CN112074297B - 结合pd-1的抗体及其用途 - Google Patents
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- CN112074297B CN112074297B CN201980021731.5A CN201980021731A CN112074297B CN 112074297 B CN112074297 B CN 112074297B CN 201980021731 A CN201980021731 A CN 201980021731A CN 112074297 B CN112074297 B CN 112074297B
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- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16621—Viruses as such, e.g. new isolates, mutants or their genomic sequences
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
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- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Profile步骤 | 温度 | 变温速度 | 保持时间 |
初始保持 | 25℃ | NA | 30s |
熔解曲线 | 25-99℃ | 0.1℃/s | NA |
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US62/657,927 | 2018-04-15 | ||
PCT/US2019/027115 WO2019204132A1 (en) | 2018-04-15 | 2019-04-12 | Antibodies binding pd-1 and uses thereof |
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CN (2) | CN112074297B (zh) |
AU (2) | AU2019255515B2 (zh) |
CA (1) | CA3096460A1 (zh) |
IL (1) | IL277969A (zh) |
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KR20230060531A (ko) * | 2020-08-31 | 2023-05-04 | 바이오션, 인코포레이티드 | Pd-1에 결합하는 항체 및 이의 용도 |
CA3206253A1 (en) * | 2021-02-04 | 2022-08-11 | Heung Rok Park | Anti-pd-1 antibody and use thereof |
CN113134090B (zh) * | 2021-03-26 | 2022-05-17 | 武汉大学中南医院 | 一种抗肿瘤药物组合物 |
CN115960233B (zh) * | 2022-10-19 | 2023-09-22 | 四川大学 | 一种抗cd22的纳米抗体及其制备方法和应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101213297A (zh) * | 2005-05-09 | 2008-07-02 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及单独使用或与其它免疫治疗剂联合使用抗pd-1抗体来治疗癌症的方法 |
CN104356236A (zh) * | 2005-07-01 | 2015-02-18 | 梅达雷克斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
WO2018053709A1 (en) * | 2016-09-21 | 2018-03-29 | Wuxi Biologics (Shanghai) Co., Ltd. | The novel monoclonal antibodies to programmed death 1 (pd-1) |
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GB201120527D0 (en) | 2011-11-29 | 2012-01-11 | Ucl Business Plc | Method |
CN103864932B (zh) | 2012-12-14 | 2015-11-25 | 苏州思坦维生物技术有限责任公司 | 拮抗抑制血管内皮细胞生长因子与其受体结合的单克隆抗体及其编码序列与用途 |
CA2910278C (en) | 2013-05-02 | 2021-09-28 | Anaptysbio, Inc. | Antibodies directed against programmed death-1 (pd-1) |
BR112015027706A2 (pt) | 2013-05-02 | 2017-08-29 | Melior Tech Inc | Métodos isento de solvente para a preparação de um material cerâmico, para a preparação de um material cerâmico puro, e de síntese de um material sólido na ausência de solvente e material, produto e composição sólidos isentos de solventes |
TWI680138B (zh) * | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
CA2955788C (en) * | 2014-07-22 | 2024-01-16 | Ziyong Sun | Anti-pd-1 antibodies |
TWI701435B (zh) | 2014-09-26 | 2020-08-11 | 日商中外製藥股份有限公司 | 測定fviii的反應性之方法 |
MA41044A (fr) * | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
TWI595006B (zh) * | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗pd-1抗體類和使用彼等之方法 |
KR102685020B1 (ko) * | 2015-09-29 | 2024-07-16 | 상하이 장지앙 바이오테크놀로지 컴퍼니 리미티드 | Pd-1 항체 및 그의 용도 |
SG11201811600PA (en) | 2016-06-30 | 2019-01-30 | Oncorus Inc | Pseudotyped oncolytic viral delivery of therapeutic polypeptides |
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2019
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101213297A (zh) * | 2005-05-09 | 2008-07-02 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及单独使用或与其它免疫治疗剂联合使用抗pd-1抗体来治疗癌症的方法 |
CN104356236A (zh) * | 2005-07-01 | 2015-02-18 | 梅达雷克斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
WO2018053709A1 (en) * | 2016-09-21 | 2018-03-29 | Wuxi Biologics (Shanghai) Co., Ltd. | The novel monoclonal antibodies to programmed death 1 (pd-1) |
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NZ769571A (en) | 2024-04-26 |
KR102673591B1 (ko) | 2024-06-07 |
KR102558418B1 (ko) | 2023-07-24 |
KR20230110841A (ko) | 2023-07-25 |
JP7054573B2 (ja) | 2022-04-14 |
CN112074297A (zh) | 2020-12-11 |
US20240270850A1 (en) | 2024-08-15 |
US12037395B1 (en) | 2024-07-16 |
JP2021520416A (ja) | 2021-08-19 |
WO2019204132A1 (en) | 2019-10-24 |
JP7493254B2 (ja) | 2024-05-31 |
KR20210014624A (ko) | 2021-02-09 |
AU2023204192A1 (en) | 2023-08-03 |
CN117568287A (zh) | 2024-02-20 |
EP3781202A4 (en) | 2022-01-05 |
EP3781202A1 (en) | 2021-02-24 |
IL277969A (en) | 2020-11-30 |
CA3096460A1 (en) | 2019-10-24 |
JP2022101558A (ja) | 2022-07-06 |
AU2019255515B2 (en) | 2023-04-06 |
AU2019255515A1 (en) | 2020-11-26 |
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