CA3093731A1 - Use of antibody drug conjugates comprising tubulin disrupting agents to treat solid tumor - Google Patents

Use of antibody drug conjugates comprising tubulin disrupting agents to treat solid tumor Download PDF

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Publication number
CA3093731A1
CA3093731A1 CA3093731A CA3093731A CA3093731A1 CA 3093731 A1 CA3093731 A1 CA 3093731A1 CA 3093731 A CA3093731 A CA 3093731A CA 3093731 A CA3093731 A CA 3093731A CA 3093731 A1 CA3093731 A1 CA 3093731A1
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Prior art keywords
antibody
cancer
mmae
carcinoma
linker
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CA3093731A
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English (en)
French (fr)
Inventor
Anthony Toa Cao
Shyra Jane Gardai
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Seagen Inc
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Seattle Genetics Inc
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Publication of CA3093731A1 publication Critical patent/CA3093731A1/en
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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