CN114288390A - Temperature-sensitive type female sanitary gel and preparation method thereof - Google Patents
Temperature-sensitive type female sanitary gel and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of gynecological care products, and particularly relates to a temperature-sensitive type gynecological sanitary gel and a preparation method thereof. The sanitary gel comprises poloxamer, disodium hydrogen phosphate, citric acid, chlorhexidine gluconate, fructus Cnidii extract, cortex Phellodendri extract, radix Sophorae Flavescentis extract and water, and is used for inhibiting bacteria and diminishing inflammation; the gel also comprises dendrobium nobile extract, oat extract, collagen, carboxymethyl chitosan and olive leaf extract, and can be further prepared into a sanitary gel for removing black and tightening skin; also comprises micromolecular sodium hyaluronate and chlorella extract, and can be further prepared into sanitary gel with repairing effect; the gel-like Chinese medicinal composition has strong adhesion, slow release of effective components, long action time, and good effects in inhibiting bacteria, relieving inflammation, and tightening, repairing and lubricating vagina mucosa and vulva skin.
Description
Technical Field
The invention belongs to the technical field of gynecological care products, and particularly relates to a temperature-sensitive type gynecological sanitary gel and a preparation method thereof.
Background
According to survey, more than 70% of Chinese women have gynecological troubles of different degrees, which are mainly manifested by symptoms of stinging, dryness, itching or peculiar smell of vagina or vulva, and even possibly serious symptoms of abdominal pain, waist soreness and the like, such as cervicitis. Gynecological inflammation brings inconvenience and adverse effects to normal life, family life, social contact and the like of vast women. Gynecological inflammation, particularly vulvitis and vaginitis have the characteristics of long and repeated disease course and difficulty in radical treatment, and the inflammation is mainly caused by the infection of pathogenic bacteria such as candida albicans, streptococcus, staphylococcus aureus, escherichia coli and other pathogens on the basis of a special open type upper reproductive structure of a female, so that the daily sanitary nursing in the private aspect of the female is an effective measure for preventing the gynecological inflammation.
Common gynecological nursing products, such as the common Fuyanjie, Jiaozan lotion, etc., are washed, and in addition, the gynecological nursing product is prepared into suppository, spray, gel, etc. Wherein, the lotion has the defects of low absorption and utilization rate, inconvenient use, short time-effect and the like; the suppository has the defects of foreign body sensation, incomplete absorption, shallow action part and the like; the spray has the defects of poor adhesion, incomplete absorption, easy pollution of foreign matters and the like; the gel has the defects of poor fluidity, difficult infiltration into the action part, incomplete absorption and the like. Thus, there is a need for a gynecological health care product that overcomes the above deficiencies.
Disclosure of Invention
In view of the above problems, the present invention aims to provide a temperature-sensitive sanitary gel for women and a preparation method thereof, wherein the obtained sanitary gel is deep into the vagina in a liquid form, is affected by body temperature to generate phase change, becomes a gel state, has strong adhesion, sustained release of active ingredients, long action time, effective inhibition of germs, inflammation elimination, protection of vulva and vaginal health, acts on vaginal mucosa and vulval skin according to different added traditional Chinese medicine extracts, and can also exert different functions of tightening, repairing, lubricating and the like.
The technical content of the invention is as follows:
the invention provides a temperature-sensitive sanitary gel for women, which comprises the components of poloxamer, disodium hydrogen phosphate, citric acid, chlorhexidine gluconate, a fructus cnidii extract, a cortex phellodendri extract, a radix sophorae flavescentis extract and water, and is used for inhibiting bacteria and diminishing inflammation;
the pH value of the sanitary gel is 4-4.5;
the poloxamer is poloxamer 407 and poloxamer 188, is in a low-viscosity fluid state at low temperature, and can be rapidly converted into semisolid gel at body temperature after being combined with vaginal mucosa. Poloxamer 407 and poloxamer 188 have good water solubility, and due to the hydrophobicity of the inner core and the hydrophilicity of the outer shell, the solubility in water is excellent;
the chlorhexidine gluconate is a disinfection preservative, has wide and strong bacteriostatic and bactericidal effects, has stronger antibacterial effects on gram-positive bacteria than gram-negative bacteria, is stronger than quaternary ammonium salt cationic surfactant, is also effective on fungi, but has no effect on acid-resistant bacteria, spores and viruses;
the fructus cnidii extract is prepared by the following steps: cleaning fructus cnidii, crushing to 400-500 meshes, and adding 3-5 times of fructus cnidii powder by volume ratio (1-3): (1-2) carrying out ultrasonic oscillation extraction for 1-2 h in a mixed solution of 50-70% ethanol and 50-70% methanol, filtering out insoluble substances to obtain a filtrate, concentrating the filtrate under reduced pressure in vacuum, and drying to obtain a common cnidium fruit extract, wherein the main chemical components of the common cnidium fruit extract comprise compounds such as coumarin, volatile oil, chromone, triterpene and the like, and the main active component is a coumarin compound mainly containing osthole, and the common cnidium fruit extract has various pharmacological activities such as anti-inflammatory, antioxidant, antibacterial itching relieving, neuroprotective effects and the like;
the preparation method of the phellodendron extract comprises the following steps: cleaning and crushing phellodendron amurense into 500-600 meshes, and adding 3-5 times of the volume ratio of (1-2): 2, performing ultrasonic oscillation extraction for 2-3 hours in a mixed solution of 80-90% ethanol and 50-60% 1, 2-propylene glycol, filtering out insoluble substances to obtain a filtrate, performing vacuum pressure reduction concentration on the filtrate, and drying to obtain a phellodendron extract, wherein the phellodendron extract has a unique curative effect on antibiosis and antiphlogosis and has an inhibiting effect on common human pathogenic bacteria such as staphylococcus aureus, meningococcus, bacillus anthracis, dysentery bacillus, diphtheria bacillus, tetanus bacillus, hemolytic streptococcus and the like;
the preparation of the sophora flavescens extract comprises the following steps: cleaning radix sophorae flavescentis, crushing the cleaned radix sophorae flavescentis into 500-600 meshes, and adding 3-5 times of radix sophorae flavescentis powder in a volume ratio of (1-2): 1, carrying out ultrasonic oscillation extraction for 1-2 h, filtering insoluble substances to obtain filtrate, concentrating the filtrate under vacuum and reduced pressure, and drying to obtain a sophora flavescens extract, wherein the main chemical components of the sophora flavescens extract are sophocarpidine and oxymatrine, and the sophocarpidine and the oxymatrine can promote apoptosis of proliferative scar fibroblasts of a human body, reduce proliferative activity of the proliferative scar fibroblasts of the human body and enable the proliferative scar fibroblasts to tend to a non-proliferative state; can also inhibit proliferation of fibroblast and collagen synthesis of hypertrophic scar, induce apoptosis and matrix metalloproteinase expression, prevent and treat hypertrophic scar, inhibit proliferation of skin cancer cell and induce apoptosis, and inhibit proliferation of epidermal keratinocyte and melanogenesis;
by mass, 10-20% of poloxamer 407, 3-10% of poloxamer 188, 1-1.5% of disodium hydrogen phosphate, 1.0-1.3% of citric acid, 0.05-0.1% of chlorhexidine gluconate, 0.2-0.8% of fructus cnidii extract, 0.01-3.6% of cortex phellodendri extract, 0.8-4.0% of radix sophorae flavescentis extract and water in balance to 100%;
wherein the content of the disodium hydrogen phosphate is preferably 1.06-1.29%, and the content of the citric acid is preferably 1.09-1.26%.
The components of the sanitary gel further comprise dendrobium nobile extract, oat extract, collagen, carboxymethyl chitosan and olive leaf extract under the basic formula, and the sanitary gel for removing black and tightening skin can be further prepared;
the dendrobium nobile lindl extract is prepared by the following steps: cleaning dendrobium nobile, crushing to 400-500 meshes, and adding 2-4 times of dendrobium nobile powder in a volume ratio of (1-3): (1-2) soaking in a mixed solution of 50-60% acetic acid and 40-50% ammonium cyanate for 2-3 h, then performing ultrasonic oscillation extraction for 1.5-2 h, filtering out insoluble substances to obtain a filtrate, performing vacuum pressure reduction concentration on the filtrate, and drying to obtain a dendrobium nobile extract, wherein the main components of the dendrobium nobile extract comprise alkaloids, polysaccharides, flavonoids, phenols, sesquiterpenes, coumarins and steroidal glycoside compounds, and the dendrobium nobile extract has the effects of moisturizing, delaying senescence, resisting oxidation and whitening, and dendrobium nobile polysaccharide has obvious bacteriostatic action on staphylococcus aureus, escherichia coli and pneumococcus, and dendrobium nobile polysaccharide has more obvious bacteriostatic action;
the oat extract mainly contains various antioxidant substances such as beta-glucan, flavonoid compounds, alkaloid and the like. The skin care product has excellent anti-aging and anti-oxidation effects, can smooth fine wrinkles, improve skin texture, increase skin activity, delay skin aging, and has the effects of whitening, moisturizing, reducing wrinkles and spots, resisting allergy, and the like;
the collagen is used as a high-quality natural polymer biological material, is rich in hydroxyproline, and has excellent moisturizing performance when being externally used; the collagen protein is used for wound surfaces, has biological characteristics of biocompatibility, hemostaticity, degradability and the like, can generate good interaction with tissues and cells, has the effects of promoting proliferation and differentiation of the cells and healing wounds, supplementing amino acids required by collagen synthesis and improving the elasticity and compactness of the tissues;
the molecular weight of the carboxymethyl chitosan is 8000-10000 Da;
the olive leaf extract is prepared by the following steps: cleaning olive leaves, then crushing to 500-600 meshes, adding 3-4 times of olive leaf powder in a volume ratio of 1: (1-2) carrying out ultrasonic oscillation extraction for 1-2 h in a mixed solution of 30-40% of sodium hydroxide and 60-70% of sodium citrate, filtering out insoluble substances to obtain a filtrate, concentrating the filtrate under vacuum and reducing pressure, and drying to obtain an olive leaf extract which contains flavonoids and oleanolic acid which are helpful for protecting skin and mucous membranes, stimulates connective tissues and normalizes the connective tissues, enhances the health of the skin and mucous membranes, prevents aging, has excellent oxidation resistance and free radical removal capability, and has a certain whitening effect;
the dendrobium nobile lindl extract comprises, by mass, 0.2-0.7% of dendrobium nobile lindl extract, 0.05-0.85% of oat extract, 1-10.0% of collagen, 0.05-1.5% of carboxymethyl chitosan, 0.01-3.6% of micromolecule hyaluronic acid, 1-15.0% of olive leaf extract and the balance of water to 100%.
The components of the sanitary gel further comprise micromolecular sodium hyaluronate and chlorella extract under the basic formula, and the sanitary gel with the repairing function can be further prepared;
the molecular weight of the micromolecular sodium hyaluronate is 600-1000 Da, and the micromolecular sodium hyaluronate has excellent effects of promoting wound healing and cell repair;
the preparation of the chlorella extract comprises the following steps: the chlorella is cleaned and then crushed to 600-800 meshes, 20-30% acetic acid solution is added to the chlorella, microwave digestion treatment is carried out, the chlorella is treated at 50-60 ℃ for 3-5 min, then extraction is carried out for 15-18 h, centrifugation is carried out, supernatant is taken and used for spray drying to form powder, and the chlorella extract is obtained, contains chlorella growth factor active ingredients, has the functions of regulating immunity, increasing resistance to diseases and promoting biological growth, is rich in polysaccharide, has good moisture retention and has the effect of conditioning skin;
according to the mass fraction, the small molecule sodium hyaluronate accounts for 13-30%, and the chlorella extract accounts for 13-30%.
The invention also provides a preparation method of the temperature-sensitive female sanitary gel, which comprises the following steps: and mixing poloxamer, disodium hydrogen phosphate, citric acid and water, keeping the temperature at 4-25 ℃ (preferably 25 ℃), stirring to fully swell the mixture, keeping the temperature unchanged, adding the rest raw materials at one time, and stirring uniformly to obtain a sanitary gel product, wherein the pH value of the obtained sanitary gel is 4.0-4.6.
Stirring to make it fully swell, maintaining the temperature unchanged, adding the rest raw materials at one time, and stirring uniformly to obtain the sanitary gel product.
The invention has the following beneficial effects:
the temperature-sensitive type sanitary gel for women adopts poloxamer as a gel matrix, has high bioavailability, can be completely absorbed, and has long action time; the prepared fructus cnidii extract is matched with the radix sophorae flavescentis extract, so that the effects of clearing heat, eliminating dampness and relieving itching can be enhanced, the combination of other traditional Chinese medicine extraction components and other auxiliary materials can be realized, and the synergistic effect is realized.
Detailed Description
The present invention is described in further detail in the following detailed description with reference to specific embodiments, which are intended to be illustrative only and not to be limiting of the scope of the invention, as various equivalent modifications of the invention will become apparent to those skilled in the art after reading the present invention and are intended to be included within the scope of the appended claims.
All the raw materials and reagents of the invention are conventional market raw materials and reagents unless otherwise specified.
Reagents used and provenance: poloxamer 407, poloxamer 188, basf china ltd; disodium hydrogen phosphate, guangzhou chemical reagent house; citric acid, manufactured by west longa science ltd; chlorhexidine gluconate, pharmaceutical chemical Limited, Wuhan La Na white; oat extract, sienna baichuan biotechnology limited; collagen, turnip lake Teffel biological products industry research institute, Inc.; carboxymethyl chitosan, shanxi zheng a pharmaceutical excipients ltd; small molecule sodium hyaluronate, Jiangsu Haihua Biotech limited.
Sterilizing related tools, preparing 1kg of gel material, weighing the raw materials according to the mass percentage of the formula, and preparing the gel material according to the following steps:
and mixing poloxamer, disodium hydrogen phosphate, citric acid and purified water, keeping the temperature at 4-25 ℃ (preferably 25 ℃), stirring to fully swell the mixture, keeping the temperature unchanged, adding the rest raw materials at one time, and stirring uniformly to obtain the sanitary gel product.
The ingredients and the dosage in the table 1 are prepared according to the above method to obtain the feminine hygiene gel of the examples 1-8, wherein the antibacterial and anti-inflammatory feminine hygiene gel of the basic formula of the examples 1-2, the black-removing and firming feminine hygiene gel of the examples 3-5, and the feminine hygiene gel with the repairing effect of the examples 6-8 are obtained.
Table 1 example composition formula
Wherein, the preparation of the fructus cnidii extract comprises the following steps: cleaning fructus cnidii, crushing to 400-500 meshes, and adding 3-5 times of fructus cnidii powder by volume ratio (1-3): (1-2) carrying out ultrasonic oscillation extraction for 1-2 h in a mixed solution of 50-70% ethanol and 50-70% methanol, filtering insoluble substances to obtain a filtrate, and carrying out vacuum reduced pressure concentration and drying on the filtrate to obtain a fructus cnidii extract;
TABLE 2 preparation of the Torilis fructus extract
The preparation method of the phellodendron extract comprises the following steps: cleaning and crushing phellodendron amurense into 500-600 meshes, and adding 3-5 times of the volume ratio of (1-2): 2, performing ultrasonic oscillation extraction for 2-3 hours in a mixed solution of 80-90% ethanol and 50-60% 1, 2-propylene glycol, filtering insoluble substances to obtain a filtrate, and performing vacuum concentration and drying on the filtrate to obtain a phellodendron extract;
TABLE 3 preparation of phellodendron extract
The preparation of the sophora flavescens extract comprises the following steps: cleaning radix sophorae flavescentis, crushing the cleaned radix sophorae flavescentis into 500-600 meshes, and adding 3-5 times of radix sophorae flavescentis powder in a volume ratio of (1-2): 1, and carrying out ultrasonic oscillation extraction for 1-2 h in a mixed solution of 50-60% ethanol and 60-70% sodium citrate, filtering insoluble substances to obtain a filtrate, and carrying out vacuum reduced pressure concentration and drying on the filtrate to obtain the sophora flavescens extract.
TABLE 4 preparation of Sophora flavescens Aiton extract
The dendrobium nobile lindl extract is prepared by the following steps: cleaning dendrobium nobile, crushing to 400-500 meshes, and adding 2-4 times of dendrobium nobile powder in a volume ratio of (1-3): (1-2) soaking the mixture of 50-60% acetic acid and 40-50% ammonium cyanate for 2-3 h, then carrying out ultrasonic oscillation extraction for 1.5-2 h, filtering out insoluble substances to obtain filtrate, and carrying out vacuum reduced pressure concentration and drying on the filtrate to obtain the dendrobium nobile extract;
TABLE 5 preparation of Dendrobium nobile extract
The molecular weight of the carboxymethyl chitosan is 8000-10000 Da;
the olive leaf extract is prepared by the following steps: cleaning olive leaves, then crushing to 500-600 meshes, adding 3-4 times of olive leaf powder in a volume ratio of 1: (1-2) carrying out ultrasonic oscillation extraction for 1-2 h in a mixed solution of 30-40% of sodium hydroxide and 60-70% of sodium citrate, filtering insoluble substances to obtain a filtrate, and carrying out vacuum reduced pressure concentration and drying on the filtrate to obtain the olive leaf extract.
TABLE 6 preparation of olive leaf extract
The molecular weight of the small-molecule sodium hyaluronate is 600-1000 Da.
The preparation of the chlorella extract comprises the following steps: washing chlorella, then crushing the chlorella to 600-800 meshes, adding 20-30% acetic acid solution, performing microwave digestion treatment, treating for 3-5 min at 50-60 ℃, then extracting for 15-18 h, centrifuging, taking supernatant, and performing spray drying to obtain powder to obtain the chlorella extract.
TABLE 7 preparation of Chlorella extract
The materials prepared above were replaced with the purchased materials for making comparative examples, and the raw materials and sources were: fructus Cnidii extract, available from Henan, New Biotech limited; phellodendron extract, sienna baichuan biotechnology ltd; sophora flavescens Aiton extract, New Biotech Co., Ltd., Henan; dendrobium nobile extract, new Biotech limited, Henan; olive leaf extract, chenopodium alpinum, kuan ji city, sanderian biological development limited; chlorella extract, Sansheng biological development Co., Ltd, Baoji City.
The formulation of the comparative example is shown in the table below:
TABLE 8 comparative example composition formula
Sterilizing related tools, preparing 1kg of gel body, weighing the raw materials according to the formula in percentage by mass, and preparing the gel body according to the following steps:
and mixing poloxamer, disodium hydrogen phosphate, citric acid and purified water, keeping the temperature at 4-25 ℃ (preferably 25 ℃), stirring to fully swell the mixture, keeping the temperature unchanged, adding the rest raw materials at one time, and stirring uniformly to obtain the sanitary gel product.
Of these, comparative examples 2, 5 and 8 were prepared as follows: all the raw materials are mixed and stirred uniformly, the temperature is raised to 32-38 ℃ (preferably 35 ℃), and the sanitary gel product is obtained after uniform stirring.
The above examples and comparative feminine hygiene gels were tested as follows:
1. microbial limit detection
The temperature-sensitive gels prepared in examples 1-8 were tested according to GB15979-2002 appendix B of hygienic Standard for Disposable sanitary articles, the microbiological test methods of the products, and the results are listed in Table 9.
TABLE 9 Table of the results of the microbial limit test in the examples
Therefore, the test results of the total bacterial colonies, the total fungal colonies, the coliform group, the staphylococcus aureus, the pseudomonas aeruginosa and the hemolytic streptococcus of the temperature-sensitive gel prepared in the embodiments 1 to 8 meet the requirements of GB15979 plus 2002 hygienic Standard for Disposable sanitary products.
2. Bacteriostasis test
According to appendix C4 of GB 15979-2002-hygienic standard for disposable sanitary products, the temperature-sensitive gel prepared according to the embodiment and the proportion of the invention respectively acts on staphylococcus aureus, escherichia coli and candida albicans for 10 minutes, and the test is repeated for 3 times to test the bacteriostasis effect. Test strains: staphylococcus aureus (ATCC6538), Escherichia coli (8099) and Candida albicans (ATCC10231) provided by food safety strain collection of food and microorganism safety engineering research and development center of Guangdong province, and all the 5 th generation fresh slant cultures were used for tests. Culture medium: nutrient agar medium, Sabouraud's agar medium. The inhibition data are shown in table 2, and the negative control shows aseptic growth.
TABLE 10 bacteriostatic test data sheet (average)
The result shows that the temperature-sensitive gel in the embodiment 1-3 of the invention has the average bacteriostasis rate of 99% to staphylococcus aureus, escherichia coli and candida albicans after being acted for 10min, and meets the requirement of more than 50% of the average bacteriostasis rate of GB15979-2002 'one-time sanitary article type biological standard'.
TABLE 11 comparative examples bacteriostatic test data sheet (average)
As can be seen from table 11, some of the raw materials and the preparation methods used in the sanitary gel of the comparative example are different from those of the examples, and the results show that the average bacteriostatic rates of the sanitary gel on staphylococcus aureus, escherichia coli and candida albicans are all different from those of the examples, and it can be seen that the preparation of the extract of the present invention is more critical to the effect of the sanitary gel;
the antibacterial effects of the comparative examples 2, 5 and 8 are remarkably reduced, because the raw materials are not swelled or dissolved uniformly due to the preparation at other temperatures, so that the effects of the components cannot be exerted, and therefore, in the preparation method of the temperature-sensitive gel, the temperature is 4-25 ℃, and the optimal temperature is 25 ℃.
3. Gelation temperature test of temperature-sensitive gels
The gelation temperature was determined by tube inversion, 2mL of the temperature sensitive gel of examples 1-8 was precisely transferred to a test tube, the test tube was placed in a constant temperature water bath (the liquid level in the test tube was below the water surface), the temperature rise rate was 0.5 ℃/min, the test temperature was 10-100 ℃, the temperature when the solution did not flow after inversion was recorded as the gelation temperature, 3 samples were run in parallel, see Table 12.
TABLE 12 example gelation temperature of temperature sensitive gels
Therefore, the average gelling temperature of the sanitary gel is within 35-36 ℃, when the sanitary gel acts on the pudendum, the sanitary gel can be in a gel state, the adhesion is strong, the effective components are slowly released, and the acting time is long.
4. Inhibition test of gel with effects of inhibiting bacteria, diminishing inflammation, removing black and tightening on tyrosinase
Taking L-tyrosine as a reaction substrate, setting four groups of sample solutions a, b, c and d shown in Table 13, respectively adding PBS buffer solution, 0.5 g/L-tyrosine solution and sample solutions with different concentrations, placing in a water bath at 37 ℃ for 10min, adding 100U/mL tyrosinase solution, mixing uniformly, placing in a water bath at 37 ℃ for reaction for 10min, quickly transferring into a cuvette, measuring absorbance values Aa, Ab, Ac and Ad at 475nm, and then calculating the inhibition rate of the sample solution on tyrosinase according to the following formula:
the inhibition rate was [1- (Ad-Ac)/(Ab-Aa) ] × 100%.
TABLE 13 composition of reaction solution (unit: mL)
TABLE 14 inhibition results
According to the calculation results, compared with comparative example 4 and comparative example 5, the sample liquid in example 3 has a remarkable inhibition effect on tyrosinase, and the inhibition rate is 64.31%, which shows that the dendrobium nobile extract and the olive leaf extract prepared by the invention have synergistic and auxiliary effects on whitening and blackening of the temperature-sensitive gel for inhibiting bacteria, diminishing inflammation, blackening and compacting, and have remarkable effects.
Claims (10)
1. A temperature-sensitive sanitary gel for women is characterized in that the components of the sanitary gel comprise poloxamer, disodium hydrogen phosphate, citric acid, chlorhexidine gluconate, fructus cnidii extract, cortex phellodendri extract, radix sophorae flavescentis extract and water;
the pH value of the sanitary gel is 4-4.5.
2. The temperature-sensitive feminine hygiene gel according to claim 1, wherein the cnidium monnieri extract is prepared by: cleaning fructus cnidii, crushing to 400-500 meshes, and adding 3-5 times of fructus cnidii powder by volume ratio (1-3): (1-2) carrying out ultrasonic oscillation extraction for 1-2 h in a mixed solution of 50-70% ethanol and 50-70% methanol, filtering insoluble substances to obtain a filtrate, and carrying out vacuum reduced pressure concentration and drying on the filtrate to obtain a fructus cnidii extract;
the preparation method of the phellodendron extract comprises the following steps: cleaning and crushing phellodendron amurense into 500-600 meshes, and adding 3-5 times of the volume ratio of (1-2): 2, performing ultrasonic oscillation extraction for 2-3 hours in a mixed solution of 80-90% ethanol and 50-60% 1, 2-propylene glycol, filtering insoluble substances to obtain a filtrate, and performing vacuum concentration and drying on the filtrate to obtain a phellodendron extract;
the preparation of the sophora flavescens extract comprises the following steps: cleaning radix sophorae flavescentis, crushing the cleaned radix sophorae flavescentis into 500-600 meshes, and adding 3-5 times of radix sophorae flavescentis powder in a volume ratio of (1-2): 1, and carrying out ultrasonic oscillation extraction for 1-2 h in a mixed solution of 50-60% ethanol and 60-70% sodium citrate, filtering insoluble substances to obtain a filtrate, and carrying out vacuum reduced pressure concentration and drying on the filtrate to obtain the sophora flavescens extract.
3. The temperature-sensitive feminine hygiene gel according to claim 1, wherein the temperature-sensitive feminine hygiene gel comprises 13 to 30% of poloxamer, 1 to 1.5% of disodium hydrogen phosphate, 1.0 to 1.3% of citric acid, 0.05 to 0.1% of chlorhexidine gluconate, 0.2 to 0.8% of fructus cnidii extract, 0.01 to 3.6% of cortex phellodendri extract, 0.8 to 4.0% of radix sophorae flavescentis extract, and water to 100% by mass.
4. The temperature-sensitive feminine hygiene gel according to claim 1, wherein the components of said hygiene gel further comprise dendrobium nobile lindl extract, oat extract, collagen, carboxymethyl chitosan, olive leaf extract.
5. The temperature-sensitive feminine hygiene gel according to claim 4, wherein the Dendrobium nobile extract is prepared by: cleaning dendrobium nobile, crushing to 400-500 meshes, and adding 2-4 times of dendrobium nobile powder in a volume ratio of (1-3): (1-2) soaking the mixture of 50-60% acetic acid and 40-50% ammonium cyanate for 2-3 h, then carrying out ultrasonic oscillation extraction for 1.5-2 h, filtering out insoluble substances to obtain filtrate, and carrying out vacuum reduced pressure concentration and drying on the filtrate to obtain the dendrobium nobile extract;
the molecular weight of the carboxymethyl chitosan is 8000-10000 Da;
the olive leaf extract is prepared by the following steps: cleaning olive leaves, then crushing to 500-600 meshes, adding 3-4 times of olive leaf powder in a volume ratio of 1: (1-2) carrying out ultrasonic oscillation extraction for 1-2 h in a mixed solution of 30-40% of sodium hydroxide and 60-70% of sodium citrate, filtering insoluble substances to obtain a filtrate, and carrying out vacuum reduced pressure concentration and drying on the filtrate to obtain the olive leaf extract.
6. The temperature-sensitive feminine hygiene gel according to claim 4, wherein the dendrobium nobile extract accounts for 0.2-0.7% by mass, the oat extract accounts for 0.05-0.85% by mass, the collagen accounts for 1-10.0% by mass, the carboxymethyl chitosan accounts for 0.05-1.5% by mass, the small molecular hyaluronic acid accounts for 0.01-3.6% by mass, the olive leaf extract accounts for 1-15.0% by mass, and the balance of water is 100%.
7. The temperature-sensitive feminine hygiene gel of claim 1, wherein the components of the hygiene gel further comprise small molecule sodium hyaluronate, chlorella extract;
the molecular weight of the small-molecule sodium hyaluronate is 600-1000 Da.
8. The temperature-sensitive feminine hygiene gel according to claim 7, wherein the chlorella extract is prepared by: washing chlorella, then crushing the chlorella to 600-800 meshes, adding 20-30% acetic acid solution, performing microwave digestion treatment, treating for 3-5 min at 50-60 ℃, then extracting for 15-18 h, centrifuging, taking supernatant, and performing spray drying to obtain powder to obtain the chlorella extract.
9. The temperature-sensitive feminine hygiene gel according to claim 7, wherein the small-molecule sodium hyaluronate comprises 13-30% and the chlorella vulgaris extract comprises 13-30% by mass.
10. A method for preparing a temperature-sensitive feminine hygiene gel according to any one of claims 1 to 9, comprising the steps of: and mixing poloxamer, disodium hydrogen phosphate, citric acid and water, keeping the temperature at 4-25 ℃, stirring to fully swell the mixture, keeping the temperature unchanged, adding the rest raw materials at one time, and stirring uniformly to obtain the sanitary gel product.
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