CN112384218B - 盐和晶体 - Google Patents

盐和晶体 Download PDF

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Publication number
CN112384218B
CN112384218B CN201980045584.5A CN201980045584A CN112384218B CN 112384218 B CN112384218 B CN 112384218B CN 201980045584 A CN201980045584 A CN 201980045584A CN 112384218 B CN112384218 B CN 112384218B
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China
Prior art keywords
iti
salt
tosylate
free base
sulfonic acid
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CN201980045584.5A
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Chinese (zh)
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CN112384218A (zh
Inventor
李鹏
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Intra Cellular Therapies Inc
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Intra Cellular Therapies Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201980045584.5A 2018-06-06 2019-06-06 盐和晶体 Active CN112384218B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862681534P 2018-06-06 2018-06-06
US62/681,534 2018-06-06
PCT/US2019/035845 WO2019236889A1 (en) 2018-06-06 2019-06-06 Novel salts and crystals

Publications (2)

Publication Number Publication Date
CN112384218A CN112384218A (zh) 2021-02-19
CN112384218B true CN112384218B (zh) 2024-04-26

Family

ID=68769581

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980045584.5A Active CN112384218B (zh) 2018-06-06 2019-06-06 盐和晶体

Country Status (11)

Country Link
US (2) US20200157100A1 (enExample)
EP (1) EP3628007B1 (enExample)
JP (1) JP7476115B2 (enExample)
KR (1) KR102888393B1 (enExample)
CN (1) CN112384218B (enExample)
AU (1) AU2019280850C1 (enExample)
BR (1) BR112020024885A2 (enExample)
CA (1) CA3102848A1 (enExample)
IL (2) IL321985A (enExample)
MX (1) MX2020013116A (enExample)
WO (1) WO2019236889A1 (enExample)

Families Citing this family (17)

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US9428506B2 (en) 2012-04-14 2016-08-30 Intra-Cellular Therapies, Inc. Substituted pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines for the treatment of nervous system disorders
HUE057055T2 (hu) 2016-08-09 2022-04-28 Teva Pharmaceuticals Int Gmbh Lumateperon-ditozilátsó szilárd halmazállapotú formái
JP7013454B2 (ja) 2016-10-12 2022-02-15 イントラ－セルラー・セラピーズ・インコーポレイテッド アモルファス固体分散体
EP3600325A4 (en) 2017-03-24 2021-01-06 Intra-Cellular Therapies, Inc. UNIQUE COMPOSITIONS AND PROCESSES
WO2019067591A1 (en) 2017-09-26 2019-04-04 Intra-Cellular Therapies, Inc. NEW SALTS AND CRYSTALS
WO2019178484A1 (en) 2018-03-16 2019-09-19 Intra-Cellular Therapies, Inc. Novel methods
SMT202600133T1 (it) 2018-03-23 2026-05-12 Intra Cellular Therapies Inc Composti organici
RS67906B1 (sr) * 2018-06-11 2026-04-30 Intra Cellular Therapies Inc Sinteza supstituisanih heterociklično fuzionisanih gama-karbolina
AU2019328528B2 (en) 2018-08-31 2025-01-23 Intra-Cellular Therapies, Inc. Novel methods
WO2020047408A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
EP4134101A1 (en) 2019-07-07 2023-02-15 Intra-Cellular Therapies, Inc. Deuterated lumateperone for the treatment of the bipolar ii disorder
JP2022549335A (ja) 2019-09-25 2022-11-24 イントラ－セルラー・セラピーズ・インコーポレイテッド 新規方法
WO2021119334A1 (en) 2019-12-11 2021-06-17 Intra-Cellular Therapies, Inc. Organic compound
IL300886A (en) * 2020-09-04 2023-04-01 Intra Cellular Therapies Inc New salts, crystals and co-crystals
TWI918905B (zh) * 2021-03-26 2026-03-21 大陸商上海雲晟研新生物科技股份有限公司 盧美哌隆藥用鹽、製備方法、含其的藥物組合物及應用
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
US20250352469A1 (en) 2024-05-16 2025-11-20 Intra-Cellular Therapies, Inc. Novel compositions, devices, and methods

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CN102046175A (zh) * 2008-03-12 2011-05-04 细胞内治疗公司 取代的杂环稠合的γ-咔啉固体
CN106535898A (zh) * 2014-04-04 2017-03-22 细胞内治疗公司 有机化合物
WO2017172784A1 (en) * 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel salts and crystals
WO2018031535A1 (en) * 2016-08-09 2018-02-15 Assia Chemical Industries Ltd. Solid state forms of lumateperone ditosylate salt

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AU2019280850C1 (en) 2025-02-13
JP7476115B2 (ja) 2024-04-30
IL279195B1 (en) 2025-08-01
MX2020013116A (es) 2021-05-12
BR112020024885A2 (pt) 2021-03-09
AU2019280850A1 (en) 2021-01-07
CA3102848A1 (en) 2019-12-12
JP2021527043A (ja) 2021-10-11
KR102888393B1 (ko) 2025-11-18
IL321985A (en) 2025-09-01
EP3628007B1 (en) 2023-05-03
CN112384218A (zh) 2021-02-19
IL279195A (en) 2021-01-31
EP3628007A4 (en) 2020-05-20
KR20210018440A (ko) 2021-02-17
EP3628007A1 (en) 2020-04-01
US20220281867A1 (en) 2022-09-08
US12195464B2 (en) 2025-01-14
AU2019280850B2 (en) 2024-08-08
US20200157100A1 (en) 2020-05-21
IL279195B2 (en) 2025-12-01
WO2019236889A1 (en) 2019-12-12

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