CN1125049C - 托拉沙得新晶体变型n - Google Patents
托拉沙得新晶体变型n Download PDFInfo
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- CN1125049C CN1125049C CN99811710A CN99811710A CN1125049C CN 1125049 C CN1125049 C CN 1125049C CN 99811710 A CN99811710 A CN 99811710A CN 99811710 A CN99811710 A CN 99811710A CN 1125049 C CN1125049 C CN 1125049C
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- Prior art keywords
- torsaemide
- crystal modifications
- acid
- new crystal
- crystal
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/62—Oxygen or sulfur atoms
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- General Health & Medical Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Liquid Crystal (AREA)
- Liquid Crystal Substances (AREA)
- Enzymes And Modification Thereof (AREA)
- Pyridine Compounds (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR980532A HRP980532B1 (en) | 1998-10-02 | 1998-10-02 | Novel crystalline torasemide modification |
| HRP980532A | 1998-10-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1321149A CN1321149A (zh) | 2001-11-07 |
| CN1125049C true CN1125049C (zh) | 2003-10-22 |
Family
ID=10946825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99811710A Expired - Fee Related CN1125049C (zh) | 1998-10-02 | 1999-10-01 | 托拉沙得新晶体变型n |
Country Status (32)
| Country | Link |
|---|---|
| US (5) | US6399637B1 (id) |
| EP (1) | EP1117643B1 (id) |
| JP (1) | JP2002526532A (id) |
| KR (1) | KR100437307B1 (id) |
| CN (1) | CN1125049C (id) |
| AT (1) | ATE286024T1 (id) |
| AU (1) | AU759291B2 (id) |
| BG (1) | BG105485A (id) |
| BR (1) | BR9915018A (id) |
| CA (1) | CA2345789A1 (id) |
| CZ (1) | CZ20011031A3 (id) |
| DE (2) | DE29924789U1 (id) |
| DK (1) | DK1117643T3 (id) |
| EE (1) | EE04341B1 (id) |
| ES (1) | ES2237158T3 (id) |
| HK (1) | HK1040250B (id) |
| HR (1) | HRP980532B1 (id) |
| HU (1) | HUP0104009A3 (id) |
| ID (1) | ID29931A (id) |
| IL (1) | IL142150A0 (id) |
| NO (1) | NO317107B1 (id) |
| NZ (1) | NZ510898A (id) |
| PL (1) | PL346975A1 (id) |
| PT (1) | PT1117643E (id) |
| RU (1) | RU2210569C2 (id) |
| SI (1) | SI1117643T1 (id) |
| SK (1) | SK4232001A3 (id) |
| TR (1) | TR200100909T2 (id) |
| UA (1) | UA72895C2 (id) |
| WO (1) | WO2000020395A1 (id) |
| YU (1) | YU24001A (id) |
| ZA (1) | ZA200102451B (id) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6394707B1 (en) | 1997-05-08 | 2002-05-28 | Jack Kennedy Metal Products & Buildings, Inc. | Yieldable mine roof support |
| HRP980532B1 (en) | 1998-10-02 | 2005-06-30 | Pliva | Novel crystalline torasemide modification |
| PL354262A1 (en) * | 1999-08-11 | 2003-12-29 | Teva Pharmaceutical Industries Ltd.Teva Pharmaceutical Industries Ltd. | Torsemide polymorphs |
| DE10013289A1 (de) * | 2000-03-17 | 2001-09-20 | Knoll Ag | Torasemid enthaltende pharmazeutische Zubereitungen |
| HRP20000162B1 (en) | 2000-03-20 | 2004-06-30 | Pliva D D | Amorphous torasemide modification |
| HRP20000328A2 (en) * | 2000-05-19 | 2002-02-28 | Pliva Farmaceutska Ind Dionik | Novel polymorph v of torasemide |
| IN192178B (id) * | 2001-08-03 | 2004-03-06 | Ranbaxy Lab | |
| HRP20020603B1 (en) * | 2002-07-19 | 2008-11-30 | Pliva D.D. | New process for the preparation of modification i n-(1-methylethylaminocarbonyl)-4-(3-methylphenylamino)-3-pyridinesulfonamide |
| CA2424644A1 (en) * | 2003-04-07 | 2004-10-07 | David John Mckenzie | Preparation of torasemide |
| US20050065183A1 (en) * | 2003-07-31 | 2005-03-24 | Indranil Nandi | Fexofenadine composition and process for preparing |
| EP1750862B1 (en) | 2004-06-04 | 2011-01-05 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical composition containing irbesartan |
| JP4406845B2 (ja) * | 2007-02-20 | 2010-02-03 | トヨタ自動車株式会社 | 二次電池電極材の剥離剤及び該剥離剤を用いた二次電池の処理方法 |
| EP2705843A1 (en) * | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating epilepsy and related disorders through reduction of epileptogenesis |
| CN104370805B (zh) * | 2013-08-13 | 2016-09-07 | 天津汉瑞药业有限公司 | 托拉塞米化合物 |
| CN106038500A (zh) * | 2016-05-26 | 2016-10-26 | 南京正科医药股份有限公司 | 一种托拉塞米片 |
| CN115417810B (zh) * | 2022-09-22 | 2023-10-10 | 南京正科医药股份有限公司 | 一种托拉塞米晶型ⅰ的精制方法 |
| CN117486789A (zh) * | 2023-12-29 | 2024-02-02 | 江西中医药大学 | 一种托拉塞米共晶盐及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4055650A (en) * | 1974-04-17 | 1977-10-25 | A. Christiaens Societe Anonyme | Certain 4-phenoxy(or phenylthio)-3-n-acylated-sulfonamido-pyridines |
| GB1477664A (en) * | 1974-04-17 | 1977-06-22 | Christiaens Sa A | Pyridine derivatives |
| US4473693A (en) | 1978-08-04 | 1984-09-25 | Stewart Walter W | Aminonaphthalimide dyes for intracellular labelling |
| DE3529529A1 (de) * | 1985-08-17 | 1987-02-19 | Boehringer Mannheim Gmbh | Verfahren zur herstellung einer stabilen modifikation von torasemid |
| US6166041A (en) * | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
| HRP980532B1 (en) | 1998-10-02 | 2005-06-30 | Pliva | Novel crystalline torasemide modification |
| US6166045A (en) * | 1998-06-02 | 2000-12-26 | Roche Diagnostics Gmbh | Torasemide of modification III |
| US5914336A (en) * | 1998-06-02 | 1999-06-22 | Boehringer Mannheim Gmbh | Method of controlling the serum solubility of orally administered torasemide and composition relating thereto |
-
1998
- 1998-10-02 HR HR980532A patent/HRP980532B1/xx not_active IP Right Cessation
-
1999
- 1999-10-01 PL PL99346975A patent/PL346975A1/xx not_active Application Discontinuation
- 1999-10-01 PT PT99949272T patent/PT1117643E/pt unknown
- 1999-10-01 ES ES99949272T patent/ES2237158T3/es not_active Expired - Lifetime
- 1999-10-01 IL IL14215099A patent/IL142150A0/xx unknown
- 1999-10-01 NZ NZ510898A patent/NZ510898A/xx unknown
- 1999-10-01 AT AT99949272T patent/ATE286024T1/de not_active IP Right Cessation
- 1999-10-01 HU HU0104009A patent/HUP0104009A3/hu unknown
- 1999-10-01 DK DK99949272T patent/DK1117643T3/da active
- 1999-10-01 RU RU2001111831/04A patent/RU2210569C2/ru not_active IP Right Cessation
- 1999-10-01 ID IDW20010958A patent/ID29931A/id unknown
- 1999-10-01 WO PCT/HR1999/000023 patent/WO2000020395A1/en active IP Right Grant
- 1999-10-01 JP JP2000574512A patent/JP2002526532A/ja active Pending
- 1999-10-01 CN CN99811710A patent/CN1125049C/zh not_active Expired - Fee Related
- 1999-10-01 SI SI9930744T patent/SI1117643T1/xx unknown
- 1999-10-01 AU AU62240/99A patent/AU759291B2/en not_active Ceased
- 1999-10-01 CZ CZ20011031A patent/CZ20011031A3/cs unknown
- 1999-10-01 EP EP99949272A patent/EP1117643B1/en not_active Revoked
- 1999-10-01 DE DE29924789U patent/DE29924789U1/de not_active Expired - Lifetime
- 1999-10-01 EE EEP200100194A patent/EE04341B1/xx not_active IP Right Cessation
- 1999-10-01 CA CA002345789A patent/CA2345789A1/en not_active Abandoned
- 1999-10-01 UA UA2001031966A patent/UA72895C2/uk unknown
- 1999-10-01 KR KR10-2001-7004079A patent/KR100437307B1/ko not_active IP Right Cessation
- 1999-10-01 BR BR9915018-2A patent/BR9915018A/pt not_active IP Right Cessation
- 1999-10-01 TR TR2001/00909T patent/TR200100909T2/xx unknown
- 1999-10-01 SK SK423-2001A patent/SK4232001A3/sk not_active Application Discontinuation
- 1999-10-01 YU YU24001A patent/YU24001A/sh unknown
- 1999-10-01 ZA ZA200102451A patent/ZA200102451B/en unknown
- 1999-10-01 DE DE69922977T patent/DE69922977C5/de not_active Revoked
- 1999-11-05 US US09/434,439 patent/US6399637B1/en not_active Expired - Fee Related
-
2001
- 2001-03-30 NO NO20011633A patent/NO317107B1/no unknown
- 2001-05-02 BG BG105485A patent/BG105485A/xx unknown
-
2002
- 2002-03-13 US US10/096,277 patent/US6833379B2/en not_active Expired - Fee Related
- 2002-03-15 HK HK02102011.9A patent/HK1040250B/zh not_active IP Right Cessation
-
2004
- 2004-06-21 US US10/871,667 patent/US20040229919A1/en not_active Abandoned
-
2006
- 2006-02-21 US US11/357,109 patent/US20060205951A1/en not_active Abandoned
-
2007
- 2007-07-03 US US11/822,274 patent/US20070276015A1/en not_active Abandoned
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