CN112386662A - Gynecological bacteriostatic temperature-sensitive gel and preparation method thereof - Google Patents
Gynecological bacteriostatic temperature-sensitive gel and preparation method thereof Download PDFInfo
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- CN112386662A CN112386662A CN202011143831.6A CN202011143831A CN112386662A CN 112386662 A CN112386662 A CN 112386662A CN 202011143831 A CN202011143831 A CN 202011143831A CN 112386662 A CN112386662 A CN 112386662A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Abstract
The invention provides a temperature-sensitive gel for gynecological bacteriostatic care, which comprises the following components in parts by weight based on the total amount of the temperature-sensitive gel for gynecological bacteriostatic care: 1.2 to 17 percent of humectant, 0.2 to 0.5 percent of chlorhexidine acetate, 1.11 to 9.4 percent of traditional Chinese medicine antibacterial compound, 16 to 30 percent of temperature-sensitive gel, 3.2 to 5.2 percent of freshener, 0.3 to 0.6 percent of preservative, 0.3 to 5.05 percent of lubricant and 46.07 to 61.7 percent of deionized water, wherein the temperature-sensitive gel is any two of glucomannan, poloxamer 407 and poloxamer 188. The invention combines the chemical bacteriostatic agent and the main bacteriostatic agent, has milder and more thorough bacteriostasis, can adjust the gelation temperature, is convenient to use and more suitable for human bodies, has safe and reliable components, has no stimulation to organisms and no accumulated toxicity.
Description
Technical Field
The invention relates to the technical field of gynecological health care nursing external products, in particular to a gynecological bacteriostatic temperature-sensitive gel and a preparation method thereof.
Background
With the increase of the age and the living pressure of women, the trouble of gynecological diseases or sanitation is increased, which not only affects the physiological health of women, but also brings about little negative effect on the psychological health of women. More and more women suffer from gynecological diseases such as abnormal leucorrhea, pudendum pruritus, irregular menstruation, leucorrhea peculiar smell, vaginal dryness and the like. In the epidemiological investigation result of the gynecological common diseases, the sequence of the prevalence rate of genital tract infection is as follows: 39.3 percent of chronic cervicitis, 15.9 percent of vaginitis caused by various reasons, 5.4 percent of genital tract chlamydia trachomatis infection, 4.1 percent of chronic pelvic inflammation, 1.5 percent of vulvitis and the like. The special physiological structure of women is easily attacked by pathogens such as candida albicans, staphylococcus aureus, streptococcus, escherichia coli, viruses and the like, and bad living habits or high working pressure are possible, so that the immunity of part of patients is poor, the gynecological diseases are usually not cured for a long time, and great inconvenience is brought to the life and the work of women.
At present, the medicines for treating gynecological inflammation are various, oral medicines mainly enter vagina parts through gastrointestinal absorption and blood circulation and kill bacteria, the onset time is slow, and the curative effect can be achieved only by long-term taking; the external antibacterial drugs for treating gynecological inflammation include suppositories, lotions, sprays and the like, are inconvenient to use and have burden feeling, but most drugs can damage the vaginal environment and the mucous membrane secretion function, so that the local immunity of the reproductive system is reduced, pathogenic bacteria can generate drug resistance and drug resistance, and finally inflammation is recurrent; how to solve the gynecological inflammation and achieve the dual purposes of bacteriostasis and nursing becomes a problem to be solved urgently.
Disclosure of Invention
The invention aims to overcome the defects in the prior art, provides the gynecological bacteriostatic nursing temperature-sensitive gel and the preparation method thereof, is mild and efficient in bacteriostasis, is convenient to use, and can achieve the dual purposes of bacteriostatic nursing.
In order to solve the technical problems, the invention adopts the technical scheme that: the gynecological bacteriostatic nursing temperature-sensitive gel comprises the following components in parts by weight based on the total amount of the gynecological bacteriostatic nursing temperature-sensitive gel:
the temperature-sensitive gel is any two of glucomannan, poloxamer 407 and poloxamer 188.
Further, the humectant is one or more of glycerin, 1, 3-propylene glycol, butanediol, glyceryl polyether-7, glyceryl polyether-26, dipropylene glycol and polyethylene glycol-8 commonly used for skin.
Further, the freshener is any two of borneol, alcohol, menthol and menthol lactate.
Further, the preservative is any two of phenoxyethanol, chlorphenesin, methylparaben, sodium benzoate, hexanediol and 1, 2-pentanediol.
Further, the lubricant agent is any two of sodium hyaluronate, hydrolyzed sclerotium rolfsii gum, glycerol polyacrylate, sodium hyaluronate cross-linked polymer and tremella sporophore extract.
Further, the traditional Chinese medicine bacteriostatic compound comprises the following components in parts by weight on the basis of the total amount of the traditional Chinese medicine bacteriostatic compound:
further, the temperature-sensitive range of the gynecological bacteriostatic nursing temperature-sensitive gel is 32-60 ℃.
In order to solve the technical problem, the invention adopts another technical scheme that: a preparation method of a gynecological bacteriostatic nursing temperature-sensitive gel comprises the following steps:
s1, weighing the humectant, the lubricant, the temperature-sensitive gel, the deionized water and the preservative which needs to be dissolved at high temperature according to the formula proportion, uniformly dispersing, heating to 85-90 ℃, mixing, stirring and dissolving at a certain rotating speed until the mixture is uniform, keeping the temperature for half an hour, and then stirring and cooling;
s2, adding chlorhexidine acetate and a pre-dissolved freshener into the mixture obtained in the S1 at the temperature of 50-60 ℃, and slowly and uniformly stirring;
s3, weighing the traditional Chinese medicine antibacterial compound according to the formula proportion, adding the traditional Chinese medicine antibacterial compound and the residual preservative into the mixture obtained in the step S2 at a certain rotation speed of 45 ℃, stirring and dissolving uniformly, and then continuously cooling;
s4, uniformly stirring the mixture obtained in the step S3, cooling to room temperature, and defoaming to obtain the light yellow to brown transparent to semitransparent gynecological bacteriostatic temperature-sensitive gel.
Compared with the prior art, the invention has the beneficial effects that: through the combination of the chemical bacteriostatic agent and the main bacteriostatic agent, the bacteriostatic agent is milder and more thorough, can adjust the gelation temperature, is convenient to use, is more suitable for human bodies, is safe and reliable in each component, has no stimulation to organisms, and has no accumulated toxicity.
Detailed Description
It is easily understood that according to the technical solution of the present invention, a person skilled in the art can propose various alternative structures and implementation ways without changing the spirit of the present invention. Therefore, the following detailed description is merely illustrative of the technical solutions of the present invention, and should not be construed as being all of the present invention or limiting or restricting the technical solutions of the present invention.
Temperature range test of temperature-sensitive gels: and (3) observing the temperature when the gelation occurs and the temperature when the gel is completely formed in the temperature reduction process of the temperature-sensitive gel preparation, and slowly heating, stirring, observing and recording the temperature when the gel is hydrated and the complete hydration temperature of the container wall after the gel is formed.
And (3) verifying the temperature-sensitive gel stability:
the prepared temperature-sensitive gel is placed in a suitable container, stability examination is carried out for 2 months under the conditions of 25 ℃, 50 ℃, 45 ℃, 5 ℃ and UV, the sensory change and the temperature change of the gel are observed, and the content of the chlorhexidine acetate is tested at 4 weeks, 6 weeks and 8 weeks.
Example 1
Weighing 8g of glycerol and 2g of butanediol as a humectant, 0.2g of borneol and 5g of ethanol as a freshener, 6g of glucomannan and 10g of poloxamer 407 as a temperature-sensitive gel, 0.1g of methyl paraben and 0.3g of chlorphenesin as a preservative, 0.1g of sodium hyaluronate and 0.2g of hydrolyzed sclerotium gum as a lubricant, 0.2g of chlorhexidine acetate and 61.7g of deionized water, uniformly dispersing the humectant, the freshener, the temperature-sensitive gel and the preservative needing to be dissolved at a high temperature in deionized water, heating to 85-90 ℃, mixing, stirring and dissolving to be uniform at a certain rotating speed, keeping the temperature for half an hour, stirring and cooling, adding the chlorhexidine acetate and the pre-dissolved freshener at 50-60 ℃, and slowly stirring to be uniform; weighing 1g of radix sophorae flavescentis extract, 2g of fructus cnidii extract, 1.4g of cortex phellodendri extract, 0.3g of radix stemonae extract and 1.5g of wild chrysanthemum extract, adding the traditional Chinese medicine antibacterial compound and the rest preservative at 45 ℃, uniformly dissolving by halving at a certain rotating speed, then continuously cooling, uniformly stirring, cooling to room temperature, and defoaming to obtain the light yellow to brown transparent to semitransparent gynecological antibacterial temperature-sensitive gel.
Temperature sensing range of test example 1: 45-50 ℃;
temperature-sensitive gel stability investigation:
example 2
Weighing 0.5g of glycerol, 0.2g of 1, 3-propylene glycol and 0.5g of glyceryl polyether-26 as moisturizers, 0.2g of menthol lactate and 3g of ethanol as coolants, 2g of glucomannan and 16g of poloxamer 407 as temperature-sensitive gels, 0.1g of methylparaben and 0.2g of chlorphenesin as preservatives, 0.05g of sodium hyaluronate and 0.5g of hydrolyzed sclerotium rolfsii as lubricants, 0.3g of chlorhexidine acetate and 67.05g of deionized water, uniformly dispersing the moisturizers, the coolants, the temperature-sensitive gels and the preservatives needing high-temperature dissolution in deionized water, heating to 85-90 ℃, mixing, stirring and dissolving at a certain rotation speed for half an hour, stirring and cooling after keeping the temperature for half an hour, adding the chlorhexidine acetate and the previously dissolved coolants at 50-60 ℃, slowly stirring uniformly; weighing 1g of radix sophorae flavescentis extract, 4g of fructus cnidii extract, 2g of cortex phellodendri extract, 0.4g of radix stemonae extract and 2g of wild chrysanthemum extract, adding the traditional Chinese medicine antibacterial compound and the rest preservative at 45 ℃, uniformly dissolving by halving at a certain rotating speed, then continuously cooling, uniformly stirring, cooling to room temperature, and defoaming to obtain the light yellow to brown transparent to semitransparent gynecological antibacterial temperature-sensitive gel.
Temperature sensing range of test example 2: 58-65 ℃;
temperature-sensitive gel stability investigation:
example 3
Weighing 10g of glycerol, 5g of dipropylene glycol, 2g of glyceryl polyether-7 and 3g of polyethylene glycol-8 as moisturizers, 0.2g of menthol and 3g of ethanol as coolants, 25g of glucomannan and 5g of poloxamer 188 as temperature-sensitive gels, 0.1g of methylparaben and 0.5g of phenoxyethanol as preservatives, 0.02g of tremella fuciformis entity extract and 1.5g of glycerol polyacrylate as lubricants, 0.5g of chlorhexidine acetate and 43.07g of deionized water, uniformly dispersing the moisturizers, the coolants, the temperature-sensitive gels and the preservatives needing high-temperature dissolution in deionized water, heating to 85-90 ℃, mixing, stirring and dissolving at a certain rotating speed for uniform mixing, keeping the temperature for half an hour, stirring and cooling, adding the chlorhexidine acetate and the pre-dissolved coolants at 50-60 ℃, slowly stirring uniformly; weighing 0.2g of radix sophorae flavescentis extract, 0.3g of fructus cnidii extract, 0.3g of cortex phellodendri extract, 0.01g of radix stemonae extract and 0.3g of wild chrysanthemum extract, adding the traditional Chinese medicine antibacterial compound and the rest preservative at 45 ℃, uniformly dissolving by halving at a certain rotating speed, then continuously cooling, uniformly stirring, cooling to room temperature, and defoaming to obtain the light yellow to brown transparent to semitransparent gynecological antibacterial temperature-sensitive gel.
Temperature sensing range of test example 3: 36-45 ℃;
temperature-sensitive gel stability investigation:
the technical scope of the present invention is not limited to the above description, and those skilled in the art can make various changes and modifications to the above-described embodiments without departing from the technical spirit of the present invention, and such changes and modifications should fall within the protective scope of the present invention.
Claims (8)
1. The temperature-sensitive gel for gynecological bacteriostatic care is characterized by comprising the following components in parts by weight based on the total amount of the temperature-sensitive gel for gynecological bacteriostatic care:
the temperature-sensitive gel is any two of glucomannan, poloxamer 407 and poloxamer 188.
2. The temperature-sensitive gel for gynecological bacteriostatic care according to claim 1, wherein the moisturizer is one or more of glycerin, 1, 3-propylene glycol, butylene glycol, glyceryl polyether-7, glyceryl polyether-26, dipropylene glycol and polyethylene glycol-8 commonly used for skin.
3. The temperature-sensitive gel for gynecological bacteriostatic care according to claim 1, wherein the cooling agent is any two of borneol, alcohol, menthol and menthol lactate.
4. The temperature-sensitive gel for gynecological bacteriostatic care according to claim 1, wherein the preservative is any two of phenoxyethanol, chlorphenesin, methylparaben, sodium benzoate, hexylene glycol and 1, 2-pentanediol.
5. The temperature-sensitive gel for gynecological bacteriostatic care according to claim 1, wherein the lubricant agent is any two of sodium hyaluronate, hydrolyzed sclerotium rolfsii gum, glycerol polyacrylate, sodium hyaluronate cross-linked polymer and tremella sporophore extract.
6. The temperature-sensitive gel for gynecological bacteriostatic care according to claim 1, which is characterized by comprising the following components in parts by weight based on the total amount of the traditional Chinese medicine bacteriostatic compound:
7. the temperature-sensitive gel for gynecological bacteriostatic care according to any one of claims 1 to 6, wherein the temperature-sensitive range of the temperature-sensitive gel for gynecological bacteriostatic care is 32-60 ℃.
8. A preparation method of temperature-sensitive gel for gynecological bacteriostatic nursing is characterized by comprising the following steps:
s1, weighing the humectant, the lubricant, the temperature-sensitive gel, the deionized water and the preservative which needs to be dissolved at high temperature according to the formula proportion, uniformly dispersing, heating to 85-90 ℃, mixing, stirring and dissolving at a certain rotating speed until the mixture is uniform, keeping the temperature for half an hour, and then stirring and cooling;
s2, adding chlorhexidine acetate and a pre-dissolved freshener into the mixture obtained in the S1 at the temperature of 50-60 ℃, and slowly and uniformly stirring;
s3, weighing the traditional Chinese medicine antibacterial compound according to the formula proportion, adding the traditional Chinese medicine antibacterial compound and the residual preservative into the mixture obtained in the step S2 at a certain rotation speed of 45 ℃, stirring and dissolving uniformly, and then continuously cooling;
s4, uniformly stirring the mixture obtained in the step S3, cooling to room temperature, and defoaming to obtain the light yellow to brown transparent to semitransparent gynecological bacteriostatic temperature-sensitive gel.
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| CN202011143831.6A CN112386662A (en) | 2020-10-23 | 2020-10-23 | Gynecological bacteriostatic temperature-sensitive gel and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113318233A (en) * | 2021-04-30 | 2021-08-31 | 杭州爱光医疗器械有限公司 | Temperature-sensitive gynecological bacteriostatic liquid composition and preparation method thereof |
| CN113599078A (en) * | 2021-08-10 | 2021-11-05 | 诺宸股份有限公司 | Antibacterial anti-galactorrhea pad |
| CN114288390A (en) * | 2022-01-25 | 2022-04-08 | 广州市诺兰精细化工有限公司 | Temperature-sensitive type female sanitary gel and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102205078A (en) * | 2011-05-10 | 2011-10-05 | 安徽宝芝堂药业有限公司 | High-efficiency compound lightyellow sophora root lotion and preparation method thereof |
| CN106466454A (en) * | 2015-08-20 | 2017-03-01 | 康多宝医疗健康产品（湖南）有限公司 | A kind of prevention and the gel for the treatment of gynecological inflammation |
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2020
- 2020-10-23 CN CN202011143831.6A patent/CN112386662A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102205078A (en) * | 2011-05-10 | 2011-10-05 | 安徽宝芝堂药业有限公司 | High-efficiency compound lightyellow sophora root lotion and preparation method thereof |
| CN106466454A (en) * | 2015-08-20 | 2017-03-01 | 康多宝医疗健康产品（湖南）有限公司 | A kind of prevention and the gel for the treatment of gynecological inflammation |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113318233A (en) * | 2021-04-30 | 2021-08-31 | 杭州爱光医疗器械有限公司 | Temperature-sensitive gynecological bacteriostatic liquid composition and preparation method thereof |
| CN113599078A (en) * | 2021-08-10 | 2021-11-05 | 诺宸股份有限公司 | Antibacterial anti-galactorrhea pad |
| CN113599078B (en) * | 2021-08-10 | 2022-09-16 | 诺宸股份有限公司 | Antibacterial anti-galactorrhea pad |
| CN114288390A (en) * | 2022-01-25 | 2022-04-08 | 广州市诺兰精细化工有限公司 | Temperature-sensitive type female sanitary gel and preparation method thereof |
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Application publication date: 20210223 |