CN112424182B - 环戊烷化合物 - Google Patents

环戊烷化合物 Download PDF

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Publication number
CN112424182B
CN112424182B CN201980046444.XA CN201980046444A CN112424182B CN 112424182 B CN112424182 B CN 112424182B CN 201980046444 A CN201980046444 A CN 201980046444A CN 112424182 B CN112424182 B CN 112424182B
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China
Prior art keywords
fluorophenyl
cyclopentyl
compound
piperidinyl
piperidin
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CN201980046444.XA
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English (en)
Chinese (zh)
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CN112424182A (zh
Inventor
张小林
潘伟涛
G·尼奇迪斯
J·S·M·林德哈根
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Dizhe Jiangsu Pharmaceutical Co ltd
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Dizhe Jiangsu Pharmaceutical Co ltd
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Publication of CN112424182A publication Critical patent/CN112424182A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201980046444.XA 2018-05-11 2019-05-09 环戊烷化合物 Active CN112424182B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2018/086503 2018-05-11
CN2018086503 2018-05-11
PCT/EP2019/061888 WO2019215268A1 (en) 2018-05-11 2019-05-09 Cyclopentane compounds

Publications (2)

Publication Number Publication Date
CN112424182A CN112424182A (zh) 2021-02-26
CN112424182B true CN112424182B (zh) 2023-05-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980046444.XA Active CN112424182B (zh) 2018-05-11 2019-05-09 环戊烷化合物

Country Status (16)

Country Link
US (2) US11274091B2 (https=)
EP (1) EP3790870B1 (https=)
JP (1) JP7418354B2 (https=)
KR (1) KR102806779B1 (https=)
CN (1) CN112424182B (https=)
AR (1) AR115382A1 (https=)
AU (1) AU2019266525B2 (https=)
BR (1) BR112020023065A2 (https=)
CA (1) CA3099507A1 (https=)
DK (1) DK3790870T3 (https=)
ES (1) ES2944735T3 (https=)
MX (1) MX2020012065A (https=)
PT (1) PT3790870T (https=)
TW (1) TWI830733B (https=)
UY (1) UY38229A (https=)
WO (1) WO2019215268A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI830733B (zh) * 2018-05-11 2024-02-01 中國大陸商迪哲（江蘇）醫藥有限公司 環戊烷化合物
JP7594274B2 (ja) 2019-10-24 2024-12-04 国立大学法人大阪大学 難聴の予防および／または治療用医薬組成物
WO2025008249A1 (en) 2023-07-06 2025-01-09 Basf Se Triazole compounds for the control of invertebrate pests

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101631778A (zh) * 2006-07-06 2010-01-20 阵列生物制药公司 作为akt蛋白激酶抑制剂的环戊二烯并[d]嘧啶
CN102015708A (zh) * 2008-01-09 2011-04-13 阵列生物制药公司 作为akt蛋白激酶抑制剂的嘧啶基环戊烷
CN102227429A (zh) * 2008-11-26 2011-10-26 辉瑞大药厂 作为趋化因子受体调节剂的3-氨基环戊烷羧酰胺
CN102459162A (zh) * 2009-06-11 2012-05-16 霍夫曼-拉罗奇有限公司 新型环戊烷衍生物
CN102884044A (zh) * 2010-03-01 2013-01-16 赛诺菲 氨基茚满的衍生物、它们的制备和它们的治疗用途
CN105308040A (zh) * 2013-06-21 2016-02-03 默克专利股份公司 1,3-二氨基环戊烷甲酰胺衍生物
CN105392785A (zh) * 2013-07-29 2016-03-09 默克专利股份公司 1,3-二取代的环戊烷衍生物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004017930A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
WO2006001958A2 (en) * 2004-05-21 2006-01-05 Merck & Co., Inc. Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity
TWI830733B (zh) * 2018-05-11 2024-02-01 中國大陸商迪哲（江蘇）醫藥有限公司 環戊烷化合物

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101631778A (zh) * 2006-07-06 2010-01-20 阵列生物制药公司 作为akt蛋白激酶抑制剂的环戊二烯并[d]嘧啶
CN102015708A (zh) * 2008-01-09 2011-04-13 阵列生物制药公司 作为akt蛋白激酶抑制剂的嘧啶基环戊烷
CN102227429A (zh) * 2008-11-26 2011-10-26 辉瑞大药厂 作为趋化因子受体调节剂的3-氨基环戊烷羧酰胺
CN102459162A (zh) * 2009-06-11 2012-05-16 霍夫曼-拉罗奇有限公司 新型环戊烷衍生物
CN102884044A (zh) * 2010-03-01 2013-01-16 赛诺菲 氨基茚满的衍生物、它们的制备和它们的治疗用途
CN105308040A (zh) * 2013-06-21 2016-02-03 默克专利股份公司 1,3-二氨基环戊烷甲酰胺衍生物
CN105392785A (zh) * 2013-07-29 2016-03-09 默克专利股份公司 1,3-二取代的环戊烷衍生物

Also Published As

Publication number Publication date
UY38229A (es) 2019-11-29
AR115382A1 (es) 2021-01-13
JP2021523178A (ja) 2021-09-02
US12378218B2 (en) 2025-08-05
AU2019266525A1 (en) 2020-11-26
KR102806779B1 (ko) 2025-05-12
EP3790870B1 (en) 2023-04-19
EP3790870A1 (en) 2021-03-17
BR112020023065A2 (pt) 2021-02-02
KR20210018287A (ko) 2021-02-17
PT3790870T (pt) 2023-05-05
US20210070733A1 (en) 2021-03-11
AU2019266525B2 (en) 2024-06-13
CA3099507A1 (en) 2019-11-14
US20220194922A1 (en) 2022-06-23
JP7418354B2 (ja) 2024-01-19
MX2020012065A (es) 2021-02-26
TW202016087A (zh) 2020-05-01
US11274091B2 (en) 2022-03-15
ES2944735T3 (es) 2023-06-23
DK3790870T3 (da) 2023-05-08
CN112424182A (zh) 2021-02-26
WO2019215268A1 (en) 2019-11-14
TWI830733B (zh) 2024-02-01

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Address after: Room 404, 405, 416, Building C, Huirong Business Plaza, No. 26 Hefeng Road, Xinwu District, Wuxi City, Jiangsu Province, 214135

Patentee after: Dizhe (Jiangsu) Pharmaceutical Co.,Ltd.

Address before: 214135 E / F, Huirong Business Plaza, Jinghui East Road, Xinwu District, Wuxi City, Jiangsu Province

Patentee before: Dizhe (Jiangsu) Pharmaceutical Co.,Ltd.