CN112189020A - 包含微管蛋白破坏剂的抗体药物缀合物用于治疗实体瘤的用途 - Google Patents
包含微管蛋白破坏剂的抗体药物缀合物用于治疗实体瘤的用途 Download PDFInfo
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- CN112189020A CN112189020A CN201980033040.7A CN201980033040A CN112189020A CN 112189020 A CN112189020 A CN 112189020A CN 201980033040 A CN201980033040 A CN 201980033040A CN 112189020 A CN112189020 A CN 112189020A
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3084—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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| US62/658,276 | 2018-04-16 | ||
| PCT/US2019/023516 WO2019183438A1 (en) | 2018-03-23 | 2019-03-22 | Use of antibody drug conjugates comprising tubulin disrupting agents to treat solid tumor |
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| JP (2) | JP2021518397A (https=) |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024179453A1 (zh) * | 2023-02-27 | 2024-09-06 | 石药集团巨石生物制药有限公司 | 重组人源化抗Nectin-4单抗-MMAE偶联药物的药物组合物 |
| WO2025185617A1 (en) * | 2024-03-05 | 2025-09-12 | Hutchmed Limited | Linker, antibody-drug conjugate and use thereof |
| CN120713867A (zh) * | 2025-08-20 | 2025-09-30 | 中国人民解放军西部战区总医院 | 一种微管蛋白破坏剂二聚体与铜死亡药物联用的纳米颗粒、其制备方法及用途 |
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| CN121422247A (zh) * | 2020-05-03 | 2026-01-30 | 乐普生物科技股份有限公司 | 抗体药物偶联物及其制剂 |
| PH12022553333A1 (en) * | 2020-06-19 | 2023-10-16 | Agensys Inc | Markers for use in methods for treating cancers with antibody drug conjugates (adc) |
| MX2023003404A (es) * | 2020-09-28 | 2023-03-31 | Seagen Inc | Anticuerpos anti-l1vi humanizados para el tratamiento del cancer. |
| AU2022238571A1 (en) | 2021-03-18 | 2023-09-14 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| IL312110A (en) | 2021-10-29 | 2024-06-01 | Seagen Inc | Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-cd30 antibody-drug conjugate |
| JP2026508672A (ja) * | 2023-03-17 | 2026-03-11 | ザイダス・ライフサイエンシーズ・リミテッド | ダラツムマブ薬物コンジュゲートおよびその調製 |
| EP4727971A1 (en) | 2023-06-13 | 2026-04-22 | Adcentrx Therapeutics Inc. | Methods and compositions related to antibodies and antibody drug conjugates (adcs) that bind nectin-4 proteins |
| WO2025264533A1 (en) | 2024-06-17 | 2025-12-26 | Adcentrx Therapeutics Inc. | Methods and compositions related to antibody drug conjugates (adcs) that bind steap-1 proteins |
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- 2019-03-22 JP JP2020550674A patent/JP2021518397A/ja active Pending
- 2019-03-22 MX MX2020009842A patent/MX2020009842A/es unknown
- 2019-03-22 AU AU2019240403A patent/AU2019240403A1/en not_active Abandoned
- 2019-03-22 KR KR1020207030320A patent/KR20200135841A/ko not_active Ceased
- 2019-03-22 EP EP19715720.9A patent/EP3768714A1/en active Pending
- 2019-03-22 WO PCT/US2019/023516 patent/WO2019183438A1/en not_active Ceased
- 2019-03-22 SG SG11202009264WA patent/SG11202009264WA/en unknown
- 2019-03-22 CN CN201980033040.7A patent/CN112189020A/zh active Pending
- 2019-03-22 US US16/362,125 patent/US20190290775A1/en not_active Abandoned
- 2019-03-22 BR BR112020018948-0A patent/BR112020018948A2/pt not_active Application Discontinuation
- 2019-03-22 MA MA052135A patent/MA52135A/fr unknown
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2020
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2022
- 2022-07-21 US US17/870,749 patent/US20230110128A1/en not_active Abandoned
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024179453A1 (zh) * | 2023-02-27 | 2024-09-06 | 石药集团巨石生物制药有限公司 | 重组人源化抗Nectin-4单抗-MMAE偶联药物的药物组合物 |
| WO2025185617A1 (en) * | 2024-03-05 | 2025-09-12 | Hutchmed Limited | Linker, antibody-drug conjugate and use thereof |
| CN120713867A (zh) * | 2025-08-20 | 2025-09-30 | 中国人民解放军西部战区总医院 | 一种微管蛋白破坏剂二聚体与铜死亡药物联用的纳米颗粒、其制备方法及用途 |
Also Published As
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| JP2024075771A (ja) | 2024-06-04 |
| BR112020018948A2 (pt) | 2021-01-05 |
| CA3093731A1 (en) | 2019-09-26 |
| US20190290775A1 (en) | 2019-09-26 |
| US20230110128A1 (en) | 2023-04-13 |
| SG11202009264WA (en) | 2020-10-29 |
| JP2021518397A (ja) | 2021-08-02 |
| MX2020009842A (es) | 2020-10-15 |
| WO2019183438A1 (en) | 2019-09-26 |
| EP3768714A1 (en) | 2021-01-27 |
| MA52135A (fr) | 2021-01-27 |
| AU2019240403A1 (en) | 2020-10-08 |
| TW202003047A (zh) | 2020-01-16 |
| IL277338A (en) | 2020-10-29 |
| KR20200135841A (ko) | 2020-12-03 |
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