CN102205078A - High-efficiency compound lightyellow sophora root lotion and preparation method thereof - Google Patents
High-efficiency compound lightyellow sophora root lotion and preparation method thereof Download PDFInfo
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- CN102205078A CN102205078A CN2011101205062A CN201110120506A CN102205078A CN 102205078 A CN102205078 A CN 102205078A CN 2011101205062 A CN2011101205062 A CN 2011101205062A CN 201110120506 A CN201110120506 A CN 201110120506A CN 102205078 A CN102205078 A CN 102205078A
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Abstract
The invention discloses high-efficiency compound lightyellow sophora root lotion and a preparation method thereof, and relates to a Chinese and western medicinal compound preparation. The lotion mainly comprises Chinese medicinal material extracting solution and a cation surface active broad-spectrum bactericide, wherein the Chinese medicinal material extracting solution is prepared from lightyellow sophora root, phellodendron, common cnidium fruit and sessile stemona root serving as Chinese herbal medicines, and 0.08 to 0.2 gram of cation surface active broad-spectrum bactericide is dissolved in 100 milliliters of Chinese medicinal material extracting solution. The high-efficiency compound lightyellow sophora root lotion has high bacteriostatic capacity, does not have irritation and side effects, has good long-term prevention and treatment curative effects, has medicinal effects which are obviously superior to those of single Chinese medicines or western medicines, is used for washing female vaginas, cleaning male and female vulvae and performing daily sanitary nursing of males and females and particularly is used as external lotion for gynecological diseases.
Description
Technical field:
The present invention relates to a kind of Chinese medicine and western medicine compound preparation, particularly a kind of external wash liquid that is used for vagina flushing, men and women's pudendum cleaning and the nursing of men and women's daily hygiene is specifically related to a kind of high-efficient compound Radix Sophorae Flavescentis washing liquid and preparation method thereof.
Background technology:
Genitourinary system is a common disease, and especially the sick group of gynaecopathia is big, for very, it is reported that 35～45% adult women suffered from gynaecopathia with the married woman that grows up, and the trend that rises is year by year arranged.Though gynaecopathia is so not serious than sexually transmitted disease (STD), but brought painful topic, influenced sexual life, even cause hyposexuality, coverd with shade for happy family, had a strong impact on people's quality of life and family harmony to the women.At present, the lotion of medication that can be used for treating gynaecopathia is more, and various lotion of medication all have the unique distinction of oneself, but also have certain deficiency simultaneously, as treatment not thoroughly, state of an illness bounce-back, life-time service can produce toxic and side effects and drug resistance etc.
Summary of the invention:
Purpose of the present invention is exactly the above-mentioned defective at prior art, and the especially lotion of medication of some gynaecopathias of a kind of new treatment genitourinary system is provided.It is the synergic pharmaceutical preparation of a kind of Chinese medicine and western medicine compatibility, has characteristics evident in efficacy, that clinical symptom disappearance rapid, the no state of an illness in healing back rebounds, the life-time service toxic and side effects is little for genitourinary system especially some gynaecopathias.
For realizing purpose of the present invention, technical scheme realizes in the following way:
High-efficient compound Radix Sophorae Flavescentis washing liquid and preparation method thereof, it is characterized in that: form by the Chinese crude drug extracting solution with the cationic surface activity wide-spectrum bactericide that the concentration of 0.08～0.2g/100ml is dissolved in this extracting solution, described Chinese medicine extraction liquid is to adopt following crude drug to be prepared from:
(1) preparation of crude drug: according to following prescription weighting raw materials: 2～10 parts of Radix Sophorae Flavescentiss, 0.1～5 part of Cortex Phellodendri, 5～18 parts of Fructus Cnidiis, 4～22 parts of the Radixs Stemonae.
(2) preparation of decoction liquor: after Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Cnidii, the Radix Stemonae mixed according to said ratio, add 6～12 times in water, decocts 3 times, decocted 1～2 hour at every turn, must three decoction liquor;
(3) preparation of Chinese medicine extraction liquid: three decoction liquor are mixed, filter, leave standstill that to get supernatant concentration to proportion after 24～48 hours be 1.02～1.04, obtain Chinese medicine extraction liquid.
The proportioning of described crude drug is: 2～8 parts of Radix Sophorae Flavescentiss, 0.1～4 part of Cortex Phellodendri, 5～15 parts of Fructus Cnidiis, 4～18 parts of the Radixs Stemonae.
The best proportioning of described crude drug is: 2 parts of Radix Sophorae Flavescentiss, 0.1 part of Cortex Phellodendri, 5 parts of Fructus Cnidiis, 4 parts of the Radixs Stemonae.
Described cationic surface activity wide-spectrum bactericide is domiphen bromide or chlorhexidine acetate.
Described high-efficient compound Radix Sophorae Flavescentis washing liquid can add hydrochloric acid solution or sodium hydroxide solution or some other strong acid weak base salt or strong base weak acid salt buffer adjusting pH value.
Described high-efficient compound Radix Sophorae Flavescentis washing liquid can also be made externally used paste, spray, gel, suppository.
In the Chinese medicine of respectively distinguishing the flavor of of above-mentioned prescription:
Radix Sophorae Flavescentis: bitter in the mouth cold in nature, GUIXIN, liver, stomach, large intestine and urinary bladder channel have heat clearing and damp drying, eliminating fire and detoxication, the merit of parasite killing diuresis;
Cortex Phellodendri: bitter in the mouth is cold in nature, returns kidney, urinary bladder channel, has heat clearing and damp drying, eliminating fire and detoxication, the merit of detumescence putrefaction removing;
Fructus Cnidii: warm in nature, the acrid in the mouth hardship is returned kidney channel, and external has dampness, parasite killing, antipruritic merit;
The Radix Stemonae: bitter in the mouth, tepor is returned lung meridian, has the merit of killing parasites for relieving itching; All medicines share, and gather the effect of heat clearing and damp drying, antibiotic diuresis, wind dispelling insecticide, detumescence putrefaction removing, killing parasites for relieving itching altogether.
Chlorhexidine acetate: it has great broad-spectrum antibacterial bactericidal action, and Integrative Chinese-Western can produce the effect of Synergistic.
Its preparation method:
A: take by weighing after Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Cnidii, the Radix Stemonae mix according to said ratio, add 6～12 times in water, decocts 3 times, decocted 1～2 hour at every turn, must three decoction liquor; Three decoction liquor are mixed, filter, leave standstill that to get supernatant concentration to proportion after 24～48 hours be 1.02～1.04, obtain Chinese medicine extraction liquid.
B:, obtain chlorhexidine acetate solution with an amount of dissolve with ethanol of chlorhexidine acetate; With the concentration of 0.08～0.2g/100ml chlorhexidine acetate solution is dissolved in the Chinese medicine extraction liquid that above-mentioned steps A makes, stirs, regulate pH value to 4.0～6.8, filter, thereby obtain high-efficient compound Radix Sophorae Flavescentis washing liquid with suitable test solution.
In above-mentioned preparation method, the used water yield is selected in to steps A, comprehensive energy savings and raising extraction efficiency are considered, the general used water yield is at least 6 times of used 4 flavor pharmaceutical decocting piece gross weights, the upper limit of institute's water consumption is controlled at 12 times of used 4 flavor pharmaceutical decocting piece gross weights is advisable.If the used water yield is very little, then the decoction extraction is insufficient, thereby influences drug effect, if but the water yield of usefulness is too many, and will cause the waste of water and can prolong decoction liquor extraction and concentration time, and cause the waste of the resource and the energy.In the selection to used decoction temperature in the steps A, be generally 80～100 ℃, be preferably 100 ℃.To decocting in the selection of number of times in the steps A, be generally 1～4 time, be preferably 3 times.Decoct at least and extract insufficient and influence drug effect if decoct number of times, but the decoction number of times is too many, can cause the waste of resource.In the selection to each decocting time in the steps A, be generally 1～3 hour, guaranteeing on the basis that effective ingredient fully extracts, preferred 1～2 hour, thus energy savings.
To leaving standstill in the steps A in the selection, be generally 24～72 hours, guaranteeing to shorten the production cycle under the abundant sedimentary prerequisite, preferred time of repose is 24～48 hours.To concentrating in the selection of final proportion in the steps A, be generally 1.01～1.05, preferably being concentrated into proportion is 1.02～1.04.
For the acid-base value that makes high-efficient compound Radix Sophorae Flavescentis washing liquid of the present invention within suitable physiological range, reduce stimulation to skin and affected part, add suitable acid-alkali accommodation test solution among the above-mentioned steps B, the kind of this adjusting test solution can be selected flexibly according to the acid-base value of preparation back solution, comprise hydrochloric acid solution, sodium hydroxide solution and some other strong acid weak base salts or strong base weak acid salt buffer, preferably regulate pH value to 4.0～6.8 with hydrochloric acid.
The invention has the beneficial effects as follows: high-efficient compound Radix Sophorae Flavescentis washing liquid bacteriostasis strong and nonirritant and side effect, and it is good to prevent and treat curative effect for a long time, drug effect significantly is better than simple Chinese medicine or Western medicine, be used for vagina flushing, men and women's pudendum cleaning and the nursing of men and women's daily hygiene, in particular for the external wash liquid of gynaecopathia.
The specific embodiment:
For the present invention is described in detail, be described further below in conjunction with specific embodiment,
Embodiment one
After taking by weighing Radix Sophorae Flavescentis 2kg, Cortex Phellodendri 0.1kg, Fructus Cnidii 5kg, Radix Stemonae 4kg mixing, add 10 times in water, decoct 3 times, decocted 2 hours at every turn, get three decoction liquor; Three decoction liquor are mixed, filter, leave standstill that to get supernatant concentration to proportion after 40 hours be 1.02, obtain Chinese medicine extraction liquid.
With an amount of dissolve with ethanol of chlorhexidine acetate, obtain chlorhexidine acetate solution, chlorhexidine acetate solution is added in the Chinese medicine extraction liquid, make and contain chlorhexidine acetate 0.14g/100ml in the solution that makes, stir, hydrochloric acid solution with 2mol/L is regulated pH value to 4.0～6.8, filters, and embedding gets final product.
Embodiment two
After taking by weighing Radix Sophorae Flavescentis 3kg, Cortex Phellodendri 0.2kg, Fructus Cnidii 6kg, Radix Stemonae 5kg mixing, add 11 times in water, decoct 3 times, decocted 2 hours at every turn, get three decoction liquor; Three decoction liquor are mixed, filter, leave standstill that to get supernatant concentration to proportion after 30 hours be 1.03, obtain Chinese medicine extraction liquid.
With an amount of dissolve with ethanol of chlorhexidine acetate, obtain chlorhexidine acetate solution, chlorhexidine acetate solution is added in the Chinese medicine extraction liquid, make and contain chlorhexidine acetate 0.14g/100ml in the solution that makes, stir, hydrochloric acid solution with 2mol/L is regulated pH value to 4.0～6.8, filters, and embedding gets final product.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in the foregoing description and the description only is preference of the present invention; be not used for limiting the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (6)
1. high-efficient compound Radix Sophorae Flavescentis washing liquid and preparation method thereof, it is characterized in that: form by the Chinese crude drug extracting solution with the cationic surface activity wide-spectrum bactericide that the concentration of 0.08～0.2g/100ml is dissolved in this extracting solution, described Chinese medicine extraction liquid is to adopt following crude drug to be prepared from:
(1) preparation of crude drug: according to following prescription weighting raw materials: 2～10 parts of Radix Sophorae Flavescentiss, 0.1～5 part of Cortex Phellodendri, 5～18 parts of Fructus Cnidiis, 4～22 parts of the Radixs Stemonae.
(2) preparation of decoction liquor: after Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Cnidii, the Radix Stemonae mixed according to said ratio, add 6～12 times in water, decocts 3 times, decocted 1～2 hour at every turn, must three decoction liquor;
(3) preparation of Chinese medicine extraction liquid: three decoction liquor are mixed, filter, leave standstill that to get supernatant concentration to proportion after 24～48 hours be 1.02～1.04, obtain Chinese medicine extraction liquid.
2. high-efficient compound Radix Sophorae Flavescentis washing liquid according to claim 1 and preparation method thereof is characterized in that, the proportioning of described crude drug is: 2～8 parts of Radix Sophorae Flavescentiss, 0.1～4 part of Cortex Phellodendri, 5～15 parts of Fructus Cnidiis, 4～18 parts of the Radixs Stemonae.
3. high-efficient compound Radix Sophorae Flavescentis washing liquid according to claim 1 and preparation method thereof is characterized in that, the best proportioning of described crude drug is: 2 parts of Radix Sophorae Flavescentiss, 0.1 part of Cortex Phellodendri, 5 parts of Fructus Cnidiis, 4 parts of the Radixs Stemonae.
4. high-efficient compound Radix Sophorae Flavescentis washing liquid according to claim 1 and preparation method thereof is characterized in that: described cationic surface activity wide-spectrum bactericide is domiphen bromide or chlorhexidine acetate.
5. according to the described high-efficient compound Radix Sophorae Flavescentis of claim 1～4 washing liquid and preparation method thereof, it is characterized in that: described high-efficient compound Radix Sophorae Flavescentis washing liquid can add hydrochloric acid solution or sodium hydroxide solution or some other strong acid weak base salt or strong base weak acid salt buffer adjusting pH value.
6. according to the described high-efficient compound Radix Sophorae Flavescentis of claim 1～4 washing liquid and preparation method thereof, it is characterized in that: described high-efficient compound Radix Sophorae Flavescentis washing liquid can also be made externally used paste, spray, gel, suppository.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526301A (en) * | 2011-12-30 | 2012-07-04 | 上海豪源生物制品有限公司 | Compound lightyellow sophora root-selinum japenious seed bacteriostatic lotion and preparation method thereof |
| CN102793832A (en) * | 2012-09-07 | 2012-11-28 | 江苏仁寿药业有限公司 | Novel micro-ecological modulator and preparation method thereof |
| CN103071092A (en) * | 2013-01-14 | 2013-05-01 | 山西大学 | Chinese medicine lotion for curing tinea of feet and hands |
| CN104984242A (en) * | 2015-07-08 | 2015-10-21 | 宁飞鹏 | Traditional Chinese medicine combination for treating gynecological diseases |
| CN105521385A (en) * | 2016-01-13 | 2016-04-27 | 山东康富森生物科技有限公司 | Gel for department of gynecology and preparation method of gel |
| CN105596683A (en) * | 2016-01-29 | 2016-05-25 | 山东益宝生物制品有限公司 | Gel for department of gynecology and preparation method thereof |
| CN106943494A (en) * | 2017-04-06 | 2017-07-14 | 湖南省健缘医疗科技有限公司 | Vagina cleaning bacteriostasis washing lotion and preparation method thereof |
| CN107519302A (en) * | 2016-06-21 | 2017-12-29 | 蒋秋萍 | A kind of external Chinese medicinal liquid for treating gynecological disease |
| CN112386662A (en) * | 2020-10-23 | 2021-02-23 | 安徽科治医疗科技有限公司 | Gynecological bacteriostatic temperature-sensitive gel and preparation method thereof |
| CN115414450A (en) * | 2022-09-19 | 2022-12-02 | 江西中科佰氏药业有限公司 | A topical skin antibacterial cream containing multiple Chinese medicinal materials and its preparation method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895602A (en) * | 2006-06-23 | 2007-01-17 | 范十足 | Externally-applied female effervescent tablet for preventing and treating gynecological disease |
-
2011
- 2011-05-10 CN CN201110120506.2A patent/CN102205078B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895602A (en) * | 2006-06-23 | 2007-01-17 | 范十足 | Externally-applied female effervescent tablet for preventing and treating gynecological disease |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526301A (en) * | 2011-12-30 | 2012-07-04 | 上海豪源生物制品有限公司 | Compound lightyellow sophora root-selinum japenious seed bacteriostatic lotion and preparation method thereof |
| CN102526301B (en) * | 2011-12-30 | 2014-02-12 | 上海豪源生物制品有限公司 | Compound lightyellow sophora root-selinum japenious seed bacteriostatic lotion and preparation method thereof |
| CN102793832A (en) * | 2012-09-07 | 2012-11-28 | 江苏仁寿药业有限公司 | Novel micro-ecological modulator and preparation method thereof |
| CN103071092A (en) * | 2013-01-14 | 2013-05-01 | 山西大学 | Chinese medicine lotion for curing tinea of feet and hands |
| CN104984242A (en) * | 2015-07-08 | 2015-10-21 | 宁飞鹏 | Traditional Chinese medicine combination for treating gynecological diseases |
| CN105521385A (en) * | 2016-01-13 | 2016-04-27 | 山东康富森生物科技有限公司 | Gel for department of gynecology and preparation method of gel |
| CN105596683A (en) * | 2016-01-29 | 2016-05-25 | 山东益宝生物制品有限公司 | Gel for department of gynecology and preparation method thereof |
| CN107519302A (en) * | 2016-06-21 | 2017-12-29 | 蒋秋萍 | A kind of external Chinese medicinal liquid for treating gynecological disease |
| CN106943494A (en) * | 2017-04-06 | 2017-07-14 | 湖南省健缘医疗科技有限公司 | Vagina cleaning bacteriostasis washing lotion and preparation method thereof |
| CN112386662A (en) * | 2020-10-23 | 2021-02-23 | 安徽科治医疗科技有限公司 | Gynecological bacteriostatic temperature-sensitive gel and preparation method thereof |
| CN115414450A (en) * | 2022-09-19 | 2022-12-02 | 江西中科佰氏药业有限公司 | A topical skin antibacterial cream containing multiple Chinese medicinal materials and its preparation method |
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| CN102205078B (en) | 2014-04-02 |
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