used in weakness of the spleen and the stomach, the deficiency of qi in middle-jiao, shortness of breath and fatigue, anorexia and loose stool, cough
The card such as asthma." Bencao Tujing " records " Radix Glycyrrhizae can solve hundred poison, for wanting for many medicines ".Modern pharmacology research finds radix glycyrrhizae preparata tool
Have: (1) similar adrenocortical hormones fuction: having inhibiting effect to gastroxia caused by histamine, and have it is antiacid and
Alleviate the effect of gastrointestinal smooth muscle spasmus；(2) contained licoflavone, enoxolone have apparent kobadrin to make in radix glycyrrhizae preparata
With；(3) anti-inflammatory, anti-allergic effects: extract of licorice root and glycyrrhizic acid have protective effect to throat and tracheae mucosal inflammation.
In conclusion this product is monarch with loguat leaf, can clearing lung and eliminating phlegm, relieving cough and asthma and clearing away the stomach-heat, preventing or arresting vomiting it is inverse.Match
Closing reed root, lily, campanulaceae, mulberry leaf is minister, and the monarch and his subjects match, and plays clearing lung-heat moistening lung, relieving cough and reducing sputum function altogether.This product is helped with dried orange peel, both
Being able to cooperate the monarch and his subjects enhances eliminating dampness and eliminating phlegm power, and energy invigorating the spleen qi-regulating, with the source of producing phlegm of shutting out, the qi-regulating of phlegm elder generation is controlled in embodiment, and gas disappears along then phlegm
Meaning.It is to make medicine, invigorating spleen, coordinating the drug actions of a prescription with radix glycyrrhizae preparata.This product prescription compatibility is rigorous, dissipates and receives suitable, mend and rush down and combine, sample
It takes into account.System of Chinese medicine, phlegm coming from spleen have been practiced simultaneously, and lung is the device for storing up phlegm.The dysfunction of the spleen in transport, wet being difficult, water-wet
It stagnates, gathers and form phlegm.Phlegm dampness in lungs, then impairment of dispersing and descending function of the lung, cough with dyspnea；Phlegm wet stops stomach, then stomach Qi rising, nausea and vomiting；Phlegm wet
It hinders in chest diaphragm, then functional activity of QI being not smooth, stomach duct and abdomen ruffian is bored, dysfunction of the spleen in transportation and transformation.
Open (bulletin) number discloses a kind of loquat for a kind of patent " loquat leaf momordica grosvenori beverage " of CN104705460B
Leaf beverage made of Momordica grosvenorii Swingle, the beverage are mixed with Siraitia grosvenorii by loguat leaf as raw material, are added pure water to boil, are filtered, by filtrate
Concentration is liquid extract, then plus pure water dilution, edible menthol ethanol solution is added and mixes composition.
The patent " a kind of loquat cough relieving tea and preparation method thereof " of open (bulletin) number for CN102177990B, invention public affairs
A kind of loquat cough relieving tea and preparation method thereof is opened.Loguat leaf, perillaseed and dried orange peel are extracted with ethyl alcohol respectively, extract adds pure
It mixes after water dilution with solar dried green tea, is made after fermenting by known Pu'er tea pile fermentation technique.
Summary of the invention
The prior art occasionally has using microbial fermentation technology, also lacks mostly by loguat leaf soak extraction using loguat leaf
Weary proprietary fermentation technique.
To solve the above technical deficiency, the present invention provides a kind of micro ecological technology fermentation loquat composition and its systems
Preparation Method and application.Loguat leaf and one or more pharmaceutically acceptable additive composition function compositions, function composition
In terms of producing for anti-inflammatory, cough-relieving and eliminating the phlegm and prevention or treating constipation and adjust the intestinal flora of human body in health drink
Using.
The present invention carries out Tiny ecosystem using Modern microbiological zymotechnique according to theory of traditional Chinese medical science many experiments, reasonable formula
Technology fermentation, greatly improved the solubility and absorptivity of natural drug, significantly improves mouthfeel, increase the agreeable to the taste of product
Property.
The present invention is achieved by the following technical solutions:
The present invention provides a kind of micro ecological technology fermentation loquat compositions, prepare the micro ecological technology fermentation loquat composition
Material proportion it is as follows: 50-100 parts of loguat leaf, 40-60 parts of reed root, 30-50 parts of lily, cream 20-40 parts of Loquat-Shaped Cake, campanulaceae 10-
30 parts, 10-30 parts of mulberry leaf, 10-30 parts of dried orange peel, 4-6 parts of radix glycyrrhizae preparata；After above-mentioned integration of drinking and medicinal herbs herbal compound is added water to cook, is concentrated,
Glucose, yeast powder, yeast extract, peptone and oligosaccharide are added, perhaps xylitol adds or do not add addition Sucralose
Add sucrose, is made via more plants of micro ecological technology fermentations.
Preferably, the probiotics is Bifidobacterium and lactobacillus.
It is furthermore preferred that the Bifidobacterium is selected from bifidobacterium bifidum, bifidobacterium breve, bifidobacterium adolescentis and baby
Bifidobacterium；The lactobacillus is selected from lactobacillus acidophilus, Lactobacillus delbrueckii, Lactobacillus casei and Lactobacillus rhamnosus, plant
Lactobacillus, lactobacillus fermenti, lactobacillus reuteri.
It is furthermore preferred that the Bifidobacterium is selected from bifidobacterium breve；The lactobacillus is selected from Lactobacillus delbrueckii, cheese
Lactobacillus, lactobacillus plantarum and lactobacillus acidophilus.
Preferably, micro ecological technology fermentation loquat composition can add one or more pharmaceutically acceptable oligosaccharide kind objects
Matter.
The preferred oligosaccharides substance is oligoisomaltose and oligofructose.
The material proportion that micro ecological technology fermentation loquat composition prepares the addition of 1000 milliliters of liquid is as follows:
(1) fermentation raw material:
Loguat leaf 100g, reed root 50g, lily 40g, Loquat-Shaped Cake cream 30g, campanulaceae 20g, mulberry leaf 20g, dried orange peel 20g, radix glycyrrhizae preparata
5g。
(2) fermentation batches: glucose 10g, peptone 5g, yeast extract 2g, yeast powder 1.5g, Sucralose 95mg.
(3) oligosaccharides added: IMO-50 type isomaltooligosaccharide syrup 40g, FOS55.75% oligofructose starches 30g.
(4) strain connects bacterium amount: in every 1000 milliliters of fermentation substrates, the inoculum concentration body containing viable bacteria 7.0 × 10 of every plant of bacterium8CFU
More than.Fermentation strain includes lactobacillus plantarum, Lactobacillus casei, lactobacillus acidophilus, lactobacillus delbruockii subspecies bulgaricus, short pair
Discrimination bacillus.
Micro ecological technology is fermented, and steps are as follows for loquat preparation method of composition:
A. loguat leaf, reed root, lily, campanulaceae, mulberry leaf, dried orange peel, radix glycyrrhizae preparata seven flavor medicine material are taken, secondary, first time 1.0 is added water to cook
~2.0 hours, second 1.0~2.0 hours, collecting decoction filtered, and filtrate decompression is concentrated into required volume, and loquat is added
Fruit cream obtains traditional Chinese medicine extraction concentrate.
B. glucose, the weight/volume that weight/volume percent is 0.6~1.5% is added in above-mentioned traditional Chinese medicine extraction concentrate
Yeast extract that yeast powder that percentage is 0.05~0.2%, weight/volume percent are 0.1~0.3%, weight/volume percent
The Sucralose that peptone, oligosaccharide, weight/volume percent for 0.3~0.6% are 0.009~0.012%, Huo Zhechong
The xylitol that amount/percent by volume is 5~8% adjusts pH7.0 ± 0.5, and sterilizes 30~60 minutes at 110~121 DEG C, temperature
When degree is down to 39 DEG C, it is inoculated with the bacterium solution of one or two kinds of Bifidobacterium of preculture, inoculates three kinds or three of preculture
Kind or more lactobacillus bacterium solution, connecing bacterium amount is 7.0 × 105CFU/mL or more cultivates under the conditions of 38 ± 1 DEG C, reaches pH
When to 4.0 ± 0.1, stops fermentation, obtain micro ecological technology fermentation liquid.
C. 80 DEG C of fermentation liquid are inactivated, it is aseptic subpackaged after cooling, or after fermentation liquid is dispensed, 105 DEG C of sterilizings obtain micro- life
State technology fermentation loquat composition.
Preferably, oligosaccharide described in step b is IMO-50 type isomaltooligosaccharide syrup, the oligomeric fruit of FOS55.75%
Syrup, additional amount are that iso-maltose syrup 30-50g is added in 1000mL fermentation liquid, and oligofructose starches 20-40g, sucrose access amount 30-
40g。
The micro ecological technology fermentation loquat composition that this patent provides can be applied in terms of improving sub-health status, anti-
Application in terms of scorching, cough-relieving and eliminating the phlegm has important application in terms of relax bowel and defecation adjusts human enteric bacteria health drink.
The beneficial effects of the present invention are: a kind of (1) micro ecological technology fermentation loquat composition provided by the invention, is loquat
Leaf provides a kind of new application approach；(2) according to theory of traditional Chinese medical science many experiments, reasonable formula will be in a variety of integration of drinking and medicinal herbs
Medicine is arranged in pairs or groups；(3) using modern micro-ecology fermentation technique, micro ecological technology fermentation is carried out, natural drug greatly improved
Solubility, absorptivity are more advantageous to human body utilization；(4) it is added to oligosaccharides, is conducive to improve human body intestinal canal Tiny ecosystem；(5) this hair
It is bright that there is beneficial effect for improving sub-health state, according to zoopery in terms of anti-inflammatory, cough-relieving and eliminating the phlegm and defaecation face
With apparent effect.
Specific embodiment
The preparation of 1 micro ecological technology of embodiment fermentation loquat composition
Each traditional Chinese medicine ingredients: loguat leaf 100g, reed root 50g, lily 40g, Loquat-Shaped Cake cream 30g, campanulaceae are weighed according to following proportion
20g, mulberry leaf 20g, dried orange peel 20g, radix glycyrrhizae preparata 5g, in addition to Loquat-Shaped Cake cream, above seven taste adds water to soak in water, and amount of water is 12 times
Medicinal material amount is impregnated 60 minutes.100 DEG C are extracted 60 minutes, and filtering or centrifugation obtain that supernatant is spare, and filter residue adds water 10 times of amounts,
100 DEG C are extracted 60 minutes, and filtering or centrifugation obtain supernatant, merge supernatant, be concentrated into about 1000ml, Loquat-Shaped Cake cream is added
It is 30g, glucose 10g, peptone 5g, yeast extract 2g, yeast powder 1.5g, isomaltooligosaccharide syrup (IMO-50 type) 40g, oligomeric
Fructose syrup (FOS55.75%) 30g, Sucralose 95mg, dissolution, sodium hydroxide adjust 7.0 ± 0.1,115 DEG C of pH value, 40 minutes
High pressure sterilization is cooled to 39 DEG C.Sterile working is respectively connected to the prewired lactobacillus plantarum supported, lactobacillus acidophilus, cheese cream bar
In sterile raw material liquid, inoculum concentration is 7.0 × 10 for bacterium, lactobacillus delbruockii subspecies bulgaricus, bifidobacterium breve bacterium solution5CFU/
ML or more.It is cultivated under the conditions of 38 ± 1 DEG C, when pH being made to reach 4.0 ± 0.1, stops fermentation, obtain micro ecological technology fermentation liquid.It will
80 DEG C of fermentation liquid inactivations, it is aseptic subpackaged to get micro ecological technology fermentation loquat composition.
The preparation of 2 micro ecological technology of embodiment fermentation loquat composition
Each integration of drinking and medicinal herbs material composition: loguat leaf 50g, reed root 40g, lily 30g, Loquat-Shaped Cake cream is weighed according to following proportion
20g, campanulaceae 10g, mulberry leaf 10g, dried orange peel 10g, radix glycyrrhizae preparata 4g, in addition to Loquat-Shaped Cake cream, above seven taste adds water to soak in water, amount of water
For 12 times of medicinal material amounts, impregnate 60 minutes.100 DEG C are extracted 60 minutes, and filtering or centrifugation obtain that supernatant is spare, and filter residue adds water 10
It measures again, 100 DEG C are extracted 60 minutes, filtering or centrifugation, obtain supernatant, and merging supernatant is concentrated into about 1000ml, Loquat-Shaped Cake is added
It is cream 20g, glucose 6g, peptone 3g, yeast extract 1g, yeast powder 0.5g, isomaltooligosaccharide syrup (IMO-50 type) 40g, oligomeric
Fructose syrup (FOS55.75%) 30g, Sucralose 90mg, dissolution, sodium hydroxide adjust 7.0 ± 0.1,115 DEG C of pH value, 40 minutes
High pressure sterilization is cooled to 39 DEG C.Sterile working is respectively connected to prewired support lactobacillus plantarum, lactobacillus acidophilus, rhamnose cream bar
Bacterium, lactobacillus delbruockii subspecies bulgaricus, bifidobacterium adolescentis bacterium solution in sterile raw material liquid, inoculum concentration is 7.0 ×
105CFU/mL or more.It is cultivated under the conditions of 38 ± 1 DEG C, when pH being made to reach 4.0 ± 0.1, stops fermentation, obtain micro ecological technology hair
Zymotic fluid.80 DEG C of fermentation liquid are inactivated, it is aseptic subpackaged to get micro ecological technology fermentation loquat composition.
The preparation of 3 micro ecological technology of embodiment fermentation loquat composition
Each integration of drinking and medicinal herbs material composition: loguat leaf 100g, reed root 60g, lily 50g, Loquat-Shaped Cake cream is weighed according to following proportion
40g, campanulaceae 30g, mulberry leaf 30g, dried orange peel 30g, radix glycyrrhizae preparata 6g, in addition to Loquat-Shaped Cake cream, the above seven flavor medicine material is soaked in water, amount of water
For 12 times of medicinal material amounts, impregnate 60 minutes.100 DEG C are extracted 60 minutes, and filtering or centrifugation obtain that supernatant is spare, and filter residue adds water 10
It measures again, 100 DEG C are extracted 60 minutes, filtering or centrifugation, obtain supernatant, and merging supernatant is concentrated into about 1000ml, Loquat-Shaped Cake is added
Cream 40g, glucose 8g, peptone 5g, yeast extract 3g, yeast powder 1g, isomaltooligosaccharide syrup (IMO-50 type) 50g, oligomeric fruit
Syrup (FOS55.75%) 40g, xylitol 60g, dissolution, sodium hydroxide adjust 7.0 ± 0.1,115 DEG C of pH value, and high pressure is gone out within 40 minutes
Bacterium is cooled to 39 DEG C.Sterile working, be respectively connected to the prewired lactobacillus plantarum supported, lactobacillus fermenti, Lactobacillus rhamnosus,
In sterile raw material liquid, inoculum concentration is 7.0 × 10 for lactobacillus delbruockii subspecies bulgaricus, bifidobacterium infantis bacterium solution5CFU/
ML or more.It is cultivated under the conditions of 38 ± 1 DEG C, when pH being made to reach 4.0 ± 0.1, stops fermentation, obtain micro ecological technology fermentation liquid.Point
Dress, 105 DEG C of sterilizings are to get micro ecological technology fermentation loquat composition.
4 micro ecological technology of embodiment fermentation the anti-inflammatory of loquat composition, cough-relieving and phlegm-dispelling functions experiment
Experiment purpose:
Micro ecological technology fermentation the anti-inflammatory of loquat composition, cough-relieving and the effect of eliminating the phlegm are investigated by animal model.
Experimental material:
Dimethylbenzene is purchased from Sinopharm Chemical Reagent Co., Ltd.；
Ammonium hydroxide is purchased from Sinopharm Chemical Reagent Co., Ltd.；
Sodium bicarbonate is purchased from Sinopharm Chemical Reagent Co., Ltd.；
It is phenol red to be purchased from Solabio.
Laboratory apparatus:
Microplate reader, TECAN
Electronic scale, Sartoriou(CPA225D).
Tested integration of drinking and medicinal herbs material:
Micro ecological technology fermentation loquat composition prepared by embodiment 1.
Experimental animal:
Cleaning grade male mouse of kunming, weight (18-22) g amount to 60, are provided by Shandong University's Experimental Animal Center.
Experimental program:
The anti-inflammatory cough-relieving research of loquat composition 1. micro ecological technology is fermented
Experiment distribution ferment loquat composition group and negative control group, fermentation loquat composition group is given by 50ml/kg stomach-filling ferments
Loquat composition stoste, negative control group give isometric purified water, and continuous 7 days, 12 h were deprived of food but not water before last dose,
After last dose 30min, mouse right ear is uniformly smeared with 20ul dimethylbenzene, cervical dislocation puts to death mouse after 30min, ears are removed,
Auricle is laid in ears same area with diameter 8mm punch and is weighed, and it is swollen that every mouse auris dextra sheet weight, which subtracts left auricle again,
Expansibility.Two groups of swelling result is subjected to one-way analysis of variance, P < 0.05 thinks that there are statistical differences.
Experimental result:
Shown in experimental result table 1, compared with negative control group, fermentation loquat composition group mouse ear swelling degree is significantly less than feminine gender
Control group, the loquat composition that shows to ferment is with certain anti-inflammatory effect.
The anti-inflammatory effect of 1 micro ecological technology of table fermentation loquat composition
| Group | Number of animals (only) | Dosage (ml/kg) | Ear swelling (mg) |
| Negative control | 10 | -- | 13.5±1.7 |
| Ferment loquat composition | 10 | 50 | 10.4±0.9* |
Note: compared with negative control group, P < 0.05 *.
The antitussive action research of micro ecological technology fermentation loquat composition
Experiment distribution ferment loquat composition group and negative control group, fermentation loquat composition group is given by 50ml/kg stomach-filling ferments
Loquat composition stoste, wherein negative control group gives isometric purified water, and continuous 7 days, 12 h fasting were not before last dose
Prohibit water, after last dose 30min, mouse is buckled into 500ml beaker, then the cotton balls for injecting 0.2ml concentrated ammonia liquor is put into rapidly
In beaker, cough number in the cough latent period of immediate record mouse and 2 minutes, by the experimental result of control group and administration group
One-way analysis of variance is carried out, P < 0.05 thinks that there are statistical differences.
Experimental result:
Shown in experimental result table 2, compared with negative control group, micro ecological technology fermentation loquat composition can extend mouse cough
Incubation period simultaneously reduces the cough number in 3min, shows that micro ecological technology fermentation loquat composition has certain antitussive action.
The antitussive action of 2 micro ecological technology of table fermentation loquat composition
| Group | Number of animals (only) | Dosage (ml/kg) | Cough latent period (s) | It coughs number (secondary) |
| Negative control | 10 | -- | 40.2±6.2 | 58.2±2.8 |
| Micro ecological technology fermentation loquat composition | 10 | 50 | 57.4±5.2* | 42.8±2.9** |
Note: compared with negative control group, P < 0.05 *；**P<0.01.
The phlegm-dispelling functions research of micro ecological technology fermentation loquat composition
Experiment divides micro ecological technology fermentation loquat composition group and negative control group, and micro ecological technology fermentation loquat composition group is pressed
Micro ecological technology fermentation loquat composition stoste is given in 50ml/kg stomach-filling, and wherein negative control group gives isometric purified water,
Continuous 7 days, 12h was deprived of food but not water before last dose, and after last dose 30min, every mouse is phenol red by weight intraperitoneal injection 5%
Solution, after injecting phenol red 30min, cervical dislocation puts to death animal, removes tracheae surrounding tissue, cuts from thyroid cartilage to tracheae branch
One section of tracheae at place, is put into and fills 5% sodium bicarbonate solution of 1mL, and 3000r/min is centrifuged 5min, takes supernatant, with light splitting light
Degree meter surveys OD value at wavelength 546nm, calculates phenol red excretion according to phenol red standard curve.By control group and administration group
Experimental result carries out one-way analysis of variance, and P < 0.05 thinks that there are statistical differences.
Experimental result:
Shown in experimental result table 3, compared with negative control group, micro ecological technology fermentation loquat composition can increase the phenol red of mouse
Excretion shows that micro ecological technology fermentation loquat composition has certain phlegm-dispelling functions.
The phlegm-dispelling functions of 3 micro ecological technology of table fermentation loquat composition
| Group | Number of animals (only) | Dosage (ml/kg) | Phenol red secretory volume (μ g/ml) |
| Negative control | 10 | -- | 1.73±0.25 |
| Ferment loquat composition | 10 | 50 | 3.41±0.41** |
Note: compared with negative control group, P < 0.01 * *.
Embodiment 5 investigates the defaecation experiment of micro ecological technology fermentation loquat composition
Experiment purpose:
The function of relaxing bowel of micro ecological technology fermentation loquat composition is investigated by animal model.
Experimental material:
India ink, purchased from leaves moisting biology
Loperamide hydrochloride capsules originate from Xian-Janssen Pharmaceutical Ltd..
Laboratory apparatus:
Meter ruler, capable production
Electronic scale, Sartoriou(CPA225D).
Test medicine:
Micro ecological technology fermentation loquat composition prepared by embodiment 1.
Experimental animal:
Cleaning grade male mouse of kunming, weight (18-22) g, each test are divided four groups by weight at random, and every group 10, two are tried
Total 80 are tested, is provided by Shandong University's Experimental Animal Center.
Experimental program:
1. mouse Intestinal pushing is tested
Experiment divides micro ecological technology fermentation loquat composition high dose group, low dose group, model group and negative control group.Tiny ecosystem
Technology fermentation loquat composition high dose group gives micro ecological technology fermentation loquat composition stoste, low dose by 50ml/kg stomach-filling
Amount group is given the purified water of same volume by same volume administration, negative control group and model group after diluting twice, and continuous 14 days.Last
12 h of fasting after administration, in addition to negative control group gives purified water, remaining mouse gives hydrochloric acid Lip river piperazine by 5mg/kg dosage stomach-filling
After butylamine capsule 30min, each group gives prepared Chinese ink by 20ml/kg dosage stomach-filling.After giving prepared Chinese ink 25min, cervical dislocation is put to death small
Mouse opens abdominal cavity and separates mesenterium, and clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, gently will
Small intestine pulls into straight line and measures.Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".
It is calculated according to the following formula ink progradation (P), ink progradation (P)=prepared Chinese ink promotes length/total small intestinal length × 100 %, will try
It tests result result and carries out one-way analysis of variance, P < 0.05 thinks that there are statistical differences.
Experimental result:
Shown in experimental result table 4, micro ecological technology ferments loquat composition high dose group mouse propulsion rate higher than model group, shows
Micro ecological technology ferments loquat composition with certain Intestinal pushing effect.
4 micro ecological technology of table fermentation loquat composition mouse Intestinal pushing test result
| Group | Number of animals (only) | Dosage (ml/kg) | Propulsion rate (%) |
| Negative control group | 10 | -- | 86.6 ± 4.6 |
| Model group | 10 | -- | 73.7±4.0* |
| Fermentation loquat composition low dose group | 10 | 50 | 72.6±4.4 |
| Fermentation loquat composition high dose group | 10 | 50 | 88.2±4.0△ |
Note: 1. low dose groups are 2 times of dilutions of high dose group；
2. compared with negative control group, P < 0.05 *；Compared with model group, P < 0.05 △.
Micro ecological technology fermentation loquat composition mouse defecation test
Experiment divides micro ecological technology fermentation loquat composition high dose group, low dose group, model group and negative control group.Tiny ecosystem
Technology is fermented, and loquat composition high dose group is given loquat composition stoste of fermenting by 50ml/kg stomach-filling, low dose group dilutes two
Give the purified water of same volume after times by same volume administration, negative control group and model group, continuous 14 days.Fasting after the last administration
12 h, in addition to negative control group gives purified water, remaining mouse gives Loperamide hydrochloride capsules by 10mg/kg dosage stomach-filling
After 30min, each group gives prepared Chinese ink by 20ml/kg dosage stomach-filling, starts simultaneously at timing, since filling prepared Chinese ink, records every animal
It defecation grain number and weighs in first grain row's melena time, 8h.Experimental result carries out one-way analysis of variance, and P < 0.05 thinks there is system
Meter learns difference.
Experimental result:
Shown in experimental result table 5, compared with model group, micro ecological technology ferments loquat composition high and low dose group mouse for the first time
Defecation time extends, and high dose group defecation number of cases and weight increase, and shows that fermentation loquat composition has certain defecating feces excretion.
5 micro ecological technology of table fermentation loquat composition mouse defecation test result
Note: 1. low dose groups are 2 times of dilutions of high dose group；
2. compared with negative control group, P < 0.01 * P < 0.05, * *；Compared with model group, P < 0.01 △ P < 0.05, △ △.
The above is only the preferred embodiment of this patent, it is noted that for the ordinary skill people of the art
For member, under the premise of not departing from the art of this patent principle, several improvement and replacement can also be made, these are improved and replacement
Also it should be regarded as the protection scope of this patent.
Claims (10)
- The loquat composition 1. a kind of micro ecological technology is fermented, which is characterized in that prepare the micro ecological technology fermentation loquat combination The material proportion of object is as follows: 50-100 parts of loguat leaf, 40-60 parts of reed root, 30-50 parts of lily, cream 20-40 parts of Loquat-Shaped Cake, campanulaceae 10-30 parts, 10-30 parts of mulberry leaf, 10-30 parts of dried orange peel, 4-6 parts of radix glycyrrhizae preparata；Above-mentioned integration of drinking and medicinal herbs herbal compound is added water to cook, is concentrated Afterwards, glucose, yeast powder, yeast extract and peptone are added, perhaps xylitol adds or do not add sugarcane to addition Sucralose Fluid composition is made via fermenting based on probiotics micro-ecological technology in sugar.
- The loquat composition 2. a kind of micro ecological technology according to claim 1 is fermented, it is characterised in that: the probiotics For Bifidobacterium and lactobacillus.
- The loquat composition 3. a kind of micro ecological technology according to claim 2 is fermented, it is characterised in that: the bifid bar Bacterium is selected from bifidobacterium bifidum, bifidobacterium breve, bifidobacterium adolescentis and bifidobacterium infantis；The lactobacillus is selected from acidophilus Lactobacillus, Lactobacillus delbrueckii, Lactobacillus casei and Lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus fermenti and Luo Yishi cream bar Bacterium.
- The loquat composition 4. a kind of micro ecological technology according to claim 3 is fermented, it is characterised in that: the bifid bar Bacterium is selected from bifidobacterium breve；The lactobacillus is selected from Lactobacillus delbrueckii, Lactobacillus casei, lactobacillus plantarum and acidophilus cream bar Bacterium.
- The loquat composition 5. a kind of micro ecological technology according to claim 1 is fermented, it is characterised in that: the Tiny ecosystem skill Art fermentation loquat composition can add one or more pharmaceutically acceptable oligosaccharides substances.
- The loquat composition 6. a kind of micro ecological technology according to claim 5 is fermented, it is characterised in that: the oligosaccharide kind Substance is oligoisomaltose and oligofructose.
- The loquat composition 7. a kind of micro ecological technology according to claim 1-6 is fermented, which is characterized in that described The material proportion that micro ecological technology fermentation loquat composition prepares the addition of 1000 milliliters of liquid is as follows:(1) fermentation raw material: loguat leaf 100g, reed root 50g, lily 40g, Loquat-Shaped Cake cream 30g, campanulaceae 20g, mulberry leaf 20g, dried orange peel 20g, radix glycyrrhizae preparata 5g；(2) fermentation batches: glucose 10g, peptone 5g, yeast extract 2g, yeast powder 1.5g, Sucralose 95mg；(3) oligosaccharides added: IMO-50 type isomaltooligosaccharide syrup 40g, FOS55.75% oligofructose starches 30g；(4) strain connects bacterium amount: in every 1000 milliliters of fermentation substrates, the inoculum concentration body containing viable bacteria 7.0 × 10 of every plant of bacterium8CFU or more； Fermentation strain includes lactobacillus plantarum, Lactobacillus casei, lactobacillus acidophilus, lactobacillus delbruockii subspecies bulgaricus, short bifid bar Bacterium.
- The loquat preparation method of composition 8. a kind of micro ecological technology according to claim 1 is fermented, which is characterized in that described Micro ecological technology is fermented, and steps are as follows for loquat preparation method of composition:A. loguat leaf, reed root, lily, campanulaceae, mulberry leaf, dried orange peel, radix glycyrrhizae preparata seven flavor medicine material are taken, secondary, first time 1.0 is added water to cook ~2.0 hours, second 1.0~2.0 hours, collecting decoction filtered, and filtrate decompression is concentrated into required volume, and loquat is added Fruit cream obtains traditional Chinese medicine extraction concentrate；B. glucose, the weight/volume percentage that weight/volume percent is 0.6~1.5% is added in above-mentioned traditional Chinese medicine extraction concentrate Than the yeast powder for 0.05~0.2%, weight/volume percent be 0.1~0.3% yeast extract, weight/volume percent be 0.3~0.6% peptone, oligosaccharide, the Sucralose that weight/volume percent is 0.009~0.012% or weight/ The xylitol that percent by volume is 5~8% adjusts pH7.0 ± 0.5, and sterilizes 30~60 minutes at 110~121 DEG C, temperature When being down to 39 DEG C, it is inoculated with the bacterium solution of one or two kinds of Bifidobacterium of preculture, inoculates three kinds or three kinds of preculture The bacterium solution of above lactobacillus, connecing bacterium amount is 7.0 × 105CFU/mL or more cultivates under the conditions of 38 ± 1 DEG C, reaches pH When 4.0 ± 0.1, stops fermentation, obtain micro ecological technology fermentation liquid；C. 80 DEG C of fermentation liquid are inactivated, it is aseptic subpackaged after cooling, or after fermentation liquid is dispensed, 105 DEG C of sterilizings obtain Tiny ecosystem skill Art fermentation loquat composition.
- The loquat preparation method of composition 9. a kind of micro ecological technology according to claim 8 is fermented, which is characterized in that step Oligosaccharide described in b is MO-50 type isomaltooligosaccharide syrup, FOS55.75% oligofructose slurry, and additional amount is 1000mL hair Iso-maltose syrup 30-50g is added in zymotic fluid, and oligofructose starches 20-40g, sucrose access amount 30-40g.
- 10. a kind of application of micro ecological technology fermentation loquat composition according to claim 8, which is characterized in that described The application of health food or drug of the composition in terms of preparation improves sub-health status, or preparing anti-inflammatory, cough-relieving and eliminating the phlegm Aspect, or the application in terms of relax bowel and defecation adjusts human enteric bacteria health drink.
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| CN114869972A (en) * | 2022-05-06 | 2022-08-09 | 黄山柒尚生物科技有限公司 | Preparation method of loquat composition based on probiotic fermentation |
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| CN114869972A (en) * | 2022-05-06 | 2022-08-09 | 黄山柒尚生物科技有限公司 | Preparation method of loquat composition based on probiotic fermentation |
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