CN112204014A - 钙蛋白酶调节剂及其治疗用途 - Google Patents

钙蛋白酶调节剂及其治疗用途 Download PDF

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Publication number
CN112204014A
CN112204014A CN201980035887.9A CN201980035887A CN112204014A CN 112204014 A CN112204014 A CN 112204014A CN 201980035887 A CN201980035887 A CN 201980035887A CN 112204014 A CN112204014 A CN 112204014A
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nhc
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布拉德·欧文·巴克曼
袁沈东
库马拉斯瓦米·艾玛研
马克·阿德勒
普拉巴·易卜拉欣
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Blade Therapeutics Inc
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Blade Therapeutics Inc
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201980035887.9A 2018-03-28 2019-03-21 钙蛋白酶调节剂及其治疗用途 Pending CN112204014A (zh)

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US201862649451P 2018-03-28 2018-03-28
US62/649,451 2018-03-28
PCT/US2019/023457 WO2019190885A1 (en) 2018-03-28 2019-03-21 Calpain modulators and therapeutic uses thereof

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EP3481835A4 (en) 2016-07-05 2020-02-26 Blade Therapeutics, Inc. CALPAIN MODULATORS AND THERAPEUTIC USE THEREOF
BR112019006110A2 (pt) 2016-09-28 2019-09-10 Blade Therapeutics Inc moduladores de calpaína e usos terapêuticos dos mesmos
KR20200139721A (ko) * 2018-03-28 2020-12-14 블레이드 테라퓨틱스, 인크. 섬유성 질환을 치료하는 방법
WO2020006294A1 (en) * 2018-06-28 2020-01-02 Blade Therapeutics, Inc. Methods of treating liver fibrosis using calpain inhibitors
PH12022553378A1 (en) 2020-06-10 2024-03-25 Univ Leuven Kath Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
JP2024525589A (ja) 2021-07-09 2024-07-12 アリゴス セラピューティクス インコーポレイテッド 抗ウイルス化合物
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections

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