CN112272674A - 抗-il-36r抗体用于治疗泛发性脓疱性银屑病的用途 - Google Patents

抗-il-36r抗体用于治疗泛发性脓疱性银屑病的用途 Download PDF

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Publication number
CN112272674A
CN112272674A CN201980019232.2A CN201980019232A CN112272674A CN 112272674 A CN112272674 A CN 112272674A CN 201980019232 A CN201980019232 A CN 201980019232A CN 112272674 A CN112272674 A CN 112272674A
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amino acid
acid sequence
antibody
seq
sequence seq
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Pending
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CN201980019232.2A
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English (en)
Chinese (zh)
Inventor
C·托马
S·J·帕杜拉
J·拉玛
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201980019232.2A 2018-03-14 2019-03-08 抗-il-36r抗体用于治疗泛发性脓疱性银屑病的用途 Pending CN112272674A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862642641P 2018-03-14 2018-03-14
US62/642,641 2018-03-14
US201862683720P 2018-06-12 2018-06-12
US62/683,720 2018-06-12
US201862699274P 2018-07-17 2018-07-17
US62/699,274 2018-07-17
US201862729518P 2018-09-11 2018-09-11
US62/729,518 2018-09-11
PCT/US2019/021335 WO2019177888A1 (en) 2018-03-14 2019-03-08 Use of anti-il-36r antibodies for treatment of generalized pustular psoriasis

Publications (1)

Publication Number Publication Date
CN112272674A true CN112272674A (zh) 2021-01-26

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Family Applications (1)

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CN201980019232.2A Pending CN112272674A (zh) 2018-03-14 2019-03-08 抗-il-36r抗体用于治疗泛发性脓疱性银屑病的用途

Country Status (13)

Country Link
US (2) US20190284285A1 (https=)
EP (1) EP3765513A1 (https=)
JP (2) JP7404256B2 (https=)
KR (1) KR102768040B1 (https=)
CN (1) CN112272674A (https=)
AU (1) AU2019236105B2 (https=)
BR (1) BR112020016738A2 (https=)
CA (1) CA3093692A1 (https=)
CL (1) CL2020002342A1 (https=)
IL (1) IL277215B2 (https=)
MX (1) MX2020009544A (https=)
PH (1) PH12020551444A1 (https=)
WO (1) WO2019177888A1 (https=)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
WO2022166977A1 (zh) * 2021-02-08 2022-08-11 上海普铭生物科技有限公司 抗人il-36r抗体及其应用
WO2022257545A1 (zh) * 2021-06-07 2022-12-15 武汉生物制品研究所有限责任公司 一种抗SARS-CoV-2的重组全人源单克隆抗体的液体制剂

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MX2021000566A (es) 2018-07-16 2021-06-23 Regeneron Pharma Anticuerpos anti-il36r.
EP3902604A1 (en) * 2018-12-27 2021-11-03 Boehringer Ingelheim International GmbH Anti-il-36r antibodies for treatment of palmoplantar pustulosis
BR112021016198A2 (pt) * 2019-03-08 2021-11-03 Boehringer Ingelheim Int Formulações de anticorpo anti-il-36r
EP4182022A1 (en) * 2020-07-17 2023-05-24 Boehringer Ingelheim International GmbH Anti-il-36r antibodies for the treatment of neutrophilic dermatoses
WO2022026829A1 (en) * 2020-07-30 2022-02-03 Anaptysbio, Inc. Anti-interleukin 36 receptor (il-36r) therapy for skin toxicity
JP2023536851A (ja) * 2020-07-30 2023-08-30 アナプティスバイオ インコーポレイティッド 魚鱗癬のための抗インターロイキン３６受容体（ｉｌ－３６ｒ）療法
CN121324515A (zh) * 2020-09-16 2026-01-13 上海市皮肤病医院 基于代谢组学的泛发性脓疱型银屑病诊断标志物及其应用
US20220119538A1 (en) * 2020-09-30 2022-04-21 Boehringer Ingelheim International Gmbh Anti-il-36r antibodies for treatment of chronic inflammatory pain
CA3209006A1 (en) * 2021-03-04 2022-09-09 Boehringer Ingelheim International Gmbh Methods for the treatment of gpp
WO2022192531A2 (en) * 2021-03-12 2022-09-15 Boehringer Ingelheim International Gmbh Biomarkers associated with anti-il-36r antibody treatment in generalized pustular psoriasis
CA3218343A1 (en) * 2021-05-12 2022-11-17 Anaptysbio, Inc. Antibody composition
CN115327130A (zh) * 2022-07-25 2022-11-11 深圳市妇幼保健院 一种免疫生物标志物在制备小儿脓毒血症诊断试剂盒中的应用
CN115724975A (zh) * 2022-10-20 2023-03-03 江苏荃信生物医药股份有限公司 抗人白介素36受体单克隆抗体及其应用

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
WO2022166977A1 (zh) * 2021-02-08 2022-08-11 上海普铭生物科技有限公司 抗人il-36r抗体及其应用
WO2022257545A1 (zh) * 2021-06-07 2022-12-15 武汉生物制品研究所有限责任公司 一种抗SARS-CoV-2的重组全人源单克隆抗体的液体制剂

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IL277215A (en) 2020-10-29
IL277215B1 (en) 2025-06-01
CL2020002342A1 (es) 2020-12-18
BR112020016738A2 (pt) 2020-12-15
AU2019236105B2 (en) 2025-07-31
JP2021517566A (ja) 2021-07-26
JP2024028951A (ja) 2024-03-05
AU2019236105A1 (en) 2020-08-27
WO2019177888A1 (en) 2019-09-19
IL277215B2 (en) 2025-10-01
CA3093692A1 (en) 2019-09-19
PH12020551444A1 (en) 2021-08-23
JP7404256B2 (ja) 2023-12-25
KR20200131871A (ko) 2020-11-24
US12503512B2 (en) 2025-12-23
US20190284285A1 (en) 2019-09-19
MX2020009544A (es) 2020-10-05
EP3765513A1 (en) 2021-01-20
US20210087285A1 (en) 2021-03-25
JP7673168B2 (ja) 2025-05-08
KR102768040B1 (ko) 2025-02-17

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