TWI830733B - 環戊烷化合物 - Google Patents
環戊烷化合物 Download PDFInfo
- Publication number
- TWI830733B TWI830733B TW108115491A TW108115491A TWI830733B TW I830733 B TWI830733 B TW I830733B TW 108115491 A TW108115491 A TW 108115491A TW 108115491 A TW108115491 A TW 108115491A TW I830733 B TWI830733 B TW I830733B
- Authority
- TW
- Taiwan
- Prior art keywords
- fluorophenyl
- compound
- cyclopentyl
- amino
- fluoro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| WOPCT/CN2018/086503 | 2018-05-11 | ||
| CN2018086503 | 2018-05-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202016087A TW202016087A (zh) | 2020-05-01 |
| TWI830733B true TWI830733B (zh) | 2024-02-01 |
Family
ID=66542241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW108115491A TWI830733B (zh) | 2018-05-11 | 2019-05-06 | 環戊烷化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11274091B2 (https=) |
| EP (1) | EP3790870B1 (https=) |
| JP (1) | JP7418354B2 (https=) |
| KR (1) | KR102806779B1 (https=) |
| CN (1) | CN112424182B (https=) |
| AR (1) | AR115382A1 (https=) |
| AU (1) | AU2019266525B2 (https=) |
| BR (1) | BR112020023065A2 (https=) |
| CA (1) | CA3099507A1 (https=) |
| DK (1) | DK3790870T3 (https=) |
| ES (1) | ES2944735T3 (https=) |
| MX (1) | MX2020012065A (https=) |
| PT (1) | PT3790870T (https=) |
| TW (1) | TWI830733B (https=) |
| UY (1) | UY38229A (https=) |
| WO (1) | WO2019215268A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI830733B (zh) * | 2018-05-11 | 2024-02-01 | 中國大陸商迪哲（江蘇）醫藥有限公司 | 環戊烷化合物 |
| JP7594274B2 (ja) | 2019-10-24 | 2024-12-04 | 国立大学法人大阪大学 | 難聴の予防および／または治療用医薬組成物 |
| WO2025008249A1 (en) | 2023-07-06 | 2025-01-09 | Basf Se | Triazole compounds for the control of invertebrate pests |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2368876A1 (en) * | 2010-03-01 | 2011-09-28 | Sanofi | Derivatives of aminoindanes, their preparation and their application in therapeutics |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004017930A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| WO2006001958A2 (en) * | 2004-05-21 | 2006-01-05 | Merck & Co., Inc. | Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity |
| EP2049500B1 (en) * | 2006-07-06 | 2011-09-07 | Array Biopharma, Inc. | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
| CN102015708B (zh) * | 2008-01-09 | 2014-03-26 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 |
| PT2370442E (pt) * | 2008-11-26 | 2013-06-27 | Pfizer | 3-aminociclopentanocarboxamidas como moduladores de receptor de quimiocina |
| US7893099B2 (en) * | 2009-06-11 | 2011-02-22 | Hoffman-La Roche Inc. | Cyclopentane derivatives |
| CN105308040B (zh) * | 2013-06-21 | 2019-06-04 | 默克专利股份公司 | 1,3-二氨基环戊烷甲酰胺衍生物 |
| SG11201600726QA (en) * | 2013-07-29 | 2016-03-30 | Merck Patent Gmbh | 1,3-disubstituted cyclopentane derivatives |
| TWI830733B (zh) * | 2018-05-11 | 2024-02-01 | 中國大陸商迪哲（江蘇）醫藥有限公司 | 環戊烷化合物 |
-
2019
- 2019-05-06 TW TW108115491A patent/TWI830733B/zh active
- 2019-05-09 WO PCT/EP2019/061888 patent/WO2019215268A1/en not_active Ceased
- 2019-05-09 MX MX2020012065A patent/MX2020012065A/es unknown
- 2019-05-09 PT PT197241524T patent/PT3790870T/pt unknown
- 2019-05-09 CA CA3099507A patent/CA3099507A1/en active Pending
- 2019-05-09 KR KR1020207035633A patent/KR102806779B1/ko active Active
- 2019-05-09 CN CN201980046444.XA patent/CN112424182B/zh active Active
- 2019-05-09 ES ES19724152T patent/ES2944735T3/es active Active
- 2019-05-09 JP JP2020563695A patent/JP7418354B2/ja active Active
- 2019-05-09 AU AU2019266525A patent/AU2019266525B2/en active Active
- 2019-05-09 DK DK19724152.4T patent/DK3790870T3/da active
- 2019-05-09 EP EP19724152.4A patent/EP3790870B1/en active Active
- 2019-05-09 BR BR112020023065-0A patent/BR112020023065A2/pt unknown
- 2019-05-10 AR ARP190101251A patent/AR115382A1/es unknown
- 2019-05-10 UY UY0001038229A patent/UY38229A/es not_active Application Discontinuation
-
2020
- 2020-11-11 US US17/095,725 patent/US11274091B2/en active Active
-
2021
- 2021-12-27 US US17/562,022 patent/US12378218B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2368876A1 (en) * | 2010-03-01 | 2011-09-28 | Sanofi | Derivatives of aminoindanes, their preparation and their application in therapeutics |
| US20130131034A1 (en) * | 2010-03-01 | 2013-05-23 | Sanofi | Derivatives of aminoindanes, their preparation and their application in therapeutics |
Also Published As
| Publication number | Publication date |
|---|---|
| UY38229A (es) | 2019-11-29 |
| AR115382A1 (es) | 2021-01-13 |
| JP2021523178A (ja) | 2021-09-02 |
| US12378218B2 (en) | 2025-08-05 |
| AU2019266525A1 (en) | 2020-11-26 |
| KR102806779B1 (ko) | 2025-05-12 |
| EP3790870B1 (en) | 2023-04-19 |
| EP3790870A1 (en) | 2021-03-17 |
| BR112020023065A2 (pt) | 2021-02-02 |
| KR20210018287A (ko) | 2021-02-17 |
| PT3790870T (pt) | 2023-05-05 |
| US20210070733A1 (en) | 2021-03-11 |
| CN112424182B (zh) | 2023-05-23 |
| AU2019266525B2 (en) | 2024-06-13 |
| CA3099507A1 (en) | 2019-11-14 |
| US20220194922A1 (en) | 2022-06-23 |
| JP7418354B2 (ja) | 2024-01-19 |
| MX2020012065A (es) | 2021-02-26 |
| TW202016087A (zh) | 2020-05-01 |
| US11274091B2 (en) | 2022-03-15 |
| ES2944735T3 (es) | 2023-06-23 |
| DK3790870T3 (da) | 2023-05-08 |
| CN112424182A (zh) | 2021-02-26 |
| WO2019215268A1 (en) | 2019-11-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6420362B2 (ja) | 大環状ピリジン誘導体 | |
| CN106164075B (zh) | 大环嘧啶衍生物 | |
| CN106536491B (zh) | 作为盐皮质激素受体调节剂的苯并噁嗪酮酰胺 | |
| US12378218B2 (en) | Cyclopentane compounds | |
| JP2022533147A (ja) | 芳香族アミン類のａｒ及びｂｅｔを標的とするタンパク質分解キメラ化合物及び使用 | |
| JP4031814B2 (ja) | ピペリジニルカルボニル−ピロリジンおよびメラノコルチンアゴニストとしてのそれらの使用 | |
| ES3053759T3 (en) | Gpr52 modulator compounds | |
| EP4065228A1 (en) | 1,2,4-oxadiazole derivatives as liver x receptor agonists | |
| KR20230160901A (ko) | 유비퀴틴 특이 프로테아제 19(usp19)의 억제제로서의 약제학적 화합물 | |
| RU2794997C9 (ru) | Соединения циклопентана | |
| RU2794997C2 (ru) | Соединения циклопентана | |
| HK40047026A (en) | Cyclopentane compounds | |
| HK40047027A (en) | Cyclopentane compounds | |
| HK40047027B (en) | Cyclopentane compounds | |
| IL324074A (en) | Fluorinated cyclic derivatives of sulfonamides and sulfones, and compositions and methods thereof | |
| KR20260042500A (ko) | 약학적 화합물 | |
| WO2026012465A1 (zh) | 苯并二氮䓬类化合物、药物组合物及其用途 | |
| WO2024088189A1 (zh) | 作为cdk9抑制剂的大环类化合物及其应用 | |
| HK40077347B (zh) | Raf激酶的抑制剂 |