AU2019280850C1 - Novel salts and crystals - Google Patents

Novel salts and crystals Download PDF

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Publication number
AU2019280850C1
AU2019280850C1 AU2019280850A AU2019280850A AU2019280850C1 AU 2019280850 C1 AU2019280850 C1 AU 2019280850C1 AU 2019280850 A AU2019280850 A AU 2019280850A AU 2019280850 A AU2019280850 A AU 2019280850A AU 2019280850 C1 AU2019280850 C1 AU 2019280850C1
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AU
Australia
Prior art keywords
salt
iti
free base
tosylate
toluenesulfonic acid
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AU2019280850A
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AU2019280850B2 (en
AU2019280850A1 (en
Inventor
Peng Li
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Intra Cellular Therapies Inc
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Intra Cellular Therapies Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2019280850A 2018-06-06 2019-06-06 Novel salts and crystals Active AU2019280850C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862681534P 2018-06-06 2018-06-06
US62/681,534 2018-06-06
PCT/US2019/035845 WO2019236889A1 (en) 2018-06-06 2019-06-06 Novel salts and crystals

Publications (3)

Publication Number Publication Date
AU2019280850A1 AU2019280850A1 (en) 2021-01-07
AU2019280850B2 AU2019280850B2 (en) 2024-08-08
AU2019280850C1 true AU2019280850C1 (en) 2025-02-13

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019280850A Active AU2019280850C1 (en) 2018-06-06 2019-06-06 Novel salts and crystals

Country Status (11)

Country Link
US (2) US20200157100A1 (enExample)
EP (1) EP3628007B1 (enExample)
JP (1) JP7476115B2 (enExample)
KR (1) KR102888393B1 (enExample)
CN (1) CN112384218B (enExample)
AU (1) AU2019280850C1 (enExample)
BR (1) BR112020024885A2 (enExample)
CA (1) CA3102848A1 (enExample)
IL (2) IL321985A (enExample)
MX (1) MX2020013116A (enExample)
WO (1) WO2019236889A1 (enExample)

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PL3497104T3 (pl) 2016-08-09 2022-02-21 Teva Pharmaceuticals International Gmbh Postacie w stanie stałym soli ditosylanowej lumateperonu
EP3525763B1 (en) 2016-10-12 2025-03-05 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
RU2767410C2 (ru) 2017-03-24 2022-03-17 Интра-Селлулар Терапиз, Инк. Новые композиции и способы
US11440911B2 (en) 2017-09-26 2022-09-13 Intra-Cellular Therapies, Inc. Salts and crystals
WO2019178484A1 (en) 2018-03-16 2019-09-19 Intra-Cellular Therapies, Inc. Novel methods
CA3240552A1 (en) * 2018-06-11 2019-12-19 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines synthesis
WO2020047408A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
BR112021003655A2 (pt) 2018-08-31 2021-05-18 Intra-Cellular Therapies, Inc. métodos novos
WO2021007245A1 (en) * 2019-07-07 2021-01-14 Intra-Cellular Therapies, Inc. Novel methods
US12478623B2 (en) 2019-09-25 2025-11-25 Intra-Cellular Therapies, Inc. Methods of treating central nervous system disorders comprising administering lumateperone and a nitric oxide donor
EP4072554A4 (en) 2019-12-11 2023-12-20 Intra-Cellular Therapies, Inc. ORGANIC CONNECTION
IL300886A (en) * 2020-09-04 2023-04-01 Intra Cellular Therapies Inc New salts, crystals and co-crystals
CN115120593A (zh) * 2021-03-26 2022-09-30 上海博志研新药物技术有限公司 卢美哌隆药用盐、制备方法、含其的药物组合物及应用
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
US20250352469A1 (en) 2024-05-16 2025-11-20 Intra-Cellular Therapies, Inc. Novel compositions, devices, and methods

Citations (2)

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Publication number Priority date Publication date Assignee Title
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WO2019102240A1 (en) * 2017-11-27 2019-05-31 Egis Gyógyszergyár Zrt. Method for the manufacture of lumateperone and its salts

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Also Published As

Publication number Publication date
KR20210018440A (ko) 2021-02-17
MX2020013116A (es) 2021-05-12
IL279195B1 (en) 2025-08-01
CN112384218B (zh) 2024-04-26
WO2019236889A1 (en) 2019-12-12
JP7476115B2 (ja) 2024-04-30
IL321985A (en) 2025-09-01
US12195464B2 (en) 2025-01-14
EP3628007A4 (en) 2020-05-20
AU2019280850B2 (en) 2024-08-08
IL279195A (en) 2021-01-31
AU2019280850A1 (en) 2021-01-07
EP3628007B1 (en) 2023-05-03
JP2021527043A (ja) 2021-10-11
CN112384218A (zh) 2021-02-19
CA3102848A1 (en) 2019-12-12
IL279195B2 (en) 2025-12-01
EP3628007A1 (en) 2020-04-01
US20200157100A1 (en) 2020-05-21
US20220281867A1 (en) 2022-09-08
KR102888393B1 (ko) 2025-11-18
BR112020024885A2 (pt) 2021-03-09

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