IL321985A - New salts and crystals - Google Patents

New salts and crystals

Info

Publication number
IL321985A
IL321985A IL321985A IL32198525A IL321985A IL 321985 A IL321985 A IL 321985A IL 321985 A IL321985 A IL 321985A IL 32198525 A IL32198525 A IL 32198525A IL 321985 A IL321985 A IL 321985A
Authority
IL
Israel
Prior art keywords
salt
iti
less
free base
toluenesulfonic acid
Prior art date
Application number
IL321985A
Other languages
English (en)
Hebrew (he)
Original Assignee
Intra Cellular Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intra Cellular Therapies Inc filed Critical Intra Cellular Therapies Inc
Publication of IL321985A publication Critical patent/IL321985A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL321985A 2018-06-06 2019-06-06 New salts and crystals IL321985A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862681534P 2018-06-06 2018-06-06
PCT/US2019/035845 WO2019236889A1 (en) 2018-06-06 2019-06-06 Novel salts and crystals

Publications (1)

Publication Number Publication Date
IL321985A true IL321985A (en) 2025-09-01

Family

ID=68769581

Family Applications (2)

Application Number Title Priority Date Filing Date
IL321985A IL321985A (en) 2018-06-06 2019-06-06 New salts and crystals
IL279195A IL279195B2 (en) 2018-06-06 2019-06-06 A method of making bis-tosylate salt of lumateparone

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL279195A IL279195B2 (en) 2018-06-06 2019-06-06 A method of making bis-tosylate salt of lumateparone

Country Status (11)

Country Link
US (2) US20200157100A1 (enExample)
EP (1) EP3628007B1 (enExample)
JP (1) JP7476115B2 (enExample)
KR (1) KR102888393B1 (enExample)
CN (1) CN112384218B (enExample)
AU (1) AU2019280850C1 (enExample)
BR (1) BR112020024885A2 (enExample)
CA (1) CA3102848A1 (enExample)
IL (2) IL321985A (enExample)
MX (1) MX2020013116A (enExample)
WO (1) WO2019236889A1 (enExample)

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EP3600325A4 (en) 2017-03-24 2021-01-06 Intra-Cellular Therapies, Inc. UNIQUE COMPOSITIONS AND PROCESSES
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SMT202600133T1 (it) 2018-03-23 2026-05-12 Intra Cellular Therapies Inc Composti organici
RS67906B1 (sr) * 2018-06-11 2026-04-30 Intra Cellular Therapies Inc Sinteza supstituisanih heterociklično fuzionisanih gama-karbolina
AU2019328528B2 (en) 2018-08-31 2025-01-23 Intra-Cellular Therapies, Inc. Novel methods
WO2020047408A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
EP4134101A1 (en) 2019-07-07 2023-02-15 Intra-Cellular Therapies, Inc. Deuterated lumateperone for the treatment of the bipolar ii disorder
JP2022549335A (ja) 2019-09-25 2022-11-24 イントラ－セルラー・セラピーズ・インコーポレイテッド 新規方法
WO2021119334A1 (en) 2019-12-11 2021-06-17 Intra-Cellular Therapies, Inc. Organic compound
IL300886A (en) * 2020-09-04 2023-04-01 Intra Cellular Therapies Inc New salts, crystals and co-crystals
TWI918905B (zh) * 2021-03-26 2026-03-21 大陸商上海雲晟研新生物科技股份有限公司 盧美哌隆藥用鹽、製備方法、含其的藥物組合物及應用
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
US20250352469A1 (en) 2024-05-16 2025-11-20 Intra-Cellular Therapies, Inc. Novel compositions, devices, and methods

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Also Published As

Publication number Publication date
AU2019280850C1 (en) 2025-02-13
JP7476115B2 (ja) 2024-04-30
IL279195B1 (en) 2025-08-01
MX2020013116A (es) 2021-05-12
BR112020024885A2 (pt) 2021-03-09
AU2019280850A1 (en) 2021-01-07
CA3102848A1 (en) 2019-12-12
JP2021527043A (ja) 2021-10-11
KR102888393B1 (ko) 2025-11-18
EP3628007B1 (en) 2023-05-03
CN112384218B (zh) 2024-04-26
CN112384218A (zh) 2021-02-19
IL279195A (en) 2021-01-31
EP3628007A4 (en) 2020-05-20
KR20210018440A (ko) 2021-02-17
EP3628007A1 (en) 2020-04-01
US20220281867A1 (en) 2022-09-08
US12195464B2 (en) 2025-01-14
AU2019280850B2 (en) 2024-08-08
US20200157100A1 (en) 2020-05-21
IL279195B2 (en) 2025-12-01
WO2019236889A1 (en) 2019-12-12

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