CN112272675A - Bcma结合抗体及其用途 - Google Patents

Bcma结合抗体及其用途 Download PDF

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Publication number
CN112272675A
CN112272675A CN201980027397.4A CN201980027397A CN112272675A CN 112272675 A CN112272675 A CN 112272675A CN 201980027397 A CN201980027397 A CN 201980027397A CN 112272675 A CN112272675 A CN 112272675A
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China
Prior art keywords
seq
antibody
bcma
cell
polypeptide
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CN201980027397.4A
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English (en)
Chinese (zh)
Inventor
马汉·阿巴西恩
亨利·陈
坎德萨米·哈里哈兰
孙正勋
安德鲁·维尔姆泽
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Celgene Corp
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Celgene Corp
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Publication of CN112272675A publication Critical patent/CN112272675A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201980027397.4A 2018-02-21 2019-02-20 Bcma结合抗体及其用途 Pending CN112272675A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862633152P 2018-02-21 2018-02-21
US62/633,152 2018-02-21
PCT/US2019/018698 WO2019164891A1 (en) 2018-02-21 2019-02-20 Bcma-binding antibodies and uses thereof

Publications (1)

Publication Number Publication Date
CN112272675A true CN112272675A (zh) 2021-01-26

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Family Applications (1)

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US (2) US11401336B2 (https=)
EP (1) EP3755718A1 (https=)
JP (1) JP2021514193A (https=)
KR (1) KR20200123155A (https=)
CN (1) CN112272675A (https=)
AR (1) AR115257A1 (https=)
AU (1) AU2019223076A1 (https=)
BR (1) BR112020017053A2 (https=)
CA (1) CA3092037A1 (https=)
EA (1) EA202091974A1 (https=)
IL (1) IL276548A (https=)
MX (1) MX2020008718A (https=)
SG (1) SG11202007495SA (https=)
TW (1) TW202000701A (https=)
WO (1) WO2019164891A1 (https=)

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AU2022207648A1 (en) 2021-01-13 2023-07-27 Monte Rosa Therapeutics Ag Isoindolinone compounds
US20250276092A1 (en) * 2024-03-01 2025-09-04 Regeneron Pharmaceuticals, Inc. Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response
WO2026072671A1 (en) 2024-09-24 2026-04-02 City Of Hope Methods comprising oncolytic viruses expressing bcmat and bcma-targeted therapies
WO2026072709A1 (en) 2024-09-25 2026-04-02 Orna Therapeutics, Inc. Chimeric antigen receptors targeting bcma

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Also Published As

Publication number Publication date
US20220324991A1 (en) 2022-10-13
US11401336B2 (en) 2022-08-02
WO2019164891A9 (en) 2020-09-17
JP2021514193A (ja) 2021-06-10
BR112020017053A2 (pt) 2020-12-15
MX2020008718A (es) 2020-12-07
EA202091974A1 (ru) 2020-12-08
AU2019223076A1 (en) 2020-10-08
TW202000701A (zh) 2020-01-01
WO2019164891A1 (en) 2019-08-29
AR115257A1 (es) 2020-12-16
US20200399386A1 (en) 2020-12-24
KR20200123155A (ko) 2020-10-28
EP3755718A1 (en) 2020-12-30
IL276548A (en) 2020-09-30
CA3092037A1 (en) 2019-08-29
SG11202007495SA (en) 2020-09-29

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Application publication date: 20210126