HUE057055T2 - Lumateperon-ditozilátsó szilárd halmazállapotú formái - Google Patents

Lumateperon-ditozilátsó szilárd halmazállapotú formái

Info

Publication number
HUE057055T2
HUE057055T2 HUE17754571A HUE17754571A HUE057055T2 HU E057055 T2 HUE057055 T2 HU E057055T2 HU E17754571 A HUE17754571 A HU E17754571A HU E17754571 A HUE17754571 A HU E17754571A HU E057055 T2 HUE057055 T2 HU E057055T2
Authority
HU
Hungary
Prior art keywords
lumateperone
solid state
state forms
ditosylate salt
ditosylate
Prior art date
Application number
HUE17754571A
Other languages
English (en)
Inventor
Ariel Mittelman
Ido Fuchs
Sharona Shachantov
Doron Rudik
Rotem Sella-Erez
Original Assignee
Teva Pharmaceuticals Int Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceuticals Int Gmbh filed Critical Teva Pharmaceuticals Int Gmbh
Publication of HUE057055T2 publication Critical patent/HUE057055T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/28Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HUE17754571A 2016-08-09 2017-08-08 Lumateperon-ditozilátsó szilárd halmazállapotú formái HUE057055T2 (hu)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662372553P 2016-08-09 2016-08-09
US201662382479P 2016-09-01 2016-09-01
US201662382977P 2016-09-02 2016-09-02
US201662400358P 2016-09-27 2016-09-27
US201762486554P 2017-04-18 2017-04-18

Publications (1)

Publication Number Publication Date
HUE057055T2 true HUE057055T2 (hu) 2022-04-28

Family

ID=59656224

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE17754571A HUE057055T2 (hu) 2016-08-09 2017-08-08 Lumateperon-ditozilátsó szilárd halmazállapotú formái

Country Status (9)

Country Link
US (3) US11332469B2 (hu)
EP (2) EP3497104B1 (hu)
ES (1) ES2901375T3 (hu)
HR (1) HRP20211666T1 (hu)
HU (1) HUE057055T2 (hu)
IL (1) IL264521A (hu)
PL (1) PL3497104T3 (hu)
SI (1) SI3497104T1 (hu)
WO (1) WO2018031535A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018031535A1 (en) * 2016-08-09 2018-02-15 Assia Chemical Industries Ltd. Solid state forms of lumateperone ditosylate salt
WO2018071233A1 (en) 2016-10-12 2018-04-19 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
BR112019019875A2 (pt) 2017-03-24 2020-04-22 Intra Cellular Therapies Inc novas composições e métodos
CN110636845A (zh) 2017-04-10 2019-12-31 雷迪博士实验室有限公司 卢美哌隆对甲苯磺酸盐的无定形形式和固体分散体
EP3687535A4 (en) 2017-09-26 2021-06-09 Intra-Cellular Therapies, Inc. NOVEL SALT AND CRYSTALS
US11655251B2 (en) 2017-11-27 2023-05-23 Egis Gyogyszergyar Zrt. Method for the production of lumateperone and its salts
WO2019178484A1 (en) * 2018-03-16 2019-09-19 Intra-Cellular Therapies, Inc. Novel methods
CN112384218B (zh) * 2018-06-06 2024-04-26 细胞内治疗公司 盐和晶体
KR20210031455A (ko) * 2018-06-11 2021-03-19 인트라-셀룰라 써래피스, 인코퍼레이티드. 치환된 헤테로환 융합 감마-카르볼린 합성
US10695345B2 (en) * 2018-08-31 2020-06-30 Intra-Cellular Therapies, Inc. Pharmaceutical capsule compositions comprising lumateperone mono-tosylate
WO2020047407A1 (en) * 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
WO2020112941A2 (en) 2018-11-27 2020-06-04 Teva Czech Industries S.R.O Solid state forms of lumateperone salts and processes for preparation of lumateperone and salts thereof
EP3893878A4 (en) * 2018-12-14 2022-08-17 Intra-Cellular Therapies, Inc. AMORPHOUS SOLID DISPERSIONS
EP3993798A4 (en) * 2019-07-07 2023-04-26 Intra-Cellular Therapies, Inc. NOVEL PROCESSES
WO2022195500A1 (en) * 2021-03-16 2022-09-22 Ami Organics Ltd. A process for the preparation of lumateperone tosylate intermediate
WO2024030835A2 (en) * 2022-07-30 2024-02-08 Intra-Cellular Therapies, Inc. Novel salts and crystals

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101796051B (zh) 2007-03-12 2013-11-06 细胞内治疗公司 与取代的杂环稠合的γ-咔啉的合成
MX2010010024A (es) 2008-03-12 2010-11-09 Intra Cellular Therapies Inc Solido de gamma-carbolinas fusionadas con heterociclos substituidos.
WO2012071425A1 (en) 2010-11-22 2012-05-31 Teva Pharmaceutical Industries Ltd. Solid state forms of sorafenib besylate, and processes for preparations thereof
EP3436016B1 (en) 2016-03-28 2022-04-27 Intra-Cellular Therapies, Inc. Novel co-crystals
WO2017172784A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel salts and crystals
WO2018031535A1 (en) * 2016-08-09 2018-02-15 Assia Chemical Industries Ltd. Solid state forms of lumateperone ditosylate salt
BR112019019875A2 (pt) 2017-03-24 2020-04-22 Intra Cellular Therapies Inc novas composições e métodos
US11655251B2 (en) 2017-11-27 2023-05-23 Egis Gyogyszergyar Zrt. Method for the production of lumateperone and its salts
CN112384218B (zh) 2018-06-06 2024-04-26 细胞内治疗公司 盐和晶体
KR20210031455A (ko) 2018-06-11 2021-03-19 인트라-셀룰라 써래피스, 인코퍼레이티드. 치환된 헤테로환 융합 감마-카르볼린 합성
US20210315891A1 (en) 2018-08-29 2021-10-14 Intra-Cellular Therapies, Inc. Novel compositions and methods
WO2020047407A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
US10695345B2 (en) 2018-08-31 2020-06-30 Intra-Cellular Therapies, Inc. Pharmaceutical capsule compositions comprising lumateperone mono-tosylate
WO2020112941A2 (en) 2018-11-27 2020-06-04 Teva Czech Industries S.R.O Solid state forms of lumateperone salts and processes for preparation of lumateperone and salts thereof

Also Published As

Publication number Publication date
US11332469B2 (en) 2022-05-17
PL3497104T3 (pl) 2022-02-21
US20230382914A1 (en) 2023-11-30
US11760757B2 (en) 2023-09-19
WO2018031535A1 (en) 2018-02-15
ES2901375T3 (es) 2022-03-22
EP3497104B1 (en) 2021-10-06
HRP20211666T1 (hr) 2022-02-18
IL264521A (en) 2019-05-30
EP4001281A1 (en) 2022-05-25
SI3497104T1 (sl) 2021-12-31
US20190211015A1 (en) 2019-07-11
EP3497104A1 (en) 2019-06-19
US20220127268A1 (en) 2022-04-28

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